1. Manganese elevations in blood of children with congenital portosystemic shunts.
- Author
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Mizoguchi, Nobuyuki, Nishimura, Yutaka, Ono, Hiroaki, Sakura, Nobuo, Mizoguchi, N, Nishimura, Y, Ono, H, and Sakura, N
- Subjects
BASAL ganglia ,HEPATIC encephalopathy ,MANGANESE ,GALACTOSEMIA ,MAGNETIC resonance imaging ,NONPARAMETRIC statistics ,PORTAL vein ,HEPATIC veins - Abstract
Unlabelled: Magnetic response imaging has demonstrated increased signal intensities within the basal ganglia in patients with hepatic encephalopathy; the densities are considered to represent manganese deposition. We measured whole blood manganese concentrations in nine children with congenital portosystemic venous shunts detected by screening tests for galactosaemia. Beyond 1 year of age, these patients showed significantly higher manganese concentrations than controls (2.40 +/- 0.43 versus 1.48 +/- 0.38 micrograms/dl; P = 0.0001). Four of the nine patients were studied by magnetic response imaging. T1-weighted images showed increased signal intensities in the basal ganglia of those four patients, suggesting manganese accumulation.Conclusion: Children with congenital portosystemic venous shunts showed manganese elevations in blood and magnetic response imaging changes in the basal ganglia. These children should avoid excessive manganese intake. [ABSTRACT FROM AUTHOR]- Published
- 2001
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