1. [Similarities between amyotrophic lateral sclerosis and frontotemporal dementia].
- Author
-
Hübers A
- Subjects
- Humans, Amyotrophic Lateral Sclerosis, Frontotemporal Dementia diagnosis, Neurodegenerative Diseases
- Abstract
Frontotemporal dementia (FTD) is characterized by degeneration of the frontal and temporal lobes. Classic symptoms include behavioural alterations and executive dysfunction. Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease of the first and second motoneurones, as well as of cortical neurons, presenting with weakness and wasting of the limb, respiratory and bulbar muscles. Accumulation of a mis-localized protein in the neuronal cytoplasma is the main neuropathological marker of ALS but has also been described in certain FTD-variants. Molecules interfering specifically on this level of mis-localization and toxic aggregation may thus represent a very interesting therapeutic approach in both, ALS and FTD., Competing Interests: L’auteure n’a déclaré aucun conflit d’intérêts en relation avec cet article.
- Published
- 2023
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