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Plastic syringes often rely on silicone oil lubrication to reduce plunger-barrel friction, leading to potential issues like oil droplet release and drug aggregation. This study explored an alternative approach combining two-photon polymerization, laser machining, and microinjection molding to manufacture micro-dimpled structures for low friction. Plastic microdimples with high area density and low aspect ratio significantly reduced the coefficient of friction against rubber, while the dimple profile proved crucial in facilitating replication and demolding. The results of this study provide valuable insights into reducing friction between rubber and plastic, particularly in applications like syringes. [ABSTRACT FROM AUTHOR]