1. Synthesis of difluoroaryldioxoles using BrF3.
- Author
-
Hagooly Y, Welch MJ, and Rozen S
- Subjects
- Fluorine Compounds chemistry, Molecular Structure, Bromine Compounds chemistry, Fluorine Compounds chemical synthesis, Oxygen chemistry
- Abstract
A novel synthesis of different aromatic and heteroaromatic difluorodioxole derivatives has been developed. The starting materials were catechols, which, after treatment with thiophosgene, formed at 0 °C the respective thiodioxoles. The latter were reacted for a short time with commercially available bromine trifluoride, producing potentially biologically important difluoroaryldioxoles in moderate to high yields.
- Published
- 2011
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