1. Significance of salicylate intolerance in diseases of the lower gastrointestinal tract.
- Author
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Raithel M, Baenkler HW, Naegel A, Buchwald F, Schultis HW, Backhaus B, Kimpel S, Koch H, Mach K, Hahn EG, and Konturek PC
- Subjects
- Aspirin adverse effects, Colitis, Ulcerative diagnosis, Colitis, Ulcerative drug therapy, Crohn Disease diagnosis, Crohn Disease drug therapy, Diet, Drug Hypersensitivity etiology, Drug Hypersensitivity physiopathology, Food Hypersensitivity diagnosis, Food Hypersensitivity drug therapy, Gastrointestinal Diseases diagnosis, Gastrointestinal Diseases etiology, Humans, Irritable Bowel Syndrome diagnosis, Irritable Bowel Syndrome drug therapy, Malabsorption Syndromes diagnosis, Malabsorption Syndromes drug therapy, Mesalamine adverse effects, Anti-Inflammatory Agents, Non-Steroidal adverse effects, Drug Hypersensitivity epidemiology, Gastrointestinal Diseases drug therapy, Lower Gastrointestinal Tract drug effects, Salicylates adverse effects
- Abstract
Salicylate intolerance is defined as a nonspecific antigen-induced pseudo-allergic hypersensitivity reaction which can occur upon contact of an organism with salicylic acid, its derivatives or other related organic or inorganic acids of similar chemical structure. Since the effects of nonsteroidal anti-inflammatory drugs (NSAID) intolerance are by no means always severe or life-endangering but may just as well present as oligosymptomatic or local disorders (e.g. abdominal pain, diarrhea, we decided to evaluate the characteristics of patients with salicylate intolerance on the basis of gastroenterological case material of Medical Department I of Erlangen University. On the basis of the findings from the Erlangen interdisciplinary data register of chronic inflammatory gastrointestinal disease, the signs and symptoms of NSAID intolerance were found to constitute a diagnosis of great practical import to clinical medicine (allergology, dermatology, immunology, other disorders etc.) including gastroenterology. For approx. 2-7% of all patients with inflammatory bowel syndrome and food allergies this poses a new diagnostic and therapeutic challenge which may concern physicians from any of the disciplines involved. When presented with patients with chronic active disease who are suffering from these symptoms one should, therefore, in future give greater thought to the possibility of salicylate intolerance, all the more as there are meaningful dietetic, diagnostic and therapeutic options available for these persons.
- Published
- 2005