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Your search keyword '"van der Pal, H.J.H."' showing total 2 results
Start Over Author "van der Pal, H.J.H." Topic fertility
2 results on '"van der Pal, H.J.H."'

1. Female reproductive function after treatment of childhood acute lymphoblastic leukemia

Author

van Dulmen-den Broeder E, van den Berg M, van Dijk M, W.J.E. (Wim) Tissing, Dorine Bresters, van den Heuvel-Eibrink M, Catharina C. M. Beerendonk, Cécile M. Ronckers, L. C. M. Kremer, van der Pal, H.J.H., Gertjan J.L. Kaspers, A. Overbeek, van der Heiden-van der Loo M, Roshandel R, Jacqueline J. Loonen, van Leeuwen F, Birgitta Versluys, C.B. Lambalk, Obstetrics and gynaecology, Pediatric surgery, CCA - Cancer Treatment and quality of life, Amsterdam Reproduction & Development (AR&D), and Guided Treatment in Optimal Selected Cancer Patients (GUTS)

Subjects
Adult, Anti-Mullerian Hormone, Pediatrics, medicine.medical_specialty, childhood cancer survivors, pregnancy outcomes, acute lymphoblastic leukemia, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], 03 medical and health sciences, Ovarian function, 0302 clinical medicine, Cancer Survivors, Pregnancy, Medicine, Humans, reproductive function, Child, Childhood Acute Lymphoblastic Leukemia, Retrospective Studies, Menarche, fertility, business.industry, Obstetrics, Hematology, Odds ratio, Total body irradiation, Precursor Cell Lymphoblastic Leukemia-Lymphoma, medicine.disease, Antral follicle, Pediatric cancer, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], pediatric cancer, Reproductive Health, Oncology, 030220 oncology & carcinogenesis, Pediatrics, Perinatology and Child Health, Cohort, Female, Follicle Stimulating Hormone, business, After treatment, 030215 immunology
Abstract

Contains fulltext : 244604.pdf (Publisher’s version ) (Closed access) BACKGROUND: The aim was to evaluate self-reported reproductive characteristics and markers of ovarian function in a nationwide cohort of female survivors of childhood acute lymphoblastic leukemia (ALL), because prior investigations have produced conflicting data. PROCEDURE: Self-reported reproductive characteristics were assessed by questionnaire among 357 adult 5-year survivors, treated between 1964 and 2002, and 836 controls. Ovarian function was assessed by serum levels of anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), and inhibin B and by antral follicle count (AFC). Differences between controls and (subgroups of) survivors (total group, chemotherapy [CT]-only group, CT and radiotherapy [RT] group) were analyzed. RESULTS: Survivors treated with CT only do not differ from controls regarding timing of menarche, virginity status, desire for children, or pregnancy rates. Compared to controls, the CT+RT group was at significantly increased risk of a younger age at menarche (P

Published
2021

2. Reproductive status in adult male long-term survivors of childhood cancer.

Author

Tromp, K., Claessens, J.J.M., Knijnenburg, S.L., van der Pal, H.J.H., van Leeuwen, F.E., Caron, H.N., Beerendonk, C.C.M., and Kremer, L.C.M.

Subjects
CHILDHOOD cancer, CANCER patients, CANCER treatment, HUMAN fertility, FOLLICLE-stimulating hormone, TESTOSTERONE, MULTIVARIATE analysis
Abstract

BACKGROUND This study assessed the long-term effects of cancer therapies on reproductive status in adult male childhood cancer survivors, evaluated the treatment-related risk factors for hypergonadotropic hypogonadism and assessed the association between the FSH levels and the later need for assisted reproductive techniques (ART). METHODS The study cohort included adult male 5-year survivors of childhood cancer who were treated in our institution between 1966 and 2003. Data concerning patient and treatment characteristics, FSH, LH and testosterone levels and pregnancy outcome were collected. Multivariate regression analyses were performed to evaluate the treatment-related risk factors for disturbances in reproductive endocrine status. The diagnostic and predictive values of FSH and later need for ART were evaluated. RESULTS Data on reproductive endocrine status were available for 488 survivors (86.4%) of the 565 male survivors who visited the outpatient clinic in adulthood. The median follow-up time from initiation of treatment to first visit to the outpatient clinic in adulthood was 15 years. The prevalence rates of elevated FSH levels and decreased testosterone levels were 33 and 12%, respectively. The use of procarbazine, cyclophosphamide, vinca-alkaloids, other alkylating agents, pelvic/abdominal irradiation, total body irradiation and testicular surgery were identified as treatment-related risk factors for elevated FSH levels. During the follow-up period, 73 men reported 120 conceptions, which resulted in 103 live births. Of these men, 56 (77%) were able to achieve conception naturally. All men whose partners conceived by assisted reproductive techniques (n = 13) had elevated FSH levels at their first visit after their 18th birthday (sensitivity: 100%; 95% CI: 71–100%) and all male survivors with a normal FSH level did not need assisted reproductive techniques (negative predictive value: 100%; 95% CI: 89–100%). CONCLUSIONS One-third of young adult male survivors of childhood cancer has elevated FSH levels. FSH appears to be a very sensitive marker for the need of assisted reproductive techniques in male childhood cancer survivors. [ABSTRACT FROM PUBLISHER]

Published
2011
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