1. The value of serum aspartate aminotransferase and gamma-glutamyl transpetidase as biomarkers in hepatotoxicity
- Author
-
Robles-Diaz, M, Garcia-Cortes, M, Medina-Caliz, I, Gonzalez-Jimenez, A, Gonzalez-Grande, R, Navarro, JM, Castiella, A, Zapata, EM, Romero-Gomez, M, Blanco, S, Soriano, G, Hidalgo, R, Ortega-Torres, M, Clavijo, E, Bermudez-Ruiz, PM, Lucena, MI, Andrade, RJ, and Spanish DILI Registry Faster Evide
- Subjects
hepatotoxicity ,aspartate aminotransferase ,R ratio value ,drug-induced liver injury ,gamma-glutamyl transpeptidase ,pattern of injury - Abstract
Background & AimsThe current definition of the pattern of liver injury in hepatotoxicity (DILI) is given by the R (ratio) value, dividing alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in upper limits of normal at DILI onset. We aimed to explore the validity of using aspartate aminotransferase (AST) and gamma-glutamyl transpeptidase (GGT) as biomarkers of hepatocelullar and cholestatic damage, respectively, when calculating the R value. MethodsClinical, laboratory and histological data from 588 DILI episodes included in the Spanish DILI Registry were analyzed. Linear regression analysis was performed to establish the most appropriate cut-off points for hepatocellular and cholestatic patterns when calculating R with AST and GGT. ResultsThe overall agreement between ALT/ALP and AST/ALP was 76%, with 96%, 61% and 41% agreement in the hepatocellular (R5), cholestatic (R2) and mixed groups respectively (P
- Published
- 2015