1. Intralesional 5-fluorouracil in keloid treatment: a systematic review.
- Author
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Bijlard E, Steltenpool S, and Niessen FB
- Subjects
- Dermatologic Agents adverse effects, Drug Administration Schedule, Drug Therapy, Combination, Fluorouracil adverse effects, Glucocorticoids administration & dosage, Humans, Injections, Intralesional, Keloid diagnosis, Skin pathology, Treatment Outcome, Triamcinolone Acetonide administration & dosage, Dermatologic Agents administration & dosage, Fluorouracil administration & dosage, Keloid drug therapy, Skin drug effects
- Abstract
In the 1990s, 5-flourouracil (5-FU) was introduced as a treatment for keloids; however, there is still no consensus on its use. In order to guide clinical practice, a systematic review of the clinical evidence on the effectiveness of 5-FU in keloid treatment was carried out. Eight databases were searched on 10 September 2014 using the terms "keloid" and "5-FU", together with all synonyms of these terms. Two reviewers selected original research reports using 5-FU alone or combined with a maximum of 2 other therapies. Eighteen papers were found that reported either on intralesional 5-FU alone, or on 5-FU combined with triamcinolone acetonide (TAC:5-FU) or excision, including 482 patients. 5-FU treatment was effective in 45-96% of patients, but only TAC:5-FU may perform better than TAC alone. Due to a poor level of evidence, further research should establish the superiority of repeated intralesional TAC:5-FU injections over TAC alone with several doses and injection schedules.
- Published
- 2015
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