1. Hot-band absorption of indocyanine green for advanced anti-stokes fluorescence bioimaging
- Author
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Xiaoxiao Fan, Zhe Feng, Jun Qian, Wen Liu, Yuhuang Zhang, Mubin He, Dingwei Xue, Andrey N. Kuzmin, Di Wu, Jie Liu, Paras N. Prasad, Zikang Ye, Jing Zhou, and Liang Zhu
- Subjects
Materials science ,genetic structures ,Hot band ,Article ,law.invention ,chemistry.chemical_compound ,Computer Science::Hardware Architecture ,Nuclear magnetic resonance ,law ,natural sciences ,Applied optics. Photonics ,cardiovascular diseases ,Absorption (electromagnetic radiation) ,Imaging and sensing ,QC350-467 ,Velocimetry ,Optics. Light ,Laser ,Fluorescence ,Atomic and Molecular Physics, and Optics ,Photon upconversion ,eye diseases ,Electronic, Optical and Magnetic Materials ,respiratory tract diseases ,TA1501-1820 ,chemistry ,Continuous wave ,Biophotonics ,Indocyanine green - Abstract
Bright anti-Stokes fluorescence (ASF) in the first near-infrared spectral region (NIR-I, 800 nm–900 nm) under the excitation of a 915 nm continuous wave (CW) laser, is observed in Indocyanine Green (ICG), a dye approved by the Food and Drug Administration for clinical use. The dependence of fluorescence intensity on excitation light power and temperature, together with fluorescence lifetime measurement, establish this ASF to be originated from absorption from a thermally excited vibrational level (hot-band absorption), as shown in our experiments, which is stronger than the upconversion fluorescence from widely-used rare-earth ion doped nanoparticles. To test the utility of this ASF NIR-I probe for advanced bioimaging, we successively apply it for biothermal sensing, cerebral blood vessel tomography and blood stream velocimetry. Moreover, in combination with L1057 nanoparticles, which absorb the ASF of ICG and emit beyond 1100 nm, these two probes generate multi-mode images in two fluorescent channels under the excitation of a single 915 nm CW laser. One channel is used to monitor two overlapping organs, urinary system & blood vessel of a live mouse, while the other shows urinary system only. Using in intraoperative real-time monitoring, such multi-mode imaging method can be beneficial for visual guiding in anatomy of the urinary system to avoid any accidental injury to the surrounding blood vessels during surgery., Hot-band absorption based anti-Stokes fluorescence of ICG for evaluating the thermal state of the tumor and multi-organ imaging.
- Published
- 2021