1. Biotin-tagged fluorescent sensor to visualize 'mobile' Zn 2+ in cancer cells.
- Author
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Fang L, Trigiante G, Kousseff CJ, Crespo-Otero R, Philpott MP, and Watkinson M
- Subjects
- Biotin chemical synthesis, Biotin toxicity, Fluorescence, Fluorescent Dyes chemical synthesis, Fluorescent Dyes toxicity, Humans, Keratinocytes drug effects, Lactams, Macrocyclic chemical synthesis, Lactams, Macrocyclic toxicity, Ligands, MCF-7 Cells, Microscopy, Fluorescence, Zinc metabolism, Biotin analogs & derivatives, Biotin pharmacology, Fluorescent Dyes pharmacology, Lactams, Macrocyclic pharmacology, Zinc analysis
- Abstract
A cancer cell-targeting fluorescent sensor has been developed to image mobile Zn2+ by introducing a biotin group. It shows a highly selective response to Zn2+in vitro, no toxicity in cellulo and images 'mobile' Zn2+ specifically in cancer cells. We believe this probe has the potential to help improve our understanding of the role of Zn2+ in the processes of cancer initiation and development.
- Published
- 2018
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