1. Phase I study of FOLFIRI plus pimasertib as second-line treatment for KRAS-mutated metastatic colorectal cancer
- Author
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Macarulla Mercadé, Teresa, Cervantes, Andrés, Tabernero, Josep, Roselló, Susana, Van Cutsem, E., Tejpar, S., Prenen, H., Martinelli, E., Troiani, T., Laffranchi, B., Jego, V, von Richter, O., Ciardiello, Fortunato, Universitat Autònoma de Barcelona, Macarulla, T, Cervantes, A., Tabernero, J., Roselló, S., Van Cutsem, E., Tejpar, S., Prenen, H., Martinelli, Erika, Troiani, Teresa, Laffranchi, B., Jego, V., Von Richter, O., and Ciardiello, Fortunato
- Subjects
Male ,Cancer Research ,Colorectal cancer ,medicine.medical_treatment ,Leucovorin ,Colorectal Neoplasm ,Pharmacology ,medicine.disease_cause ,pimasertib ,combination therapy ,Antineoplastic Combined Chemotherapy Protocols ,Neoplasm Metastasis ,combination therapy second-line treatment ,Aged, 80 and over ,Proto-Oncogene Protein ,Cetuximab ,KRAS-mutated metastatic colorectal cancer ,Medicine (all) ,MEK inhibitor ,Middle Aged ,Neoplasm Metastasi ,Treatment Outcome ,Oncology ,Fluorouracil ,FOLFIRI ,Second-line treatment ,Female ,KRAS ,Colorectal Neoplasms ,Pimasertib ,Human ,medicine.drug ,Niacinamide ,Proto-Oncogene Proteins p21(ras) ,Proto-Oncogene Proteins ,medicine ,Humans ,Combination therapy ,neoplasms ,Aged ,Chemotherapy ,Antineoplastic Combined Chemotherapy Protocol ,business.industry ,KRAS -mutated metastatic colorectal cancer ,Genes, ra ,ras Protein ,medicine.disease ,digestive system diseases ,Genes, ras ,second-line treatment ,Mutation ,ras Proteins ,Clinical Study ,Cancer research ,Camptothecin ,Human medicine ,business - Abstract
BACKGROUND: The mitogen-activated protein kinase (MAPK) pathway has been implicated in the molecular pathogenesis of human cancers, including metastatic colorectal cancer (mCRC). This provides a rationale for the development of MAPK-targeted agents such as pimasertib. METHODS: Patients with KRAS mutant mCRC were treated in the second-line setting with FOLFIRI (5-fluorouracil/folinic acid/irinotecan) plus pimasertib. The primary objective of the safety run-in phase was to determine the maximum-tolerated dose (MTD) and the recommended phase II dose of pimasertib combined with FOLFIRI. RESULTS: Sixteen patients were enrolled in the trial. Ten and six patients were treated daily with 45 and 60 mg of pimasertib plus FOLFIRI, respectively. The MTD was considered to be 45 mg per day. The most common treatment-emergent adverse events were diarrhoea, nausea, vomiting, asthenia and skin/rash event. Of the 15 patients in the efficacy analysis group, two patients had partial response, nine patients had stable disease, three patients had progressive disease as their best overall response and one patient could not be evaluated. CONCLUSIONS: Dose escalation of pimasertib in combination with FOLFIRI was limited by toxicity. At the MTD of 45 mg per day, pimasertib was adequately tolerated in patients with mCRC and no unexpected or new safety signals or concerns were identified. ispartof: British Journal of Cancer vol:112 issue:12 pages:1874-1881 ispartof: location:England status: published
- Published
- 2015