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Aim: In the present study, we aimed to compare the effects of cetrorelix and leuprolide on endometriosis. Methods: This randomized, placebo-controlled, single-blind, experimental study was performed on 45 Wistar adult female rats in the Experimental Surgery Laboratory at Ondokuz Mayis University. After the peritoneal implantation of endometrial tissue, rats were randomized to three equal intervention groups: (i) control group, (ii) leuprolide group, and (iii) cetrorelix group. Six weeks later, following implant volume measurements (volume-1) by performing a second laparotomy, saline (0.1 cc/rat) was administered subcutaneously to the control group once a week, leuprolide (0.075 mg/kg) subcutaneously to the leuprolide group twice at 4-week intervals and cetrorelix (0.001 mg/rat/day) subcutaneously to the cetrorelix group for 8 weeks. At the end of the treatment, by performing a third laparotomy, implant volumes were remeasured (volume-2) and implants were totally excised for histopathological examination. The volume-1 and volume-2 values within the groups, and stromal and glandular tissue scores between the groups were compared. Results: In both the leuprolide group and the cetrorelix group, volume-2 as compared to volume-1 had significantly reduced ( P < 0.01, P < 0.01 respectively), while there was no significant volume change in the control group ( P > 0.05). In this group, when compared with the control group, glandular and stromal tissues had significantly lessened ( P < 0.01, P < 0.01 respectively). Conclusion: Leuprolide and cetrorelix were found to have similar efficacy in the regression of both the size and the histological structure of experimental endometriotic implants. [ABSTRACT FROM AUTHOR]

Objective: To investigate the efficacy of imiquimod on endometriosis.Design: Randomized, placebo-controlled, single-blind, experimental study.Setting: Experimental surgery laboratory at a university in Turkey.Animal(s): Thirty Wistar female rats.Intervention(s): After the peritoneal implantation of endometrial tissue, rats were randomized to two equal intervention groups: [1] the control group and [2] the imiquimod group. Six weeks later, after implant volume was measured (volume 1) by performing a second laparotomy, imiquimod (10 mg intraperitoneally per rat, 2 times per wk) was administered to the imiquimod group, and saline solution (0.1 mL SC, once per wk), to the control group, for 8 weeks. At the end of the treatment, a third laparotomy was performed to remeasure implant volumes (volume 2), and implants were totally excised for histopathologic examination.Main Outcome Measure(s): To compare volume 1 and volume 2 within the groups, as well as stromal and glandular tissues between the groups.Result(s): In the imiquimod group, volume 2 was statistically significantly reduced compared with volume 1, whereas there was no significant volume change in the control group. In the imiquimod group, when compared with the control group, both glandular and stromal tissues had statistically significantly lessened.Conclusion(s): Imiquimod was seen to regress significantly both the size and the histological structure of endometriotic implants. [ABSTRACT FROM AUTHOR]