Search

Your search keyword '"Vanuytsel, T."' showing total 13 results
Start Over Author "Vanuytsel, T." Topic gastroenterology
13 results on '"Vanuytsel, T."'

1. Worldwide prevalence and burden of gastroparesis-like symptoms as defined by the United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on gastroparesis.

Author

Huang IH, Schol J, Khatun R, Carbone F, Van den Houte K, Colomier E, Balsiger LM, Törnblom H, Vanuytsel T, Sundelin E, Simrén M, Palsson OS, Bangdiwala SI, Sperber AD, and Tack J

Subjects
Consensus, Humans, Nausea diagnosis, Nausea epidemiology, Nausea etiology, Prevalence, Quality of Life, Vomiting diagnosis, Vomiting epidemiology, Vomiting etiology, Cannabinoids, Dyspepsia, Gastroenterology, Gastroparesis complications, Gastroparesis diagnosis, Gastroparesis epidemiology
Abstract

Background/objectives: The global epidemiology of gastroparesis is unknown. The European UEG and European Society for Neurogastroenterology and motility consensus defines Gastroparesis as a condition characterized by delayed gastric emptying in the absence of mechanical obstruction, with a symptom pattern of nausea and/or vomiting and overlapping postprandial distress syndrome (PDS). Real-world evidence of this gastroparesis-like symptom pattern is a crucial step in understanding the epidemiology of gastroparesis., Methods: In the Rome Foundation Global Epidemiology Study, 54,127 respondents from 26 countries completed the Rome IV Diagnostic Questionnaire and variables associated with disorders of gut-brain interaction via Internet. We selected subjects with gastroparesis-like symptoms (GPLS) (nausea and/or vomiting ≥1 day/week and simultaneous PDS). Patients reporting organic gastrointestinal disease, or fulfilling criteria for self-induced vomiting, cyclic vomiting or cannabinoid hyperemesis syndrome were excluded. We determined prevalence, associated comorbidities, quality of life (QoL) (PROMIS Global-10), symptoms of anxiety and depression (PHQ-4), somatic symptoms (PHQ-12), and healthcare utilization., Results: The global prevalence of GPLS was 0.9% overall and 1.3% among diabetic individuals. Subjects with GPLS showed frequent overlapping of epigastric pain syndrome and irritable bowel syndrome. Subjects with GPLS had significantly lower body mass index, QoL, more non-gastrointestinal somatic complaints, symptoms of anxiety and depression, higher medication usage and doctor visits in the overall and diabetic population, compared to subjects without these symptoms., Conclusions: GPLS are common worldwide and more common in diabetic patients. The symptom complex is associated with multiple aspects of illness and an increased healthcare consumption., (© 2022 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC. on behalf of United European Gastroenterology.)

Published
2022
Full Text
View/download PDF

4. A survey on the impact of the COVID-19 pandemic on motility and functional investigations in Europe and considerations for recommencing activities in the early recovery phase.

Author

Tack J, Schol J, Geeraerts A, Huang IH, Mori H, Scarpellini E, Sinonquel P, Carbone F, Colomier E, Geysen H, Jandee S, Moonen A, Pannemans J, Timmermans L, Van den Houte K, Verbeure W, Wauters L, Bisschops R, Hoffman I, Roelandt P, Rommel N, Simren M, Suzuki H, Tornblom H, Verbeke K, and Vanuytsel T

Subjects
COVID-19, Coronavirus Infections prevention & control, Europe epidemiology, Gastroenterology standards, Health Personnel standards, Humans, Patient Care methods, Patient Care standards, Pneumonia, Viral prevention & control, Practice Guidelines as Topic standards, Protective Clothing standards, SARS-CoV-2, Surveys and Questionnaires, Betacoronavirus, Coronavirus Infections epidemiology, Gastroenterology methods, Gastrointestinal Motility physiology, Pandemics prevention & control, Pneumonia, Viral epidemiology, Recovery of Function physiology
Abstract

Background: The COVID-19 pandemic, declared by WHO on March 13, 2020, had a major global impact on the healthcare system and services. In the acute phase, the presence of the SARS-CoV-2 virus in the aerodigestive tract limited activities in the gastroenterology clinic and procedures to emergencies only. Motility and function testing was interrupted and as we enter the recovery phase, restarting these procedures requires a safety-focused approach with adequate infection prevention for patients and healthcare professionals., Methods: We summarized knowledge on the presence of the SARS-CoV-2 virus in the aerodigestive tract and the risk of spread with motility and functional testing. We surveyed 39 European centers documenting how the pandemic affected activities and which measures they are considering for restarting these measurements. We propose recommendations based on current knowledge as applied in our center., Results: Positioning of catheters for gastrointestinal motility tests carries a concern for aerosol-borne infection of healthcare workers. The risk is low with breath tests. The surveyed centers stopped almost all motility and function tests from the second half of March. The speed of restarting and the safety measures taken varied highly., Conclusions and Inferences: Based on these findings, we provided recommendations and practical relevant information for motility and function test procedures in the COVID-19 pandemic era, to guarantee a high-quality patient care with adequate infection prevention., (© 2020 John Wiley & Sons Ltd.)

Published
2020
Full Text
View/download PDF

5. European Society for Neurogastroenterology and Motility recommendations for conducting gastrointestinal motility and function testing in the recovery phase of the COVID-19 pandemic.

Author

Tack J, Vanuytsel T, Serra J, Accarino A, Stanghellini V, and Barbara G

Subjects
COVID-19, Coronavirus Infections diagnosis, Coronavirus Infections therapy, Europe epidemiology, Expert Testimony methods, Expert Testimony standards, Health Personnel standards, Humans, Pandemics prevention & control, Pneumonia, Viral diagnosis, Pneumonia, Viral therapy, Protective Clothing standards, SARS-CoV-2, Societies, Medical standards, Betacoronavirus, Coronavirus Infections epidemiology, Gastroenterology standards, Gastrointestinal Motility physiology, Neurology standards, Pneumonia, Viral epidemiology, Practice Guidelines as Topic standards, Recovery of Function physiology
Abstract

Background: During the peak of the COronaVIrus Disease 2019 (COVID-19) pandemic, care for patients with gastrointestinal motility and functional disorders was largely suspended. In the recovery phases of the pandemic, non-urgent medical care is resumed, but there is a lack of guidance for restarting and safely conducting motility and function testing. Breath tests and insertion of manometry and pH-monitoring probes carry a risk of SARS-CoV-2 spread through droplet formation., Methods: A panel of experts from the European Society for Neurogastroenterology and Motility (ESNM) evaluated emerging national and single-center recommendations to provide the best current evidence and a pragmatic approach to ensure the safe conduct of motility and function testing for both healthcare professionals and patients., Results: At a general level, this involves evaluation of the urgency of the procedure, evaluation of the infectious risk associated with the patient, the investigation and the healthcare professional(s) involved, provision of the test planning and test units, education and training of staff, and use of personnel protection equipment. Additional guidance is provided for specific procedures such as esophageal manometry, pH monitoring, and breath tests., Conclusions and Inferences: The ESNM guidelines provide pragmatic and appropriate guidance for the safe conduct of motility and function testing in the COVID-19 pandemic and early recovery phase., (© 2020 John Wiley & Sons Ltd.)

Published
2020
Full Text
View/download PDF

8. From the editor's desk...

Author

Lanthier N and Vanuytsel T

Subjects
Humans, Gastroenterology
Abstract

Competing Interests: The authors declare that they have no conflict of interest

Published
2020

9. United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on functional dyspepsia

Author

Wauters, L., Dickman, R., Drug, V., Mulak, A., Serra, J., Enck, P., Tack, J., Accarino, A., Barbara, G., Bor, S., Coffin, B., Corsetti, M., De Schepper, H., Dumitrascu, D., Farmer, A., Gourcerol, G., Hauser, G., Hausken, T., Karamanolis, G., Keszthelyi, D., Malagelada, C., Milosavljevic, T., Muris, J., O'Morain, C., Papathanasopoulos, A., Pohl, D., Rumyantseva, D., Sarnelli, G., Savarino, E., Schol, J., Sheptulin, A., Smet, A., Stengel, A., Storonova, O., Storr, M., Tornblom, H., Vanuytsel, T., Velosa, M., Waluga, M., Zarate, N., Zerbib, F., Kestzhelyi, D., Interne Geneeskunde, MUMC+: MA Maag Darm Lever (9), RS: NUTRIM - R2 - Liver and digestive health, RS: CAPHRI - R5 - Optimising Patient Care, Family Medicine Education, Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université de Paris - UFR Médecine Paris Centre [Santé] (UP Médecine Paris Centre), Université de Paris (UP), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Service de physiologie digestive, urinaire, respiratoire et de l'exercice [CHU Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), ESNM FD Consensus Grp, Wauters L., Dickman R., Drug V., Mulak A., Serra J., Enck P., Tack J., Accarino A., Barbara G., Bor S., Coffin B., Corsetti M., De Schepper H., Dumitrascu D., Farmer A., Gourcerol G., Hauser G., Hausken T., Karamanolis G., Keszthelyi D., Malagelada C., Milosavljevic T., Muris J., O'Morain C., Papathanasopoulos A., Pohl D., Rumyantseva D., Sarnelli G., Savarino E., Schol J., Sheptulin A., Smet A., Stengel A., Storonova O., Storr M., Tornblom H., Vanuytsel T., Velosa M., Waluga M., Zarate N., Zerbib F., ESNM FD Consensus Group, Wauters, L., Dickman, R., Drug, V., Mulak, A., Serra, J., Enck, P., Tack, J., Accarino, A., Barbara, G., Bor, S., Coffin, B., Corsetti, M., De Schepper, H., Dumitrascu, D., Farmer, A., Gourcerol, G., Hauser, G., Hausken, T., Karamanolis, G., Keszthelyi, D., Malagelada, C., Milosavljevic, T., Muris, J., O'Morain, C., Papathanasopoulos, A., Pohl, D., Rumyantseva, D., Sarnelli, G., Savarino, E., Schol, J., Sheptulin, A., Smet, A., Stengel, A., Storonova, O., Storr, M., Tornblom, H., Vanuytsel, T., Velosa, M., Waluga, M., Zarate, N., and Zerbib, F.

Subjects
Male, Proton Pump Inhibitor, Delphi Technique, IRRITABLE-BOWEL-SYNDROME, Gastrointestinal Diseases, Physiology, [SDV]Life Sciences [q-bio], Placebo-controlled study, GASTROESOPHAGEAL-REFLUX DISEASE, Sex Factor, PLACEBO-CONTROLLED TRIAL, Epigastric pain, Endoscopy, Gastrointestinal, DOUBLE-BLIND, 0302 clinical medicine, Quality of life, Risk Factors, QUALITY-OF-LIFE, UPPER GASTROINTESTINAL SYMPTOMS, Irritable bowel syndrome, Societies, Medical, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina, evidence‐based medicine, based medicine, Gastroenterology, Neurogastroenterology, Postprandial Period, 3. Good health, consensus, endoscopy, evidence‐based medicine, functional dyspepsia, proton pump inhibitors, Europe, Oncology, Neurology, 030220 oncology & carcinogenesis, Anxiety, 030211 gastroenterology & hepatology, Original Article, Female, medicine.symptom, Symptom Assessment, proton pump inhibitors, evidence-based medicine, consensus, endoscopy, functional dyspepsia, Human, medicine.medical_specialty, Consensu, Satiation, evidence&#8208, Helicobacter Infections, 03 medical and health sciences, Sex Factors, HELICOBACTER-PYLORI, Internal medicine, IMPAIRED GASTRIC ACCOMMODATION, medicine, Humans, DUODENAL ACID EXPOSURE, Dyspepsia, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine, Gastric emptying, Helicobacter pylori, Endocrine and Autonomic Systems, business.industry, Risk Factor, Evidence-based medicine, NATURAL-HISTORY, NONULCER DYSPEPSIA, medicine.disease, HELICOBACTER-PYLORI INFECTION, Abdominal Pain, Quality of Life, Human medicine, business, Helicobacter Infection
Abstract

Background Functional dyspepsia (FD) is one of the most common conditions in clinical practice. In spite of its prevalence, FD is associated with major uncertainties in terms of its definition, underlying pathophysiology, diagnosis, treatment, and prognosis. Methods A Delphi consensus was initiated with 41 experts from 22 European countries who conducted a literature summary and voting process on 87 statements. Quality of evidence was evaluated using the grading of recommendations, assessment, development, and evaluation (GRADE) criteria. Consensus (defined as >80% agreement) was reached for 36 statements. Results The panel agreed with the definition in terms of its cardinal symptoms (early satiation, postprandial fullness, epigastric pain, and epigastric burning), its subdivision into epigastric pain syndrome and postprandial distress syndrome, and the presence of accessory symptoms (upper abdominal bloating, nausea, belching), and overlapping conditions. Also, well accepted are the female predominance of FD, its impact on quality of life and health costs, and acute gastrointestinal infections, and anxiety as risk factors. In terms of pathophysiological mechanisms, the consensus supports a role for impaired gastric accommodation, delayed gastric emptying, hypersensitivity to gastric distention, Helicobacter pylori infection, and altered central processing of signals from the gastroduodenal region. There is consensus that endoscopy is mandatory for establishing a firm diagnosis of FD, but that in primary care, patients without alarm symptoms or risk factors can be managed without endoscopy. There is consensus that H. pylori status should be determined in every patient with dyspeptic symptoms and H. pylori positive patients should receive eradication therapy. Also, proton pump inhibitor therapy is considered an effective therapy for FD, but no other treatment approach reached a consensus. The long‐term prognosis and life expectancy are favorable. Conclusions and Inferences A multinational group of European experts summarized the current state of consensus on the definition, diagnosis and management of FD., Key summary Current knowledge Functional dyspepsia is one of the most common conditions encountered in clinical practice.There is a lack of guidance for clinicians in guiding diagnosis and treatment of this prevalent condition.No treatments are currently approved for the treatment of functional dyspepsia in Europe. What is new here A Delphi panel consisting of 41 experts from 22 European countries established the level of consensus on 87 statements regarding functional dyspepsia.The statements reaching consensus serve to guide clinicians in recognizing, diagnosing and treating FD in clinical practice.Endoscopy is mandatory for establishing a firm diagnosis of functional dyspepsia D, but in primary care patients without alarm symptoms or risk factors can be managed without endoscopy. Helicobacter pylori status should be determined in every patient with dyspeptic symptoms and H. Pylori positive patients should receive eradication therapy.Proton pump inhibitor‐therapy is considered an effective therapy for FD, but no other treatment approach reached consensus support.

Published
2021
Full Text
View/download PDF

10. From the editor's desk

Author

Lanthier, N, Vanuytsel, T, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, and UCL - (SLuc) Service de gastro-entérologie

Subjects
Belgian Week of Gastroenterology, Belgium, Gastroenterology, Humans, Scientific societies, Belgian Liver and Intestine Committee
Abstract

No abstract available

Published
2022

11. Chronic Intestinal Failure in Children: An International Multicenter Cross-Sectional Survey

Author

Antonella Lezo, Antonella Diamanti, Evelyne M. Marinier, Merit Tabbers, Anat Guz-Mark, Paolo Gandullia, Maria I. Spagnuolo, Sue Protheroe, Noel Peretti, Laura Merras-Salmio, Jessie M. Hulst, Sanja Kolaček, Looi C. Ee, Joanna Lawrence, Jonathan Hind, Lorenzo D’Antiga, Giovanna Verlato, Ieva Pukite, Grazia Di Leo, Tim Vanuytsel, Maryana K. Doitchinova-Simeonova, Lars Ellegard, Luisa Masconale, María Maíz-Jiménez, Sheldon C. Cooper, Giorgia Brillanti, Elena Nardi, Anna S. Sasdelli, Simon Lal, Loris Pironi, Regione Piemonte Azienda Ospedaliera - S. Anna [Turin, Italy] (OIRM-S), Ospedale Bambin Gesù [Rome, Italy] (OBG), Centre de Référence des Maladies Digestives Rares [AP-HP Hôpital Robert-Debré] (CRMDR), AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Emma Children’s Hospital, Amsterdam UMC - Amsterdam University Medical Center, Schneider Children’s Medical Center [Petah Tikva, Israel] (SCMC), Tel Aviv University (TAU), IRCCS Istituto Giannina Gaslini [Genoa, Italy], University of Naples Federico II = Università degli studi di Napoli Federico II, Birmingham Women's and Children's NHS Foundation Trust, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital Femme Mère Enfant [CHU - HCL] (HFME), Hospices Civils de Lyon (HCL), Helsinki University Hospital [Finland] (HUS), Eramus MC-Sophia Children’s Hospital, Partenaires INRAE, Children’s Hospital Srebrnjak [Zagreb, Croatia], Children’s Health Queensland [Brisbane] (CHQ), Royal Children’s Hospital & Department of Paediatrics [Parkville, VIC, Australia], King‘s College London, Hospital Papa Giovanni XXIII (Hosp P Giovanni XXIII), Azienda Ospedale Università di Padova = Hospital-University of Padua (AOUP), Children's Clinical University Hospital [Riga, Latvia] (CCUH), Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo' [Trieste], Leuven Intestinal Failure and Transplantation [Leuven, Belgium] (LIFT), University Hospitals Leuven [Leuven], Bulgarian Association of Patients with Malnutrition [Sofia, Bulgaria] (BAPM), Sahlgrenska University Hospital [Gothenburg], Ospedale Orlandi [Bussolengo, Italy] (2O), Hospital Universitario 12 de Octubre [Madrid], Alma Mater Studiorum University of Bologna (UNIBO), University of Bologna/Università di Bologna, Azienda Ospedaliero-Universitaria di Bologna [Bolohna, Italy] (AOUB), Salford Royal NHS Foundation Trust [Salford, UK], CarMeN, laboratoire, Pediatrics, Pediatric surgery, Clinicum, HUS Children and Adolescents, Children's Hospital, University of Helsinki, Paediatric Gastroenterology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, ARD - Amsterdam Reproduction and Development, Lezo A., Diamanti A., Marinier E.M., Tabbers M., Guz-Mark A., Gandullia P., Spagnuolo M.I., Protheroe S., Peretti N., Merras-Salmio L., Hulst J.M., Kolacek S., Ee L.C., Lawrence J., Hind J., D'antiga L., Verlato G., Pukite I., Di Leo G., Vanuytsel T., Doitchinova-Simeonova M.K., Ellegard L., Masconale L., Maiz-Jimenez M., Cooper S.C., Brillanti G., Nardi E., Sasdelli A.S., Lal S., Pironi L., Lezo, Antonella, Diamanti, Antonella, Marinier, Evelyne M., Tabbers, Merit, Guz-Mark, Anat, Gandullia, Paolo, Spagnuolo, Maria I., Protheroe, Sue, Peretti, Noel, Merras-Salmio, Laura, Hulst, Jessie M., Kola( (c))ek, Sanja, Ee, Looi C., Lawrence, Joanna, Hind, Jonathan, D'Antiga, Lorenzo, Verlato, Giovanna, Pukite, Ieva, Di Leo, Grazia, Vanuytsel, Tim, Doitchinova-Simeonova, Maryana K., Ellegard, Lar, Masconale, Luisa, Ma('(i))z-Jim('(e))nez, Mar('(i))a, Cooper, Sheldon C., Brillanti, Giorgia, Nardi, Elena, Sasdelli, Anna S., Lal, Simon, and Pironi, Loris

Subjects
Adult, Male, Short Bowel Syndrome, [SDV]Life Sciences [q-bio], YOUNG-PEOPLE, ENTERAL NUTRITION, CLASSIFICATION, home parenteral nutrition, Intestinal Failure, children, body growth, Humans, chronic intestinal failure, intravenous supplementation, intestinal transplantation, transition, ADULT PATIENTS, HEPATOLOGY, Child, Cross-Sectional Studie, Nutrition and Dietetics, Science & Technology, Intestinal Disease, Nutrition & Dietetics, GASTROENTEROLOGY, PREVALENCE, [SDV] Life Sciences [q-bio], Intestinal Diseases, Cross-Sectional Studies, ITALIAN SOCIETY, Chronic Disease, HOME PARENTERAL-NUTRITION, Female, REHABILITATION PROGRAMS, 3143 Nutrition, Parenteral Nutrition, Home, Life Sciences & Biomedicine, Food Science, Human
Abstract

Background: The European Society for Clinical Nutrition and Metabolism database for chronic intestinal failure (CIF) was analyzed to investigate factors associated with nutritional status and the intravenous supplementation (IVS) dependency in children. Methods: Data collected: demographics, CIF mechanism, home parenteral nutrition program, z-scores of weight-for-age (WFA), length or height-for-age (LFA/HFA), and body mass index-for-age (BMI-FA). IVS dependency was calculated as the ratio of daily total IVS energy over estimated resting energy expenditure (%IVSE/REE). Results: Five hundred and fifty-eight patients were included, 57.2% of whom were male. CIF mechanisms at age 1−4 and 14−18 years, respectively: SBS 63.3%, 37.9%; dysmotility or mucosal disease: 36.7%, 62.1%. One-third had WFA and/or LFA/HFA z-scores < −2. One-third had %IVSE/REE > 125%. Multivariate analysis showed that mechanism of CIF was associated with WFA and/or LFA/HFA z-scores (negatively with mucosal disease) and %IVSE/REE (higher for dysmotility and lower in SBS with colon in continuity), while z-scores were negatively associated with %IVSE/REE. Conclusions: The main mechanism of CIF at young age was short bowel syndrome (SBS), whereas most patients facing adulthood had intestinal dysmotility or mucosal disease. One-third were underweight or stunted and had high IVS dependency. Considering that IVS dependency was associated with both CIF mechanisms and nutritional status, IVS dependency is suggested as a potential marker for CIF severity in children. ispartof: NUTRIENTS vol:14 issue:9 ispartof: location:Switzerland status: published

Published
2022
Full Text
View/download PDF

12. Mast cell-nerve interactions correlate with bloating and abdominal pain severity in patients with non-celiac gluten / wheat sensitivity

Author

Giacomo Caio, Elena Bonora, Dorien Beeckmans, Umberto Volta, Anna Costanzini, Tim Vanuytsel, Francesca Bianco, Rocco Latorre, Fiorella Giancola, Roberta Repossi, Florencia Carbone, Alessandra Gori, Roberto De Giorgio, Vincenzo Stanghellini, Karen Van den Houte, Elisa Boschetti, Jan Tack, Giancola F., Volta U., Repossi R., Latorre R., Beeckmans D., Carbone F., Van den Houte K., Bianco F., Bonora E., Gori A., Costanzini A., Boschetti E., Caio G., Vanuytsel T., Stanghellini V., Tack J., and De Giorgio R.

Subjects
Adult, Male, Abdominal pain, medicine.medical_specialty, Adolescent, Glutens, functional bloating, Physiology, Duodenum, Wheat Hypersensitivity, Gastroenterology, Severity of Illness Index, NO, Young Adult, Bloating, Internal medicine, medicine, Humans, In patient, Mast Cells, Pathological, chemistry.chemical_classification, Neurons, gluten-sensitive enteropathy, Endocrine and Autonomic Systems, business.industry, glutensensitive enteropathy, food sensitivity, functional abdominal pain, functional bloating, functional dyspepsia, glutensensitive enteropathy, Middle Aged, functional dyspepsia, Mast cell, Gluten, food sensitivity, Abdominal Pain, functional abdominal pain, medicine.anatomical_structure, chemistry, Immunohistochemistry, Female, medicine.symptom, business
Abstract

Background: Gastrointestinal (GI) and extra-GI symptoms/manifestations represent key clinical features of patients with non-celiac gluten/wheat sensitivity (NCG/WS). This study aimed to investigate neuro-immune (focusing on mast cells, MCs) interactions in the duodenal submucosa of patients with NCG/WS. Methods: Submucosal whole mounts from duodenal biopsies of 34 patients with self-reported NCG/WS, 28 with celiac disease (CD), 13 with functional dyspepsia (FD), and 24 healthy controls (HC) were analyzed by immunohistochemistry. Quantitative data on neuronal and MCs density and the percentage of MCs in close vicinity to nerves were obtained, and correlations among neurons, MC density and MC-nerve distance (D), and symptoms were assessed in the three groups. Key Results: The number of submucosal neurons was not different among groups. In NCG/WS, MC density was not different from HC, while it was slightly increased vs. CD (P=.07) and significantly decreased vs. FD (P&nbsp

Published
2019

13. The 2018 ISDE achalasia guidelines

Author

Giovanni Sarnelli, Tim Vanuytsel, Blair A. Jobe, Cathy Bennett, David I. Watson, Piero M. Fisichella, Ivan Cecconello, Ulysses Ribeiro, Richard H. Holloway, D. Liu, M. Y. A. van Herwaarden-Lindeboom, Edoardo Savarino, Rubens Antonio Aissar Sallum, Daniel Sifrim, David A. Katzka, Eric S. Hungness, John E. Pandolfino, Fernando A. M. Herbella, Silvana Perretta, Roger P. Tatum, Lee L. Swanstrom, Guy E. Boeckxstaens, Chandra Prakash Gyawali, Richard Ricachenevsky Gurski, Marco G. Patti, L. Faccio, George Triadafilopoulos, Nathaniel J. Soper, D. Inama, M. F. Vaezi, Frank Zerbib, Sheraz R. Markar, Joel E. Richter, An Moonen, S. Vermigli, Pankaj J. Pasricha, Ines Gockel, Nelson Adami Andreollo, Guido Costamagna, Peter J. Kahrilas, Francisco Schlottmann, Giovanni Zaninotto, Mark K. Ferguson, M. F. Vela, Stuart Gittens, Karl-Hermann Fuchs, Renato Salvador, Donald E. Low, C. Pontillo, J. R. M. Da Rocha, Jan Tack, Mario Costantini, Roberto Penagini, Kulwinder S. Dua, Michio Hongo, Ary Nasi, Zaninotto, G, Bennett, C, Boeckxstaens, G, Costantini, M, Ferguson, M K, Pandolfino, J E, Patti, M G, Ribeiro, U, Richter, J, Swanstrom, L, Tack, J, Triadafilopoulos, G, Markar, S R, Salvador, R, Faccio, L, Andreollo, N A, Cecconello, I, Costamagna, G, da Rocha, J R M, Hungness, E S, Fisichella, P M, Fuchs, K H, Gockel, I, Gurski, R, Gyawali, C P, Herbella, F A M, Holloway, R H, Hongo, M, Jobe, B A, Kahrilas, P J, Katzka, D A, Dua, K S, Liu, D, Moonen, A, Nasi, A, Pasricha, P J, Penagini, R, Perretta, S, Sallum, R A A, Sarnelli, G, Savarino, E, Schlottmann, F, Sifrim, D, Soper, N, Tatum, R P, Vaezi, M F, van Herwaarden-Lindeboom, M, Vanuytsel, T, Vela, M F, Watson, D I, Zerbib, F, Gittens, S, Pontillo, C, Vermigli, S, Inama, D, and Low, D E

Subjects
Adult, Male, Myotomy, Chagas disease, medicine.medical_specialty, Botulinum Toxins, medicine.medical_treatment, Achalasia, Esophageal Disorder, Severity of Illness Index, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Severity of illness, otorhinolaryngologic diseases, medicine, Humans, Disease management (health), Child, Evidence-Based Medicine, DIRETRIZES PARA A PRÁTICA CLÍNICA, business.industry, General surgery, Gastroenterology, Disease Management, achalaisa, guidelines, General Medicine, Evidence-based medicine, Guideline, medicine.disease, Dilatation, Dysphagia, Esophageal Achalasia, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Esophagoscopy, Symptom Assessment, medicine.symptom, business
Abstract

Achalasia is a relatively rare primary motor esophageal disorder, characterized by absence of relaxations of the lower esophageal sphincter and of peristalsis along the esophageal body. As a result, patients typically present with dysphagia, regurgitation and occasionally chest pain, pulmonary complication and malnutrition. New diagnostic methodologies and therapeutic techniques have been recently added to the armamentarium for treating achalasia. With the aim to offer clinicians and patients an up-to-date framework for making informed decisions on the management of this disease, the International Society for Diseases of the Esophagus Guidelines proposed and endorsed the Esophageal Achalasia Guidelines (I-GOAL). The guidelines were prepared according the Appraisal of Guidelines for Research and Evaluation (AGREE-REX) tool, accredited for guideline production by NICE UK. A systematic literature search was performed and the quality of evidence and the strength of recommendations were graded according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE). Given the relative rarity of this disease and the paucity of high-level evidence in the literature, this process was integrated with a three-step process of anonymous voting on each statement (DELPHI). Only statements with an approval rate >80% were accepted in the guidelines. Fifty-one experts from 11 countries and 3 representatives from patient support associations participated to the preparations of the guidelines. These guidelines deal specifically with the following achalasia issues: Diagnostic workup, Definition of the disease, Severity of presentation, Medical treatment, Botulinum Toxin injection, Pneumatic dilatation, POEM, Other endoscopic treatments, Laparoscopic myotomy, Definition of recurrence, Follow up and risk of cancer, Management of end stage achalasia, Treatment options for failure, Achalasia in children, Achalasia secondary to Chagas' disease.

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results