Abstract: Understanding the time scales and pathways for response and recovery of rivers and floodplains to episodic changes in erosion and sedimentation has been a long standing issue in fluvial geomorphology. Floodplains are an important component of watershed systems because they affect downstream storage and delivery of overbank flood waters, and they also serve as sources and temporary sinks for sediments and toxic substances delivered by river systems. Here, 14C and 137Cs isotopic dating methods are used along with ages of culturally related phenomena associated with mining and agriculture to determine rates of sedimentation and morphologic change for a reach of the upper Mississippi River and adjacent tributaries in southwestern Wisconsin and northwestern Illinois. The most important environmental change that influenced fluvial activity in this region during last 10,000 years involved the conversion of a late Holocene mosaic of prairie and forest to a landscape dominated by cropland and pastureland associated with Euro-American settlement. Results presented herein for the Upper Mississippi Valley (UMV) show that the shift from pre-agriculture, natural land cover to landscape dominance by agricultural land use of the last 175–200 years typically increased rates and magnitudes of floodplain sedimentation by at least an order of magnitude. Accelerated overbank flooding led to increased bank heights on tributary streams and, in turn, contributed to more frequent deep flows of high energy. These high energy flows subsequently promoted bank erosion and lateral channel migration, and the formation of a historical meander belt whose alluvial surface constitutes a new historical floodplain inset against the earlier historical floodplain. The new historical floodplain serves as a “flume-like” channel that provides efficient downstream transport of water and sediment associated with moderate and large magnitude floods. Floodplains on lower tributaries, however, continue to experience rates of overbank sedimentation that are of anomalously high magnitude given improved land cover and land conservation since about 1950. This lower valley anomaly is explained by minimal development of historical (agriculture period) meander belts because of relatively low stream power in these channel and floodplain reaches of relatively low gradient. In general, long-term pre-agriculture rates of vertical accretion between about 10,000 and 200 years ago averaged about 0.2 mm yr−1 in tributary watersheds smaller than about 700 km2 and about 0.9 mm yr−1 on the floodplain of the upper Mississippi River where the contributing watershed area increases to about 170,000 km2. On the other hand, rates of historical vertical accretion during the period of agricultural dominance of the last 200 years average between 2 and 20 mm yr−1, with short episodes of even higher rates during times of particularly poor land conservation practices. Significant hydrologic effects of mining and agricultural started by the 1820s and became widespread in the study region by the mid-19th century. The hydrologic and geomorphic influences of mining were relatively minor compared to those related to agriculture. High resolution dating of floodplain vertical accretion deposits shows that large floods have frequently provided major increments of sedimentation on floodplains of tributaries and the main valley upper Mississippi River. The relative importance of large floods as contributors to floodplain vertical accretion is noteworthy because global atmospheric circulation models indicate that the main channel upper Mississippi River should experience increased frequencies of extreme hydrologic events, including large floods, with anticipated continued global warming. Instrumental and stratigraphic records show that, coincident with global warming, a shift to more frequent large floods occurred since 1950 on the upper Mississippi River, and these floods generally contributed high magnitudes of floodplain sedimentation. [Copyright &y& Elsevier]