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Introduction: The main goal of this study was to describe the Czech population of patients with MG in terms of demographics, disease characteristics, management approaches, and treatment trends. Methods: We selected all patients, both incident and prevalent, who were enrolled in the Czech MyReg registry between August 24, 2015 and November 19, 2021. For the descriptive analysis, all patients enrolled in the registry, regardless of their date of diagnosis or date of enrolment, were included. We analyzed the following disease-related endpoints: myasthenia gravis composite (MGC) score, forced vital capacity (FVC), and Myasthenia Gravis Foundation of America (MGFA) clinical classification. Results: The incidence showed a consistent increasing trend from 0.62 to 3.13. The mean MGC score was 5.0 (median 4.0, 95% CI 4.7, 5.3) representing mild form of MG. The difference in FVC from the predicted value in patients during and without myasthenic crisis was 58.93% (95% CI 37.27, 80.59) and 75.93% (95% CI 74.87, 77.00), respectively. We identified 70 patients (5.0%) with refractory MG, of whom 58.6% were female. The MGFA classifications in those with refractory vs. non-refractory disease was as follows: IIa 21.8% vs 23.2%, IIb 45.3% vs 33.6%, and IIIb 14.1% vs 4.6%, respectively. Conclusion: Our analysis shows that the incidence of MG is increasing in the Czech Republic and that patients with refractory disease, of whom up to 58% are female, have a higher burden of disease than non-refractory patients. [ABSTRACT FROM AUTHOR]

Vegetation indices, especially the normalized difference vegetation index (NDVI), are widely used in urban vegetation assessments. However, estimating the vegetation abundance in urban scenes using the NDVI has constraints due to the complex spectral signature related to the urban structure, materials and other factors compared to natural ground surfaces. This paper employs the 3D discrete anisotropic radiative transfer (DART) model to simulate the spectro-directional reflectance of synthetic urban scenes with various urban geometries and building materials using a flux-tracking method under shaded and sunlit conditions. The NDVI is calculated using the spectral radiance in the red (0.6545 μm) and near-infrared bands (0.865 μm). The effects of the urban material heterogeneity and 3D structure on the NDVI, and the performance of three NDVI-based fractional vegetation cover (FVC) inversion algorithms, are evaluated. The results show that the effects of the building material heterogeneity on the NDVI are negligible under sunlit conditions but not negligible under shaded conditions. The NDVI value of building components within synthetic scenes is approximately zero. The shaded road exhibits a higher NDVI value in comparison to the illuminated road because of scattering from adjacent pixels. In order to correct the effects of scattering caused by building geometry, the reflectance of the Landsat 8/OLI image is corrected using the sky view factor (SVF) and then used to calculate the FVC. Jilin-1 satellite images with high spatial resolution (0.5 m) are used to extract the vegetation cover and then aggregated to 30 m spatial resolution to calculate the FVC for validation. The results show that the RMSE is up to 0.050 after correction, while the RMSE is 0.169 before correction. This study makes a contribution to the understanding of the effects of the urban 3D structure and material reflectance on the NDVI and provides insights into the retrieval of the FVC in different urban scenes. [ABSTRACT FROM AUTHOR]

Manganese ore, as an important strategic metal resource for the country, was subject to unreasonable mining practices and outdated smelting technologies in early China, leading to severe ecological damage in mining areas. This study examines the trends in vegetation cover change in the historical manganese mining areas of Yongzhou under the influence of policy, providing technical references for mitigating the ecological impact of these legacy mining areas and offering a basis for adjusting mine restoration policies. This paper takes the manganese mining area in Yongzhou City, Hunan Province as a case study and selects multiple periods of Landsat satellite images from 2000 to 2023. By calculating the Normalized Difference Vegetation Index (NDVI) and the Fractional Vegetation Coverage (FVC), the spatiotemporal changes and driving factors of vegetation coverage in the Yongzhou manganese mining area from 2000 to 2023 were analyzed. The analysis results show that, in terms of time, from 2000 to 2012, the vegetation coverage in the manganese mining area decreased from 0.58 to 0.21, while from 2013 to 2023, it gradually recovered from 0.21 to 0.40. From a spatial perspective, in areas where artificial reclamation was conducted, the vegetation was mainly mildly and moderately degraded, while in areas where no artificial restoration was carried out, significant vegetation degradation was observed. Mining activities were the primary anthropogenic driving force behind the decrease in vegetation coverage, while effective ecological protection projects and proactive policy guidance were the main anthropogenic driving forces behind the increase in vegetation coverage in the mining area. [ABSTRACT FROM AUTHOR]

Fractional vegetation cover (FVC) is an important indicator of regional ecological environment change, and quantitative research on the spatial and temporal distribution of FVC and the trend of change is of great significance to the monitoring, evaluation, protection, and restoration of regional ecology. This study estimates the FVC of the eastern Tibetan Plateau margin from 2000 to 2020 using the image element dichotomous model based on the Google Earth Engine platform using MODIS-NDVI images. It also investigates the temporal and spatial changes of the FVC in this region and its drivers using the Theil–Sen and Mann–Kendall trend tests, spatial autocorrelation analysis, geodetector, and machine learning approaches impact. The results of this study indicated a generally erratic rising tendency, with the Min River Basin (MRB) near the eastern tip of the Tibetan Plateau having an annual average FVC of 0.67 and an annual growth rate of 0.16%. The percentage of places with better vegetation reached 60.37%. The regional FVC showed significant positive spatial autocorrelation and was clustered. Driver analyses showed that soil type, DEM, temperature, potential evapotranspiration, and land use type were the main drivers influencing FVC on the eastern margin of the Tibetan Plateau. In addition, the random forest (RF) model outperformed the support vector machine (SVM), backpropagation neural network (BP), and long short-term memory network (LSTM) in FVC regression fitting. In summary, this study shows that the overall FVC in the eastern margin of the Tibetan Plateau is on an upward trend, and the regional ecological environment has improved significantly over the past two decades. [ABSTRACT FROM AUTHOR]

Background: Sleep's impact on the human immune system and inflammatory responses makes it a potential risk factor for lung function impairment. However, the relationship between sleep duration and lung function impairment in middle-aged and young adults has been rarely investigated. Methods: A total of 9,284 aged 20–64 years were categorized into four groups according to sleep duration (≤ 6 h, 7 h, 8 h, and ≥ 9 h), with 7 h as the reference, by using the U.S. NHANES data, 2007–2012. Forced expiratory volume in the 1 s (FEV1), forced vital capacity (FVC), FEV1 to FVC (FEV1/FVC) ratio, peak expiratory flow (PEF), and forced expiratory flow at 25–75% (FEF25 − 75%) were measured by spirometry. Restrictive impairment was defined as baseline FVC < 80% predicted and obstructive impairment as FEV1/FVC < 0.70. Generalized linear regression and logistic regression were performed to estimate the associations between sleep duration and lung function. Results: Compared with 7 h of sleep duration, shorter and longer sleep duration were associated with decreases in FEV1 (≤ 6 h: β=-0.010, 95% CI=-0.014 to -0.006; 8 h: β=-0.005, 95% CI=-0.009 to -0.001), FVC (≤ 6 h: β=-0.018, 95% CI=-0.014 to -0.007; 8 h: β=-0.005, 95% CI=-0.009 to -0.002), and PEF (≤ 6 h: β=-0.006, 95% CI=-0.010 to -0.002; 8 h: β=-0.007, 95% CI=-0.011 to -0.002; ≥ 9 h: β=-0.012, 95% CI=-0.020 to -0.004). Similarly, shorter (≤ 6 h: OR = 1.346, 95% CI = 1.065 to 1.700) and longer (≥ 9 h: OR = 1.827, 95% CI = 1.236 to 2.700) sleep duration were associated with increased risks of restrictive impairment. Moreover, the aforementioned associations were more pronounced among male participants. Conclusions: Compared with 7 h of sleep duration, shorter and longer sleep duration were associated with impaired lung function among adults aged 20–64 years, and these associations were stronger among males. [ABSTRACT FROM AUTHOR]

Abstract Background Leptospirosis, a spirochaete infection, can lead to Leptospirosis Pulmonary Haemorrhage Syndrome (LPHS), which requires intensive care admission and has a high mortality. Although data on short-term outcomes are available, the long-term respiratory sequelae of LPHS survivors are not known. We aimed to identify the post-discharge pulmonary functions and functional limitations in survivors of LPHS. Methods We conducted a prospective cohort study from January to December 2022 at the Medical Intensive Care Unit (ICU) of the National Hospital of Sri Lanka to assess the sequential changes in the spirometry parameters in patients who survived LPHS. The Forced Vital Capacity (FVC) and Forced Expiratory Volume in 1 s (FEV1) were measured on the day of discharge from the ICU (D0), 7th day after discharge (D7) and 28th day after discharge (D28). The predicted lung volume was calculated using the gender, age and height as per standard protocol. Physical and functional role limitations were assessed on D28 using the modified Medical Outcomes Study Questionnaire Short Form 36 Health Survey (SF-36). Results Twenty-one patients with a mean age of 44 years (SD 16.07) were enrolled for the study. The majority were male patients (n = 19, 90.5%). Leptospirosis was serologically confirmed in all individuals. Seventeen (81%) patients had reduced FEV1 and FVC on D0, indicating a restrictive lung abnormality. FVC and FEV1 improved during the first 7 days (p

Yu Yang,1,2 Shuqi Wang,1,3 Boying Jia,1,3 Shuchun Chen1,3 1Department of Internal Medicine, Hebei Medical University, Shijiazhuang, People’s Republic of China; 2Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China; 3Department of Endocrinology, Hebei General Hospital, Shijiazhuang, People’s Republic of ChinaCorrespondence: Shuchun Chen, Department of Endocrinology, Hebei General Hospital, 348 heping West Road, Shijiazhuang, Hebei, 050051, People’s Republic of China, Tel/Fax +86 311 85988406, Email chenshuc2014@163.comPurpose: To investigate the relationship between the triglyceride-glucose (TyG) index and pulmonary function metrics among the general population undergoing health examinations.Materials and Methods: The enrollment totaled 696 participants. Fasting triglycerides and glucose levels were used to calculate the TyG index. Participants were divided into two categories according to their median TyG: one with high TyG and the other with low TyG. A portable spirometer was used to assess lung function. Fundamental clinical features and lung function indicators were compared between the two groups, and the relationship between the TyG index and lung function parameters was explored.Results: Compared with the low TyG group, the high TyG group exhibited significantly reduced levels of FEV1/FVC, FVC% pred, FEV1% pred, FEV3% pred, FEV3/FVC, FEF75, FEF75% pred, FEF25-75% pred, and MVV% pred, suggesting poor pulmonary function. The TyG index was significantly inversely correlated with multiple pulmonary function metrics, including FVC% pred, FEV1% pred, FEV3% pred, FEV1/FVC, FEV3/FVC, FEF75, FEF75% pred and FEF25-75% pred, which persisted even after accounting for confounding variables.Conclusion: In summary, the present study establishes a correlation between the TyG index and some lung function indicators, offering a new indicator of metabolic abnormalities related to lung functionality.Keywords: triglyceride-glucose index, lung function, insulin resistance, FEV1, FVC

Background: It is known that the consumption of single phytochemicals improves respiratory function in chronic obstructive pulmonary disease (COPD) patients. Since phytochemicals have a synergistic effect on health, a more comprehensive analysis is needed. The aim of this study was to estimate the intake of phytochemicals using the dietary phytochemical index (DPI) and assess their association with respiratory function, inspiratory muscle strength and function, and peripheral muscle strength. Methods: This study was conducted at the Special Hospital for Pulmonary Diseases in Zagreb (September 2023 to May 2024). The DPI was assessed using three 24 h recalls from 71 COPD patients (66.5 ± 8.4 years; 53.5% men). Anthropometric measurements, respiratory function, inspiratory muscle function and strength, and peripheral muscle strength were assessed during pulmonary rehabilitation following standard protocols. Results: Patients were divided into DPI tertiles with mean values of 7.3 ± 3.0, 16.0 ± 3.0, and 32.2 ± 8.8, respectively. After controlling for confounding factors, a significant association was found between DPI tertiles and FEV1 (p-trend < 0.001), FVC (p-trend = 0.002), FEV1/FVC (p-trend < 0.001), MIP (p-trend = 0.012), and MSUE (p-trend = 0.002). In addition, an inverse association was found between DPI tertiles and diaphragm thickness during inhalation (p-trend = 0.012) and exhalation (p-trend = 0.013). Conclusions: This study suggests that a higher intake of phytochemicals could be beneficial in dietary interventions for COPD therapy. Future prospective studies are needed to confirm these findings. [ABSTRACT FROM AUTHOR]

Background: The telomere has long been regarded as a dependable biomarker for cellular senescence. The lung function can reflect the function and status of the lungs. As individuals age beyond adulthood, there is a gradual decline in lung function. However, the existence of a associated between leukocyte telomere length (LTL) and lung function remains uncertain. Methods: A two-sample Mendelian randomization (MR) analysis was used. The Single-nucleotide polymorphisms (SNPs) of LTL from the genome-wide association (GWAS) study were used as exposure instruments variable, and the lung function indicator including Forced expiratory volume in 1-s (FEV1), FEV1 Best measure, FEV1 predicted and Forced vital capacity (FVC) from the Neale Lab and MRC-IEU were used as outcomes. The associated between the exposures and outcomes was assessed using inverse-variance weighted (IVW), MR-Egger, and weighted median methods. Sensitivity analysis was conducted using Cochran's Q-test, MR-Egger intercept test, MR-PRESSO, leave-one-out analysis, and Steriger test. Results: Using the IVW method, a significant association was identified between genetically determined telomere length extension and enhanced lung function in FEV1, with ukb-a-336 (P = 0.127, OR = 1.028,95CI% = 1.003–1.042) and ukb-b-19657 (P = 7.26E-05, OR = 1.051,95CI% = 1.025–1.077),in FEV1 predicted, ukb-a-234 (P = 0.013, OR = 1.029,95CI% = 1.003–1.042), ukb-b-8428 (P = 0.001, OR = 1.032,95CI% = 1.012–1.052), in FEV1 best measure, ukb-a-231 (P = 7.24E-05, OR = 1.050,95CI% = 1.025–1.075), ukb-b-11141 (P = 1.40E-09, OR = 1.067,95CI% = 1.045–1.090).The sensitivity analysis did not reveal heterogeneity or horizontal pleiotropy.Meanwhile, the Steriger test results also indicate that the directionality between exposure and outcome is correct. Therefore, the results indicated robustness. Conclusion: There is a correlation between longer LTL and better lung function in the European dataset. [ABSTRACT FROM AUTHOR]

Objectives To investigate the prognostic utility of 28 serum biomarkers in systemic sclerosis (SSc), SSc-associated interstitial lung disease (SSc-ILD) and clinically relevant disease subgroups. Methods Participants with sera, high-resolution CT and lung function within 12 months of baseline were identified from the Australian Scleroderma Cohort Study. Baseline was the time of serum collection. Twenty-seven of the prespecified 28 serum biomarkers were analysed and biomarker associations with mortality and ILD progression were investigated in univariable and multivariable analyses, including within disease subgroups and combined with established risk factors for poorer prognosis in SSc. Results A total of 407 participants were identified, 252 (61.9%) with SSc-ILD. The median (interquartile range) follow-up after biomarker measurement was 6.31 (3.11–9.22) years. Sixteen biomarkers were associated with increased mortality. High levels of VCAM-1 were most strongly associated with mortality [hazard ratio (HR) 3.55; 95% CI 2.37–5.33; P <  0.001]. Five additional biomarkers had an HR >2: SP-D (2.28, 1.57–3.31; P <  0.001), E-selectin (2.19, 1.53–3.14; P <  0.001), IL-6 (2.15, 1.50–3.09; P <  0.001), MMP-3 (2.05, 1.42–2.95; P <  0.001) and ET-1 (2.03, 1.40–2.92; P <  0.001). Eleven biomarkers were independently associated with mortality following adjustment for sex, age and baseline forced vital capacity (FVC%predicted). Three biomarkers were associated with ILD progression at 1-year follow-up: CXCL4 (odds ratio 2.67, 1.46–4.88; P  = 0.001), MMP-1 (2.56, 1.43–4.59; P =  0.002) and ET-1 (2.18, 1.24–3.83; P =  0.007). Conclusion Multiple biomarkers, especially VCAM-1, E-selectin, SP-D and CXCL4, provide prognostic utility beyond that of established risk factors for patients with SSc. [ABSTRACT FROM AUTHOR]

Fractional vegetation cover (FVC) plays a key role in ecological and environmental status assessment because it directly reflects the extent of vegetation cover and its status, yet vegetation is an important component of ecosystems. FVC estimation methods have evolved from traditional manual interpretation to advanced remote sensing technologies, such as satellite data analysis and unmanned aerial vehicle (UAV) image processing. Extraction methods based on high-resolution UAV data are being increasingly studied in the fields of ecology and remote sensing. However, research on UAV-based FVC extraction against the backdrop of the high soil reflectance in arid regions remains scarce. In this paper, based on 12 UAV visible light images in differentiated scenarios in the Ebinur Lake basin, Xinjiang, China, various methods are used for high-precision FVC estimation: Otsu's thresholding method combined with 12 Visible Vegetation Indices (abbreviated as Otsu-VVIs) (excess green index, excess red index, excess red minus green index, normalized green–red difference index, normalized green–blue difference index, red–green ratio index, color index of vegetation extraction, visible-band-modified soil-adjusted vegetation index, excess green minus red index, modified green–red vegetation index, red–green–blue vegetation index, visible-band difference vegetation index), color space method (red, green, blue, hue, saturation, value, lightness, 'a' (Green–Red component), and 'b' (Blue–Yellow component)), linear mixing model (LMM), and two machine learning algorithms (a support vector machine and a neural network). The results show that the following methods exhibit high accuracy in FVC extraction across differentiated scenarios: Otsu–CIVE, color space method ('a': Green–Red component), LMM, and SVM (Accuracy > 0.75, Precision > 0.8, kappa coefficient > 0.6). Nonetheless, higher scene complexity and image entropy reduce the applicability of precise FVC extraction methods. This study facilitates accurate, efficient extraction of vegetation information in differentiated scenarios within arid and semiarid regions, providing key technical references for FVC estimation in similar arid areas. [ABSTRACT FROM AUTHOR]

Fractional vegetation cover (FVC) is a crucial indicator for measuring the growth of surface vegetation. The changes and predictions of FVC significantly impact biodiversity conservation, ecosystem health and stability, and climate change response and prediction. Southwest China (SWC) is characterized by complex topography, diverse climate types, and rich vegetation types. This study first analyzed the spatiotemporal variation of FVC at various timescales in SWC from 2000 to 2020 using FVC values derived from pixel dichotomy model. Next, we constructed four machine learning models—light gradient boosting machine (LightGBM), support vector regression (SVR), k-nearest neighbor (KNN), and ridge regression (RR)—along with a weighted average heterogeneous ensemble model (WAHEM) to predict growing-season FVC in SWC from 2000 to 2023. Finally, the performance of the different ML models was comprehensively evaluated using tenfold cross-validation and multiple performance metrics. The results indicated that the overall FVC in SWC predominantly increased from 2000 to 2020. Over the 21 years, the FVC spatial distribution in SWC generally showed a high east and low west pattern, with extremely low FVC in the western plateau of Tibet and higher FVC in parts of eastern Sichuan, Chongqing, Guizhou, and Yunnan. The determination coefficient R2 scores from tenfold cross-validation for the four ML models indicated that LightGBM had the strongest predictive ability whereas RR had the weakest. WAHEM and LightGBM models performed the best overall in the training, validation, and test sets, with RR performing the worst. The predicted spatial change trends were consistent with the MODIS-MOD13A3-FVC and FY3D-MERSI-FVC, although the predicted FVC values were slightly higher but closer to the MODIS-MOD13A3-FVC. The feature importance scores from the LightGBM model indicated that digital elevation model (DEM) had the most significant influence on FVC among the six input features. In contrast, soil surface water retention capacity (SSWRC) was the most influential climate factor. The results of this study provided valuable insights and references for monitoring and predicting the vegetation cover in regions with complex topography, diverse climate types, and rich vegetation. Additionally, they offered guidance for selecting remote sensing products for vegetation cover and optimizing different ML models. [ABSTRACT FROM AUTHOR]

Open-pit coal mining inevitably damages the soil and vegetation in mining areas. Currently, the restoration of cold and arid open-pit mines in Xinjiang, China, is still in the initial exploratory stage, especially the changes in soil nutrients in spoil dumps over time. Dynamic remote sensing monitoring of vegetation in mining areas and their correlation are relatively rare. Using the Heishan Open Pit in Xinjiang, China, as a case, soil samples were collected during different discharge periods to analyze the changes in soil nutrients and uncover the restoration mechanisms. Based on four Landsat images from 2018 to 2023, the remote sensing ecological index (RSEI) and fractional vegetation cover (FVC) were obtained to evaluate the effect of mine restoration. Additionally, the correlation between vegetation changes and soil nutrients was analyzed. The results indicated that (i) the contents of nitrogen (N), phosphorus (P), potassium (K), and organic matter (OM) in the soil increased with the duration of the restoration period. (ii) When the restoration time of the dump exceeds 5 years, N, P, K, and OM content is higher than that of the original surface-covered vegetation area. (iii) Notably, under the same restoration aging, the soil in the artificial mine restoration demonstration base had significantly higher contents of these nutrients compared to the soil naturally restored in the dump. (iv) Over the past five years, the RSEI and FVC in the Heishan Open Pit showed an overall upward trend. The slope remediation and mine restoration project significantly increased the RSEI and FVC values in the mining area. (v) Air humidity and surface temperature were identified as key natural factors affecting the RSEI and FVC in cold and arid open pit. The correlation coefficients between soil nutrient content and vegetation coverage were higher than 0.78, indicating a close and complementary relationship between the two. The above results can clarify the time–effect relationship between natural recovery and artificial restoration of spoil dumps in cold and arid mining areas in Xinjiang, further promoting the research and practice of mine restoration technology in cold and arid open pits. [ABSTRACT FROM AUTHOR]

Featured Application: Accuracy verification of large-scale remote sensing fractional vegetation cover products; precision agriculture; ecological research. When recording the vegetation distribution with a camera, shadows can form due to factors like camera angle and direct sunlight. These shadows result in the loss of pixel information and texture details, significantly reducing the accuracy of fractional vegetation coverage (FVC) extraction. To address this issue, this study proposes an efficient double-exposure algorithm. The method reconstructs the pixel information in shadow areas by fusing normal-exposure and overexposed images. This approach overcomes the limitations of the camera's dynamic range in capturing pixel information in shadowed regions. The study evaluates images with five levels of overexposure combined with five vegetation extraction indices. The aim is to determine the best-performing double-exposure combination under shadow conditions and the most suitable vegetation index. Experimental results reveal that the R² value between the best vegetation index and the FVC calculated from the fused double-exposure images and the ground truth FVC increases from 0.750 to 0.969. The root mean square error (RMSE) reduces from 0.146 to 0.046, and the intersection over union (IOU) increases from 0.856 to 0.943. These results demonstrate the excellent vegetation extraction capability of the double-exposure algorithm under shadow conditions, offering a straightforward and effective solution to low accuracy of FVC in shadowed areas. [ABSTRACT FROM AUTHOR]

Abstract The Taihangshan-Yanshan region (TYR) is an important ecological barrier area for Beijing-Tianjin-Hebei, and the effectiveness of its ecological restoration and protection is of great significance to the ecological security pattern of North China. Based on the FVC data from 2000 to 2021, residual analysis, parametric optimal geodetector technique (OPGD) and multi-scale geographically weighted regression analysis (MGWR) were used to clarify the the multivariate driving mechanism of the evolution of FVC in the TYR. Results show that: (1) FVC changes in the TYR show a slowly fluctuating upward trend, with an average growth rate of 0.02/10a, and a spatial pattern of "high in the northwest and low in the southeast"; more than half of the FVC increased during the 22-year period. (2) The results of residual analysis showed that the effects of temperature and precipitation on FVC were very limited, and a considerable proportion (80.80% and 76.78%) of the improved and degraded areas were influenced by other factors. (3) The results of OPGD showed that the main influencing factors of the spatial differentiation of FVC included evapotranspiration, surface temperature, land use type, nighttime light intensity, soil type, and vegetation type (q > 0.2); The explanatory rates of the two-factor interactions were greater than those of the single factor, which showed either nonlinear enhancement or bifactorial enhancement, among which, the interaction of evapotranspiration with mean air and surface temperature has the strongest effect on the spatial and temporal evolution of FVC (q = 0.75). Surface temperature between 4.98 and 10.4 °C, evapotranspiration between 638 and 762 mm/a, and nighttime light between 1.96 and 7.78 lm/m2 favoured an increase in vegetation cover, and vegetation developed on lysimetric soils was more inclined to be of high cover. (4) The correlation between each variable and FVC showed different performance, GDP, elevation, slope and FVC showed significant positive correlation in most regions, while population size, urban population proportion, GDP proportion of primary and secondary industries, and nighttime light intensity all showed negative correlation with FVC to different degrees. The results can provide data for formulating regional environmental protection and restoration policies.

Abstract Background Pulmonary function is very important for the healthy development of children and adolescents. However, fewer studies have been conducted on pulmonary function trends in children and adolescents in remote areas. The aim of this study was to estimate the forced vital capacity (FVC) trend and its relationship with body mass index (BMI) among young people in Xinjiang during 1985–2014 using data from seven successive national surveys. Methods A total of 19,449 Xinjiang children and adolescents aged 7–18 years were extracted from the Chinese National Survey on Students’ Constitution and Health. Height, weight, and FVC were measured repeatedly in each survey. FVC comparisons between adjacent surveys by age and sex were conducted by nonparametric Kruskal-Wallis after Kolmogorov-Smirnov of normality. One-way ANOVA and least significant difference(LSD) method was used to compare differences in FVC levels of Xinjiang children and adolescents with different BMI. The relationship between BMI and FVC was investigated using a nonlinear regression model. Results The FVC levels of Xinjiang children and adolescents peaked in 2000, with overall FVC levels being 8.7% higher in 2000 than in 1985. Since then, a substantial decline occurred, contrasting to 2000, with FVC levels decreasing by 27% in 2014, which was still lower than that in 1985 by 20.73%. The proportion of overnutrition boys increased from 0.2% in 1985 to 22.1% in 2014, and girls from 0.5% in 1985 to 14.5% in 2014. An inverted U-shape association between FVC and BMI values was obtained for Xinjiang children and adolescents. Conclusions Targeted measures should be carried out in schools to control BMI levels to ensure good lung function in children and adolescents in Xinjiang. Future studies should pay more attention to other factors affecting FVC, such as dietary behaviour, physical activity, and racial differences among children and adolescents.

Under the background of global change, the lake water environment is facing a huge threat from eutrophication. The rapid increase in curly-leaf pondweed (Potamogeton crispus L.) in recent years has seriously threatened the ecological balance and the water diversion safety of the eastern route of China's South-to-North Water Diversion Project. The monitoring and control of curly-leaf pondweed is imperative in shallow lakes of northern China. Unmanned Aerial Vehicles (UAVs) have great potential for monitoring aquatic vegetation. However, merely using satellite remote sensing to detect submerged vegetation is not sufficient, and the monitoring of UAVs on aquatic vegetation is rarely systematically evaluated. In this study, taking Nansi Lake as a case, we employed Red–Green–Blue (RGB) UAV and satellite datasets to evaluate the monitoring of RGB Vegetation Indices (VIs) in pondweed and mapped the dynamic patterns of the pondweed Fractional Vegetation Coverage (FVC) in Nansi Lake. The pondweed FVC values were extracted using the RGB VIs and the machine learning method. The extraction of the UAV RGB images was evaluated by correlations, accuracy assessments and separability. The correlation between VIs and FVC was used to invert the pondweed FVC in Nansi Lake. The RGB VIs were also calculated using Gaofen-2 (GF-2) and were compared with UAV and Sentinel-2 data. Our results showed the following: (1) The RGB UAV could effectively monitor the FVC of pondweed, especially when using Support Vector Machine that (SVM) has a high ability to recognize pondweed in UAV RGB images. Two RGB VIs, RCC and RGRI, appeared best suited for monitoring aquatic plants. The correlations between four RGB VIs based on GF-2, i.e., GCC, BRI, VDVI, and RGBVI and FVCSVM calculated by the UAV (p < 0.01) were better than those obtained with other RGB VIs. Thus, the RGB VIs of GF-2 were not as effective as those of the UAV in pondweed monitoring. (2) The binomial estimation model constructed by the Normalized Difference Water Index (NDWI) of Sentinel-2 showed a high accuracy (R2 = 0.7505, RMSE = 0.169) for pondweed FVC and can be used for mapping the FVC of pondweed in Nansi Lake. (3) Combined with the Sentinel-2 time-series data, we mapped the dynamic patterns of pondweed FVC in Nansi Lake. It was determined that the flooding of pondweed in Nansi Lake has been alleviated in recent years, but the rapid increase in pondweed in part of Nansi Lake remains a challenging management issue. This study provides practical tools and methodology for the innovative remote sensing monitoring of submerged vegetation. [ABSTRACT FROM AUTHOR]

Rationale: Idiopathic pulmonary fibrosis is a fatal and progressive disease with limited treatment options. Objectives: We sought to assess the efficacy and safety of CC-90001, an oral inhibitor of c-Jun N-terminal kinase 1, in patients with idiopathic pulmonary fibrosis. Methods: In a Phase 2, randomized (1:1:1), double-blind, placebo-controlled study ( ID: NCT 03142191), patients received CC-90001 (200 or 400 mg) or placebo once daily for 24 weeks. Background antifibrotic treatment (pirfenidone) was allowed. The primary endpoint was change in the percentage of predicted FVC (ppFVC) from baseline to Week 24; secondary endpoints included safety. Measurements and Main Results: In total, 112 patients received at least one dose of study drug. The study was terminated early because of a strategic decision made by the sponsor. Ninety-one patients (81%) completed the study. The least-squares mean changes from baseline in ppFVC at Week 24 were −3.1% (placebo), −2.1% (200 mg), and −1.0% (400 mg); the differences compared with placebo were 1.1% (200 mg; 95% confidence interval: −2.1, 4.3; P = 0.50) and 2.2% (400 mg; 95% confidence interval: −1.1, 5.4; P = 0.19). Adverse event frequency was similar in patients in the combined CC-90001 arms versus placebo. The most common adverse events were nausea, diarrhea, and vomiting, which were more frequent in patients in CC-90001 arms versus placebo. Fewer patients in the CC-90001 arms than in the placebo arm experienced cough and dyspnea. Conclusions: Treatment with CC-90001 over 24 weeks led to numerical improvements in ppFVC in patients with idiopathic pulmonary fibrosis compared with placebo. CC-90001 was generally well tolerated, which was consistent with previous studies. Clinical trial registered with (NCT 03142191). [ABSTRACT FROM AUTHOR]

We aimed to determine the prevalence and outcomes for forced vital capacity percent predicted (FVCpp) decline among patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD). We identified patients with RA-ILD in the Mass General Brigham Healthcare system. RA-ILD diagnosis was determined by review of high-resolution computed tomography (HRCT) imaging by up to three thoracic radiologists. We abstracted FVCpp measurements, covariates, lung transplant, and ILD-related death from the medical record. We employed a relative FVCpp decline cutoff of > 10% within 24 months. We also used a group-based trajectory model to obtain patterns of change from RA-ILD diagnosis. We then assessed for associations of each FVC decline definition with risk of lung transplant or ILD-related death using multivariable logistic regression. We analyzed 172 patients with RA-ILD with a median of 6 FVCpp measurements per patient over 6.5 years of follow-up (mean age 62.2 years, 36% male). There were seven (4%) lung transplants and 44 (26%) ILD-related deaths. Ninety-eight (57%) patients had relative decline of FVCpp by > 10% in 24 months. We identified three trajectory groups of FVCpp change: rapidly declining (n = 24/168 [14%]), slowly declining (n = 90/168 [54%]), and stable/improving (n = 54/168 [32%]). The rapidly declining group and FVCpp > 10% had adjusted odds ratios (aOR) for lung transplant/ILD-related death of 19.2 (95%CI 4.9 to 75.5) and 2.8 (95%CI 1.3 to 6.1) respectively. Over half of patients with RA-ILD had declining FVCpp. The different trajectory patterns demonstrate the importance of FVC monitoring for identifying patients at the highest risk of poor outcomes. Key Points • Over half of patients with RA-ILD had declining FVCpp over a median of 6.5 years of follow-up. • The rapidly declining FVCpp trajectory group had stronger associations with lung transplant and ILD-related death compared to those with FVCpp decline by > 10%. • Clinicians can employ FVC monitoring to proactively treat patients who are at risk of poor outcomes. [ABSTRACT FROM AUTHOR]

The Taihangshan-Yanshan region (TYR) is an important ecological barrier area for Beijing-Tianjin-Hebei, and the effectiveness of its ecological restoration and protection is of great significance to the ecological security pattern of North China. Based on the FVC data from 2000 to 2021, residual analysis, parametric optimal geodetector technique (OPGD) and multi-scale geographically weighted regression analysis (MGWR) were used to clarify the the multivariate driving mechanism of the evolution of FVC in the TYR. Results show that: (1) FVC changes in the TYR show a slowly fluctuating upward trend, with an average growth rate of 0.02/10a, and a spatial pattern of "high in the northwest and low in the southeast"; more than half of the FVC increased during the 22-year period. (2) The results of residual analysis showed that the effects of temperature and precipitation on FVC were very limited, and a considerable proportion (80.80% and 76.78%) of the improved and degraded areas were influenced by other factors. (3) The results of OPGD showed that the main influencing factors of the spatial differentiation of FVC included evapotranspiration, surface temperature, land use type, nighttime light intensity, soil type, and vegetation type (q > 0.2); The explanatory rates of the two-factor interactions were greater than those of the single factor, which showed either nonlinear enhancement or bifactorial enhancement, among which, the interaction of evapotranspiration with mean air and surface temperature has the strongest effect on the spatial and temporal evolution of FVC (q = 0.75). Surface temperature between 4.98 and 10.4 °C, evapotranspiration between 638 and 762 mm/a, and nighttime light between 1.96 and 7.78 lm/m2 favoured an increase in vegetation cover, and vegetation developed on lysimetric soils was more inclined to be of high cover. (4) The correlation between each variable and FVC showed different performance, GDP, elevation, slope and FVC showed significant positive correlation in most regions, while population size, urban population proportion, GDP proportion of primary and secondary industries, and nighttime light intensity all showed negative correlation with FVC to different degrees. The results can provide data for formulating regional environmental protection and restoration policies. [ABSTRACT FROM AUTHOR]

Background: Pulmonary function is very important for the healthy development of children and adolescents. However, fewer studies have been conducted on pulmonary function trends in children and adolescents in remote areas. The aim of this study was to estimate the forced vital capacity (FVC) trend and its relationship with body mass index (BMI) among young people in Xinjiang during 1985–2014 using data from seven successive national surveys. Methods: A total of 19,449 Xinjiang children and adolescents aged 7–18 years were extracted from the Chinese National Survey on Students' Constitution and Health. Height, weight, and FVC were measured repeatedly in each survey. FVC comparisons between adjacent surveys by age and sex were conducted by nonparametric Kruskal-Wallis after Kolmogorov-Smirnov of normality. One-way ANOVA and least significant difference(LSD) method was used to compare differences in FVC levels of Xinjiang children and adolescents with different BMI. The relationship between BMI and FVC was investigated using a nonlinear regression model. Results: The FVC levels of Xinjiang children and adolescents peaked in 2000, with overall FVC levels being 8.7% higher in 2000 than in 1985. Since then, a substantial decline occurred, contrasting to 2000, with FVC levels decreasing by 27% in 2014, which was still lower than that in 1985 by 20.73%. The proportion of overnutrition boys increased from 0.2% in 1985 to 22.1% in 2014, and girls from 0.5% in 1985 to 14.5% in 2014. An inverted U-shape association between FVC and BMI values was obtained for Xinjiang children and adolescents. Conclusions: Targeted measures should be carried out in schools to control BMI levels to ensure good lung function in children and adolescents in Xinjiang. Future studies should pay more attention to other factors affecting FVC, such as dietary behaviour, physical activity, and racial differences among children and adolescents. [ABSTRACT FROM AUTHOR]

The association between newborn DNA methylation (DNAm) and asthma acquisition (AA) during adolescence has been suggested. Lung function (LF) has been shown to be associated with asthma risk and its severity. However, the role of LF in the associations between DNAm and AA is unclear, and it is also unknown whether the association between DNAm and AA is consistent with that between DNAm and LF. We address this question through assessing newborn epigenetic features of preadolescence LF and of AA during adolescence, along with their biological pathways and processes. Our study's primary medical significance lies in advancing the understanding of asthma's early life origins. By investigating epigenetic markers in newborns and their association with lung function in preadolescence, we aim to uncover potential early biomarkers of asthma risk. This could facilitate earlier detection and intervention strategies. Additionally, exploring biological pathways linking early lung function to later asthma development can offer insights into the disease's pathogenesis, potentially leading to novel therapeutic targets. Methods: The study was based on the Isle of Wight Birth cohort (IOWBC). Female subjects with DNAm data at birth and with no asthma at age 10 years were included (n = 249). The R package ttScreening was applied to identify CpGs potentially associated with AA from 10 to 18 years and with LF at age 10 (FEV1, FVC, and FEV1/FVC), respectively. Agreement in identified CpGs between AA and LF was examined, along with their biological pathways and processes via the R function gometh. We tested the findings in an independent cohort, the Avon Longitudinal Study of Parents and Children (ALSPAC), to examine overall replicability. Results: In IOWBC, 292 CpGs were detected with DNAm associated with AA and 1517 unique CpGs for LF (514 for FEV1, 436 for FVC, 408 for FEV1/FVC), with one overlapping CpG, cg23642632 (NCKAP1) between AA and LF. Among the IOWBC-identified CpGs, we further tested in ALSPAC and observed the highest agreement between the two cohorts in FVC with respect to the direction of association and statistical significance. Epigenetic enrichment analyses indicated non-specific connections in the biological pathways and processes between AA and LF. Conclusions: The present study suggests that FEV1, FVC, and FEV1/FVC (as objective measures of LF) and AA (incidence of asthma) are likely to have their own specific epigenetic features and biological pathways at birth. More replications are desirable to fully understand the complexity between DNAm, lung function, and asthma acquisition. [ABSTRACT FROM AUTHOR]

BackgroundThe telomere has long been regarded as a dependable biomarker for cellular senescence. The lung function can reflect the function and status of the lungs. As individuals age beyond adulthood, there is a gradual decline in lung function. However, the existence of a associated between leukocyte telomere length (LTL) and lung function remains uncertain.MethodsA two-sample Mendelian randomization (MR) analysis was used. The Single-nucleotide polymorphisms (SNPs) of LTL from the genome-wide association (GWAS) study were used as exposure instruments variable, and the lung function indicator including Forced expiratory volume in 1-s (FEV1), FEV1 Best measure, FEV1 predicted and Forced vital capacity (FVC) from the Neale Lab and MRC-IEU were used as outcomes. The associated between the exposures and outcomes was assessed using inverse-variance weighted (IVW), MR-Egger, and weighted median methods. Sensitivity analysis was conducted using Cochran’s Q-test, MR-Egger intercept test, MR-PRESSO, leave-one-out analysis, and Steriger test.ResultsUsing the IVW method, a significant association was identified between genetically determined telomere length extension and enhanced lung function in FEV1, with ukb-a-336 (P = 0.127, OR = 1.028,95CI% = 1.003–1.042) and ukb-b-19657 (P = 7.26E-05, OR = 1.051,95CI% = 1.025–1.077),in FEV1 predicted, ukb-a-234 (P = 0.013, OR = 1.029,95CI% = 1.003–1.042), ukb-b-8428 (P = 0.001, OR = 1.032,95CI% = 1.012–1.052), in FEV1 best measure, ukb-a-231 (P = 7.24E-05, OR = 1.050,95CI% = 1.025–1.075), ukb-b-11141 (P = 1.40E-09, OR = 1.067,95CI% = 1.045–1.090).The sensitivity analysis did not reveal heterogeneity or horizontal pleiotropy.Meanwhile, the Steriger test results also indicate that the directionality between exposure and outcome is correct. Therefore, the results indicated robustness.ConclusionThere is a correlation between longer LTL and better lung function in the European dataset.

Abdullah Alzayed Department of Pediatrics, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 13317, Saudi ArabiaCorrespondence: Abdullah Alzayed, Department of Pediatrics, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 13317, Saudia Arabia, Email aaalzayed@imamu.edu.saObjective: This study aims to evaluate the association between socioeconomic conditions and the lung function of children below 18 years old.Design: Systematic review.Methods: PRISMA guidelines were followed to browse relevant studies from 2013 to 2023. Data from the included studies were extracted after the Newcastle–Ottawa risk of bias tool was applied.Main Outcome: Forced expiratory volume in the first second (FEV1) liters.Results: 20 papers with 89,619 participants were included. Logistic regression model for FEV1 based on multiple SES indices, suggested a positive association between lower respiratory function and a lower SES, with an interquartile odds ratio (OR) of 1.67 (95% CI 1.03– 1.34).Conclusion: Children from a lower socioeconomic status (SES) do exhibit lower lung function and addressing the causes of this can contribute to developing preventive public health strategies.Limitations: Lack of appropriate reference values and varied indicators of socioeconomic status in the studies contributed to significant statistical differences.Prospero Registration Number: CRD 42020197658.Keywords: socioeconomic status, SES, lung function, children, FEV1, FVC

Manganese ore, as an important strategic metal resource for the country, was subject to unreasonable mining practices and outdated smelting technologies in early China, leading to severe ecological damage in mining areas. This study examines the trends in vegetation cover change in the historical manganese mining areas of Yongzhou under the influence of policy, providing technical references for mitigating the ecological impact of these legacy mining areas and offering a basis for adjusting mine restoration policies. This paper takes the manganese mining area in Yongzhou City, Hunan Province as a case study and selects multiple periods of Landsat satellite images from 2000 to 2023. By calculating the Normalized Difference Vegetation Index (NDVI) and the Fractional Vegetation Coverage (FVC), the spatiotemporal changes and driving factors of vegetation coverage in the Yongzhou manganese mining area from 2000 to 2023 were analyzed. The analysis results show that, in terms of time, from 2000 to 2012, the vegetation coverage in the manganese mining area decreased from 0.58 to 0.21, while from 2013 to 2023, it gradually recovered from 0.21 to 0.40. From a spatial perspective, in areas where artificial reclamation was conducted, the vegetation was mainly mildly and moderately degraded, while in areas where no artificial restoration was carried out, significant vegetation degradation was observed. Mining activities were the primary anthropogenic driving force behind the decrease in vegetation coverage, while effective ecological protection projects and proactive policy guidance were the main anthropogenic driving forces behind the increase in vegetation coverage in the mining area.

Traffic-Related Air Pollution (TRAP) exposure has been connected to significant health impacts among children. A cross-sectional comparative study was conducted among school children in Malaysia to determine the relationship between their exposure to TRAP and respiratory health effects. Air monitoring was conducted in schools and residences, while the children's routines were investigated using a diary of daily activities. Respondents' background and respiratory symptoms were obtained from a validated questionnaire, while a spirometry test was performed to determine their lung function status. The distances between schools and residences from the had contributed to the higher concentration of air pollutants in this study, which had associations with the children's respiratory symptoms and lung function status. PM2.5 was the main predictor influencing the respondents' respiratory symptoms and lung function abnormalities. In conclusion, exposure of school children to a high TRAP level might increase their risk of getting respiratory symptoms and lung function reduction. [ABSTRACT FROM AUTHOR]

Background: Diabetes mellitus is a chronic disease with microvascular and macrovascular complications. The pulmonary complications of diabetes mellitus have been poorly characterized. Pulmonary function tests (PFTs) are noninvasive tests that show how well the lungs are working. Objectives: The aim of this study is to compare pulmonary PFTs in type 2 diabetic and non diabetic patients undergoing elective major abdominal surgeries under general anesthesia. Materials & Methods: A total of 100 patients (50 diabetic & 50 non diabetic), undergoing elective major abdominal surgeries under general anesthesia were enrolled for the study. Pulmonary function tests were performed 60 minutes before and after the end of surgery. The PFTs recorded were FEV1, FVC, FEV1/FVC, FEF 25%, and Peak expiratory flow rate (PEFR). Results: Majority of the subjects (34% diabetic and 42% non diabetic) was 51-55 years age group, the mean age among diabetics was 52.9 ± 4.8 and non diabetic group were 51.3 ± 4.8 years. The male were slightly higher than female in both the groups. The mean age, gender and BMI of both the groups was not statistically different and both the groups were comparable at baseline. The pulmonary function test (FEV1, FVC, FEF 25%, and PEFR) were significantly reduced in diabetic subjects compared with non diabetic subject, except FEV1/FVC. Conclusion: The mean scores of FVC, FEV1, PEFR, and FEF 25% were significantly reduced among type 2 diabetic patients as compared to non-diabetic subjects, except FEV1/FVC ratio [ABSTRACT FROM AUTHOR]

As China has recently launched the GaoFen-1 satellite (GF-1) carrying on the wide-field view (WFV) sensor, it is a challenging task to make full use of its observations to produce the fractional vegetation cover (FVC). In light of this, our study presents a comprehensive algorithm to generate a 16 m/10-day FVC product by considering the vegetation types characteristics. For forests, considering the foliage clumping effect, FVC was estimated from the gap probability theory using GF-1 leaf area index (LAI) and clumping index (CI) as a priori knowledge; for non-forests, FVC was estimated from the dimidiate pixel model using GF-1 normalized difference vegetation index (NDVI). The performance of GF-1 FVC from 2018 to 2020 was evaluated using FVC ground measurements obtained from 7 sites for crops, grasslands, and forests in China. The direct validation indicated that the performance of the FVC product was satisfactory, as evidenced by R2 = 0.55, RMSE = 0.15 and BIAS = 0.01 for all vegetation types. Furthermore, the GF-1 FVC exhibited better performance compared to the GEOV3 FVC at a spatial resolution of 300 meters. Moreover, the 10-day temporal interval of GF-1 FVC product successfully facilitated the extraction of regional phenological information at a spatial resolution of 16 meters.

Fractional vegetation cover (FVC) plays a key role in ecological and environmental status assessment because it directly reflects the extent of vegetation cover and its status, yet vegetation is an important component of ecosystems. FVC estimation methods have evolved from traditional manual interpretation to advanced remote sensing technologies, such as satellite data analysis and unmanned aerial vehicle (UAV) image processing. Extraction methods based on high-resolution UAV data are being increasingly studied in the fields of ecology and remote sensing. However, research on UAV-based FVC extraction against the backdrop of the high soil reflectance in arid regions remains scarce. In this paper, based on 12 UAV visible light images in differentiated scenarios in the Ebinur Lake basin, Xinjiang, China, various methods are used for high-precision FVC estimation: Otsu’s thresholding method combined with 12 Visible Vegetation Indices (abbreviated as Otsu-VVIs) (excess green index, excess red index, excess red minus green index, normalized green–red difference index, normalized green–blue difference index, red–green ratio index, color index of vegetation extraction, visible-band-modified soil-adjusted vegetation index, excess green minus red index, modified green–red vegetation index, red–green–blue vegetation index, visible-band difference vegetation index), color space method (red, green, blue, hue, saturation, value, lightness, ‘a’ (Green–Red component), and ‘b’ (Blue–Yellow component)), linear mixing model (LMM), and two machine learning algorithms (a support vector machine and a neural network). The results show that the following methods exhibit high accuracy in FVC extraction across differentiated scenarios: Otsu–CIVE, color space method (‘a’: Green–Red component), LMM, and SVM (Accuracy > 0.75, Precision > 0.8, kappa coefficient > 0.6). Nonetheless, higher scene complexity and image entropy reduce the applicability of precise FVC extraction methods. This study facilitates accurate, efficient extraction of vegetation information in differentiated scenarios within arid and semiarid regions, providing key technical references for FVC estimation in similar arid areas.

Open-pit coal mining inevitably damages the soil and vegetation in mining areas. Currently, the restoration of cold and arid open-pit mines in Xinjiang, China, is still in the initial exploratory stage, especially the changes in soil nutrients in spoil dumps over time. Dynamic remote sensing monitoring of vegetation in mining areas and their correlation are relatively rare. Using the Heishan Open Pit in Xinjiang, China, as a case, soil samples were collected during different discharge periods to analyze the changes in soil nutrients and uncover the restoration mechanisms. Based on four Landsat images from 2018 to 2023, the remote sensing ecological index (RSEI) and fractional vegetation cover (FVC) were obtained to evaluate the effect of mine restoration. Additionally, the correlation between vegetation changes and soil nutrients was analyzed. The results indicated that (i) the contents of nitrogen (N), phosphorus (P), potassium (K), and organic matter (OM) in the soil increased with the duration of the restoration period. (ii) When the restoration time of the dump exceeds 5 years, N, P, K, and OM content is higher than that of the original surface-covered vegetation area. (iii) Notably, under the same restoration aging, the soil in the artificial mine restoration demonstration base had significantly higher contents of these nutrients compared to the soil naturally restored in the dump. (iv) Over the past five years, the RSEI and FVC in the Heishan Open Pit showed an overall upward trend. The slope remediation and mine restoration project significantly increased the RSEI and FVC values in the mining area. (v) Air humidity and surface temperature were identified as key natural factors affecting the RSEI and FVC in cold and arid open pit. The correlation coefficients between soil nutrient content and vegetation coverage were higher than 0.78, indicating a close and complementary relationship between the two. The above results can clarify the time–effect relationship between natural recovery and artificial restoration of spoil dumps in cold and arid mining areas in Xinjiang, further promoting the research and practice of mine restoration technology in cold and arid open pits.

When recording the vegetation distribution with a camera, shadows can form due to factors like camera angle and direct sunlight. These shadows result in the loss of pixel information and texture details, significantly reducing the accuracy of fractional vegetation coverage (FVC) extraction. To address this issue, this study proposes an efficient double-exposure algorithm. The method reconstructs the pixel information in shadow areas by fusing normal-exposure and overexposed images. This approach overcomes the limitations of the camera’s dynamic range in capturing pixel information in shadowed regions. The study evaluates images with five levels of overexposure combined with five vegetation extraction indices. The aim is to determine the best-performing double-exposure combination under shadow conditions and the most suitable vegetation index. Experimental results reveal that the R² value between the best vegetation index and the FVC calculated from the fused double-exposure images and the ground truth FVC increases from 0.750 to 0.969. The root mean square error (RMSE) reduces from 0.146 to 0.046, and the intersection over union (IOU) increases from 0.856 to 0.943. These results demonstrate the excellent vegetation extraction capability of the double-exposure algorithm under shadow conditions, offering a straightforward and effective solution to low accuracy of FVC in shadowed areas.

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Background: Asthma, being a commonest chronic disease in children, is leading to disability as well as school absence. Present study was aimed to Study of clinical profile of asthma and other comorbidities among school going children. Material and Methods: Present study was prospective, observational study, conducted in school going children in urban Bangalore, age group between 6 to 15 years. On the basis of the history, students with suspected asthma were subjected to PEFR & spirometry. Results: During present study, total 8 schools were selected randomly, among 1000 subjects were enrolled into the study. Based on questionnaire 85 of subjects were suspected of asthma. 563 subjects were male and the prevalence of asthma in males is 38(6.75%) and 437 subjects were female and the prevalence of asthma in the female is 47 (10.76%). The P-Value is 0.02 statistically significant, indicating that females were more risk than males. The p-value was statistically significant for exposure to cigarette smoke at home, exposure to household smoke & pets at home; indicating that those were significant high risk factor to develop asthma. Among 1000 subjects, 85 subjects were suspected asthma, for them Pulmonary function was performed. Among 85 asthma suspected subjects, 5 (5.88%) subjects have PEFR less than 60 followed by 12 (14.11%) subjects have PEFR between 60-70, 25 (29.41%) subjects have PEFR between 70-80 and 43 (50.58%) subjects have PEFR more than 80. Conclusion: In the present study, the overall prevalence of bronchial asthma among children of the school-going age group was found to be 8.5%. The risk factors were exposure to cigarette smoke at home, exposure to household smoke, and pets at home are significantly high-risk factors to develop asthma. [ABSTRACT FROM AUTHOR]

It is of great practical significance to regional ecological conservation and restoration to explore the spatiotemporal variation characteristics of habitat quality in the ecologically fragile Loess Plateau. This study firstly explored the habitat quality in the Loess Plateau during 2000-2020 with the Integrated Valuation of Ecosystem Services and Trade-offs model. Then this study revealed the response characteristics of habitat quality to the fractional vegetation cover (FVC) change and human disturbance with the geographically weighted regression (GWR) model. Results showed habitat quality tended to improve in 51.16% of the study area, and area of high or very high habitat quality increased by 1.78%. Besides, FVC showed dominantly significant increase (62.42%) and high stability (69.66%) in the study area, and human disturbance increased remarkably in 18.11% of the study area but maintained the same level in 91.83% of the study area. Additionally, areas with positive correlation between habitat quality change and FVC and between habitat quality change and human disturbance change accounted for 52.56% and 37.38% of the study area, respectively, indicating FVC played dominant role in affecting the regional habitat quality variation. This study can provide important decision support information for the future ecological conservation of the Loess Plateau. [ABSTRACT FROM AUTHOR]

Vegetation cover in the Loess Plateau region is an important component of ecological protection in the Yellow River Basin, and this study provides a scientific reference for further vegetation restoration. Based on Landsat images and related data, we utilized the dimidiate pixel model and Geodetector method to study the vegetation cover in the Wuding River Basin from 2000 to 2022. The results indicated the spatial and temporal distribution of the vegetation cover and its changes over the study period. Additionally, the driving factors influencing its spatial changes were also uncovered. We also propose a land use shift vegetation cover contribution formula to quantify the effect of land type change on the FVC. The study showed that (1) the overall vegetation cover of the watershed increased significantly, and the FVC showed an increasing trend from 2000 to 2013 and a slow decline from 2013 to 2022, with the gradual transformation of low-graded FVC into a higher graded one. (2) The FVC increased spatially from northwest to southeast, and the trend of future changes is mainly decreasing. (3) The strongest explanatory power for the FVC change is the land use type and its interactive combination with rainfall. (4) The conversion of grassland to cropland contributes the most to the vegetation cover at 1.52%, and the increase in the cropland area is more conducive to the increase in the vegetation cover. [ABSTRACT FROM AUTHOR]

Introduction: Abnormal lung function in people with multiple sclerosis (PwMS) could be considered as the result of muscle weakness or MS-specific structural central nervous system (CNS) abnormalities as a precipitant factor for the worsening of motor impairment or cognitive symptoms. Methods: This is a cross-sectional observational study in PwMS. Forced spirometry was conducted, and normative metrics of forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), and the relation FEV1/FVC were calculated. Qualitative and quantitative brain magnetic resonance imaging (MRI) examinations were carried out. Results: A total of 371 PwMS were included in the study. Of those, 196 (53%) had RRMS, 92 (25%) SPMS, and 83 (22%) PPMS. Low FVC and FEV1 was present in 16 (8%), 16 (19%), and 23 (25%) of the patients in the RRMS, PPMS, and SPMS, respectively. PwMS with T2-FLAIR lesions involving the corpus callosum (CC) had a significantly higher frequency of abnormally low FVC and FEV1 (OR 3.62; 95% CI 1.33–9.83; p = 0.012) than patients without lesions in that region. This association remained significant in the RRMS group (OR 10.1; 95% CI 1.3–67.8; p 0.031) when the model excluded PPMS and SPMS. According to our study, for every increase of 1 z score of FVC, we observed an increase of 0.25 cm3 of hippocampal volume (β 0.25; 95% CI 0.03–0.47; p 0.023) and 0.43 cm3 of left hippocampus volume (β 0.43; 95% CI 0.16–0.71; p 0.002). Conclusions: We observed an incremental prevalence of abnormally low pulmonary function tests that parallels a sequence from more early relapsing courses to long-standing progressive courses (RRMS to PPMS or SPMS). [ABSTRACT FROM AUTHOR]

• Respiratory function is relatively frequently impaired in adult SMA patients. • Respiratory dysfunction correlates with worse motor function and disease severity. • Respiratory function appears to stabilize in adulthood, except for walking patients. • Disease duration and age do not correlate with respiratory dysfunction. Due to poor data in literature, we aimed to investigate the respiratory function in a large cohort of naïve Italian adult (≥18 years) SMA patients in a multi-centric cross-sectional study. The following respiratory parameters were considered: forced vital capacity (FVC), forced expiratory volume in one second (FEV1) and need for non-invasive ventilation (NIV). We included 145 treatment-naïve adult patients (SMA2=18, SMA3=125; SMA4=2), 58 females (40 %), with median age at evaluation of 37 years (range 18–72). Fifty-six (37 %) and 41 (31 %) patients had abnormal (<80 %) values of FVC and FEV1, respectively. Fourteen (14 %) patients needed NIV, started at median age of 21 (range 4–68). Motor function, measured by Hammersmith Functional Motor Scale Expanded and Revised Upper Limb Module as well as SMA2, loss of walking ability, surgery for scoliosis, use of NIV, and cough assisting device (CAD) were all significantly associated to lower FVC and FEV1 values, while no association with age at baseline, disease duration, gender or 6 min walking test was observed, except for a correlation between FVC and age in SMA3 walkers (p < 0.05). In conclusion, respiratory function in adult SMA patients is relatively frequently impaired, substantially stable, and significantly correlated with motor function and disease severity. [ABSTRACT FROM AUTHOR]

The purpose of this study was to determine pulmonary function, respiratory muscle strength, and aerobic capacity and the correlation of each with Apnea Hypopnea Index (AHI) in non-obese patients with mild-to-moderate Obstructive Sleep Apnea (OSA). Forty patients 20 and 50 years of age with mild to moderate OSA were recruited. Spirometry, respiratory muscle pressure, aerobic capacity, and polysomnography were measured. The means value for FVC, FEV1, MIP, MEP, and VO2 peak were 78.33 ± 11.10%, 86.95 ± 10.75%, 62.35 ± 22.56 cmH2O, 66.90 ± 20.10, and 34.94 ± 5.07 mL·kg-1·min-1, respectively. AHI was observed to have a low negative correlation with FEF25-75% (r = - 0.345; P = 0.029). The findings indicate that non-obese patients with OSA had a compromised pulmonary function. Also, a significant association was observed between small airway disease parameter and OSA severity in this population. [ABSTRACT FROM AUTHOR]

Objective: To study the spirometry parameters of children six months after severe acute coronavirus 2 (SARS-CoV-2) infection. Methods: This single center descriptive study enrolled children aged 7–18 years after 6 months of SARS-CoV-2 infection. A detailed interval history and clinical examination was recorded. Spirometry was performed and best of the three attempts was taken into consideration to measure forced vital capacity (FVC) and forced expiratory volume 1 second (FEV1). Results: A convenience sample of 40 (21 boys) children was enrolled, median (IQR) age 13 (10.75, 17) years. Twelve (30%) children had abnormal spirometry with low FVC (<80%); 10/12 (83.3%) had FEV1<80%. Children who were underweight had higher odds of having abnormal spirometry [OR (95% CI) 5.13 (1.19, 22.11); P=0.028]. There was no significant association of abnormal spirometry with age, sex, severity of initial infection and oxygen requirement during the initial infection (P>0.05). Conclusion: Abnormal spirometry results were observed in one-third children post-SARS-CoV-2 infection at six months follow-up. [ABSTRACT FROM AUTHOR]

Context: Thoracic hyperkyphosis, one of the most common spinal deformities, may lead to undesirable pulmonary outcomes . Objective: To study, the efficacy of virtual reality exercise training on thoracic hyperkyphosis and respiratory parameters in young women. Design: Randomized clinical trial. Se#ing. Laboratory setting. Participants and Intervention: Participants were randomly assigned to one of two 4-week exercise training groups: regular training (RT), which involved stretch and strength training, or virtual reality with RT (VRRT), which involved dance training with the Xbox 360 Kinect® game in addition to the exercises, which the RT group received. Main Outcome Measures : The authors measured kyphosis angle with a Flexicurve ruler and recorded respiratory parameters (forced vital capacity [FVC] and forced expiratory volume in 1 s [FEV i ]) with a spirometer in each participant at baseline and postintervention. Separate 2x2 repeated-measure analysis of variances were used to analyze differences between means for kyphosis angle, FEVI, and FVC. Based on the significant interactions between time and group, the paired t test was used to compare the results at baseline and postintervention, and the independent sample t test was used to compare the differences in changes between groups. Level of significance was considered at P <.05 except for paired t test that was adjusted to P <.025 for each variable in 2 groups. Results: The results showed statistically significant interactions between time and group for kyphosis angle, FEVi, and FVC. Postintervention thoracic kyphosis angle decreased and FVC increased significantly in both groups and FEVI improved significantly in virtual reality with RT group. The improvements in thoracic kyphosis, FVC, and FEV 1 in the virtual reality with RT group were significantly greater ( P <. 001 ) than in the RT group . Conclusion: Dance training with the Xbox 360 Kinect game was an effective therapy in improving thoracic kyphosis angle, FVC, and FEVi in young women with thoracic hyperkyphosis. [ABSTRACT FROM AUTHOR]

Summary: Background: We aimed to assess whether exposure to risk factors in early life from conception to puberty continue to contribute to lung function decline later in life by using a pooled cohort comprising approx. 11,000 adults followed for more than 20 years and with up to three lung function measurements. Methods: Participants (20–68 years) in the ECRHS and NFBC1966 cohort studies followed in the periods 1991–2013 and 1997–2013, respectively, were included. Mean annual decline in maximum forced expired volume in 1 s (FEV1) and forced vital capacity (FVC) were main outcomes. Associations between early life risk factors and change in lung function were estimated using mixed effects linear models adjusted for sex, age, FEV1, FVC and height at baseline, accounting for personal smoking. Findings: Decline in lung function was accelerated in participants with mothers that smoked during pregnancy (FEV1 2.3 ml/year; 95% CI: 0.7, 3.8) (FVC 2.2 ml/year; 0.2, 4.2), with asthmatic mothers (FEV1 2.6 ml/year; 0.9, 4.4) (FEV1/FVC 0.04 per year; 0.04, 0.7) and asthmatic fathers (FVC 2.7 ml/year; 0.5, 5.0), and in women with early menarche (FVC 2.4 ml/year; 0.4, 4.4). Personal smoking of 10 pack-years contributed to a decline of 2.1 ml/year for FEV1 (1.8, 2.4) and 1.7 ml/year for FVC (1.3, 2.1). Severe respiratory infections in early childhood were associated with accelerated decline among ever-smokers. No effect-modification by personal smoking, asthma symptoms, sex or cohort was found. Interpretation: Mothers’ smoking during pregnancy, parental asthma and early menarche may contribute to a decline of FEV1 and FVC later in life comparable to smoking 10 pack-years. Funding: European Union's Horizon 2020; Research Council of Norway; Academy of Finland; University Hospital Oulu; European Regional Development Fund; Spanish Ministry of Science and Innovation; Generalitat de Catalunya.

It is of great practical significance to regional ecological conservation and restoration to explore the spatiotemporal variation characteristics of habitat quality in the ecologically fragile Loess Plateau. This study firstly explored the habitat quality in the Loess Plateau during 2000-2020 with the Integrated Valuation of Ecosystem Services and Trade-offs model. Then this study revealed the response characteristics of habitat quality to the fractional vegetation cover (FVC) change and human disturbance with the geographically weighted regression (GWR) model. Results showed habitat quality tended to improve in 51.16% of the study area, and area of high or very high habitat quality increased by 1.78%. Besides, FVC showed dominantly significant increase (62.42%) and high stability (69.66%) in the study area, and human disturbance increased remarkably in 18.11% of the study area but maintained the same level in 91.83% of the study area. Additionally, areas with positive correlation between habitat quality change and FVC and between habitat quality change and human disturbance change accounted for 52.56% and 37.38% of the study area, respectively, indicating FVC played dominant role in affecting the regional habitat quality variation. This study can provide important decision support information for the future ecological conservation of the Loess Plateau.

Five countries in the Lancang–Mekong region, including Myanmar, Laos, Thailand, Cambodia, and Vietnam, are facing the threat of deforestation, despite having a high level of forest coverage. Quantitatively assessing the forest ecosystem status and its variations based on remote sensing products for vegetation parameters is a crucial prerequisite for the ongoing phase of our future project. In this study, we analyzed forest health in the year 2020 using four vegetation indicators: forest coverage index (FCI), leaf area index (LAI), fraction of green vegetation cover (FVC), and gross primary productivity (GPP). Additionally, we introduced an ecosystem quality index (EQI) to assess the quality of forest health. To understand the long-term trends in the vegetation indicators and EQI, we also performed a linear regression analysis from 2010 to 2020. The results revealed that Laos ranked as the top-performing country for forest ecosystem status in the Lancang–Mekong region in 2020. However, the long-term trend analysis results showed that Cambodia experienced the most significant decline across all indicators, while Vietnam and Thailand demonstrated varying degrees of improvement. This study provides a quality assessment of forest health and its variations in the Lancang–Mekong region, which is crucial for implementing effective conservation strategies. [ABSTRACT FROM AUTHOR]

Physical inactivity is a crucial contributor to the obesity epidemic. Previous studies demonstrated that physical inactivity and obesity have been linked with the impairments of pulmonary and respiratory muscle function. However, the impact of physical activity (PA) on pulmonary and respiratory muscle function in obese young adults remains unclear. The study aimed to compare pulmonary and respiratory muscle function between physically inactive and active obese young adults. Obese young adults (BMI ≥ 25 kg/m² ) aged between 18 - 25 years old were included. They were classified into 2 groups, physically inactive obese (IO, n = 16) and active obese (AO, n = 14) groups according to the metabolic equivalent of task (MET) obtained from the global physical activity questionnaire (GPAQ). Then, pulmonary and respiratory muscle function were measured. The results showed that there were no differences in baseline data between groups. The AO group showed significantly higher forced expiratory volume in 1 second (FEV1) (2.90 ± 0.55 vs 3.40 ± 0.79, p = 0.04), and maximal inspiratory pressure (MIP) (96.25 ± 6.18 vs 124.50 ± 12.28, p = 0.01) than those IO group. There were no differences between the groups in regard to FVC, FEV1/FVC ratio, %FVC, %FEV1, MVV, %MVV and maximum expiratory pressure (MEP) (all p > 0.05). In addition, FEV1 (r = 0.43, p = 0.01) and MIP (r = 0.40, p = 0.03) were positively moderately correlated with MET. Higher in FEV1 and MIP which observed in physically active obese young adults indicate that regular PA appears to be beneficial to pulmonary function and inspiratory muscle strength in obese individuals. [ABSTRACT FROM AUTHOR]

This article presents the findings of a research study conducted at the Sriwijaya State Sports School in South Sumatra, Indonesia. The study aimed to assess the physical fitness of student football athletes by measuring their VO2Max and Forced Vital Capacity (FVC) lung parameters. The results showed that the majority of the athletes had low levels of physical fitness, with 96.9% categorized as "less" and 3.1% as "very less". The study suggests the need for a rigorous and structured training program to improve the athletes' aerobic capacity and lung capacity. The article highlights the importance of physical fitness in soccer and the role of cardiopulmonary endurance in achieving optimal performance. [Extracted from the article]

Vegetation is one of the most important parts of the Earth's land surface system. To investigate the impact and uncertainty of multi-source vegetation data on climate simulations in East Asia, we have compared two Fractional Vegetation Cover (FVC) and five Leaf Area Index (LAI) products and then performed seven experiments from 1999 to 2018 with the WRF model. The results suggest that the sensitivity of vegetation climatology is large especially in south East Asia, with a maximum difference of 4 m2/m2 in LAI and 16% in FVC. For the mean temperature, the responses in East Asia are between ± 0.4 K, and the uncertainty over the Chinese Mainland gradually enhances with the rapid vegetation growth. The feedback of precipitation is highly heterogeneous with sensitivities ranging between ± 1 mm. For interannual variability, vegetation has a greater impact in summer and autumn. The uncertainty of temperature and precipitation in summer over the Chinese Mainland is 118 and 1754 times that in winter. In addition, the linear trend results also indicate that the maximum trend difference in temperature is around 0.04 K/a in eastern China, while the precipitation has a larger range of 0.04–0.10 mm/a in southern East Asia. Besides, the biophysical mechanism analysis suggests that vegetation impact on surface energy budget is mainly a competition between albedo feedback and moisture feedback, and the large differences in multi-source FVC and LAI are sufficient to simulate different or even opposite feedbacks. [ABSTRACT FROM AUTHOR]