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Start Over Descriptor "Azulenes toxicity" Topic fluorescent dyes

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1. Azulene-Derived Fluorescent Probe for Bioimaging: Detection of Reactive Oxygen and Nitrogen Species by Two-Photon Microscopy.

Author

Murfin LC, Weber M, Park SJ, Kim WT, Lopez-Alled CM, McMullin CL, Pradaux-Caggiano F, Lyall CL, Kociok-Köhn G, Wenk J, Bull SD, Yoon J, Kim HM, James TD, and Lewis SE

Subjects
Azulenes toxicity, Cell Survival drug effects, Fluorescent Dyes toxicity, HeLa Cells, Humans, Limit of Detection, Azulenes chemistry, Fluorescent Dyes chemistry, Microscopy, Fluorescence, Multiphoton methods, Reactive Nitrogen Species analysis, Reactive Oxygen Species analysis
Abstract

Two-photon fluorescence microscopy has become an indispensable technique for cellular imaging. Whereas most two-photon fluorescent probes rely on well-known fluorophores, here we report a new fluorophore for bioimaging, namely azulene. A chemodosimeter, comprising a boronate ester receptor motif conjugated to an appropriately substituted azulene, is shown to be an effective two-photon fluorescent probe for reactive oxygen species, showing good cell penetration, high selectivity for peroxynitrite, no cytotoxicity, and excellent photostability. more...

Published
2019
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