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Fluoride profiles (period of estimation 24 hours) after oral intake of 6 different preparations were made in human plasma and parotid saliva. It was shown that the fluoride concentration was highest when NaF was administered. Concentration returned to normal after about 8 hours. The values in parotid saliva were slightly lower than in plasma. Both profiles ran approximately parallel. A pre-eruptive, caries-prophylactic action can here be expected where bio-availability is especially favourable.

In six male subjects fluoride bio-availability after oral application of NaF and MgF2 was examined and the influence of food on fluoride absorption was studied by recording fluoride level in plasma and parotid saliva for 24 hours. In addition, fluoride profiles in the plasma of four beagle dogs after the intake of fluoride as NaF, MgF2 and CaF2 with and without addition of milk and dairy products were established. There were great differences in extent and speed of absorption among the different preparations some of which were demonstrated not to release fluoride at all. As was expected, absorption was quicker and more complete in patients with empty stomach than with simultaneous food intake. Milk and dairy products delay fluoride uptake without considerably reducing the overally amount of fluoride resorption.

In 12- and 22-week old rats the fluoride levels in plasma and in the femur were studied over a period of 24 hours. Without fluoride administration, the normal fluoride concentration was 0.01 to 0.03 ppm in plasma and an average 50 ppm in the femur. Peak values were observed in the plasma 20 to 40 minutes after fluoride intake, with the peak levels being the same irrespective of the age of the animals and the duration of fluoride administration. A quick and obvious fluoride retention in the femur was registered in young animals. Fluoride elimination from the plasma is influenced by the age of the animals and the previous fluoride load.

Fluorine enriched drinking water (1 ppm F-) is partially defluoridated with the aid of a simple (laboratory) apparatus. The material employed is tricalcium phosphate. The pH-values and electrical conductivity due to fluoridation are significantly changed by defluoridation. The duration of the defluoridation process appears acceptable and the efficiency of the system is adequate. The experimental conditions as well as the results show that an acceptable alternative exists to fluoridated drinking water in the household.