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Purpose of Review The current systematic review and meta-analysis was done to evaluate the effects of selenium and probiotic co-supplementation on lipid profile and glycemia indices of the adult population using randomized controlled clinical trials (RCTs). Recent Findings Five studies involving 282 participants with a sample size ranging from 38 to 79 were eligible to be enrolled in the current study. Co-supplementation with probiotic and selenium reduced fasting plasma glucose (WMD = −4.02 mg/dL; 95% CI: −5.87 to −2.18; P P P P P P = 0.029), and triglyceride (WMD = −14.38 mg/dL; 95% CI: −23.13 to −5.62; P = 0.001). Summary The findings of the current systematic review and meta-analysis suggested that co-supplementation with probiotics and selenium may benefit adults in terms of glycemia indices and lipid profile. However, due to the small number of included studies, further trials are needed to confirm our findings.