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Copyright of Journal of Harran University Medical Faculty / Harran Üniversitesi Tıp Fakültesi Dergisi is the property of Harran University Medical Faculty and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To assess and compare alterations in the morphology and function of platelets occurring in gestational diabetes and healthy pregnancies. Material and Methods: A retrospective study was performed of 77 pregnant women: 42 cases with gestational diabetes and 35 healthy controls. The two groups were compared in terms of demographics and platelet parameters derived from complete blood counts. Results: The mean platelet volume (p=0.001) and HbA1c (p<0.001) were significantly increased in the patients with gestational diabetes. The mean platelet volume was well correlated with the platelet distribution width (rs=0.404, p<0.001) and the platelet count (rs=0.355, p=0.002) Conclusion: The mean platelet volume and other platelet parameters may significantly aid the identification of diabetic pregnants at risk for vascular complications. The role and possible clinical relevance of these changes during diabetic pregnancy need to be investigated in further studies. [ABSTRACT FROM AUTHOR]

Objective: In the present study, we investigated the demographic, clinical, laboratory, birth information, treatment method and maternal-fetal outcomes of pregnant patients who were diagnosed with chronic immune thrombocytopenic purpura. Methods: Hospital records of 24 women with the diagnosis of chronic immune thrombocytopenic purpura and their 26 pregnancies in the obstetrics department were retrospectively analyzed. Results: All the patients had immune trobositopenik purpura diagnosed before pregnancy. The mean age of the cases was 29.50±7.03 years (17-42), mean parity was 2.88±2.86 (0-10), mean gestational age was 36.00±3.40 weeks (27-39), respectively. The cases were admitted to our clinic with causes including the beginning of birth pains (65%), preterm labor (15%), premature rupture of membranes (4%), mort fetus (4%), headache (4%), abruptio placentae (4%), gestational hypertension (4%) and intrauterine growth restriction (4%). Although 15 (57.6%) patients were treated prednisolone during pregnancy, others did not receive any treatment. The mean platelet counts of patients before and after delivery were 62,226±38.04/mm3 and 70,061±22.93/mm3, respectively. Ten cases (40%) with the mean platelet counts 28,240/mm3 received treatments containing platelet apheresis, fresh frozen plasma, random platelets or combined treatments in order to increase the platelet count. Eleven cases (42%) were born vaginally and 15 (58%) by cesarean. The birth with cesarean section was performed according to obstetric causes in fourteen cases (93%). None of the patients experienced postpartum complications. The mean platelet count of newborn babies was 201,521±95.46/mm3 (range, 35,900-446,000) and none of them experienced hemorrhagic complication. Conclusion: Although women with immune thrombocytopenic purpura carry the risk in pregnancy, birth and after birth, maternal and fetal outcomes are better than expected by appropriate treatment. Decision regarding the form of birth can be made according to obstetric causes in these patients. [ABSTRACT FROM AUTHOR]

Objective: We aimed to retrospectively analyze the cases of partial and complete hydatidiform mole in our clinic. Methods: In the present study, hospital records of 89 patients with gestational trophoblastic disease between January 2015 and January 2018 was obtained and evaluated, retrospectively. A total of 89 patients' records were examined. Patients were divided into two groups; 76 patients with complete molar and 13 patients with partial molar pregnancies. Age, gravida, parity, abortus, blood groups, β-HCG, ß-HCG values before vacuum curettage, serum thyroid stimulating hormone (TSH), free thyroxine (T4) and free triiodothyronine (T3) values, and histopathological findings of the patients were recorded from the existing records. Results: The total number of births was 3,927 between January 2015 and January 2018. The incidence of gestational trophoblastic disease was 22.6/1000 births. When the age distribution of the women included in the study was examined; the mean age was found as 29.55 ± 9.79 years. In the study, the mean values of beta HCG were 229082 ± 354929.69 mIU / ml and 258017.47±379942 mIU/ml in patients diagnosed with partial mole and complete mole, respectively. There was no statistically significant difference between the two groups in terms of beta HCG values (p = 0.784). When thyroid function tests of the cases were examined, it was found that 13.4% (12) had hyperthyroidism. In accordance with the histopathological results vacuum-curettage materials of the patients, it was observed that 85.4% (76) of the cases were complete mole and 14.6% (13) were partial mole. Conclusion: Thyroid function tests were influenced in view of examinations and treatments in molar pregnancy cases. In these cases, it is required to evaluate thyroid function tests before anesthesia. Patients should be informed about performing β-hCG follow-ups after curettage and it should be explained that if there is no follow-up, life risk may occur. [ABSTRACT FROM AUTHOR]