1. C–H 18F-fluorination of 8-methylquinolines with Ag[18F]F.
- Author
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Lee, So Jeong, Brooks, Allen F., Ichiishi, Naoko, Makaravage, Katarina J., Mossine, Andrew V., Sanford, Melanie S., and Scott, Peter J. H.
- Subjects
QUINOLINE derivatives ,FLUORINATION ,CARBON-hydrogen bonds ,SUBSTITUTION reactions ,RADIOCHEMISTRY - Abstract
This report describes a Pd-mediated C–H radiofluorination of 8-methylquinoline derivatives with no-carrier-added Ag[
18 F]F. To achieve this transformation, a new method was developed for the generation of Ag[18 F]F using a sep-pak cartridge. The C–H radiofluorination was then optimized and applied to a series of substituted 8-methylquinoline derivatives. Finally, this method was fully automated using a radiochemistry synthesis module. [ABSTRACT FROM AUTHOR]- Published
- 2019
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