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3. Polypyrrole colloidal nanospheres as an effective fluorescent sensing platform for DNA detection

Author

Lu, Wenbo, Luo, Yonglan, Chang, Guohui, Qin, Xiaoyun, Liao, Fang, and Sun, Xuping

Subjects
*PYRROLES, *COLLOIDS, *NANOPARTICLES, *FLUORESCENCE, *NUCLEIC acid hybridization, *DNA, *DETECTORS
Abstract

Abstract: In the present study, we demonstrate the first use of polypyrrole colloidal nanospheres (PPyCNPs) as an effective sensing platform for fluorescence-enhanced DNA detection by the following two steps: (1) PPyCNP adsorbs and quenches a dye-labeled single-stranded DNA (ssDNA) probe; (2) The subsequent hybridization of the probe with its target produces a double-stranded DNA (dsDNA) which detaches from PPyCNP, leading to recovery of dye fluorescence. The present system shows a detection limit as low as 1nM and has a high selectivity down to single-base mismatch. [Copyright &y& Elsevier]

Published
2011
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