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161 results on '"S.P. Bhatia"'

1. RIFM FRAGRANCE INGREDIENT SAFETY ASSESSMENT, 2-Methylbutanol, CAS Registry Number 137-32-6

Author

Valerie T. Politano, M. Date, Maria Lúcia Zaidan Dagli, J. Wahler, I. G. Sipes, A. Patel, D. Belsito, B Wall, D. Salvito, C. Deodhar, W. Dekant, A. Lapczynski, D. Browne, S. La Cava, D. Botelho, T. W. Schultz, Magnus Bruze, S.P. Bhatia, D. O'Brien, Allison D. Fryer, D K Wilcox, J F Lalko, Jie Shen, J. Romine, R. Parakhia, K. Joshi, A.M. Api, L Kromidas, G. Ritacco, T. M. Penning, S. Tsang, D. C. Liebler, Y. Thakkar, and Peter Calow

Subjects
medicine.medical_specialty, business.industry, TOXICOLOGIA AMBIENTAL, 04 agricultural and veterinary sciences, General Medicine, Pharmacology, Toxicology, Fragrance ingredient, 040401 food science, 0404 agricultural biotechnology, Family medicine, medicine, business, CAS Registry Number, Food Science
Published
2017
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2. RIFM fragrance ingredient safety assessment, 2-Hydroxy-α,α,4-trimethylcyclohexanemethanol, CAS Registry Number 42822-86-6

Author

T. W. Schultz, W. Dekant, D. O'Brien, J. Buschmann, D. Belsito, D K Wilcox, L Kromidas, D. C. Liebler, G. Ritacco, J. Shen, Maria Lúcia Zaidan Dagli, I. G. Sipes, R. Parakhia, A.M. Api, Allison D. Fryer, T. M. Penning, Magnus Bruze, B Wall, S.P. Bhatia, S. La Cava, V. T. Politano, Peter Calow, G. A. Burton, D. Salvito, A. Lapczynski, and Publica

Subjects
Drug, medicine.medical_specialty, Consumer Product Safety, No-observed-adverse-effect level, Endpoint Determination, media_common.quotation_subject, Drug Evaluation, Preclinical, MEDLINE, TOXICOLOGIA AMBIENTAL, Cyclohexane Monoterpenes, Pharmacology, Toxicology, Risk Assessment, 0404 agricultural biotechnology, Cyclohexanes, Internal medicine, Toxicity Tests, medicine, Animals, media_common, No-Observed-Adverse-Effect Level, Dose-Response Relationship, Drug, business.industry, 04 agricultural and veterinary sciences, General Medicine, Fragrance ingredient, 040401 food science, Perfume, Rats, Menthol, Risk assessment, business, CAS Registry Number, DNA Damage, Food Science
Abstract

The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic nor does it have skin sensitization potential and provided a MOE >100 for the repeated dose endpoint. The developmental and reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 mg/kg/day and 1.4 mg/day, respectively). The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra along with data on the target material. The environmental endpoint was completed as described in the RIFM Framework.

Published
2016
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3. RIFM fragrance ingredient safety assessment, 3-methyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)pent-4-en-2-ol, CAS Registry Number 67801-20-1

Author

J. Romine, W. Dekant, T. M. Penning, Valerie T. Politano, M. Date, A. Lapczynski, Peter Calow, D. Belsito, A. Burton, Yoshiki Miyachi, Magnus Bruze, L Kromidas, Maria Lúcia Zaidan Dagli, S. La Cava, I. G. Sipes, B Wall, C. Deodhar, Y. Thakkar, G. Ritacco, D. Browne, D. C. Liebler, A. Patel, D. Salvito, D. Botelho, S. Tsang, J. Shen, Yoshiki Tokura, J. Buschmann, R. Parakhia, Allison D. Fryer, K. Joshi, A.M. Api, T. W. Schultz, D. O'Brien, D K Wilcox, J F Lalko, S.P. Bhatia, J. Wahler, and Publica

Subjects
No-Observed-Adverse-Effect Level, Endpoint Determination, Chemistry, Drug Administration Routes, TOXICOLOGIA AMBIENTAL, General Medicine, Toxicology, Fragrance ingredient, Risk Assessment, Medicinal chemistry, Perfume, Consumer Product Safety, Toxicity Tests, Animals, Humans, Sesquiterpenes, Databases, Chemical, CAS Registry Number, Food Science
Published
2018

4. RIFM fragrance ingredient safety assessment, (Z)-2-penten-1-ol, CAS Registry Number 1576-95-0

Author

Peter Calow, Terry W Schultz, L Kromidas, Jie Shen, Maria Lúcia Zaidan Dagli, G. Ritacco, A.M. Api, D. C. Liebler, Valerie T. Politano, Yoshiki Miyachi, I. G. Sipes, S.P. Bhatia, D. Salvito, W. Dekant, A. Lapczynski, D K Wilcox, J F Lalko, B Wall, S. La Cava, Allison D. Fryer, D. Belsito, and Magnus Bruze

Subjects
No-Observed-Adverse-Effect Level, Dose-Response Relationship, Drug, Endpoint Determination, business.industry, Skin sensitization, Drug Evaluation, Preclinical, TOXICOLOGIA AMBIENTAL, General Medicine, Pharmacology, Toxicology, Fragrance ingredient, Risk Assessment, Perfume, Pentanols, Consumer Product Safety, Toxicity Tests, Animals, Humans, Medicine, business, CAS Registry Number, DNA Damage, Food Science
Published
2015
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5. RIFM fragrance ingredient safety assessment, Linalyl acetate, CAS Registry Number 115-95-7

Author

Peter Calow, Maria Lúcia Zaidan Dagli, I. G. Sipes, Allison D. Fryer, S.P. Bhatia, D K Wilcox, J F Lalko, W. Dekant, S. La Cava, Valerie T. Politano, A.M. Api, D. Belsito, T. W. Schultz, Yoshiki Miyachi, L Kromidas, G. Ritacco, Jie Shen, Magnus Bruze, D. C. Liebler, D. Salvito, A. Lapczynski, and B Wall

Subjects
chemistry.chemical_compound, chemistry, business.industry, PERFUME (AVALIAÇÃO), Medicine, General Medicine, Food science, Linalyl acetate, Toxicology, Fragrance ingredient, business, CAS Registry Number, Food Science
Abstract

Please cite this article as: A.M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M.L. Dagli, W. Dekant, A.D. Fryer, L. Kromidas, S. La Cava, J.F. Lalko, A. Lapczynski, D.C. Liebler, Y. Miyachi, V.T. Politano, G. Ritacco, D. Salvito, J. Shen, T.W. Schultz, I.G. Sipes, B. Wall, D.K. Wilcox, RIFM FRAGRANCE INGREDIENT SAFETY ASSESSMENT, Linalyl acetate, CAS Registry Number 115-95-7, Food and Chemical Toxicology (2015), http://dx.doi.org/doi: 10.1016/j.fct.2015.01.010.

Published
2015
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6. RIFM fragrance ingredient safety assessment, allyl phenylacetate, CAS registry number 1797-74-6

Author

Valerie T. Politano, D. Salvito, D. C. Liebler, D. Belsito, I. G. Sipes, A.M. Api, Maria Lúcia Zaidan Dagli, S. La Cava, B Wall, A. Lapczynski, W. Dekant, Lambros Kromidas, Yoshiki Miyachi, Peter Calow, D K Wilcox, J F Lalko, S.P. Bhatia, Terry W Schultz, Jie Shen, Magnus Bruze, G. Ritacco, and Allison D. Fryer

Subjects
Male, No-Observed-Adverse-Effect Level, Dose-Response Relationship, Drug, Endpoint Determination, Chemistry, General Medicine, Pharmacology, Toxicology, Fragrance ingredient, Risk Assessment, Perfume, Rats, Mice, Phenylacetate, Consumer Product Safety, Toxicity Tests, Animals, Humans, Organic chemistry, Female, CAS Registry Number, DNA Damage, Phenylacetates, Food Science
Published
2015
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7. RIFM fragrance ingredient safety assessment, allyl (cyclohexyloxy)acetate, CAS registry number 68901-15-5

Author

Jie Shen, S. La Cava, Valerie T. Politano, Allison D. Fryer, Terry W Schultz, Yoshiki Miyachi, I. G. Sipes, Peter Calow, A. Lapczynski, D. C. Liebler, B Wall, Maria Lúcia Zaidan Dagli, D. Belsito, S.P. Bhatia, D. Salvito, W. Dekant, Magnus Bruze, D K Wilcox, J F Lalko, A.M. Api, L Kromidas, and G. Ritacco

Subjects
Male, No-Observed-Adverse-Effect Level, Dose-Response Relationship, Drug, Endpoint Determination, Chemistry, General Medicine, Pharmacology, Toxicology, Fragrance ingredient, Risk Assessment, Glycolates, Perfume, Rats, Mice, Consumer Product Safety, Toxicity Tests, Animals, Humans, Organic chemistry, Female, CAS Registry Number, DNA Damage, Food Science
Published
2015
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8. RIFM fragrance ingredient safety assessment, 2,6-Dimethyl-5-heptenal, CAS Registry Number 106-72-9

Author

Maria Lúcia Zaidan Dagli, B Wall, Valerie T. Politano, I. G. Sipes, W. Dekant, D K Wilcox, J F Lalko, S. La Cava, S.P. Bhatia, Peter Calow, D. Belsito, Allison D. Fryer, Jie Shen, A.M. Api, Yoshiki Miyachi, L Kromidas, G. Ritacco, D. C. Liebler, A. Lapczynski, D. Salvito, Terry W Schultz, and Magnus Bruze

Subjects
Male, medicine.medical_specialty, Endpoint Determination, Pharmacology, Toxicology, Risk Assessment, Mice, Toxicity Tests, Animals, Humans, Medicine, Aldehydes, No-Observed-Adverse-Effect Level, Dose-Response Relationship, Drug, business.industry, Skin sensitization, PERFUME (AVALIAÇÃO), General Medicine, Fragrance ingredient, Dermatology, Perfume, Rats, Consumer Product Safety, Female, business, CAS Registry Number, DNA Damage, Food Science
Published
2015
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9. Comparison of Cramer classification between Toxtree, the OECD QSAR Toolbox and expert judgment

Author

Jie Shen, S.P. Bhatia, David W. Roberts, A.M. Api, Terry W Schultz, and Lambros Kromidas

Subjects
Quantitative structure–activity relationship, Concordance, Decision Trees, Decision tree, Quantitative Structure-Activity Relationship, General Medicine, Toxicology, Fragrance ingredient, Risk Assessment, Toolbox, Perfume, Human health, Human exposure, Statistics, Computer Simulation, Risk assessment, Mathematics
Abstract

The Threshold of Toxicological Concern (TTC) is a pragmatic approach in risk assessment. In the absence of data, it sets up levels of human exposure that are considered to have no appreciable risk to human health. The Cramer decision tree is used extensively to determine these exposure thresholds by categorizing non-carcinogenic chemicals into three different structural classes. Therefore, assigning an accurate Cramer class to a material is a crucial step to preserve the integrity of the risk assessment. In this study the Cramer class of over 1000 fragrance materials across diverse chemical classes were determined by using Toxtree (TT), the OECD QSAR Toolbox (TB), and expert judgment. Disconcordance was observed between TT and the TB. A total of 165 materials (16%) showed different results from the two programs. The overall concordance for Cramer classification between TT and expert judgment is 83%, while the concordance between the TB and expert judgment is 77%. Amines, lactones and heterocycles have the lowest percent agreement with expert judgment for TT and the TB. For amines, the expert judgment agreement is 45% for TT and 55% for the TB. For heterocycles, the expert judgment agreement is 55% for TT and the TB. For lactones, the expert judgment agreement is 56% for TT and 50% for the TB. Additional analyses were conducted to determine the concordance within various chemical classes. Critical checkpoints in the decision tree are identified. Strategies and guidance on determining the Cramer class for various chemical classes are discussed.

Published
2015
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10. RIFM fragrance ingredient safety assessment, dihydro-α-terpineol, CAS Registry Number 498-81-7

Author

I. G. Sipes, J. Romine, K. Joshi, A.M. Api, A. Burton, W. Dekant, B Wall, D. Salvito, T. W. Schultz, Peter Calow, D. O'Brien, Yoshiki Miyachi, J. Wahler, Allison D. Fryer, Valerie T. Politano, D K Wilcox, J F Lalko, Jie Shen, S. La Cava, D. Browne, A. Lapczynski, Y. Thakkar, S. Tsang, Maria Lúcia Zaidan Dagli, J. Buschmann, M. Date, C. Deodhar, A. Patel, T. M. Penning, S.P. Bhatia, R. Parakhia, Magnus Bruze, L Kromidas, G. Ritacco, D. Belsito, Yoshiki Tokura, D. C. Liebler, and D. Botelho

Subjects
business.industry, TOXICOLOGIA AMBIENTAL, 04 agricultural and veterinary sciences, General Medicine, Pharmacology, Toxicology, Fragrance ingredient, 040401 food science, chemistry.chemical_compound, 0404 agricultural biotechnology, Terpineol, chemistry, Medicine, business, CAS Registry Number, Food Science
Published
2017

11. RIFM fragrance ingredient safety assessment, terpineol, CAS Registry Number 8000-41-7

Author

Y. Thakkar, D. C. Liebler, M. Date, B Wall, Jie Shen, I. G. Sipes, D. Belsito, W. Dekant, K. Joshi, A.M. Api, T. W. Schultz, S. Tsang, D. O'Brien, D. Botelho, Peter Calow, Yoshiki Tokura, D. Browne, D K Wilcox, J F Lalko, R. Parakhia, D. Salvito, J. Buschmann, Maria Lúcia Zaidan Dagli, J. Romine, A. Burton, C. Deodhar, J. Wahler, L Kromidas, S. La Cava, G. Ritacco, A. Lapczynski, Allison D. Fryer, A. Patel, Yoshiki Miyachi, S.P. Bhatia, T. M. Penning, Magnus Bruze, and Valerie T. Politano

Subjects
Chemistry, TOXICOLOGIA AMBIENTAL, 04 agricultural and veterinary sciences, General Medicine, 010501 environmental sciences, Toxicology, Fragrance ingredient, 040401 food science, 01 natural sciences, chemistry.chemical_compound, 0404 agricultural biotechnology, Terpineol, Organic chemistry, CAS Registry Number, 0105 earth and related environmental sciences, Food Science
Published
2017

12. RIFM fragrance ingredient safety assessment, methyl hexyl oxo cyclopentanone carboxylate, CAS Registry Number 37172-53-5

Author

Valerie T. Politano, D. Salvito, R. Parakhia, G. A. Burton, Y. Thakkar, Maria Lúcia Zaidan Dagli, L Kromidas, A. Lapczynski, G. Ritacco, M. Date, A. Patel, Allison D. Fryer, W. Dekant, D. Belsito, D. Browne, S.P. Bhatia, D. C. Liebler, J. Shen, I. G. Sipes, S. La Cava, J. Wahler, Peter Calow, T. M. Penning, Magnus Bruze, B Wall, D. Botelho, T. W. Schultz, D. O'Brien, D K Wilcox, J F Lalko, K. Joshi, A.M. Api, C. Deodhar, S. Tsang, J. Buschmann, J. Romine, and Publica

Subjects
Chemistry, TOXICOLOGIA AMBIENTAL, 04 agricultural and veterinary sciences, General Medicine, Toxicology, Fragrance ingredient, Cyclopentanone, 040401 food science, chemistry.chemical_compound, 0404 agricultural biotechnology, Organic chemistry, heterocyclic compounds, Carboxylate, CAS Registry Number, Food Science
Abstract

• Methyl hexyl oxo cyclopentanone carboxylate safety assessment based on RIFM's criteria.

Published
2017

13. RIFM fragrance ingredient safety assessment, tetrahydro-4-methyl-2-(2-methylpropen-1-yl)pyran, CAS Registry Number 16409-43-1

Author

I. G. Sipes, R. Parakhia, Maria Lúcia Zaidan Dagli, A. Lapczynski, A. Patel, T. M. Penning, Jie Shen, Yoshiki Tokura, S.P. Bhatia, K. Joshi, J. Romine, A.M. Api, S. La Cava, W. Dekant, T. W. Schultz, Allison D. Fryer, D. Browne, Yoshiki Miyachi, D. O'Brien, Valerie T. Politano, M. Date, L Kromidas, D. Salvito, Magnus Bruze, D K Wilcox, J F Lalko, G. Ritacco, Peter Calow, J. Wahler, S. Tsang, J. Buschmann, C. Deodhar, A. Burton, Y. Thakkar, D. C. Liebler, D. Belsito, B Wall, D. Botelho, and Publica

Subjects
chemistry.chemical_compound, 0404 agricultural biotechnology, Chemistry, Pyran, Organic chemistry, TOXICOLOGIA AMBIENTAL, 04 agricultural and veterinary sciences, General Medicine, Toxicology, Fragrance ingredient, 040401 food science, CAS Registry Number, Food Science
Published
2017

14. RIFM fragrance ingredient safety assessment, 5-Ethylidenebicyclo[2.2.1]hept-2-yl propionate, CAS Registry Number 73347-77-0

Author

Peter Calow, A. Lapczynski, Valerie T. Politano, J. Shen, Magnus Bruze, Maria Lúcia Zaidan Dagli, D. C. Liebler, A.M. Api, S. La Cava, T. W. Schultz, L Kromidas, B Wall, W. Dekant, D. Salvito, I. G. Sipes, G. Ritacco, Yoshiki Miyachi, D K Wilcox, J F Lalko, D. Belsito, Allison D. Fryer, and S.P. Bhatia

Subjects
chemistry.chemical_classification, business.industry, Skin sensitization, TOXICOLOGIA AMBIENTAL, 04 agricultural and veterinary sciences, General Medicine, Pharmacology, Toxicology, Fragrance ingredient, medicine.disease_cause, 040401 food science, 0404 agricultural biotechnology, chemistry, Environmental safety, Propionate, Medicine, business, CAS Registry Number, Genotoxicity, Food Science
Published
2017

15. RIFM fragrance ingredient safety assessment, 4-(3,4-methylenedioxyphenyl)-2-butanone, CAS Registry Number 55418-52-5

Author

Peter Calow, T. W. Schultz, Valerie T. Politano, Maria Lúcia Zaidan Dagli, D. O'Brien, G. A. Burton, D. C. Liebler, C. Deodhar, D K Wilcox, J. Romine, I. G. Sipes, J F Lalko, D. Salvito, B Wall, A. Patel, Y. Thakkar, M. Date, W. Dekant, Magnus Bruze, T. M. Penning, D. Browne, D. Botelho, Allison D. Fryer, S. Tsang, A. Lapczynski, J. Buschmann, S.P. Bhatia, S. La Cava, L Kromidas, G. Ritacco, K. Joshi, A.M. Api, Jie Shen, R. Parakhia, J. Wahler, D. Belsito, and Publica

Subjects
Traditional medicine, business.industry, TOXICOLOGIA AMBIENTAL, 04 agricultural and veterinary sciences, General Medicine, Toxicology, Fragrance ingredient, 040401 food science, 0404 agricultural biotechnology, Medicine, 2-butanone, business, CAS Registry Number, Food Science
Published
2016

16. RIFM Fragrance Ingredient Safety Assessment, d-Cyclocitronellene acetate, CAS Registry Number 25225-10-9

Author

A. Lapczynski, J. Wahler, T. M. Penning, T. W. Schultz, M. Date, I. G. Sipes, D. O'Brien, L Kromidas, D. Browne, G. Ritacco, S.P. Bhatia, C. Deodhar, Peter Calow, Magnus Bruze, D K Wilcox, J F Lalko, D. Salvito, R. Parakhia, Yoshiki Miyachi, Allison D. Fryer, Y. Thakkar, S. Tsang, D. C. Liebler, J. Buschmann, Jie Shen, J. Romine, A.M. Api, G. A. Burton, D. Belsito, S. La Cava, Maria Lúcia Zaidan Dagli, A. Patel, W. Dekant, Valerie T. Politano, B Wall, D. Botelho, and Publica

Subjects
SENSIBILIDADE CUTÂNEA, 0404 agricultural biotechnology, business.industry, Organic chemistry, Medicine, 04 agricultural and veterinary sciences, General Medicine, Toxicology, business, Fragrance ingredient, 040401 food science, CAS Registry Number, Food Science
Published
2016

17. RIFM fragrance ingredient safety assessment, elemol, CAS Registry Number 639-99-6

Author

B Wall, I. G. Sipes, D. Botelho, Maria Lúcia Zaidan Dagli, A. Lapczynski, J. Shen, R. Parakhia, Y. Thakkar, A. Patel, T. M. Penning, T. W. Schultz, D. Belsito, W. Dekant, D. O'Brien, Peter Calow, D. C. Liebler, G. A. Burton, D. Browne, D K Wilcox, J F Lalko, Allison D. Fryer, L Kromidas, D. Salvito, G. Ritacco, K. Joshi, A.M. Api, S. La Cava, M. Date, V. T. Politano, S. Tsang, J. Buschmann, C. Deodhar, J. Romine, Magnus Bruze, S.P. Bhatia, and J. Wahler

Subjects
medicine.medical_specialty, business.industry, TOXICOLOGIA AMBIENTAL, 04 agricultural and veterinary sciences, General Medicine, Pharmacology, Toxicology, Fragrance ingredient, 040401 food science, 0404 agricultural biotechnology, Family medicine, Medicine, business, CAS Registry Number, Food Science
Published
2016

18. RIFM fragrance ingredient safety assessment, isobornyl propionate, CAS Registry Number 2756-56-1

Author

S.P. Bhatia, A.M. Api, Peter Calow, Allison D. Fryer, L Kromidas, I. G. Sipes, Maria Lúcia Zaidan Dagli, G. Ritacco, T. W. Schultz, J. Shen, D K Wilcox, J F Lalko, V. T. Politano, D. Belsito, D. C. Liebler, Yoshiki Miyachi, S. La Cava, W. Dekant, B Wall, A. Lapczynski, D. Salvito, and Magnus Bruze

Subjects
No-Observed-Adverse-Effect Level, Camphanes, Dose-Response Relationship, Drug, Chemistry, Endpoint Determination, Drug Evaluation, Preclinical, TOXICOLOGIA AMBIENTAL, 04 agricultural and veterinary sciences, General Medicine, Toxicology, Fragrance ingredient, 040401 food science, Risk Assessment, Perfume, Rats, Isobornyl propionate, 0404 agricultural biotechnology, Consumer Product Safety, Toxicity Tests, Organic chemistry, Animals, Propionates, CAS Registry Number, Food Science, DNA Damage
Published
2016

19. RIFM fragrance ingredient safety assessment, 1,3,3-trimethyl-2-norbornanyl acetate, CAS registry number 13851-11-1

Author

I. G. Sipes, B Wall, Peter Calow, Magnus Bruze, L Kromidas, A. Lapczynski, T. W. Schultz, G. Ritacco, D K Wilcox, J F Lalko, Maria Lúcia Zaidan Dagli, D. Belsito, S. La Cava, Yoshiki Miyachi, V. T. Politano, D. Salvito, Allison D. Fryer, W. Dekant, D. C. Liebler, A.M. Api, S.P. Bhatia, and J. Shen

Subjects
Consumer Product Safety, No-observed-adverse-effect level, Endpoint Determination, Drug Evaluation, Preclinical, TOXICOLOGIA AMBIENTAL, Pharmacology, Acetates, Toxicology, Risk Assessment, 0404 agricultural biotechnology, Toxicity Tests, Organic chemistry, Animals, No-Observed-Adverse-Effect Level, Dose-Response Relationship, Drug, Chemistry, 04 agricultural and veterinary sciences, General Medicine, Fragrance ingredient, 040401 food science, Norbornanes, Perfume, Rats, CAS Registry Number, Food Science, DNA Damage
Published
2016

20. RIFM fragrance ingredient safety assessment, Isopropylphenylbutanal, CAS Registry Number 125109-85-5

Author

D. Salvito, W. Dekant, A. Lapczynski, A.M. Api, L Kromidas, T. W. Schultz, Allison D. Fryer, G. Ritacco, Peter Calow, B Wall, D K Wilcox, J F Lalko, J. Shen, Maria Lúcia Zaidan Dagli, Magnus Bruze, S.P. Bhatia, D. C. Liebler, V. T. Politano, I. G. Sipes, D. Belsito, and S. La Cava

Subjects
medicine.medical_specialty, Consumer Product Safety, No-observed-adverse-effect level, Endpoint Determination, MEDLINE, Drug Evaluation, Preclinical, TOXICOLOGIA AMBIENTAL, Pharmacology, Toxicology, Risk Assessment, 0404 agricultural biotechnology, Toxicity Tests, medicine, Benzene Derivatives, Animals, Intensive care medicine, Aldehydes, No-Observed-Adverse-Effect Level, Dose-Response Relationship, Drug, business.industry, 04 agricultural and veterinary sciences, General Medicine, Fragrance ingredient, 040401 food science, Perfume, Rats, Risk assessment, business, CAS Registry Number, Food Science, DNA Damage
Published
2016

21. RIFM fragrance ingredient safety assessment, benzyl butyrate, CAS Registry Number 103-37-7

Author

T. W. Schultz, W. Dekant, D K Wilcox, J F Lalko, A. Lapczynski, B Wall, D. Belsito, Magnus Bruze, Maria Lúcia Zaidan Dagli, D. Salvito, A.M. Api, S.P. Bhatia, J. Shen, Allison D. Fryer, I. G. Sipes, L Kromidas, G. Ritacco, Peter Calow, V. T. Politano, S. La Cava, and D. C. Liebler

Subjects
Endpoint Determination, Drug Evaluation, Preclinical, TOXICOLOGIA AMBIENTAL, Butyrate, Pharmacology, Toxicology, medicine.disease_cause, Risk Assessment, 0404 agricultural biotechnology, Environmental safety, Benzyl Compounds, Toxicity Tests, medicine, Animals, No-Observed-Adverse-Effect Level, Dose-Response Relationship, Drug, business.industry, Skin sensitization, 04 agricultural and veterinary sciences, General Medicine, Fragrance ingredient, 040401 food science, Perfume, Rats, Butyrates, Consumer Product Safety, business, CAS Registry Number, Genotoxicity, DNA Damage, Food Science
Abstract

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog benzyl acetate (CAS # 140-11-4) show that this material is not genotoxic nor does it have skin sensitization potential and also provided a MOE100 for the repeated dose, developmental and reproductive, and local respiratory toxicity endpoints. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

Published
2016

22. RIFM fragrance ingredient safety assessment, 1-(3,3-dimethylcyclohexyl)pent-4-en-1-one, CAS Registry Number 56973-87-6

Author

Allison D. Fryer, J. Shen, D. C. Liebler, D. Salvito, S.P. Bhatia, Yoshiki Miyachi, Peter Calow, V. T. Politano, A.M. Api, T. W. Schultz, A. Lapczynski, D K Wilcox, W. Dekant, J F Lalko, D. Belsito, Magnus Bruze, S. La Cava, Maria Lúcia Zaidan Dagli, L Kromidas, G. Ritacco, B Wall, and I. G. Sipes

Subjects
Consumer Product Safety, medicine.medical_specialty, Stereochemistry, Endpoint Determination, Drug Evaluation, Preclinical, TOXICOLOGIA AMBIENTAL, Toxicology, Risk Assessment, 0404 agricultural biotechnology, Cyclohexanes, Toxicity Tests, Medicine, Animals, No-Observed-Adverse-Effect Level, Dose-Response Relationship, Drug, business.industry, 04 agricultural and veterinary sciences, General Medicine, Fragrance ingredient, 040401 food science, Perfume, Rats, Emergency medicine, Risk assessment, business, CAS Registry Number, Food Science, DNA Damage
Published
2016

23. RIFM fragrance ingredient safety assessment, 2-Methylundecanol, CAS Registry Number 10522-26-6

Author

A. Lapczynski, Maria Lúcia Zaidan Dagli, Allison D. Fryer, W. Dekant, D. C. Liebler, D. Salvito, J. Shen, Magnus Bruze, T. M. Penning, B Wall, S. La Cava, L Kromidas, G. Ritacco, S.P. Bhatia, Peter Calow, D. Belsito, V. T. Politano, I. G. Sipes, A.M. Api, T. W. Schultz, D K Wilcox, and J F Lalko

Subjects
Endpoint Determination, Drug Evaluation, Preclinical, Developmental toxicity, TOXICOLOGIA AMBIENTAL, Pharmacology, Toxicology, medicine.disease_cause, Risk Assessment, 0404 agricultural biotechnology, 2-methylundecanol, Toxicity Tests, Animals, Medicine, No-Observed-Adverse-Effect Level, Dose-Response Relationship, Drug, business.industry, 04 agricultural and veterinary sciences, General Medicine, Fragrance ingredient, 040401 food science, Perfume, Rats, Consumer Product Safety, Toxicity, Fatty Alcohols, business, Phototoxicity, Reproductive toxicity, Genotoxicity, CAS Registry Number, DNA Damage, Food Science
Abstract

This material was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the suitable read across analogs 2-butyloctan-1-ol (CAS # 3913-02-8) and 2-ethyl-1-hexanol (CAS # 104-76-7) show that this material is not genotoxic nor does it have skin sensitization potential. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 and 1.4 mg/day, respectively). The repeated dose toxicity endpoint was completed using 2-ethyl-1-hexanol (CAS # 104-76-7) and 1-heptanol, 2-propyl (CAS # 10042-59-8) as suitable read across analogs, which provided a MOE > 100. The developmental toxicity endpoint was completed using 2-ethyl-1-hexanol (CAS # 104-76-7) as a suitable read across analog, which provided a MOE > 100 The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

Published
2016

24. Fragrance material review on 7-octen-2-ol, 2-methyl-6-methylene-, dihydro derivative

Author

A. Lapczynski, D. McGinty, C.S. Letizia, A.M. Api, and S.P. Bhatia

Subjects
Octanols, Carcinogenicity Tests, Mutagenicity Tests, Stereochemistry, business.industry, Reproduction, General Medicine, Toxicology, Fragrance ingredient, chemistry.chemical_compound, Teratogens, chemistry, Odorants, Animals, Humans, Medicine, Organic chemistry, Carcinogenicity Test, Methylene, Mutagenicity Test, business, Derivative (chemistry), Food Science
Abstract

A toxicologic and dermatologic review of 7-octen-2-ol, 2-methyl-6-methylene-, dihydro derivative when used as a fragrance ingredient is presented.

Published
2010
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25. Fragrance material review on (3aα,4α,6α,7α,7aα)-3a,4,5,6,7,7a-hexahydro-3-methyl-5-methylene-4,7-methano-1H-inden-6-yl acetate

Author

S.P. Bhatia, C.S. Letizia, A.M. Api, and L. Jones

Subjects
chemistry.chemical_compound, Chemistry, Stereochemistry, Organic chemistry, General Medicine, Methylene, Toxicology, Fragrance ingredient, Food Science
Abstract

A toxicologic and dermatologic review of (3aalpha,4alpha,6alpha,7alpha,7aalpha)-3a,4,5,6,7,7a-hexahydro-3-methyl-5-methylene-4,7-methano-1H-inden-6-yl acetate when used as a fragrance ingredient is presented.

Published
2008
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26. Fragrance material review on 1,7,7-trimethylbicyclo[4.4.0]dec-3-yl acetate

Author

C.S. Letizia, A.M. Api, and S.P. Bhatia

Subjects
Bridged Bicyclo Compounds, Chemistry, Animals, Humans, Organic chemistry, General Medicine, Acetates, Cyclodecanes, Toxicology, Fragrance ingredient, Perfume, Food Science
Abstract

A toxicologic and dermatologic review of 1,7,7-trimethylbicyclo[4.4.0]dec-3-yl acetate when used as a fragrance ingredient is presented.

Published
2008
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27. Fragrance material review on tricyclodecenyl acetate

Author

C.S. Letizia, A.M. Api, L. Jones, and S.P. Bhatia

Subjects
Chemistry, Animals, Humans, Organic chemistry, General Medicine, Acetates, Cyclodecanes, Toxicology, Fragrance ingredient, Perfume, Skin, Food Science
Abstract

A toxicologic and dermatologic review of tricyclodecenyl acetate when used as a fragrance ingredient is presented.

Published
2008
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28. Fragrance material review on 2-(1-methylpropyl)-1-vinylcyclohexyl acetate

Author

C.S. Letizia, A.M. Api, and S.P. Bhatia

Subjects
Vinyl Compounds, Chemistry, Animals, Humans, Organic chemistry, General Medicine, Acetates, Cyclohexanols, Toxicology, Fragrance ingredient, Perfume, Skin, Food Science
Abstract

A toxicologic and dermatologic review of 2-(1-methylpropyl)-1-vinylcyclohexyl acetate when used as a fragrance ingredient is presented.

Published
2008
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29. Fragrance material review on vetiverol

Author

C.S. Letizia, S.P. Bhatia, A.M. Api, and D. McGinty

Subjects
Molecular Structure, Traditional medicine, Drug Administration Routes, media_common.quotation_subject, Guinea Pigs, General Medicine, Art, Toxicology, Fragrance ingredient, Perfume, Rats, Mice, Animals, Humans, Rabbits, Sesquiterpenes, Food Science, media_common
Abstract

A toxicologic and dermatologic review of vetiverol when used as a fragrance ingredient is presented.

Published
2008
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30. Fragrance material review on sclareol

Author

C.S. Letizia, A.M. Api, D. McGinty, and S.P. Bhatia

Subjects
Molecular Structure, Sclareol, Drug Administration Routes, General Medicine, Toxicology, Fragrance ingredient, Perfume, Rats, Mice, chemistry.chemical_compound, chemistry, Animals, Humans, Organic chemistry, Rabbits, Diterpenes, Food Science
Abstract

A toxicologic and dermatologic review of sclareol when used as a fragrance ingredient is presented.

Published
2008
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31. Fragrance material review on santalol

Author

D. McGinty, S.P. Bhatia, A.M. Api, and C.S. Letizia

Subjects
Polycyclic Sesquiterpenes, Traditional medicine, business.industry, Drug Administration Routes, General Medicine, Toxicology, Fragrance ingredient, Perfume, Rats, Animals, Humans, Medicine, Rabbits, business, Sesquiterpenes, Food Science
Abstract

A toxicologic and dermatologic review of santalol when used as a fragrance ingredient is presented.

Published
2008
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32. Fragrance material review on myrtenol

Author

C.S. Letizia, D. McGinty, A.M. Api, and S.P. Bhatia

Subjects
Molecular Structure, Chemistry, Drug Administration Routes, General Medicine, Toxicology, Fragrance ingredient, Perfume, Rats, Mice, Myrtenol, Monoterpenes, Animals, Humans, Organic chemistry, Rabbits, Bicyclic Monoterpenes, Food Science
Abstract

A toxicologic and dermatologic review of myrtenol when used as a fragrance ingredient is presented.

Published
2008
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33. Fragrance material review on menthol racemic

Author

S.P. Bhatia, C.S. Letizia, D. McGinty, and A.M. Api

Subjects
Molecular Structure, Mutagenicity Tests, Drug Administration Routes, Stereoisomerism, General Medicine, Toxicology, Fragrance ingredient, Perfume, Rats, Menthol, Mice, chemistry.chemical_compound, chemistry, Salmonella, Cricetinae, Animals, Humans, Organic chemistry, Rabbits, Food Science
Abstract

A toxicologic and dermatologic review of menthol racemic when used as a fragrance ingredient is presented.

Published
2008
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34. Fragrance material review on geraniol

Author

A. Lapczynski, S.P. Bhatia, A.M. Api, R.J. Foxenberg, and C.S. Letizia

Subjects
Molecular Structure, Terpenes, Stereochemistry, Acyclic Monoterpenes, Drug Administration Routes, General Medicine, Toxicology, Fragrance ingredient, Perfume, Rats, Mice, chemistry.chemical_compound, chemistry, Animals, Humans, Organic chemistry, Rabbits, Geraniol, Food Science
Abstract

A toxicologic and dermatologic review of geraniol when used as a fragrance ingredient is presented.

Published
2008
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35. Fragrance material review on dl-citronellol

Author

A. Lapczynski, S.P. Bhatia, A.M. Api, and C.S. Letizia

Subjects
Citronellol, Acyclic Monoterpenes, Drug Administration Routes, Guinea Pigs, General Medicine, Toxicology, Fragrance ingredient, Perfume, Rats, Mice, chemistry.chemical_compound, chemistry, Monoterpenes, Animals, Humans, Organic chemistry, Rabbits, Food Science
Abstract

A toxicologic and dermatologic review of dl-citronellol when used as a fragrance ingredient is presented.

Published
2008
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36. Fragrance material review on dehydrolinalool

Author

A. Lapczynski, S.P. Bhatia, A.M. Api, and C.S. Letizia

Subjects
Molecular Structure, Mutagenicity Tests, Chemistry, Acyclic Monoterpenes, General Medicine, Toxicology, Fragrance ingredient, Perfume, Rats, Monoterpenes, Animals, Humans, Organic chemistry, Rabbits, Mutagenicity Test, Food Science, Dehydrolinalool
Abstract

A toxicologic and dermatologic review of dehydrolinalool when used as a fragrance ingredient is presented.

Published
2008
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37. Fragrance material review on α-bisabolol

Author

C.S. Letizia, D. McGinty, A.M. Api, and S.P. Bhatia

Subjects
Molecular Structure, Mutagenicity Tests, Chemistry, Drug Administration Routes, General Medicine, Toxicology, Fragrance ingredient, Rats, Monocyclic Sesquiterpenes, Mice, chemistry.chemical_compound, Animals, Humans, Organic chemistry, Mutagenicity Test, Sesquiterpenes, Bisabolol, Food Science
Abstract

A toxicologic and dermatologic review of alpha-bisabolol when used as a fragrance ingredient is presented.

Published
2008
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38. Fragrance material review on geranodyle

Author

C.S. Letizia, D. McGinty, A.M. Api, and S.P. Bhatia

Subjects
Bacteria, Molecular Structure, Traditional medicine, Mutagenicity Tests, media_common.quotation_subject, Guinea Pigs, Cyclohexane Monoterpenes, General Medicine, Art, Toxicology, Fragrance ingredient, Perfume, Rats, Menthol, Cricetinae, Animals, Humans, Rabbits, Geranodyle, Food Science, media_common
Abstract

A toxicologic and dermatologic review of geranodyle when used as a fragrance ingredient is presented.

Published
2008
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39. Fragrance material review on alpha-terpineol

Author

A.M. Api, C.S. Letizia, and S.P. Bhatia

Subjects
Molecular Structure, Mutagenicity Tests, Chemistry, Drug Administration Routes, Guinea Pigs, Alpha-terpineol, Cyclohexane Monoterpenes, General Medicine, Toxicology, Fragrance ingredient, Rats, Perfume, Mice, chemistry.chemical_compound, Terpineol, Cyclohexenes, Monoterpenes, Animals, Humans, Organic chemistry, Rabbits, Mutagenicity Test, Food Science
Abstract

A toxicologic and dermatologic review of p-menth-1-en-8-ol (S) when used as a fragrance ingredient is presented.

Published
2008
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40. Fragrance material review on rhodinol

Author

C.S. Letizia, A.M. Api, S.P. Bhatia, and A. Lapczynski

Subjects
Octanols, Engineering, Molecular Structure, business.industry, Drug Administration Routes, General Medicine, Toxicology, Fragrance ingredient, Perfume, Rats, Rhodinol, Mice, chemistry.chemical_compound, chemistry, Monoterpenes, Animals, Humans, Organic chemistry, business, Food Science
Abstract

A toxicologic and dermatologic review of rhodinol when used as a fragrance ingredient is presented.

Published
2008
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41. Fragrance material review on nerol

Author

S.P. Bhatia, A.M. Api, C.S. Letizia, A. Lapczynski, and R.J. Foxenberg

Subjects
Molecular Structure, Terpenes, Chemistry, Acyclic Monoterpenes, Drug Administration Routes, General Medicine, Toxicology, Fragrance ingredient, Perfume, Rats, Mice, chemistry.chemical_compound, Nerol, Animals, Humans, Organic chemistry, Rabbits, Food Science
Abstract

A toxicologic and dermatologic review of nerol when used as a fragrance ingredient is presented.

Published
2008
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42. Fragrance material review on borneol

Author

A.M. Api, S.P. Bhatia, and C.S. Letizia

Subjects
Camphanes, Molecular Structure, Drug Administration Routes, General Medicine, Toxicology, Fragrance ingredient, Perfume, Rats, Borneol, Mice, chemistry.chemical_compound, Dogs, chemistry, Animals, Humans, Organic chemistry, Food Science
Abstract

A toxicologic and dermatologic review of borneol when used as a fragrance ingredient is presented.

Published
2008
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43. Fragrance material review on l-menthol

Author

A.M. Api, C.S. Letizia, S.P. Bhatia, and D. McGinty

Subjects
Bacteria, Molecular Structure, Mutagenicity Tests, Stereochemistry, Chemistry, Drug Administration Routes, Guinea Pigs, Stereoisomerism, General Medicine, Toxicology, Fragrance ingredient, Perfume, Rats, Menthol, Mice, Cats, Animals, Humans, Organic chemistry, L menthol, Mutagenicity Test, Food Science
Abstract

A toxicologic and dermatologic review of l-menthol when used as a fragrance ingredient is presented.

Published
2008
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44. Fragrance material review on p-mentha-1,8-dien-7-ol

Author

S.P. Bhatia, C.S. Letizia, D. McGinty, and A.M. Api

Subjects
Molecular Structure, Chemistry, Drug Administration Routes, General Medicine, Toxicology, Fragrance ingredient, Perfume, Rats, Dogs, Botany, Monoterpenes, Animals, Humans, Organic chemistry, Rabbits, Food Science
Abstract

A toxicologic and dermatologic review of p-mentha-1,8-dien-7-ol when used as a fragrance ingredient is presented.

Published
2008
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45. Fragrance material review on butyl cinnamate

Author

J F Lalko, J. Cocchiara, C.S. Letizia, S.P. Bhatia, A.M. Api, and G.A. Wellington

Subjects
Butyl cinnamate, Chemistry, Skin Absorption, Administration, Oral, Skin Irritancy Tests, General Medicine, Administration, Cutaneous, Toxicology, Fragrance ingredient, Risk Assessment, Perfume, Cinnamates, Consumer Product Safety, Toxicity Tests, Irritants, Animals, Humans, Organic chemistry, Skin, Skin Tests, Food Science
Abstract

A toxicologic and dermatologic review of butyl cinnamate when used as a fragrance ingredient is presented.

Published
2007
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46. Fragrance material review on isoamyl cinnamate

Author

C.S. Letizia, J F Lalko, G.A. Wellington, S.P. Bhatia, A.M. Api, and J. Cocchiara

Subjects
Isoamyl cinnamate, Stereochemistry, Chemistry, Skin Absorption, Skin Irritancy Tests, General Medicine, Toxicology, Fragrance ingredient, Risk Assessment, Perfume, Cinnamates, Consumer Product Safety, Pentanes, Toxicity Tests, Irritants, Animals, Humans, Organic chemistry, Skin, Skin Tests, Food Science
Abstract

A toxicologic and dermatologic review of isoamyl cinnamate when used as a fragrance ingredient is presented.

Published
2007
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47. Fragrance material review on methyl-β-ionone

Author

A.M. Api, J F Lalko, S.P. Bhatia, C.S. Letizia, D. McGinty, and A. Lapczynski

Subjects
Dose-Response Relationship, Drug, Stereochemistry, Chemistry, Skin Absorption, Skin Irritancy Tests, General Medicine, Toxicology, Fragrance ingredient, Ionone, Norisoprenoids, Risk Assessment, Perfume, chemistry.chemical_compound, Consumer Product Safety, Toxicity Tests, Irritants, Animals, Humans, Organic chemistry, Skin, Skin Tests, Food Science
Abstract

A toxicologic and dermatologic review of methyl-beta-ionone when used as a fragrance ingredient is presented.

Published
2007
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48. Fragrance material review on 4-(2,4,6-trimethyl-3-cyclohexen-1-yl)-3-buten-2-one

Author

D. McGinty, A. Lapczynski, C.S. Letizia, A.M. Api, J F Lalko, and S.P. Bhatia

Subjects
Dose-Response Relationship, Drug, Chemistry, Stereochemistry, Skin Absorption, General Medicine, 3-buten-2-one, Skin Irritancy Tests, Toxicology, Fragrance ingredient, Risk Assessment, Perfume, Consumer Product Safety, Cyclohexenes, Toxicity Tests, Butanes, Irritants, Animals, Humans, Organic chemistry, Skin, Skin Tests, Food Science
Abstract

A toxicologic and dermatologic review of 4-(2,4,6-trimethyl-3-cyclohexen-1-yl)-3-buten-2-one when used as a fragrance ingredient is presented.

Published
2007
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49. Fragrance material review on hexyl salicylate

Author

D. McGinty, L. Jones, A. Lapczynski, C.S. Letizia, A.M. Api, and S.P. Bhatia

Subjects
medicine.medical_specialty, Stereochemistry, Skin Absorption, Toxicology, Risk Assessment, Toxicity Tests, medicine, Animals, Humans, Skin pathology, Skin, Skin Tests, Hexyl salicylate, Dose-Response Relationship, Drug, business.industry, Skin Irritancy Tests, General Medicine, Allergens, Fragrance ingredient, Dermatology, Salicylates, Perfume, Consumer Product Safety, Irritants, business, Food Science
Abstract

A toxicologic and dermatologic review of hexyl salicylate when used as a fragrance ingredient is presented.

Published
2007
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50. Fragrance material review on α-isodamascone

Author

A. Lapczynski, A.M. Api, S.P. Bhatia, J F Lalko, C.S. Letizia, and D. McGinty

Subjects
Consumer Product Safety, Dose-Response Relationship, Drug, business.industry, Skin Absorption, Skin Irritancy Tests, General Medicine, Allergens, Toxicology, Norisoprenoids, Fragrance ingredient, Risk Assessment, Perfume, Toxicity Tests, Irritants, Humans, Medicine, Food science, business, Skin, Skin Tests, Food Science
Abstract

A toxicologic and dermatologic review of alpha-isodamascone when used as a fragrance ingredient is presented.

Published
2007
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