1. A Catalytic Peterson-like Synthesis of Alkenyl Nitriles
- Author
-
Francesco Ferlin, Luigi Vaccaro, Stefano Santoro, Matteo Alonzi, and Daniela Lanari
- Subjects
Acetonitriles ,010405 organic chemistry ,Organic Chemistry ,010402 general chemistry ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,Catalysis ,chemistry.chemical_compound ,chemistry ,Organic chemistry ,Physical and Theoretical Chemistry ,Selectivity ,Fluoride ,Stoichiometry - Abstract
A heterogeneous fluoride catalyst was found to enable the straightforward formation of alkenyl nitriles from the reaction of aldehydes and simple or substituted acetonitriles, in the presence of commercially available silazanes and in solvent-free conditions. The protocol afforded the products in good to excellent yields with selectivity values dependent on the nature of the substrates. It represents an alternative to classic approaches using stoichiometric strong bases, and the catalyst can be easily recovered and reused for consecutive cycles.
- Published
- 2016