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The results of complex simulations using PIC-GEANT4 (particle-in-cell and Monte-Carlo) codes based on the generation of a high-energy electron bunch by a short laser pulse propagating in a relativistic self-trapping regime in a near-critical plasma has been applied to assess the possibility of medical isotope production and nuclear waste transmutation. It has been demonstrated that a 10 Hz 30 fs 4 J laser pulse is well suited to the production of therapeutic amounts of several standard medical radionuclides (111In, 123I, 103Pd, 62Cu, 64Cu). The use of direct electron irradiation has an advantage over the use of bremsstrahlung gamma radiation from the converter due to the simplification of the production scheme without loss of radionuclide yield. The study of the transmutation of long-lived fusion products showed low efficiency and the need for preliminary isotope separation. Achieving as little as 10% reduction in the activity of a 10 g sample requires the continuous operation of the next-generation laser system at a high repetition rate (1 MHzâ€"100 kHz) for (one to ten) years. [ABSTRACT FROM AUTHOR]

Very efficient generation of a high-charge electron beam by a laser pulse propagating in a self-trapping mode in near-critical density plasma makes it possible to produce a high yield of gamma rays for radiography of samples located deep in a dense medium. The three-dimensional particle-in-cell and Monte Carlo simulations performed with end-to-end modeling from laser–plasma interaction to the final gamma-imaging of deeply shielded objects located at distances up to several meters clearly demonstrate the promise of laser pulses of several hundred TW for single-shot radiography by using a high-performance scheme of electron acceleration in the laser pulse self-trapping regime. This is illustrated by two examples with the same laser–target design used for a bremsstrahlung gamma source and an all-optical nonlinear inverse Compton source. [ABSTRACT FROM AUTHOR]

Electron acceleration has been optimized based on 3D particle-in-cell simulations of a short laser pulse interacting with low-density plasma targets to find the pulse propagation regime that maximizes the charge of high-energy electron bunches. This regime corresponds to laser pulse propagation in a self-trapping mode where the diffraction divergence is balanced by the relativistic nonlinearity such that relativistic self-focusing on the axis does not happen and the laser beam radius stays unchanged during pulse propagation in a plasma over many Rayleigh lengths. Such a regime occurs for a near-critical density if the pulse length considerably exceeds both the plasma wavelength and the pulse width. Electron acceleration occurs in a traveling cavity filled with a high-frequency laser field and a longitudinal electrostatic single-cycle field ("self-trapping regime"). Monte Carlo simulations demonstrated that a high electron yield allows an efficient production of gamma radiation, electron–positron pairs, neutrons, and even pions from a catcher-target. [ABSTRACT FROM AUTHOR]