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4 results on '"Rosetti, Beatrice"'

1. Supramolecular Hydrogels from a Tripeptide and Carbon Nano-Onions for Biological Applications.

Author

Marin, Davide, Bartkowski, Michał, Kralj, Slavko, Rosetti, Beatrice, D'Andrea, Paola, Adorinni, Simone, Marchesan, Silvia, and Giordani, Silvia

Subjects
HYDROGELS, CARBON, SUPRAMOLECULAR chemistry, TRIPEPTIDES, CYTOCOMPATIBILITY
Abstract

Nanocomposite hydrogels have attracted researchers' attention in recent years to achieve superior performances in a variety of materials applications. In this work, we describe the outcome of three different strategies to combine a self-assembling tripeptide and carbon nano-onions (CNOs), through covalent and non-covalent approaches, into supramolecular and nanostructured hydrogels. Importantly, the tripeptide coated the nano-onions and extended their aqueous dispersions' stability by several hours. Furthermore, CNOs could be loaded in the tripeptide hydrogels at the highest level ever reported for nanocarbons, indicating high compatibility between the components. The materials were formed in phosphate-buffered solutions, thus paving the way for biological applications, and were characterized by several spectroscopic, microscopic, thermogravimetric, and rheological techniques. In vitro experiments demonstrated excellent cytocompatibility. [ABSTRACT FROM AUTHOR]

Published
2023
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2. Self-Assembly of Homo- and Hetero-Chiral Cyclodipeptides into Supramolecular Polymers towards Antimicrobial Gels.

Author

Rosetti, Beatrice, Scarel, Erica, Colomina-Alfaro, Laura, Adorinni, Simone, Pierri, Giovanni, Bellotto, Ottavia, Mamprin, Kevin, Polentarutti, Maurizio, Bandiera, Antonella, Tedesco, Consiglia, and Marchesan, Silvia

Subjects
*ANTIMICROBIAL polymers, *POLYMER colloids, *SUPRAMOLECULAR polymers, *INTERMOLECULAR interactions, *DIKETOPIPERAZINES, *DRUG resistance in microorganisms
Abstract

There is an increasing interest towards the development of new antimicrobial coatings, especially in light of the emergence of antimicrobial resistance (AMR) towards common antibiotics. Cyclodipeptides (CDPs) or diketopiperazines (DKPs) are attractive candidates for their ability to self-assemble into supramolecular polymers and yield gel coatings that do not persist in the environment. In this work, we compare the antimicrobial cyclo(Leu-Phe) with its heterochiral analogs cyclo(D-Leu-L-Phe) and cyclo(L-Leu-D-Phe), as well as cyclo(L-Phe-D-Phe), for their ability to gel. The compounds were synthesized, purified by HPLC, and characterized by 1H-NMR, 13C-NMR, and ESI-MS. Single-crystal X-ray diffraction (XRD) revealed details of the intermolecular interactions within the supramolecular polymers. The DKPs were then tested for their cytocompatibility on fibroblast cells and for their antimicrobial activity on S. aureus. Overall, DKPs displayed good cytocompatibility and very mild antimicrobial activity, which requires improvement towards applications. [ABSTRACT FROM AUTHOR]

Published
2022
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3. Supramolecular Hydrogels from a Tripeptide and Carbon Nano-Onions for Biological Applications

Author

Davide Marin, Michał Bartkowski, Slavko Kralj, Beatrice Rosetti, Paola D’Andrea, Simone Adorinni, Silvia Marchesan, Silvia Giordani, Marin, Davide, Bartkowski, Michał, Kralj, Slavko, Rosetti, Beatrice, D'Andrea, Paola, Adorinni, Simone, Marchesan, Silvia, and Giordani, Silvia

Subjects
gel, D-amino acid, nanocomposite, hydrogelation, carbon nanomaterial, General Chemical Engineering, biomaterial, self-assembly, D-amino acids, biomaterials, carbon nano-onions, carbon nanomaterials, gels, nanocomposites, peptides, supramolecular chemistry, peptide, carbon nano-onion, General Materials Science
Abstract

Nanocomposite hydrogels have attracted researchers’ attention in recent years to achieve superior performances in a variety of materials applications. In this work, we describe the outcome of three different strategies to combine a self-assembling tripeptide and carbon nano-onions (CNOs), through covalent and non-covalent approaches, into supramolecular and nanostructured hydrogels. Importantly, the tripeptide coated the nano-onions and extended their aqueous dispersions’ stability by several hours. Furthermore, CNOs could be loaded in the tripeptide hydrogels at the highest level ever reported for nanocarbons, indicating high compatibility between the components. The materials were formed in phosphate-buffered solutions, thus paving the way for biological applications, and were characterized by several spectroscopic, microscopic, thermogravimetric, and rheological techniques. In vitro experiments demonstrated excellent cytocompatibility.

Published
2023

4. Self-Assembly of Homo- and Hetero-Chiral Cyclodipeptides into Supramolecular Polymers towards Antimicrobial Gels

Author

Beatrice Rosetti, Erica Scarel, Laura Colomina-Alfaro, Simone Adorinni, Giovanni Pierri, Ottavia Bellotto, Kevin Mamprin, Maurizio Polentarutti, Antonella Bandiera, Consiglia Tedesco, Silvia Marchesan, Rosetti, Beatrice, Scarel, Erica, Colomina-Alfaro, Laura, Adorinni, Simone, Pierri, Giovanni, Bellotto, Ottavia, Mamprin, Kevin, Polentarutti, Maurizio, Bandiera, Antonella, Tedesco, Consiglia, and Marchesan, Silvia

Subjects
gel, cyclo(Phe-Phe), D-amino acid, Polymers and Plastics, diketopiperazine, chirality, General Chemistry, self-assembly, gels, D-amino acids, antimicrobial, cyclo(Leu-Phe), cyclodipeptides, diketopiperazines, peptides, D<%2Fspan>-amino+acids%22">D-amino acids, cyclodipeptide
Abstract

There is an increasing interest towards the development of new antimicrobial coatings, especially in light of the emergence of antimicrobial resistance (AMR) towards common antibiotics. Cyclodipeptides (CDPs) or diketopiperazines (DKPs) are attractive candidates for their ability to self-assemble into supramolecular polymers and yield gel coatings that do not persist in the environment. In this work, we compare the antimicrobial cyclo(Leu-Phe) with its heterochiral analogs cyclo(D-Leu-L-Phe) and cyclo(L-Leu-D-Phe), as well as cyclo(L-Phe-D-Phe), for their ability to gel. The compounds were synthesized, purified by HPLC, and characterized by 1H-NMR, 13C-NMR, and ESI-MS. Single-crystal X-ray diffraction (XRD) revealed details of the intermolecular interactions within the supramolecular polymers. The DKPs were then tested for their cytocompatibility on fibroblast cells and for their antimicrobial activity on S. aureus. Overall, DKPs displayed good cytocompatibility and very mild antimicrobial activity, which requires improvement towards applications.

Published
2022
Full Text
View/download PDF

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