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Aim: To find out the impact of blood pressure (BP) and fluid overload (OH), using bioimpedance spectroscopy (BIS), on the left ventricle (LV) geometry and function in chronic hemodialysis (HD) patients. Methods: In 45 HD patients [female/male: 15/30; age: 60 (57-66) years; duration of HD 3,5 (1-5) years] we performed a one-year retrospective analysis of average monthly OH, measured by BIS before HDand BP (BPs-systolic, BPd- diastolic, MAP - mean arterial pressure, PP -pulse pressure) and their impact on the geometry and LV function. BP and hydration parameters (extracellular fluid - ECW, ICW intracellular fluid, total body water -TBW, ratio of ECW/ICW, ECW/TBW and OH/ECW) were correlated with LV ejection fraction (LVEF), LV mass (LVM), LV mass index (LVMI), left atrium size (LA), interventricular septum (IVS), LV end-diastolic diameter (LVEDD), LV relative wall thickness (LVRWT), posterior wall thickness, maximum speed of the phase of rapid (E) and late (A) filling, ratio E/A, deceleration time (DCT) and isovolumic time (IVRT). Results: Normal LV geometry was found in 11 patients (25%), 5 patients (11%) had concentric remodelling, 25 patients (55%) concentric hypertrophy and 4 (9%) patients eccentric hypertrophy. We confirmed significant correlation between BP and LVEF (BPs: p=0.001; BPd: p=0.002; PP: p=0.0009; MAP: p=0.001), LVEDD (BPs: p=0003; BPd: p=0.005; PP: p=0.0001; MAP: p=0.0005), IVS (BPs: p=0.00002; BPd: p=0.0005; PP: p=0.00001; MAP: p=0.00003), posterior wall thickness (BPs:p=0.0005; BPd:p=0.01; PP:p=0.0002; MAP: p=0.001), but not LVM, LVMI, LA, relative wall thickness or diastolic parameters. Hydratation parameters before hemodialysis were as follows: overhydratation 2.8 (1.7-3.9; median, Q1-Q3) l, interdialytic weight gain 3 (2-4)%, ECW volume 20 (17-22) l, ICW volume 20 (16-23) l. From among all correlations between hydratation and echocardiographic parameters three were significant: ECW and EF (p=0.004), ECW and LVMI (p=0.02), TBW and LVRWT (p=0.01). Conclusions: In this study, the impact of systolic, diastolic and pulse pressure on LV ejection fraction, LV end-diastolic diameter, interventricular septum and LV posterior wall thickness in chronic hemodialysis patients was confirmed. The degree of fluid overload at the end of interdialytic period was very high, enlarged extracellular fluid volume was equal to intracellular fluid volume. Bioimpedance spectroscopy showed the impact of fluid overload in chronic hemodialysis patients on some parameters of left ventricular geometry and function. Fig. 1,Tab. 3, Ref. 13, Online full text (Free, PDF) www.cardiology.sk [ABSTRACT FROM AUTHOR]