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ABSTRACT Because self-report hand preference measures are limited to investigating cognitive aspects of manual laterality, valid, easy-to-administer and economic behavioural methods are needed for capturing the motoric component of handedness. Therefore, this study introduces the Handedness Index Practical Task (HI 20 ) and tests it in a sample of 206 students ( M age  = 23.79 years, SD age  = 3.01 years), half of whom were self-specified left-handers. After confirming good reliabilities at the subscale and total scale levels, k -means cluster analysis allowed an empirically based partitioning of test subjects into left- ( n  = 72), mixed- ( n  = 23) and right-handers ( n  = 111). To validate this categorization and the HI 20 index, data were compared with the Edinburgh Handedness Inventory (EHI), EHI-short, HI 22 and hand grip strength. The congruency between the HI 20 clusters and alternative categorizations ranged from 95.6% to 84.0%, while the clusters explained large portions of variance in grip strength differences. The HI 20 sub- and total scores showed strong correlations with other measures of lateral preference. Altogether, the freely available HI 20 emerges as a reliable and valid alternative for behavioural handedness assessment, whose power lies in explaining differential hand use patterns and enabling fine-grained examinations of handedness.

Background: Right-hand preference is related to stronger right-directional asymmetry in the length of proximal upper-limb bones, although the relationships of hand preference with directional asymmetry in phalangeal bone lengths are not known. Furthermore, dorsal digit length is an easy-to-measure, faithful proxy of X-rayed phalangeal bone length (which is costly and difficult to measure)., Aim: To study the effects of hand preference, sex, and age on right-left (R-L) asymmetry in dorsal digit lengths., Methods: We measured all dorsal digit lengths (except the thumb) in comparable numbers of left-handers and right-handers in samples of adults (N = 151, age: M = 22.6 years, SD = 3.3) and children (N = 65, age: M = 5.0 years, SD = 1.0)., Results: Right-handers and adults had stronger right-directional asymmetry in digit lengths than left-handers and children. A Bayesian analysis yielded an 'extremely strong likelihood' of no sex differences in the R-L asymmetry of dorsal digit lengths 2 and 4., Conclusions: The effects of hand preference, sex, and age on R-L asymmetry appear to be similar for phalangeal bone length and other (proximal) upper-limb bone lengths. Two distinct biologic mechanisms (i.e., a general right-directional asymmetry mechanism and a handedness-related directional asymmetry mechanism) may contribute to observed R-L asymmetry in limbs. Fingertip fat and bone digit length do not seem to contribute to sex differences in the R-L asymmetry (Dr-l) of the widely studied second-to-fourth digit ratio (2D:4D)., (Copyright © 2020 Elsevier B.V. All rights reserved.)

Background: Prenatal sex hormones may not exclusively determine effects of hand preference on digit ratios. Genetic determination is an alternative possibility., Aim: To study the likelihood of similar effects of hand preference on digit lengths and digit ratios., Methods: We selected similar numbers of left-handers and right-handers in samples of kindergarten children (N = 101, age range: 3.5-7 years) and adults (N = 189, age range: 17-28 years) and measured digit lengths (excluding the thumb) directly on the palmar hand., Results: Compared to right-handers, left-handers had longer digits and lower third-to-fourth (3D:4D) digit ratios among children, whereas an opposite pattern of handedness differences occurred among adults., Conclusions: Effects of hand preference on digit lengths and ratios might be genetically/ontogenetically determined. Also discussed are implications of this set of findings for digit ratio research., (Copyright © 2020 Elsevier B.V. All rights reserved.)

Non-right-handedness appears to be more common among bisexuals and homosexuals than among heterosexuals, which might be indirect evidence of effects of prenatal androgen exposure. Current data suggest higher prenatal testosterone levels among bisexual and homosexual women, but are inconclusive for men. This study examined the association between sexual orientation and non-right-handedness for sex differences and whether higher rates of mixed-handedness, rather than left-handedness, might be the driving factor. This allowed for more specific tests regarding the predictions of two competing theories of prenatal androgen exposure, the Geschwind-Galaburda theory and the callosal hypothesis, than in previous research. Being a potentially better indicator of cerebral lateralization than handedness, associations with footedness were also explored. To counter inconsistencies and shortcomings of previous research, we utilized two large discovery and replication datasets (ns = 2368 and 1565) and applied latent variable analysis to reliably classify lateral preferences (i.e., handedness, footedness). This maximized the statistical conclusion validity and allowed for direct tests of replicability. Sexual orientation was differentially associated with lateral preferences among men and women. Associations among women were consistent with predictions of the Geschwind-Galaburda theory, whereas among men they were consistent with predictions of the callosal hypothesis. The results were further consistent with models of homosexuality that suggest a role of parental epigenetic marks on sexually dimorphic fetal development. Research efforts should be increased with regard to footedness and epigenetic theories of homosexuality.

Objective: Mixed-handedness among children has recently been proposed as a marker of neurodevelopmental disorder and ADHD. This study expanded this initial evidence to the questions of whether mixed-handedness as well as mixed-footedness are similarly associated with ADHD among adults., Method: Self-reported ADHD symptoms, handedness, footedness, and current depression and anxiety were assessed in a large, heterogeneous general population sample ( N = 2,592). Latent variable analysis was used to investigate the structure and measurement properties of ADHD symptoms, the dimensionality of footedness, and the classification of lateral preferences., Results: Mixed-footedness was associated with probable ADHD (odds ratio [OR] = 1.76 [1.07, 2.89], p = .026). Left- and mixed-footedness were associated with higher inattention and impulsivity scores., Conclusion: Developmental continuities of the associations of mixed lateral preferences with ADHD from child to adult age seem to exist. In particular, mixed-footedness, rather than mixed-handedness, appears to be an ADHD marker among adults.

This study investigated the familial transmission of handedness, footedness, eyedness, earedness, and of underlying sidedness in a sample of adults (n = 592 families; 1528 individuals in total), using multi-item inventories and probabilistic methods for preference classification. Our results corroborate three classes of lateral preferences and of sidedness each, right, mixed, and left. Consistent with genetic studies, we obtained evidence of parent-of-origin and sex-of-children effects, suggesting important roles of maternal mixed preferences and of paternal left preferences. Further, parental age at conception predicted mixed preferences in the child. We recommend a trichotomous classification of lateral preferences also in future studies, and to intensify research into the genetic bases of footedness, eyedness and earedness.

Mixed-handedness was reported indicative of schizotypy, relevant to psychosis and schizophrenia. However, studies suffered from validity threats and did not systematically investigate associations with footedness. Moreover, there is a dearth of studies in the general population and it is currently untested whether widely used self-report scales measure schizotypy in a comparable way in student and community samples. The present study used two large and independent community and student samples (total N>2800) and utilized latent class analysis (LCA) for the classification of handedness and footedness. Psychometric properties and measurement equivalence of the Schizotypal Personality Questionnaire-Brief form (SPQ-B) in the two samples were also examined. We found that mixed-handedness (<6% prevalence), but also much more common mixed-footedness (25% prevalence), was specifically and similarly associated with higher schizotypy in both samples, Cohen d=0.15-0.18. Findings indicate that schizotypal traits in conjunction with mixed lateral preferences are thus more prevalent in the overall population than previously assumed, and that footedness may be the more relevant predictor of schizotypy than handedness. Findings are further consistent with evidence on neurodevelopmental instability, but also epigenetic mechanisms involving the sex chromosomes, regarding possible common causes of both mixed-handedness and psychosis-relevant traits., (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)

Lateral preferences are important for the study of cerebral lateralization and may be indicative of neurobehavioral disorders, neurodevelopmental instability, and deficits in lateralization. Previous studies showed that self-reported preferences are also concordantly interrelated, suggesting a common genetic or biological origin, sidedness. However, with regard to the assessment and classification of lateral preferences, there is a dearth of psychometric studies, but a need for psychometrically validated instruments that can be reliably used in applied research. Based on three independent large samples (total N>15,100), this study investigated the psychometric properties of widely-used lateral preference scales of handedness, footedness, eyedness, and earedness. Preferences were consistently and replicably categorical, consisting of right, mixed, and left preferences each, underlining that primarily qualitative, rather than quantitative, differences differentiate lateral preferences. Right-, mixed-, and left-sidedness underlay the individual preferences, but sidedness alone could not fully explain the observed inter-relations. Footedness was the single most important indicator of sidedness. Our data were further consistent with predictions of right shift theory and corroborated a 'pull-to-concordance' in hand-foot preferences. We recommend the use of psychometrically validated scales and of a trichotomous classification of lateral preferences in future research, but conclude that handedness may be a biased indicator of underlying sidedness. Footedness needs to be examined more closely with regard to cerebral lateralization, neurodevelopmental disorders, and neurodevelopmental instability., (Copyright © 2014 Elsevier Ltd. All rights reserved.)

According to the Geschwind-Galaburda theory of cerebral lateralization, high intrauterine testosterone levels delay left brain hemisphere maturation and thus promote left-handedness. Human circulating testosterone levels are higher in the male fetus and also vary with length of photoperiod. Therefore, a higher prevalence of left-handedness, coupled with seasonal anisotropy (i.e., a non-uniform distribution of handedness across birth months or seasons), may be expected among men. Prior studies yielded inconsistent evidence for seasonal anisotropy and suffered from confounding and a number of shortcomings affecting statistical power. This study examined hand preference and associations of handedness with sex, age, and season of birth in independent discovery (n = 7658) and replication (n = 5062) samples from Central Europe with latent class analysis (LCA). We found clear evidence of a surplus of left-handed men born during the period November-January, which is consistent with predictions from the Geschwind-Galaburda theory. Moreover, seasonal anisotropy fully accounted for the higher prevalence of left-handedness among men, relative to women. Implications of these findings with regard to seasonal anisotropy research and handedness assessment and classification are discussed., (Copyright © 2014 Elsevier Ltd. All rights reserved.)

Hand clasping (HC) and arm folding (AF) are bilateral limb postures which are subject to lateral preferences. Previous research suggested that left HC and left AF are "canonical" among European populations, i.e., generally preferred by right-handers. However, evidence on the associations of handedness with HC and AF to date is sparse and inconsistent, with studies mostly relying on relatively small sample sizes and arbitrary classifications of handedness. Utilizing latent class analysis for handedness classification, we present data from two large and independent middle-European samples, a discovery (n = 7,658) and replication (n = 5,062) sample. Our results indicate that right HC, not left HC, is overall preferred and that right-handedness is associated with right HC/left AF, and left- and mixed-handedness with left HC/right AF. Moreover, lateral preferences increased with age, and men had a higher preference of right HC, independent of handedness. We discuss our findings with regard to the generalizability of previous results.

This study investigated handedness and drawing by preschoolers. An observational method for repeated measurement of hand preference is presented. A sample of 381 children (191 girls, 190 boys) ranging in age from 48 to 71 mo. was tested for drawing and hand preference on 14 tasks. Consistent hand preference was defined as always using a particular hand (left or right) for the same task. Girls with consistent hand preference showed better drawing scores compared to girls with inconsistent hand preference. The results showed the importance of a reliable method for measuring hand preference within a single task as early as preschool age.

Sexually differentiated digit ratios of the hand (2D:4D and other) are currently widely studied, owing to their presumed role as a retrospective diagnostic window into prenatal androgen action. This study was only the second one (following McFadden & Shubel, 2002) to examine all 6 possible finger-length ratios (excluding the thumb) and all 10 possible toe-length ratios (including the big toe). Data from a sample of 59 male and 69 female Austrian adults (M age = 27 yr., SD = 7.9) were collected. Replicating the prior study, the majority of toe-length ratios exhibited significant sex differences, which was similar to finger-length ratios, but of weaker effect size. Ipsilateral correlations of toe-length and finger-length ratios were largely absent, except for those of corresponding or adjacent length ratios of the right body side among women. However, these associations were directionally opposite, such that among women, feminized finger-length ratios corresponded to masculinized toe-length ratios. Foot preference (among both sexes) and wearing of toe rings (among women) were not correlates of toe-length ratios. Discussed are implications of these findings for digit ratio research, along with ideas for further inquiry on this topic.

Patterns of directional asymmetry in the length of index and ring finger (2D and 4D) may be sexually differentiated. Martin, Puts, and Breedlove (2008) found leftward bias, i.e., both a longer 2D and 4D in the left than in the right hand, more frequently in men, whereas rightward bias occurred more frequently in women. Further, rightward vs leftward bias seemed a substantial source of variation in digit ratio (2D:4D), a putative marker for prenatal androgen levels. Given the generally small effects, unreplicable results, and inconsistent findings of 2D:4D research, these findings potentially are important as the type of directional digit asymmetry could moderate or obfuscate real associations between 2D:4D and target traits. Based on six samples totaling about 3,000 individuals, the present study replicated the first finding of Martin, Puts, and Breedlove (2008): leftward bias was more frequent among men and rightward bias more frequent among women. This sex effect was small. However, the present study did not replicate the second finding of Martin, et al. (2008): relative to participants' sex the contributions of leftward vs rightward asymmetry to individual variation in 2D:4D were smaller by orders of magnitude and not significant. Implications of these findings for 2D:4D research are discussed.

Different methods for measuring the second-to-fourth digit ratio (2D:4D), a putative marker for prenatal androgen exposure, may lead to varying values of 2D:4D. Specifically, it has been hypothesized that fingertip fat pads may be differentially deformed when taking palm images (photocopies or flatbed scans), but not when fingers are measured directly, thus yielding lower 2D:4D values from image-based measurements rather than direct ones. A measurement protocol for fingertip size is unavailable, as are data on finger and sex differences in this trait. Introducing such a protocol, this study found very large finger differences in adult fingertip size (largest for 4D, smaller for 3D and 5D, smallest for 2D), large side differences (larger in the left than in the right hand of right-handed subjects), but only small and not significant sex differences. Fingertip size was unrelated to image-based 2D:4D measurements, suggesting that fingertip size and the extent of finger and sex differences therein are unlikely to explain discrepant 2D:4D values obtained from image-based versus direct measurements.

Sex and side differences in relative thumb length of children and adolescents have been reported by prior researchers. These findings mirror those reported for the second-to-fourth digit ratio (2D:4D), a likely biomarker for the organizational (permanent) effects of prenatal androgens on the human brain and body. The present study investigated relative thumb length, in particular, its associations with all possible digit ratios (2D:3D, 2D:4D, 2D:5D, 3D:4D, 3D:5D, and 4D:5D), in a sample of young adults (60 men and 64 women). Relative thumb length was less precisely measurable than direct or image-based finger-length measurements, as used in digit ratio research. There were no significant sex or side differences in relative thumb length. Contrary to expectation, thumb size was not positively correlated with any digit ratios. Relative thumb length appears to be developmentally unstable (decreases during childhood and adolescence). Additional findings, such as the magnitude ranking of sex differences in digit ratios and the comparability of direct versus image-based finger-length measurements, are also discussed.

The second to fourth digit ratio (2D:4D) is a sexually dimorphic trait (men tend to have lower values than women) and a likely biomarker for the organizational (permanent) effects of prenatal androgens on the human brain and body. Prenatal testosterone, as reflected by 2D:4D, has many extragenital effects, including its relevance for the formation of an efficient cardiovascular system. Previous research, reviewed here, has therefore investigated possible associations of 2D:4D with sport performance. Several studies found more masculinized digit ratio patterns (low 2D:4D values or a negative right-minus-left difference in 2D:4D) to be related to high performance in running, soccer, and skiing. The present research tested this hypothesis in a sample of 54 tournament fencers, predominantly from Austria. For men, negative right-left differences in 2D:4D corresponded significantly to better current as well as highest national fencing rankings, independent of training intensity and fencing experience. The mean 2D:4D values of these fencers were significantly lower and the proportion of left-handers was elevated relative to the local general population. For the right hand, the ratio was somewhat lower in male sabre fencers than in male epée and foil fencers combined and significantly lower in left-handed compared to right-handed fencers. Although nonsignificant due to low statistical power, effect sizes suggested that crossed versus congruent hand-eye and hand-foot preferences might also be related to fencing performance. The present findings add to the evidence that 2D:4D might be a performance indicator for men across a variety of sports.