1. The correlations between Th1 and Th2 cytokines in human alveolar echinococcosis
- Author
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Wei Wang, Hui-xia Cai, Yu-fang Liu, Xuefei Zhang, Yongshun Wang, Pei-yun Liu, Kemei Shi, Na Liu, Peizhen Zhan, Qing Zhang, Jia Liu, Junying Ma, Jianye Zhou, Xiao Ma, Jing-xiao Zhang, Haining Fan, Wen Lei, Xiongying Zhang, and Cunzhe Zhao
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Alveolar echinococcosis ,Th2 cytokines ,Echinococcus multilocularis ,lcsh:Infectious and parasitic diseases ,03 medical and health sciences ,Medical microbiology ,Th1 cytokines ,Echinococcosis ,Healthy control ,medicine ,Animals ,Humans ,lcsh:RC109-216 ,Th1-Th2 Balance ,biology ,business.industry ,Correlation analysis ,Middle Aged ,030108 mycology & parasitology ,biology.organism_classification ,medicine.disease ,Serum cytokine ,030104 developmental biology ,Infectious Diseases ,Parasitology ,Parasitic disease ,Immunology ,Cytokines ,Female ,business ,Research Article - Abstract
Background Alveolar echinococcosis (AE) is a zoonotic parasitic disease caused by Echinococcus multilocularis larval tapeworm infections in humans that severely impairs the health of affected patients in the northern hemisphere. Methods The expression levels of 20 cytokines associated with AE infection were measured by enzyme-linked immunosorbent assay, and the correlations between these cytokines were analysed in the R programming language. Results Serum cytokine levels differed among individuals in both the AE patient and healthy control groups. The results of the correlations among the cytokines showed obvious differences between the two groups. In the AE patients group, Th1 and Th2 cytokines formed a more complicated network than that in the healthy control group. Conclusions The altered correlations between Th1 and Th2 cytokines may be closely associated with AE infection, which may provide a new explanation for the essential differences between AE patients and healthy individuals.
- Published
- 2020