1. Glucose-dependent insulinotropic peptide is an integrative hormone with osteotropic effects.
- Author
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Bollag RJ, Zhong Q, Ding KH, Phillips P, Zhong L, Qin F, Cranford J, Mulloy AL, Cameron R, and Isales CM
- Subjects
- Animals, Bone Development drug effects, Disease Models, Animal, Female, Gastric Inhibitory Polypeptide administration & dosage, Humans, Immunoblotting, In Situ Hybridization, Male, Osteoporosis drug therapy, Ovariectomy, RNA, Messenger metabolism, Rats, Rats, Sprague-Dawley, Receptors, Gastrointestinal Hormone genetics, Receptors, Gastrointestinal Hormone metabolism, Tumor Cells, Cultured, Bone Density drug effects, Gastric Inhibitory Polypeptide pharmacology
- Abstract
Glucose-dependent insulinotropic peptide (GIP) is a gut-derived hormone known to be important in modulating glucose-induced insulin secretion. In addition, GIP receptors are widely distributed and may have effects on multiple other tissues: fat cells, adrenal glands, endothelium and brain. We have demonstrated recently that GIP also has anabolic effects on bone-derived cells. We now demonstrate that GIP administration prevents the bone loss associated with ovariectomy. We propose that GIP plays a unique role in signaling the bone about nutrient availability, indicating the importance of the gut hormones in directing absorbed nutrients to the bone, and suggesting the concept of an 'entero-osseous axis'. Thus, GIP plays an integrative role helping coordinate efficient and targeted nutrient absorption and distribution.
- Published
- 2001
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