1. Acute premature constriction of the ductus arteriosus after maternal self-medication with nimesulide.
- Author
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Prefumo F, Marasini M, De Biasio P, and Venturini PL
- Subjects
- Acute Disease, Adult, Constriction, Pathologic chemically induced, Constriction, Pathologic diagnostic imaging, Cyclooxygenase 2 Inhibitors administration & dosage, Ductus Arteriosus diagnostic imaging, Female, Fetal Diseases diagnostic imaging, Heart Diseases diagnostic imaging, Humans, Pregnancy, Self Medication adverse effects, Sulfonamides administration & dosage, Ultrasonography, Prenatal, Cyclooxygenase 2 Inhibitors adverse effects, Ductus Arteriosus drug effects, Fetal Diseases chemically induced, Fetal Diseases diagnosis, Heart Diseases chemically induced, Heart Diseases diagnosis, Sulfonamides adverse effects
- Abstract
Objective: To describe clinical findings in a case of premature ductal constriction associated with maternal use of nimesulide, a cyclo-oxygenase type-2 inhibitor., Methods: Case report., Results: A mother self-administered nimesulide at 39 weeks of gestation due to lower back pain. Less than 24 h later premature ductal constriction was diagnosed by echocardiography following a suspicious fetal heart rate recording with baseline tachycardia and absent accelerations., Conclusion: In a term pregnancy, nimesulide administration can rapidly cause premature ductal constriction. This condition may induce abnormalities in the fetal heart rate trace., (Copyright 2008 S. Karger AG, Basel.)
- Published
- 2008
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