1. TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients
- Author
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Teresa Collazo Mesa, Yaíma Zúñiga Rosales, Yadira Hernández Pérez, Estela Morales Peralta, Elvia Nelmi Santos González, Hilda Roblejo Balbuena, Beatriz Marcheco Teruel, and María de los Ángeles González Torres
- Subjects
Medicine (General) ,congenital, hereditary, and neonatal diseases and abnormalities ,Genetic polymorphism ,TaqI POLYMORPHISM ,Coronavirus disease 2019 (COVID-19) ,business.industry ,COVID-19 ,Cuba ,QH426-470 ,Calcitriol receptor ,R5-920 ,Medicine public health ,Correspondence ,Immunology ,Genotype ,Genetics ,Medicine ,Vitamin D ,business ,Gene ,Alleles ,Genetics (clinical) ,Receptor - Abstract
Purpose To determine the relationship between the genotypes of the TaqI polymorphism of VDR gene and the clinical forms of COVID-19 in Cuban patients. Methods TaqI polymorphism was determined by the PCR in 104 Cuban patients, who suffered different clinical forms of COVID-19. Results There was a greater possibility of presenting symptomatic forms [OR = 2.081, 95% CI: 0.243–17.842], even severe [OR = 1.200, 95% CI: 0.217–6.638], related to the tt genotype. Conclusion There are signs of association between the risk of developing COVID-19 and the genotypes of the TaqI polymorphism of the VDR gene in the studied Cuban patients.
- Published
- 2021
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