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Your search keyword '"Scott, Peter J. H."' showing total 2 results
Start Over Author "Scott, Peter J. H." Topic fluorination Topic radioactive tracers
2 results on '"Scott, Peter J. H."'

1. Copper-Mediated Radiofluorination of Arylstannanes with [18F]KF.

Author

Makaravage, Katarina J., Brooks, Allen F., Mossine, Andrew V., Sanford, Melanie S., and Scott, Peter J. H.

Subjects
*FLUORINATION, *COPPER, *STANNANE, *RADIOACTIVE tracers, *CHEMICAL reagents, *PHENYLALANINE
Abstract

A copper-mediated nucleophilic radiofluorination of aryl- and vinylstannanes with [18F]KF is described. This method is fast, uses commercially available reagents, and is compatible with both electron-rich and electron-deficient arene substrates. This method has been applied to the manual synthesis of a variety of clinically relevant radiotracers including protected [18F]F-phenylalanine and [18F]F-DOPA. In addition, an automated synthesis of [18F]MPPF is demonstrated that delivers a clinically validated dose of 200 ± 20 mCi with a high specific activity of 2400 ± 900 Ci/mmol. [ABSTRACT FROM AUTHOR]

Published
2016
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2. Copper-Catalyzed [18F]Fluorination of (Mesityl)(aryl)iodoniumSalts.

Author

Ichiishi, Naoko, Brooks, Allen F., Topczewski, Joseph J., Rodnick, Melissa E., Sanford, Melanie S., and Scott, Peter J. H.

Subjects
*IODONIUM salts, *COPPER catalysts, *FLUORINATION, *MESITYLENE, *RADIOACTIVE tracers, *ARYL fluorides
Abstract

A practical, rapid, and highly regioselectiveCu-catalyzed radiofluorinationof (mesityl)(aryl)iodonium salts is described. This protocol utilizes[18F]KF to access 18F-labeled electron-rich,-neutral, and -deficient aryl fluorides under a single set of mildconditions. This methodology is applied to the synthesis of protectedversions of two important radiotracers: 4-[18F]fluorophenylalanineand 6-[18F]fluoroDOPA. [ABSTRACT FROM AUTHOR]

Published
2014
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