11 results on '"Nayely Leyva-López"'
Search Results
2. Antioxidant potential, cytokines regulation, and inflammation‐related genes expression of phenolic extracts from Mexican oregano
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Nayely Leyva‐López, Erick P. Gutiérrez‐Grijalva, J. Basilio Heredia, Rosalio Ramos‐Payan, Laura A. Contreras‐Angulo, Jose R. Gonzalez‐Galaviz, and Libia Z. Rodriguez‐Anaya
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Pharmacology ,Biophysics ,Cell Biology ,Food Science - Abstract
The Mexican population traditionally uses oregano infusions to treat oxidative and inflammation-related disorders. Therefore, this study was focused on the examination of the antioxidant capacity and potential against inflammation from three Mexican oregano species (Lippia graveolens [LG], Lippia palmeri [LP], and Hedeoma patens [HP]). The extracts from LG showed a superior total phenolic content. LG, LP, and HP exhibited a higher capacity to inhibit the radical DPPH (up to 90.33 ± 0.25%) and significantly lowered the release of MCP-1 and IL-6. At the same time, LG and HP increased the secretion of IL-10. Extracts from LG, LP, and HP did not significantly diminish the expression of il-1β or inos, although a slight decrease in inos expression was observed. Our findings support that phenolic extracts from L. graveolens, L. palmeri, and H. patens possess antioxidant and anti-inflammatory properties and might be potential therapeutic candidates against oxidative and inflammation-related diseases. PRACTICAL APPLICATIONS: Oregano species have traditionally been exploited as remedies against inflammatory-related diseases, namely headaches, asthma, bowel disorders, and rheumatism. This study explored the antioxidant potential of three Mexican oregano species (Lippia graveolens, Lippia palmeri, and Hedeoma patens) and their anti-inflammatory effects in a murine cell model. Phenolic extracts from oregano showed antioxidant capacity and exerted activity against inflammation by improving anti-inflammatory cytokines secretion or negatively regulating pro-inflammatory cytokines. The results of our study demonstrate that the phenolic extracts from these Mexican oregano species have the potential in treating inflammation-related diseases.
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- 2022
3. Bioaccessibility of Phenolic Compounds from Mistletoe Infusions and Effect of In Vitro Digestion on Its Antioxidant and Pancreatic Lipase Inhibitory Activity
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Erick Paul Gutiérrez-Grijalva, Victor Eduardo Zamudio-Sosa, Laura Aracely Contreras-Angulo, Nayely Leyva-López, and J. Basilio Heredia
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Health (social science) ,antioxidants ,bioaccessibility ,in vitro digestion ,mistletoe ,pancreatic lipase ,phenolic acids ,polyphenols ,Plant Science ,Health Professions (miscellaneous) ,Microbiology ,Food Science - Abstract
Phoradendron brachystachyum is an American mistletoe distributed in México and used ethnobotanically in infusions to treat hypertriglyceridemia and lower cholesterol levels. This study aimed to evaluate the bioaccessibility of the phenolic acids from mistletoe infusions and the effect of simulated digestion on its antioxidant and lipase inhibitory properties. The in vitro digestion process decreased the antioxidant capacity activity by the TEAC and ORAC assays in infusions from leaves, stems, and whole plant samples. Moreover, the individual phenolic content of mistletoe infusions was also affected by the in vitro digestion process; the most abundant individual phenolic constituents at the end of the digestion process were ferulic and quinic acids. These compounds showed low bioaccessibility values ranging from 7.48% to 22.60%. In addition, the in vitro digestion diminished the pancreatic lipase inhibition percentage of leaves and whole plant infusions but increased it in the stem samples. This research showed that given the phenolic content and pancreatic lipase inhibitory activity of mistletoe infusions, it could be used as a potential source for the development of functional foods and nutraceuticals; nonetheless, its phenolic content is affected by gastrointestinal digestion; thus, encapsulation strategies are encouraged to protect these metabolites from the gastrointestinal environment while preserving their antioxidant and hypolipidemic potentials.
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- 2022
4. Oregano as a potential source of antidiabetic agents
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Erick P. Gutiérrez‐Grijalva, Nayely Leyva‐López, Gabriela Vazquez‐Olivo, and J. Basilio Heredia
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Pharmacology ,Lamiaceae ,Phenols ,Plant Extracts ,Origanum ,Biophysics ,Humans ,Hypoglycemic Agents ,Cell Biology ,Food Science - Abstract
Oregano is the name given to a great variety of herbs belonging mainly to the Lamiaceae and Verbenaceae botanical families. Oregano species are rich sources of phytochemicals such as phenolic compounds like rosmarinic acid, salvianolic acid, and luteolin, among others. A few articles have previously accessed some potential pharmacological bioactivities of oregano plants; however, none has focused on the antidiabetic studies. This review aims to summarize recent studies about the potential effect of phenolic compounds from oregano plant species. The reports were retrieved from electronic databases such as PubMed, Web of Science, National Center for Biotechnology Information (NCBI), and Scopus. In addition, articles related to the mentioned topics and published between 2004-2022 were selected. The results from this study show that the antidiabetic pharmacological reports of oregano phenolic compounds are mainly in vitro reports. Therefore, the diversity of oregano species yields a broad variety of phenolic constituents, where preclinical and clinical studies are strongly recommended.
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- 2022
5. Corn husk extracts as an antioxidant additive in diets for Nile tilapia (Oreochromis niloticus) fingerlings: Effect on growth performance, feed intake and toxicity//Extractos de hoja de mazorca de maíz como aditivo antioxidante en dietas para juveniles de tilapia del Nilo (Oreochromis niloticus): Efectos sobre el crecimiento, el consumo de alimento y la toxicidad
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Cynthia E. Lizárraga-Velázquez, Erika Yazmín Sánchez-Gutiérrez, Crisantema Hernández, José Basilio Heredia, Nayely Leyva-López, and José Andrés Galeana-López
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Community and Home Care ,food.ingredient ,food ,Tilapia ,Food science ,Biology - Abstract
Corn stover, a corn harvest by-product, can be used to add value to feeds for farmed fish through their extracts, which are rich in phenolic compounds (PCs) and could confer antioxidant properties and possible health benefits to fish. In this study, PCs from corn husk extracts (CHE) were identified by ultra performance liquid chromatography-electrospray ionization-quadrupole time of fly-mass spectroscopy (UPLCESI-Q-ToF-MS/MS), and used to provide antioxidant potential to diets for Nile tilapia fingerlings. Three experimental diets for tilapia were formulated with 0, 100 and 200 mg PCs from CHE/kg feed and their antioxidant capacity was determined by DPPH• and ORAC assays. A total of 180 Nile tilapia fingerlings (0.35 ± 0.06 g) were fed for 14 days to determine the effect of experimental diets on feed intake and growth performance. PCs from CHE such as ferulic, p-coumaric and chlorogenic acids were the most abundant. The inclusion of PCs into tilapia diets increases linearly (p < 0.05) their antioxidant capacity (DPPH and ORAC). Growth performance and feed intake increased linearly (p < 0.05) as the level of CHE inclusion increased. Results suggest that the CHE can provide antioxidant potential to tilapia diets, promote growth performance and feed intake without toxic effects.RESUMENLa mazorca de maíz, un subproducto de la cosecha de maíz, puede usarse para agregar valor a los alimentos para peces de cultivo a través de sus extractos, que son ricos en compuestos fenólicos (PCs) y los cuales podrían conferir propiedades antioxidantes y posibles beneficios a la salud de los peces. En este estudio, las PCs de los extractos de cáscara de maíz (CHE) se identificaron mediante cromatografía líquida de ultra resolución-tiempo de vuelo con cuadrupolo acoplado a espectrometría de masas con ionización por electrospray (UPLC-ESI-Q-ToF-MS/MS), y se utilizaron para proporcionar potencial antioxidante a las dietas para alevines de tilapia del Nilo. Se formularon tres dietas experimentales para tilapia con 0, 100 y 200 mg de PCs de CHE/kg de alimento y su capacidad antioxidante se determinó mediante ensayos DPPH• y ORAC. Se alimentaron un total de 180 alevines de tilapia del Nilo (0.35 ± 0.06 g) durante 14 días para determinar el efecto de las dietas experimentales, sobre el consumo de alimento y el crecimiento. Los PCs de CHE como los ácidos ferúlico, p-cumárico y clorogénico fueron las más abundantes. La inclusión de PCs en las dietas para tilapia, aumenta linealmente (p
- Published
- 2020
6. Corn Husk Phenolics Modulate Hepatic Antioxidant Response in Nile Tilapia (Oreochromis niloticus) Exposed to Hypoxia
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Nayely Leyva-López, J. Basilio Heredia, Crisantema Hernández, José Andrés Galeana-López, and Cynthia E. Lizárraga-Velázquez
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Pharmaceutical Science ,phenolic compounds ,medicine.disease_cause ,Zea mays ,Feed conversion ratio ,Article ,Antioxidants ,Analytical Chemistry ,Superoxide dismutase ,Nile tilapia ,QD241-441 ,Phenols ,antioxidant enzymes ,Drug Discovery ,medicine ,Animals ,corn by-product ,Food science ,Physical and Theoretical Chemistry ,Hypoxia ,chemistry.chemical_classification ,Glutathione Peroxidase ,biology ,Plant Extracts ,Superoxide Dismutase ,Glutathione peroxidase ,Organic Chemistry ,Cichlids ,Hypoxia (medical) ,Catalase ,biology.organism_classification ,Animal Feed ,Diet ,Oxidative Stress ,Oreochromis ,Liver ,chemistry ,Chemistry (miscellaneous) ,Dietary Supplements ,biology.protein ,Molecular Medicine ,medicine.symptom ,Oxidative stress - Abstract
The hypoxia conditions in intensive farming systems generate oxidative stress related to oxidative damage and mortality of fish. Corn husk meal (CHM), as a source of antioxidants, might modulate the antioxidant response and prevent the damage elicited by hypoxia. This study evaluated CHM’s ability to modulate a hepatic response in Nile tilapia exposed to hypoxia. A control and a test diet supplemented with 25 g CHM/kg feed were formulated. Ninety Nile tilapias (5.09 ± 0.55 g initial weight) were fed for 36 days to evaluate growth, feed efficiency, and hepatic antioxidant response (CAT, catalase, SOD, superoxide dismutase, and GPx, glutathione peroxidase) in normal oxygen conditions (normoxia). After the feeding trial (36 days), fish were exposed to hypoxia (1.5 ± 0.2 mg/L dissolved oxygen), and the hepatic antioxidant response was determined. There was no significant effect of CHM on growth and feed efficiency. The CAT activity was significantly increased in tilapias exposed to hypoxia and fed the test diet compared to the control group exposed to hypoxia. The SOD and GPx activities were unchanged in tilapias in normoxia and hypoxia conditions. Results suggest that CHM dietary supplementation promotes the antioxidant response in Nile tilapia exposed to hypoxia through CAT modulation.
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- 2021
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7. Polyphenolic Extracts from Spent Coffee Grounds Prevent H2O2-Induced Oxidative Stress in Centropomus viridis Brain Cells
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Melissa Peraza-Arias, Anaguiven Avalos-Soriano, Crisantema Hernández, Cynthia E. Lizárraga-Velázquez, J. Basilio Heredia, and Nayely Leyva-López
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Fish Proteins ,Antioxidant ,DPPH ,medicine.medical_treatment ,Fisheries ,Pharmaceutical Science ,Coffea ,antioxidant capacity ,medicine.disease_cause ,Coffee ,Article ,Antioxidants ,Analytical Chemistry ,Superoxide dismutase ,Lipid peroxidation ,chemistry.chemical_compound ,QD241-441 ,Drug Discovery ,Caffeic acid ,medicine ,Animals ,Food science ,Physical and Theoretical Chemistry ,white snook ,Cells, Cultured ,biology ,Chemistry ,Plant Extracts ,Superoxide Dismutase ,Organic Chemistry ,catalase ,food and beverages ,Brain ,Polyphenols ,lipid peroxidation ,Free Radical Scavengers ,Hydrogen Peroxide ,Perciformes ,Oxidative Stress ,Chemistry (miscellaneous) ,Polyphenol ,Catalase ,biology.protein ,Molecular Medicine ,Oxidative stress - Abstract
Oxidative stress in aquatic organisms might suppress the immune system and propagate infectious diseases. This study aimed to investigate the protective effect of polyphenolic extracts from spent coffee grounds (SCG) against oxidative stress, induced by H2O2, in C. viridis brain cells, through an in vitro model. Hydrophilic extracts from SCG are rich in quinic, ferulic and caffeic acids and showed antioxidant capacity in DPPH, ORAC and FRAP assays. Furthermore, pretreatment of C. viridis brain cells with the polyphenolic extracts from SCG (230 and 460 µg/mL) for 24 h prior to 100 µM H2O2 exposure (1 h) significantly increased antioxidant enzymes activity (superoxide dismutase and catalase) and reduced lipid peroxidation (measured by MDA levels). These results suggest that polyphenols found in SCG extracts exert an antioxidative protective effect against oxidative stress in C. viridis brain cells by stimulating the activity of SOD and CAT.
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- 2021
8. Effect of cooking and germination on bioactive compounds in pulses and their health benefits
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Erick P. Gutiérrez-Grijalva, Leticia X. López-Martínez, J. Basilio Heredia, and Nayely Leyva-López
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chemistry.chemical_classification ,Nutrition and Dietetics ,Nutrition. Foods and food supply ,Medicine (miscellaneous) ,food and beverages ,Germination ,04 agricultural and veterinary sciences ,Health benefits ,040401 food science ,Bioactive compounds ,Bioavailability ,0404 agricultural biotechnology ,Enzyme ,Nutrient ,chemistry ,Nutrient absorption ,Protein digestibility ,TX341-641 ,Palatability ,Food science ,Cooking ,Pulses ,Food Science - Abstract
Pulses supply many bioactive substances, such as enzyme inhibitors, lectins, phytates and phenolic compounds. Phenolic compounds are found in minor amounts in food but have significant metabolic and/or physiological effects. Enzyme inhibitors can diminish protein digestibility, and lectins can reduce nutrient absorption, but both have little effect after cooking. Because bioactive compounds can be beneficial or adverse, depending on the processing conditions, an assessment of their various physiological effects is necessary to determine whether they should be preserved or eliminated. Pulses are normally consumed after processing, which not only improves the palatability of foods but also increases the bioavailability of nutrients and bioactive compounds. Recent findings from the literature published within the last 10 years about the effect of cooking and germination is compiled and summarized.
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- 2017
9. Exploitation of Agro-Industrial Waste as Potential Source of Bioactive Compounds for Aquaculture
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Crisantema Hernández, Nayely Leyva-López, Erika Yazmín Sánchez-Gutiérrez, and Cynthia E. Lizárraga-Velázquez
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Pollution ,antioxidant ,Health (social science) ,food.ingredient ,media_common.quotation_subject ,Review ,phenolic compounds ,Plant Science ,lcsh:Chemical technology ,Health Professions (miscellaneous) ,Microbiology ,Industrial waste ,immunostimulants ,03 medical and health sciences ,food ,Aquaculture ,Biological property ,lcsh:TP1-1185 ,Potential source ,Disease resistant ,030304 developmental biology ,media_common ,fish ,0303 health sciences ,Waste management ,business.industry ,Food additive ,biological activities ,04 agricultural and veterinary sciences ,040102 fisheries ,0401 agriculture, forestry, and fisheries ,Environmental science ,%22">Fish ,food by-products ,prebiotics ,business ,Food Science - Abstract
The agroindustry generates a large amount of waste. In postharvest, food losses can reach up to 50%. This waste represents a source of contamination of soil, air, and bodies of water. This represents a problem for the environment as well as for public health. However, this waste is an important source of bioactive compounds, such as phenolic compounds, terpenes, and β-glucans, among others. Several biological activities have been attributed to these compounds; for example, antioxidant, antimicrobial, gut microbiota, and immune system modulators. These properties have been associated with improvements in health. Recently, the approach of using these bioactive compounds as food additives for aquaculture have been addressed, where it is sought that organisms, in addition to growing, preserve their health and become disease resistant. The exploitation of agro-industrial waste as a source of bioactive compounds for aquaculture has a triple objective—to provide added value to production chains, reduce pollution, and improve the well-being of organisms through nutrition. However, to make use of the waste, it is necessary to revalue them, mainly by determining their biological effects in aquaculture organisms. The composition of bioactive compounds of agro-industrial wastes, their biological properties, and their application in aquaculture will be addressed here.
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- 2020
10. Phenolic compounds: Natural alternative in inflammation treatment. A Review
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Dulce L. Ambriz-Pérez, Nayely Leyva-López, Erick P. Gutiérrez-Grijalva, and J. Basilio Heredia
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0301 basic medicine ,Physical agents ,lcsh:TP368-456 ,Mechanism (biology) ,Chemistry ,lcsh:S ,Inflammation ,phenolic compounds ,Pharmacology ,Agricultural and Biological Sciences (miscellaneous) ,anti-inflammatory capacity ,Inflammation Process ,lcsh:Agriculture ,03 medical and health sciences ,lcsh:Food processing and manufacture ,030104 developmental biology ,0302 clinical medicine ,Immune system ,inflammation ,030220 oncology & carcinogenesis ,medicine ,medicine.symptom ,Adverse effect ,Tissue homeostasis ,Food Science - Abstract
Inflammation is a biological defense mechanism caused by the interruption of the tissue homeostasis caused by the presence of a biological, chemical, or physical agents in the body; immune system produces a series of pro-inflammatory mediators, however their overproduction, as occurs in chronic inflammation, might lead to the occurrence of several chronic diseases. For this reason, slowing down the inflammation process becomes very important, and with this purpose non-steroid anti-inflammatory drugs are generally used with the subsequent occurrence of adverse side effects. As an alternative in inflammation treatment, folklore medicine has used several plants and herbs with minimal or null side effects, with the phenolic compounds being one of their principal components. Phenolic compounds are able to inhibit either the production or the action of pro-inflammatory mediators, resulting in anti-inflammatory capacity.
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- 2016
11. Bioavailability of dietary phenolic compounds: review
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Nayely Leyva-López, José Basilio Heredia, Ramón Ignacio Castillo-López, Dulce L. Ambriz-Pérez, and Erick P. Gutiérrez-Grijalva
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Metabolismo ,Nutrition and Dietetics ,RC620-627 ,Chemistry ,Nutrition. Foods and food supply ,Dietary intake ,Fenoles ,Metabolism ,Phenols ,Biotransformation ,TX341-641 ,Food science ,Biotransformación ,Nutritional diseases. Deficiency diseases ,Food Science - Abstract
Phenolic compounds are ubiquitous in plant-based foods. High dietary intake of fruits, vegetables and cereals is related to a decreased rate in chronic diseases. Phenolic compounds are thought to be responsible, at least in part, for those health effects. Nonetheless, phenolic compounds bioaccessibility and biotransformation is often not considered in these studies; thus, a precise mechanism of action of phenolic compounds is not known. In this review we aim to present a comprehensive knowledge of the metabolic processes through which phenolic compounds go after intake. Los compuestos fenólicos son ubicuos en alimentos de origen vegetal. La alta ingesta de frutas, vegetales y cereales está relacionada con un bajo índice en padecimientos crónicos. Se cree que los compuestos fenólicos son, en parte, responsables de este efecto benéfico. Sin embargo, la bioaccesibilidad y biotransformación de los compuestos fenólicos generalmente no es considerada en este tipo de estudios. Por lo tanto, no se ha podido obtener un mecanismo de acción de los compuestos fenólicos. En este trabajo, presentamos una revisión de literatura de los procesos metabólicos a través de los cuales los compuestos fenólicos son sometidos después de ser ingeridos.
- Published
- 2015
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