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3 results on '"Davidson DW"'

1. Inhibition of gonadotrophin secretion by induced hyperprolactinaemia in the male rat.

Author

McNeilly AS, Sharpe RM, Davidson DW, and Fraser HM

Subjects
Animals, Chorionic Gonadotropin metabolism, Follicle Stimulating Hormone blood, Gonadotropin-Releasing Hormone metabolism, Hypothalamus metabolism, Luteinizing Hormone blood, Male, Organ Size, Pituitary Gland metabolism, Pituitary Gland transplantation, Prolactin metabolism, Rats, Testis metabolism, Testosterone blood, Transplantation, Autologous, Follicle Stimulating Hormone metabolism, Luteinizing Hormone metabolism, Prolactin blood
Published
1978
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2. Pituitary-ovarian relationships in polycystic ovary syndrome.

Author

Baird DT, Corker CS, Davidson DW, Hunter WM, Michie EA, and Van Look PF

Subjects
Adult, Clomiphene, Estradiol metabolism, Estrone metabolism, Ethinyl Estradiol, Female, Gonadotropin-Releasing Hormone, Humans, Polycystic Ovary Syndrome physiopathology, Androstenedione metabolism, Estrogens metabolism, Follicle Stimulating Hormone metabolism, Luteinizing Hormone metabolism, Ovulation, Polycystic Ovary Syndrome metabolism
Abstract

The spontaneous pattern of pituitary gonadotropins and ovarian steroids and their response to dynamic tests were measured in 12 women with polycystic ovarian syndrome (PCO) and the results compared to those from 6 normal women during the early follicllar phase of the cycle (controls). As judged by serial measurements of urinary total estrogen and pregnanediol over a 12-week period, in PCO patients 75% of cycles were anovulatory (anovulatory PCO) as compared to 100% ovulatory in controls. The basal concentrations of LH, androstenedione and estrone were significantly higher and the concentration os FSH significantly lower in anovulatory PCO than in the controls (P less than .05). In PCO patients the concentration of LH was lower following an ovulatory cycle than that following a period of anovulation. Negative and positive feedback responses to an estrogen provocation test (200 microgram ethinyl estradiol per day for 3 days) were normal in anovulatory PCO although the LH peak occurred 24 h earlier than in the controls. The amplitude of the pulses of LH was significantly greater in anovulatory PCO than in the controls and was suppressed in both groups after ethinyl estradiol. The peak release of LH in response to 56 microgram LRF in ovulatory PCO was similar in controls but LH responses in anovulatory PCO were significantly greater. It is suggested that the abnormalities in gonadotropin secretion in PCO are secondary to excessive and prolonged extraglandular production of estrogen from androstenedione.

Published
1977
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3. Pituitary-Ovarian Relationships in Polycystic Ovary Syndrome

Author

W.M. Hunter, C. S. Corker, David T. Baird, Van Look Pf, Michie Ea, and Davidson Dw

Subjects
Adult, Ovulation, endocrine system, medicine.medical_specialty, Estrone, medicine.drug_class, Endocrinology, Diabetes and Metabolism, media_common.quotation_subject, Clinical Biochemistry, Biology, Ethinyl Estradiol, Biochemistry, Clomiphene, Gonadotropin-Releasing Hormone, Anovulation, Follicle-stimulating hormone, chemistry.chemical_compound, Endocrinology, Internal medicine, medicine, Humans, media_common, Estradiol, Biochemistry (medical), Androstenedione, Estrogens, Luteinizing Hormone, medicine.disease, Polycystic ovary, eye diseases, chemistry, Estrogen, cardiovascular system, Pregnanediol, Female, Follicle Stimulating Hormone, Luteinizing hormone, human activities, Polycystic Ovary Syndrome, circulatory and respiratory physiology
Abstract

The spontaneous pattern of pituitary gonadotropins and ovarian steroids and their response to dynamic tests were measured in 12 women with polycystic ovarian syndrome (PCO) and the results compared to those from 6 normal women during the early follicllar phase of the cycle (controls). As judged by serial measurements of urinary total estrogen and pregnanediol over a 12-week period, in PCO patients 75% of cycles were anovulatory (anovulatory PCO) as compared to 100% ovulatory in controls. The basal concentrations of LH, androstenedione and estrone were significantly higher and the concentration os FSH significantly lower in anovulatory PCO than in the controls (P less than .05). In PCO patients the concentration of LH was lower following an ovulatory cycle than that following a period of anovulation. Negative and positive feedback responses to an estrogen provocation test (200 microgram ethinyl estradiol per day for 3 days) were normal in anovulatory PCO although the LH peak occurred 24 h earlier than in the controls. The amplitude of the pulses of LH was significantly greater in anovulatory PCO than in the controls and was suppressed in both groups after ethinyl estradiol. The peak release of LH in response to 56 microgram LRF in ovulatory PCO was similar in controls but LH responses in anovulatory PCO were significantly greater. It is suggested that the abnormalities in gonadotropin secretion in PCO are secondary to excessive and prolonged extraglandular production of estrogen from androstenedione.

Published
1977

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