1. Tendonitis in variant hyperimmunoglobulinaemia D and periodic fever syndrome--a rare disease with a new symptom.
- Author
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Armbrust, Sven, Drenth, Joost P. H., Schröder, Carmen, Domning, Ester, Poeschl, Ernestine, Wiersbitzky, Siegfried K. W., and Schröder, Carmen
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TENDINITIS , *FEVER , *SYNDROMES , *CHROMOSOMES , *ARTHRITIS , *ENZYMES - Abstract
Unlabelled: Hyperimmunoglobulinaemia D syndrome (HIDS) is defined as recurrent fever, generalised lymphadenitis, abdominal pain, arthritis and raised polyclonal serum IgD >100 IU/ml. The cause is a mutation in the mevalonate kinase gene. Other periodic fever syndromes are known. We report a new patient and describe orbital tendonitis as a hitherto unreported symptomConclusion: Without any underlying cause, the tendonitis must be seen as new symptom of variant hyperimmunoglobulinaemia D syndrome. We speculate that the inflammation of the Tenon spatium is similar to the process of inflammation of the connective tissue in the joint in hyperimmunoglobulinaemia D syndrome where deposits of C3 and IgM are present. Variant hyperimmunoglobulinaemia D syndrome can be present in one family. [ABSTRACT FROM AUTHOR]- Published
- 2005
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