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Start Over Author "Gregoretti B" Topic fullerenes
2 results on '"Gregoretti B"'

1. Hemolytic effects of water-soluble fullerene derivatives.

Author

Bosi S, Feruglio L, Da Ros T, Spalluto G, Gregoretti B, Terdoslavich M, Decorti G, Passamonti S, Moro S, and Prato M

Subjects
Cell Survival drug effects, Fullerenes chemistry, Humans, Solubility, Fullerenes pharmacology, Hemolysis drug effects
Abstract

A series of water-soluble fullerene C(60) derivatives has been investigated for their cytotoxic and hemolytic properties, with the aim to correlate structure with toxicity. We observed that cationic chains induce significant toxicity while the presence of neutral or anionic moieties did not produce any response in our model. A validation of these experimental observations has been performed by theoretical studies in which hydrophilic and hydrophobic surface areas were correlated quantitatively with hemolytic properties.

Published
2004
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2. Hemolytic Effects of Water-Soluble Fullerene Derivatives

Author

Stefano Moro, Michela Terdoslavich, Tatiana Da Ros, Maurizio Prato, Barbara Gregoretti, Giampiero Spalluto, Luigi Feruglio, Giuliana Decorti, Susanna Bosi, Sabina Passamonti, Bosi, Susanna, Feruglio, L, DA ROS, Tatiana, Spalluto, Giampiero, Gregoretti, B, Terdoslavich, M, Decorti, Giuliana, Passamonti, Sabina, Moro, S, and Prato, Maurizio

Subjects
Fullerene, Cell Survival, Chemistry, fullerene, bisaddition, cytotoxicity, Cationic polymerization, medicine.disease, Hemolysis, Chemical synthesis, Medicinal chemistry, In vitro, Solubility, Drug Discovery, Toxicity, medicine, Humans, Molecular Medicine, Organic chemistry, Fullerenes, Cytotoxicity
Abstract

A series of water-soluble fullerene C60 derivatives has been investigated for their cytotoxic and hemolytic properties, with the aim to correlate structure with toxicity. It was observed that cationic chains induce significant toxicity while the presence of neutral or anionic moieties did not produce any response in our model. A validation of these experimental observations has been performed by theoretical studies in which hydrophilic and hydrophobic surface areas were correlated quantitatively with hemolytic properties.

Published
2004

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