1. I3-naringenin-II8--4'OMe-eriodictyol: a new potential analgesic agent isolated from Rheedia gardneriana leaves.
- Author
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Cechinel Filho V, da Silva KL, de Souza MM, Oliveira AE, Yunes RA, Guimarães CL, Verdi LG, Simionatto EL, and Delle Monache F
- Subjects
- Acetaminophen pharmacology, Acetic Acid, Analgesics isolation & purification, Analgesics pharmacology, Animals, Aspirin pharmacology, Dipyrone pharmacology, Flavanones, Flavonoids isolation & purification, Flavonoids pharmacology, Formaldehyde, Indomethacin pharmacology, Male, Mice, Models, Molecular, Molecular Conformation, Molecular Structure, Pain chemically induced, Pain physiopathology, Plant Leaves, Analgesics chemistry, Biflavonoids, Flavonoids chemistry, Pain drug therapy, Plants, Medicinal chemistry
- Abstract
This paper describes the isolation, identification and analgesic activity of a new biflavonoid from Rheedia gardneriana leaves, which correspond to I3-naringenin-II8-4'-OMe-eriodictyol (GB-2a-II-4'-OMe) (1), with a methoxyl group in position 4 of ring-II. Its structure was determined by spectroscopic data and confirmed by an alkaline hydrolysis. Its analgesic effect was evaluated in a writhing test and a formalin test in mice. It was found that this compound exhibits potent and dose-related analgesic action in both experimental models, with ID50's values of 4.5 micromol/kg against the writhing test and 8.2 and 6.8 micromol/kg against the first and second phase of the formalin test, respectively. It was several times more potent than some well-known analgesic drugs used as reference.
- Published
- 2000
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