1. Evidence for the presence of lipofibroblasts in human lung.
- Author
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Rehan VK, Sugano S, Wang Y, Santos J, Romero S, Dasgupta C, Keane MP, Stahlman MT, and Torday JS
- Subjects
- Actins genetics, Adult, Azo Compounds, Biomarkers, Cells, Cultured, Coloring Agents, Fetus cytology, Homeostasis physiology, Humans, Inclusion Bodies metabolism, PPAR gamma genetics, Parathyroid Hormone-Related Protein genetics, RNA, Messenger, Reverse Transcriptase Polymerase Chain Reaction, Fibroblasts cytology, Fibroblasts metabolism, Pulmonary Alveoli cytology, Triglycerides pharmacokinetics
- Abstract
The lipid-containing alveolar interstitial fibroblast (lipofibroblast) is known to be critically involved in rodent lung development, homeostasis, and injury/repair. However, there is lack of information on their presence and function in the human lung. Based on a number of morphological (lipid staining), molecular (presence of characteristic lipogenic and absence of myogenic markers), and functional (triglyceride uptake) characteristics that are the hallmarks of the rodent lung lipofibroblast, using human lung fibroblasts of embryonic (WI-38) and adult origin and lung tissue from human autopsy specimens, the authors for the first time clearly demonstrate the presence of lipofibroblasts in the human lung.
- Published
- 2006
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