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1. Fertility preservation and sperm donation in transgender individuals: The current situation within the French CECOS network

Author

Fanny Magnan, Nicolas Mendes, Vanessa Loup-Cabaniols, Charlotte Dupont, Catherine Patrat, Florence Eustache, Cynthia Frapsauce, Joffrey Mons, Bérengère Ducrocq, Aline Papaxanthos, Célia Ravel, Sylviane Hennebicq, Pascale May-Panloup, Stéphanie Mestres, Oxana Blagosklonov, Beatrice Delepine, Françoise Schmitt, Hortense Drapier, Marie-Ange Carlotti, Emmanuelle Thibault, Louis Bujan, Nathalie Rives, Aurélie Rives-Feraille, Rosalie Cabry, Rachel Levy, Catherine Metzler-Guillemain, Nelly Frydman, Véronique Drouineaud, Isabelle Koscinski, Florence Brugnon, Anne Mayeur, Sophie Mirallié, Patricia Fauque, Catherine Morinière, Cécile Grèze, Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA), CHU Gabriel Montpied [Clermont-Ferrand], and CHU Clermont-Ferrand

Subjects
Adult, Male, Sperm donation, Sperm Retrieval, Reproductive Techniques, Assisted, [SDV]Life Sciences [q-bio], Urology, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Health Services for Transgender Persons, Reproductive technology, Transgender women, film.subject, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, 030225 pediatrics, Transgender, medicine, Humans, Fertility preservation, ComputingMilieux_MISCELLANEOUS, National health, 030219 obstetrics & reproductive medicine, Assisted reproductive technology, Fertility Preservation, Bioethics, Patient Acceptance of Health Care, 16. Peace & justice, 3. Good health, Reproductive Medicine, film, Female, France, Psychology, Transsexualism, Demography
Abstract

BACKGROUND Many studies reported that reproductive desire could be high among transgender individuals. In France, fertility preservation and sperm donation were very little proposed to transgender individuals until recently, mainly because the Bioethics Law allows the use of assisted reproductive technologies only in infertile couples and prohibits surrogacy. OBJECTIVES To evaluate the distribution of care on the French territory concerning fertility preservation and sperm donation in transgender individuals. MATERIALS AND METHODS A multicentric national survey was carried out between January 2019 and October 2020 in 28 assisted reproductive technology centres of the French CECOS (Centres d'Etudes et de Conservation des Oeufs et du Sperme) network. Each centre was questioned to find out how many transgender individuals came, were informed and cared for fertility preservation and sperm donation. RESULTS Concerning fertility preservation, 71.4% of centres received transgender individuals and performed gamete cryopreservation; 581 transgender individuals consulted for fertility preservation. Transgender women were more likely to desire (p

Published
2021
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3. Pregnancies and obstetrical prognosis after oocyte donation in Turner Syndrome A multicentric study

Author

Béatrice Delepine-Panisset, Mathilde Domin-Bernhard, Hélène Andre, Isabelle Koscinski, Florence Scheffler, Florence Eustache, Célia Ravel, Ségolène Veau, Annie Benhaim, Hélène Letur-Konirsch, Céline Pimentel, Patricia Fauque, Oxana Blagosklonov, Solène Vorilhon, Gérard Priou, CHU Pontchaillou [Rennes], Institut Mutualiste de Montsouris (IMM), Clinique mutualiste La Sagesse, Centre d’Études et de Conservation des Œufs et du Sperme [CHU Jean Verdier] (CECOS), Hôpital Jean Verdier [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Clermont-Ferrand, Hôpital Lapeyronie [Montpellier] (CHU), Laboratoire de Biologie de la reproduction CECOS - [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), CHU Amiens-Picardie, Œstrogènes, reproduction, cancer (OeReCa), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), CECOS Midi-pyrénées, Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Maternité Régionale Adolphe Pinard [Nancy], Institut de recherche en santé, environnement et travail (Irset), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), École des Hautes Études en Santé Publique [EHESP] (EHESP), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Jonchère, Laurent

Subjects
Adult, medicine.medical_specialty, media_common.quotation_subject, Turner syndrome, Fertility, [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, Preeclampsia, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, medicine, Humans, 030212 general & internal medicine, media_common, Retrospective Studies, 030219 obstetrics & reproductive medicine, Obstetrics, business.industry, Oocyte donation, Obstetrics and Gynecology, Retrospective cohort study, medicine.disease, 3. Good health, Gestational diabetes, Pregnancy Complications, [SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, Reproductive Medicine, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Maternal death, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, business, Live birth
Abstract

International audience; Introduction - Turner syndrome is one of the most frequent chromosomal abnormalities in women, with a prevalence estimated to be 1 of 2500 live birth. Pregnancy in women with Turner syndrome is known to be at high risk, whether it is spontaneous or after oocyte donation, because of miscarriages and potential cardio-vascular complications which can be life-threatening. All of these patients should therefore be screened with a comprehensive cardio-vascular assessment before pregnancy, and have a close follow-up during and after pregnancy.Patients and methods - It is a retrospective study, conducted in 10 of the 27 French oocyte donation centers between 2012 and 2016, on all the patients presenting with Turner syndrome included in an oocyte donation program.Results - 151 embryo transfers were realized in 73 patients, resulting in 39 pregnancies. Among these pregnancies, 24 children were born healthy, 11 spontaneous miscarriages, 3 voluntary abortions, 1 extra-uterine pregnancy and 1 maternal death from non-cardio-vascular origin occurred. Pregnancies were complicated by gravid arterial hypertension in 28.2% of cases, preeclampsia in 10.3% of cases, and gestational diabetes in 7.7% of cases.Conclusion - This study bring out obstetrical complications of the same magnitude than the ones described in the literature. Lead over a period of 4 years, in 10 French oocyte donation centers, it doesn't reveal any cardio-vascular complications, conversely to other studies published before French and American recommendations. This study reinforces the usefulness of specific recommendations for the care of these particular patients.

Published
2019
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4. Donor sperm insemination after failed intra-couple intracytoplasmic sperm injection

Author

Véronique Drouineaud, Mehdi Benchaib, Sylviane Hennebicq, Nathalie Rives, Isabelle Berthaut, Oxana Blagosklonov, Florence Eustache, Cynthia Frapsauce, Catherine Guillemain, Beatrice Delepine, Jean-François Guérin, Sophie Mirallié, Aline Papaxanthos, Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU de Bordeaux Pellegrin [Bordeaux], Laboratoire de Biologie de la reproduction CECOS - [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Gamétogenèse et Qualité du Gamète - ULR 4308 (GQG), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Université de Lille, CHU Rouen, Normandie Université (NU), CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Médecine et Biologie de la Reproduction, Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Service de biologie de la reproduction, Hospices Civils de Lyon (HCL), Département de Médecine et Biologie de la Reproduction, Faculté de médecine-CECOS, Gamétogenèse et Qualité du Gamète (GQG), Normandie Université (NU)-Normandie Université (NU)-Université de Lille, Droit et Santé-Université de Lille, Histologie et biologie de la reproduction, Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
Adult, Male, 0301 basic medicine, medicine.medical_specialty, Pregnancy Rate, Urology, medicine.medical_treatment, Insemination, Intracytoplasmic sperm injection, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Risk Factors, Odds Ratio, medicine, Humans, Sperm Injections, Intracytoplasmic, Treatment Failure, Infertility, Male, ComputingMilieux_MISCELLANEOUS, Retrospective Studies, Gynecology, 030219 obstetrics & reproductive medicine, urogenital system, business.industry, Artificial insemination, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, medicine.disease, 3. Good health, Pregnancy rate, Fertility, Logistic Models, 030104 developmental biology, Reproductive Medicine, Multivariate Analysis, Insemination, Artificial, Heterologous, Female, France, Parity (mathematics), business, Infertility, Female, Donor sperm, Embryo quality, Maternal Age
Abstract

The purpose of the present multicenter study was to investigate whether an artificial insemination with donor sperm (AID) procedure after intra-couple intracytoplasmic sperm injection (ICSI) failure offers a significant chance of pregnancy and to identify prognostic factors for pregnancy after an AID procedure. An eleven-year retrospective multicenter study was conducted among 13 Centre d'Etude et de Conservation des Oeufs et du Sperme (CECOS) centers. A total of 319 couples having undergone an AID procedure after intra-conjugal ICSI failure were included in this study; a total of 1,159 AID and 1,011 intra-conjugal ICSI cycles were performed. Among the prognostics parameters, the parity and the embryo quality could not be adequately addressed, therefore the parity was not included in the statistical analysis and the embryo quality has been presented as preliminary observations. The pregnancy rate per cycle was 12.0% (139/1,159) and the overall AID pregnancy rate per couple was 43.6% (139/319). Normal or oligoasthenoteratozoospermia (OAT) semen and women aged 34 years or above at the time of AID procedure obtained the lowest AID clinical pregnancy rate. Azoospermia or cryptozoospermia semen and women aged below 34 years obtained the highest AID clinical pregnancy rate. In conclusion, the transition to the AID procedure after intra-conjugal ICSI failure allows such couples to obtain a pregnancy, however after each ART failure AID transition should be proposed according to the woman's age and sperm characteristics.AID: artificial insemination with donor sperm; ICSI: intracytoplasmic sperm injection; CECOS: Centre d'Etude et de Conservation des Oeufs et du Sperme; OAT: oligoasthenoteratozoospermia; IVF: in vitro fertilization; ART: artificial reproductive technology; β hCG: beta human chorionic gonadotrophin; SD: standard deviation; OR: Odds ratio.

Published
2018
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5. Sperm cryopreservation in adolescents and young adults with cancer: results of the French national sperm banking network (CECOS)

Author

Jean-Marie Kunstmann, Florence Brugnon, Claire Thomas, Rosalie Cabry-Goubet, Françoise Touati, Sandrine Giscard d'Estaing, Ethel Szerman, Jean-Marc Rigot, Isabelle Berthaut, Oxana Blagosklonov, Véronique Drouineaud, Louis Bujan, Claire Barthélémy, Isabelle Koscinski, Florence Eustache, Mohamed Benhamed, Françoise Schmitt, Marie Walschaerts, Patrick Thonneau, Aline Papaxanthos-Roche, Thomas Fréour, Nathalie Rives, Myriam Daudin, Jacqueline Saïas-Magnan, Marie-Claude Mélin-Blocquaux, Dominique Le Lannou, Groupe de recherche en fertilité humaine ( GRFH), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT), Gamétogenèse et Qualité du Gamète - ULR 4308 (GQG), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Université de Lille, CHU Rouen, Normandie Université (NU), Laboratoire de Biologie de la reproduction CECOS - [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Hôpital Côte de Nacre [CHU Caen], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Service de Biologie de la Reproduction, CHU Strasbourg, U 567, Institut National de la Santé et de la Recherche Médicale (INSERM), Génétique, Reproduction et Développement (GReD), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Service de biologie de la reproduction — CECOS, Hôpital de l'Hôtel-Dieu, Faculté de Médecine Henri Warembourg - Université de Lille, CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), French Institute of Sport (INSEP), Laboratory Sport, Expertise and Performance (EA7370) (SEP (EA7370)), Institut national du sport, de l'expertise et de la performance (INSEP), Systèmes et Applications des Technologies de l'Information et de l'Energie (SATIE), École normale supérieure - Cachan (ENS Cachan)-Université Paris-Sud - Paris 11 (UP11)-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-École normale supérieure - Rennes (ENS Rennes)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Centre National de la Recherche Scientifique (CNRS), Groupe d'Activité de Médecine de la Reproduction [CHU Toulouse] (CECOS Toulouse), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Lille 2 - Faculté de Médecine, Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), French Institute of Sport (INSEP), Research Department, Laboratory Sport, Expertise and Performance (EA7370) (SEP (EA7370)), Université Paris-Seine-Université Paris-Seine-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Centre National de la Recherche Scientifique (CNRS), CECOS Midi-Pyrénées, centre de sterilité masculine et équipe d'accueil Fertilité Humaine, Hôpital Paule de Viguier, CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), HESAM Université (HESAM)-HESAM Université (HESAM)-Centre National de la Recherche Scientifique (CNRS), and CHU Toulouse [Toulouse]

Subjects
Male, medicine.medical_specialty, Adolescent, fertility preservation, media_common.quotation_subject, [SDV]Life Sciences [q-bio], Fertility, [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, Adolescents, Community Networks, Young Adult, Neoplasms, medicine, cancer, Humans, Fertility preservation, Young adult, Child, ComputingMilieux_MISCELLANEOUS, media_common, Retrospective Studies, Gynecology, Cryopreservation, business.industry, Sperm Banks, Obstetrics and Gynecology, Cancer, Retrospective cohort study, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, Sperm bank, medicine.disease, Sperm, Confidence interval, 3. Good health, sperm cryopreservation, Reproductive Medicine, age, France, business, Demography, Semen Preservation
Abstract

Objective To determine the feasibility of fertility preservation in adolescent males with cancer. Design Large multicenter retrospective study of male patients ≤20 years from 23 centers of a national network of sperm banks over a 34-year period. Setting Sperm banks. Patient(s) A total of 4,345 boys and young men aged 11 to 20 years. Intervention(s) Age, cancer diagnosis, feasibility of sperm banking, and sperm parameters. Main Outcome Measure(s) Description of patients, and success of their fertility preservation. Result(s) We observed a mean yearly increase in referred patients of 9.5% (95% confidence interval, 9.1%–9.8%) between 1973 and 2007. Over the study period, the percentage of younger cancer patients who banked their sperm increased, especially in the 11–14 year age group, rising from 1% in 1986 to 9% in 2006. We found that 4,314 patients attempted to produce a semen sample, 4,004 succeeded, and sperm was banked for 3,616. The mean total sperm count was 61.75 × 10 6 for the 11–14 year age group, and 138.81 × 10 6 for the 18–20 year age group. It was noteworthy that intercenter variations in practices involving young patients seeking to preserve their fertility before cancer therapy were observed within this national network. Conclusion(s) Our results emphasize the need for decisive changes in public health policy to facilitate the access to reproductive health-care for young cancer patients.

Published
2014
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