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Background: Few studies on speech performance of children after cochlear implantation (CI) described isolated large vestibular aqueduct syndrome (LVAS). Objective: To investigate speech developmental trajectories of infants with LVAS after CI, and to compare with those who have structurally normal inner ears. Materials and methods: 1112 infants with congenital severe to profound hearing loss participated in this study. 150 infants in group A were diagnosed with LVAS, 962 infants in group B with structurally normal inner ear. The speech performance was assessed via the Meaningful Use of Speech Scale (MUSS). The evaluations were performed pre-implant, 1, 3, 6, 9, 12, 24, 36, 48 and 60 months after CI. Results: The mean scores of the MUSS improved over a 5-year period after implantation in both groups A and B. The LVAS group presented similar speech developmental trajectory to the non-LVAS group at each assessment interval, except pre-operation. There were significant differences in mean scores between vocalizing behavior and oral communication skills, clarification skills of infants in both two groups. Conclusions and significance: Speech performance of infants with LVAS developed rapidly after CI and was similar to infants with structurally normal inner ear. For infants with isolated LVAS, CI had a significant effect and should be recommended as a therapeutic option.

Objective The purpose of this study was to investigate the development of speech skills in young children with Mondini dysplasia and age-matched deaf children with radiologically normal inner ears over a period of 5 years after cochlear implantation (CI). Methods In total, 700 congenitally severely to profoundly deaf children (281 girls and 419 boys) participated in this study. All of the participants had undergone unilateral CI surgery before 36 months of age. The participants were categorized into two groups based on the absence or presence of Mondini dysplasia in the implanted ear, as assessed via high-resolution, thin-slice computerized tomography or magnetic resonance imaging: group A comprised 592 children with radiologically normal inner ears and group B comprised 108 children with Mondini dysplasia. The Meaningful Use of Speech Scale (MUSS) and Speech Intelligibility Rating (SIR) were used to evaluate the speech performance of all young children at various time points: pre-surgery and at 1, 3, 6, 12, 24, 36, 48, and 60 months after switch-on programming. Results The mean scores of SIR and MUSS in children from both group A and group B showed significant improvements over time. No significant differences were found in the mean scores of SIR between the two groups at any time interval during the 5-year follow-up. The mean score of MUSS was significantly different between group A and group B at 12, 24, and 36 months after implantation, whereas no obvious differences were noted pre-surgery, and at 1, 3, 6, 48, and 60 months post-operation. Conclusions Young children with Mondini dysplasia develop their speech skills at a fast rate and achieve similar speech acquisition compared to age-matched children with radiologically normal inner ears 5 years post-operation. Therefore, CI is an effective intervention method for young children with Mondini dysplasia.

Background: It is beneficial for CI patients listen to music. However it is necessary to take steps to improve the musicality of CI patients.Objectives: The aims of the study were to evaluate the p...

Oncolytic viruses are emerging as important tools for immunotherapy for cancer treatment; however, most of the clinically tested oncolytic candidates are still administered by intratumoral injection, and new viruses capable of intravenous injection are urgently needed. The M1 virus is a positive-sense single-stranded RNA virus that belongs to the alphavirus family, and it was identified as an oncolytic virus that can selectively replicate in and kill tumor cells after intravenous injection. To further develop M1 for clinical research through intravenous injection, we systematically investigated the biodistribution characteristics of the M1 virus in normal rats, cynomolgus monkeys, and tumor-bearing immunocompromised mice. The data showed that the M1 virus was eliminated gradually from normal tissue but replicated and increased rapidly in tumor tissue. More importantly, the virus also infiltrated the blood-brain barrier and specifically replicated in and killed malignant glioma in immunocompetent mice. Our data proved the tumor selectivity and safety of the M1 virus, supporting its further clinical development.

Objective: The purpose of the present study was to examine the effects of NLFC fitting in hearing aids and auditory acclimatisation on speech perception and sound-quality rating in hearing-impaired...

The main purpose of the current study was to assess the development of auditory and speech perception and the effects of the age at implantation in CI children after long-period follow up.Five hundred and forty-four young children participated in this study (339 males and 205 females). The age at implantation ranged from 6 months to 36 months. All subjects were prelingually bilateral profound sensorineural hearing loss. They were divided into 3 groups according to the implant ages: group 1 (age at implantation 12 months, n = 109); group 2 (12 months age at implantation 24 months, n = 284); and group 3 (24 months age at implantation 36 months, n = 151). The categorical auditory performance (CAP) was used to assess auditory abilities and the speech intelligibility rating (SIR) was used to assess the speech intelligibility of these CI children. The tests were administered at pre-surgery and 1, 3, 6, 12, 24, 36, 48- and 60-months post-surgery.All the subjects demonstrated improvements of auditory abilities and speech intelligibility after CI surgery. The auditory ability developed quickly in 12 months after implantation. However, the speech intelligibility scores show rapid improvement within 24 months post implantation. Significant difference was found between group 1 and group 3, group 2 and group 3 before 12 months post-implantation for CAP and SIR. The three groups of children showed similar development pattern for their auditory abilities and speech intelligibility.The results of this study suggested dramatic and continuous improvement of the auditory and speech abilities post implantation in these CI children. Furthermore, the age at implantation played a considerably smaller role in the improvement of hearing and speech abilities. However, earlier implantation still benefits the language development.

The present study examined the change in spectral properties of Mandarin vowels and fricatives caused by nonlinear frequency compression (NLFC) used in hearing instruments and how these changes affect the perception of speech sounds in normal-hearing listeners. Speech materials, including a list of Mandarin monosyllables in the form of /dV/ (12 vowels) and /Ca/ (five fricatives), were recorded from 20 normal-hearing, native Mandarin-speaking adults (ten males and ten females). NLFC was based on Phonak SoundRecover algorithms. The speech materials were processed with six different NLFC parameter settings. Detailed acoustic analysis revealed that the high front vowel /i/ and certain compound vowels containing /i/ demonstrated positional deviation in certain processed conditions in comparison to the unprocessed condition. All five fricatives showed acoustic changes in spectral features in all processed conditions. Fourteen Mandarin-speaking, normal-hearing adult listeners performed phoneme recognition with the six NLFC processing conditions. When the cut-off frequency was set relatively low, recognition of /s/ was detrimentally affected, whereas none of the NLFC processing configurations affected the other phonemes. The discrepancy between the considerable acoustic changes and the negligible adverse effects on perceptual outcomes is partially accounted for by the phonology system and phonotactic constraints in Mandarin.

Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide, and precision therapeutic will be a benefit for the NAFLD regression. In this study, we observed low microRNA 146 b (miR-146 b) expression in NAFLD mice model induced by methionine–choline-deficient diet (MCD) compared with control group. Furthermore, miR-146b−/− mice induced MCD exhibited severe liver steatosis and hepatitis. A bio-distribution study showed that novel Lactosylated PDMAEMA nanoparticles effectively targeted hepatocytes Lac-PDMAEMA. We coupled miR-146b mimic with Lac-PDMAEMA and then were administrated to NAFLD mice model, which could obviously alleviate the hepatic steatosis. Lac-PDMAEMA effectively delivered miR-146b mimic to hepatocytes with a ∼8-fold upregulation of miR-146b mimic targeting MyD88 and IRAK1, and in turn suppressed the expression of PPARγ. Meanwhile, TNF-α and IL-6 mRNA levels were decreased after administration of Lac-PDMAEMA/miR-146b mimic. So, we made a conclusion that targeted delivering miR-146b mimic to the hepatocytes by, coupling Lac-PDMAEMA nanoparticles could effectively alleviate the hepatic steatosis in NAFLD mice, which maybe bring a new and effective way to intervene and therapy the NAFLD.

Objectives The primary purpose of this study was to investigate the longitudinal speech performance over 3 years in pediatric users of the Nurotron ® cochlear implant system. The secondary purpose was to compare the speech performances of younger and older children with cochlear implants (CIs). Methods The Mandarin Early Speech Perception (MESP), Meaningful Use of Speech Scale (MUSS), and Putonghua Chinese Communicative Development Inventory (PCDI) were used to evaluate speech performance of 22 Mandarin-speaking pediatric CI users throughout the first 36 months post-implantation. The subjects were grouped according to the age at implantation, i.e., younger CI group ( 3 years). Results All the subjects demonstrated improvement in speech performance throughout the first 3 years of implant use with mean scores reaching the maximum performance at 36 months post-implantation. The median categories of MESP increased from 0.23 pre-implantation to 5.57 three years post-implantation. Likewise, the median percentage of MUSS was 5.57% to 73.75%; the median performance of PCDI was 55 to 400 for PCDI-comprehension and 32 to 384 for PCDI-production at the same interval. At nearly all test intervals, the older group performed better than the younger group except 24 months post-implantation, at which the MUSS score of the younger CI group was higher than that of the older CI group. Conclusion The children with Nurotron ® Venus™ CI system showed considerable gains in speech and language development including tone performance which improved with hearing age. Earlier implantations haven’t presented significantly positive performances until 24 months post-implantation in all the tests.

OBJECTIVE The aim was to evaluate the development of music and lexical tone perception in Mandarin-speaking adult cochlear implant (CI) users over a period of 1 year. STUDY DESIGN Prospective patient series. SETTING Tertiary hospital and research institute. PATIENTS Twenty five adult CI users, with ages ranging from 19 to 75 years old, participated in a year-long follow-up evaluation. There were also 40 normal hearing adult subjects who participated as a control group to provide the normal value range. INTERVENTIONS Musical sounds in cochlear implants (Mu.S.I.C.) test battery was undertaken to evaluate music perception ability. Mandarin Tone Identification in Noise Test (M-TINT) was used to assess lexical tone recognition. The tests for CI users were completed at 1, 3, 6, and 12 months after the CI switch-on. MAIN OUTCOMES MEASURES Quantitative and statistical analysis of their results from music and tone perception tests. RESULTS The performance of music perception and tone recognition both demonstrated an overall improvement in outcomes during the entire 1-year follow-up process. The increasing trends were obvious in the early period especially in the first 6 months after switch-on. There was a significant improvement in the melody discrimination (p

Cathepsin C is an important exopeptidase of papain superfamily and plays a number of great important roles during the parasitic life cycle. The amino acid sequence of cathepsin C from Clonorchis sinensis (C. sinensis) showed 54, 53, and 49 % identities to that of Schistosoma japonicum, Schistosoma mansoni, and Homo sapiens, respectively. Phylogenetic analysis utilizing the sequences of papain superfamily of C. sinensis demonstrated that cathepsin C and cathepsin Bs came from a common ancestry. Cathepsin C of C. sinensis (Cscathepsin C) was identified as an excretory/secretory product by Western blot analysis. The results of transcriptional level and translational level of Cscathepsin C at metacercaria stage were higher than that at adult worms. Immunolocalization analysis indicated that Cscathepsin C was specifically distributed in the suckers (oral sucker and ventral sucker), eggs, vitellarium, intestines, and testis of adult worms. In the metacercaria, it was mainly detected on the cyst wall and excretory bladder. Combining with the results mentioned above, it implies that Cscathepsin C may be an essential proteolytic enzyme for proteins digestion of hosts, nutrition assimilation, and immune invasion of C. sinensis. Furthermore, it may be a potential diagnostic antigen and drug target against C. sinensis infection.

Recently, accumulating evidences indicate that nitric oxide (NO) is a potent mediator with diverse roles in regulating cellular functions, signaling pathways, and variety of pathological processes. In the present study, using data from the published genomic for Clonorchis sinensis (C. sinensis), we investigated a gene encoding nitric oxide synthase-interacting protein (NOSIP) of C. sinensis. Recombinant CsNOSIP (rCsNOSIP) was expressed and purified from Escherichia coli BL21. The open reading frame of CsNOSIP comprises 867 bp which encodes 289 amino acids and shares 72.9, 45.2, 47, 46.4, and 45.8 % identity with NOSIP from Schistosoma mansoni, Xenopus laevis, Rattus norvegicus, Mus musculus, and Homo sapiens, respectively. Bioinformatics analysis suggested that the full-length sequence contains an eNOS-interacting domain and numerous B-cell epitopes. Quantitative RT-PCR indicated that CsNOSIP differentially transcribed throughout the adult worms, metacercariae, and egg stages of C. sinensis, and were highly expressed in the adult worms. Moreover, western blot analysis showed that the rCsNOSIP could be detected by the serum from BALB/c mice infected with C. sinensis and the serum from BALB/c mice immunized with excretory/secretory products (ESPs). Furthermore, immunolocalization assay showed that CsNOSIP was specifically localized in the intestine, vitellarium, and eggs of adult worm. Both immunoblot and immunolocalization results demonstrated that CsNOSIP was one component of ESPs of C. sinensis, which could be supported by SignalP analysis. Moreover, analysis of the antibody subclass and cytokine profile demonstrated that subcutaneously immunized BALB/c mice with rCsNOSIP could significantly enhance serum IgG1 level and up-regulate expression of IL-4 and IL-6 in the splenocytes. Our results suggested that CsNOSIP was an important antigen exposed to host immune system and probably involved in immune regulation of host by inducing Th2-polarized immune response.

This study indicates that Mandarin-speaking subjects acquire significant benefit from a cochlear implant (CI) and audio processor with the fine structure processing (FSP) coding strategy. It can take adult Mandarin CI users time to become accustomed to their CI and appreciate the benefits.This study aimed to determine speech perception outcomes in Mandarin-speaking adults who received the FSP coding strategy.This was a prospective study. Ten adults who were implanted unilaterally with a PULSARCI(100), and received an OPUS 1 or OPUS 2 speech processor, were included in this study. The mean age at implantation was 31.1 years. We determined the benefit to postlingually deafened Mandarin-speaking adults with a severe to profound hearing loss using the tests: monosyllables in quiet, sentences in quiet and the Mandarin Hearing in Noise Test (MHINT). Tone perception was evaluated using a tone perception test. A visual analog scale (VAS) was used to score sound quality and ease of listening.The results showed a significant improvement between first fitting and 6 months in all speech tests and in tone perception. The VAS scores showed a significant improvement over 6 months in sound quality and an immediate benefit in ease of listening.

We conducted a case-control study to assess the association between single nucleotide polymorphisms in the ERCC5 promoter (rs2094258 and rs751402) and development of gastric cancer in a Chinese population. This investigation included 184 patients with pathologically diagnosed gastric cancer and 206 healthy subjects recruited between October 2012 and December 2014. The genotyping of ERCC5 rs2094258 and rs751402 variants was performed by polymerase chain reaction coupled with restriction fragment length polymorphism. Genotype distributions of these polymorphisms conformed to Hardy-Weinberg equilibrium in both patient (P = 0.25 for rs2094258 and P = 0.61 for rs751402) and control groups (P = 0.48 for rs2094258 and P = 0.42 for rs751402). Using unconditional logistic regression analysis, we found that neither of these ERCC5 variants was associated with increased risk of gastric cancer under co-dominant, dominant, or recessive models (P < 0.05). In conclusion, we suggest that the rs2094258 and rs751402 polymorphisms are not connected to the development of this disease under codominant, dominant, and recessive models.

The investigated experimental coding strategies significantly improved tone identification as compared with the participants' everyday audio processor settings. However, this benefit could not be attributed entirely to temporal fine structure stimulation but seems to be caused by decreasing the lower corner frequency of the filter bank. The 6 week habituation period used in this study might have been too short to allow the listeners to derive additional lexical information from the unfamiliar stimulation patterns.To evaluate a cochlear implant coding strategy that explicitly conveys temporal fine structure information in the context of the tonal language Mandarin.The study was designed as a longitudinal, monocentric, prospective, controlled, and randomized cross-over study and included 12 postlingually deafened adults, who were experienced cochlear implant users. Two experimental coding strategies, one of which explicitly presents temporal fine structure information, were compared to the participants' personal TEMPO+ speech processors, which do not convey fine structure information.Both experimental coding strategies improved tone identification by approximately 11 percentage points. This improvement was significant in the female speaker test. Sentence perception, as assessed with the M-HINT test, and quality of life scores were identical with all three coding strategies.

As the hearing loss becomes more severe, the tone recognition performance of hearing-impaired listeners gradually but slowly reduces. The tone recognition performance of cochlear implant listeners is below or close to the performance of severely hearing-impaired listeners.The present study aimed to investigate the Mandarin lexical tone recognition performance of sensorineural hearing-impaired listeners and post-lingually deafened cochlear implant users.Tone recognition performance was measured for 30 normal-hearing subjects, 41sensorineural hearing-impaired listeners, and 12 cochlear implant users using 128 monosyllables recorded by a male and a female adult native Mandarin speaker.The results indicated that the accuracy of tone recognition was 99.3%, 96.4%, 93.7%, 83.9%, and 81.0% for the normal-hearing, moderate, moderate to severe, severely hearing-impaired, and cochlear implant subjects, respectively. For the hearing-impaired subjects, a significantly negative correlation was observed between tone recognition performance and the audiometric hearing thresholds. For cochlear implant subjects, Tone 3 was the easiest one to perceive and Tone 2 was the hardest one to perceive. They tended to misperceive Tone 1 as Tone 2, and misperceive Tone 2 as Tones 1 and 3.

Objective The purpose of the current study was to evaluate the relationship between the presence or absence of cortical auditory evoked potentials (CAEPs) to speech stimuli and the performance of speech perception in Chinese pediatric recipients of the Nurotron® cochlear implant (CI).We also wanted to determine how the CAEPs might be used as an indicator for predicting early speech perception and could provide objective evidence for clinical applications of CAEPs. Methods 23 pediatric unilateral CI recipients participated in this study. 15 males 8 females, and their ages at implantation ranged from 13 to 68 months, with a mean age of 36 months. CAEPs and Mandarin Early Speech Perception (MESP) tests were used to evaluate the audibility and speech perception of these CI users. The tests were administered at the first, second, third, and fourth year after the CI surgery. Results All the subjects demonstrated improvements in detection of speech sounds with CI. The percentages of participants who could detect all three stimuli were 26% (6/23) at first year, to 100% (23/23) at the fourth year post-implantation. The percentages of participants who passed the Category 6 of MESP were from 9% (2/23) at first year, to 91% (21/23) at the fourth year post-implantation. Significant correlations (p

The aim of this study was to develop comprehensive test material for Mandarin tone identification in noise for a male and a female talker. Additionally, the sensitivity index d' as a measure for the listeners' performance to identify individual tones was evaluated.The study followed a prospective design.The complete material comprises 72 loudness-balanced syllables in all 4 Mandarin tones. For a selection of 20 syllables, i.e. 80 test words, performance-versus-intensity functions were measured in spectrally matched noise for 16 normal-hearing participants.The average speech reception thresholds in noise were -12.9 dB for the male and -13.6 dB for the female talker recordings. The corresponding slopes were 8.6%/dB and 7.3%/dB. As a performance measure for individual tones, the proportion of correct responses to specific tones was substantially contaminated by response bias. The sensitivity index d', calculated according to detection theory, provided reasonable and unbiased performance versus intensity functions.The results firstly indicate that the material is homogenous enough for use as a speech test in clinical work and research. Secondly, to assess the discrimination performance for individual tones, d' values outperform the simple proportion of correct responses.

Objectives: Lexical tone recognition tends to be poor in cochlear implant users. The HiResolution (HiRes) sound-processing strategy is designed to better preserve temporal fine structure, or the detailed envelope information, of an acoustic signal. The newer HiRes 120 strategy builds on HiRes by increasing the amount of potential spectral information delivered to the implant user. The purpose of this study was to examine lexical tone recognition in native Mandarin Chinese-speaking children with cochlear implants using the HiRes and HiRes 120 sound-processing strategies. Tone recognition performance was tested with HiRes at baseline and then after up to 6 mo of HiRes 120 experience in the same subjects. Design: Twenty prelingually deafened, native Mandarin-speaking children, with ages ranging from 3.5 to 16.5 yr, participated. All children completed a computerized tone contrast test on three occasions: (1) using HiRes immediately before conversion to HiRes 120 (baseline), (2) 1 mo after conversion, and (3) 3 mo after conversion. Twelve of the 20 children also were tested 6 mo after conversion. In addition, the parents of 18 children completed a questionnaire at the 3-mo follow-up visit regarding the preference of sound-processing strategies and the children’s experience related to various aspects of auditory perception and speech production using HiRes 120. Results: As a group, no statistically significant differences were seen between the tone recognition scores using HiRes and HiRes 120. Individual scores showed great variability. Tone recognition performance ranged from chance (50% correct) to nearly perfect. Using the conventional HiRes strategy, 6 of the 20 children achieved high-level tone recognition performance (i.e., 90% correct), whereas 7 performed at a level not significantly different from chance (50–60% correct). At the final test, either 3 or 6 mo after conversion, all children achieved tone recognition performance with HiRes 120 that was equal to or better than that with HiRes, although some children’s tone recognition performance was worse initially at the 1 or 3 mo follow-up intervals than at baseline. Eight of the 20 children showed statistically significant improvement in tone recognition performance with HiRes 120 on at least one of the follow-up tests. Age at implantation was correlated with tone recognition performance at all four test intervals. Parents of most of the children indicated that the children preferred HiRes 120 more than HiRes. Conclusions: As a group, HiRes 120 did not provide significantly improved lexical tone recognition compared to HiRes, at least throughout the length of the study (up to 6 mo). There were large individual differences in lexical tone recognition among the prelingually deafened, native Mandarin-speaking children with cochlear implants using either HiRes or HiRes 120. Six of the 20 children performed at or near ceiling in the baseline HiRes condition. Of the remainder, approximately half showed significantly better tone recognition when subsequently tested with HiRes 120, although the extent to which this improvement may be attributable to factors other than the change in processing strategy (e.g., general development) is unknown. The children who benefited most from HiRes 120 tended to be those who were implanted at younger ages.

Application of the Vibrant Soundbridge to the round window (RW) membrane can be utilized as an efficient therapy for congenital oval window (OW) atresia.To report the surgical technique and auditory outcome of an active middle ear implant (AMEI) system used in patients with congenital OW atresia.Nine subjects with congenital OW atresia (six males and three females, ranging in age from 5.5 to 25 years, average 12.5 years) were implanted with an AMEI (Vibrant Soundbridge) at the round window (RW-Vibroplasty). Five cases were diagnosed as having isolated congenital OW atresia while four patients presented with combined external/middle ear malformation.An improvement of 30 dB in average pure-tone air conduction thresholds (0.5-4 kHz) was achieved, with the high frequencies showing greater results. The subjects achieved postoperative speech recognition scores of 80-100% on the Computerized Mandarin Speech Test System (CMSTS) sentence test. Bone conduction thresholds were confirmed as stable in all subjects postoperatively. Decline in auditory benefit was noticed in two subjects, who then underwent revision surgery. One of these revision surgery patients then experienced stable hearing recovery, while the other patient's hearing declined.

The aim of this study was to develop comprehensive test material for Mandarin tone identification in noise (M-TINT) based on the linguistic characteristics in Chinese.In keeping with both the reliability and efficiency in clinical practice, a primary list consisted of 320 words(80 syllables in four tones each) was designed according to the following principles: shortness of the lists, word familiarity and with a meaning in all four tones. The digital sound file was recorded by a male speaker and a female speaker (both of them are radio broadcaster).The tonal identification material database, which included 288 items (72 loudness-balanced syllables in all 4 Mandarin tones) was established by digital filler and balanced for equal loudness. The complete material was recorded in two CDs in a male version and a female version. The speaker-specific masking noises were generated by filtering Gaussian white noise to the speaker's long-term average speech spectrum (LTASS) and by scaling the masking noises to the same RMS amplitudes, as those of the speech, in order to acquire the effective sound masking. The speaker-specific masking noises could be able or disable during the word presentation. The sound pressure level could be selected concerning on the test setting.The mandarin tonal identification materials were designed by both the tonal acoustic properties and the psychophysics characteristic of adults. It is an useful speech test in clinical work and research, and can potentially be used as the basic list for other tonal language identification test in the future.

The purpose of this study is to analyze the development of musicality in children after cochlear implantation, and provide a clinical database for the evaluation of their musicality.Twenty-six children with cochlear implants (CI group) participated in this research. They received cochlear implants at the age of 11 to 68 months with a mean of 35.6 months. Seventy-six infants as a control group aged from 1 to 24 months with a mean of 6.1 months participated in this study, whose hearing were considered normal by passing the case history collection, high-risk registers for hearing loss and hearing screening using DPOAE. The music and young children with CIs: Musicality Rating Scale was used to evaluate their musicality. The evaluation was performed before cochlear implantation and 1, 3, 6, 9, 12, 24 months after cochlear implantation for children with cochlear implants. The evaluation was also performed at 1, 3, 6, 9, 12, 24 months for children with normal hearing.The mean scores of musicality showed significant improvements with time of CI use for CI group (P0.05). The mean scores of musicality also showed significant improvements with time for control group (P0.05). There were no significant differences in mean scores between CI group and control group at 1, 3, 6, 9, 12 months of hearing age by rank sum test (P0.05). Significant difference was noted between the two groups at 24 months (P0.05).The musicality of children with cochlear implants improved significantly with time after cochlear implantation. The most rapid growth was found in the first year after cochlear implantation.

To provide a clinical reference by comparing the conventional 226 Hz tympanometry with 1000 Hz tympanometry in two groups of young children with otitis media effusion evidenced by CT scan.One hundred and seventy-seven young children (226 ears), from 1 to 60 months, with otitis media effusion were involved in this study. They were divided into six groups by age: 0-6 months group, 6-12 months group, 12-18 months group, 18-24 months group, 24-36 months group, 36-60 months group. They were tested with tympanometry of 2 probe-tones of 226 and 1 000 Hz. Type A tympanogram was defined as a normal middle ear function in 226 Hz and single-or double-peak in 1 000 Hz tympanometry. One hundred and fifty-eight normal young children (266 ears) were selected as control group. The results were analysed with Chi square test. Receiver operator characteristic (ROC) analysis was performed to evaluate the two methods.In the young children with otitis media effusion, the detection rate of 226 Hz tympanogram in six groups was 21.1%, 35.2%, 46.9%, 42%, 62.5% and 68% respectively, while 94.7%, 98.1%, 96.9%, 91.2%, 95.8% and 88% respectively in 1 000 Hz tympanogram. In the young children with normal middle ear function, the detection rate of 226 Hz tympanogram in six groups was 95.1%, 88.6%, 85.1%, 93.3%, 88.5% and 93.5%, while 87.8%, 94.3%, 89.4%, 95.6%, 94.2% and 97.8% respectively in 1 000 Hz tympanogram. The detection rate was significantly different between 226 and 1 000 Hz tympanogram in the young children under 36-month old.A single-or double-peak 1000 Hz tympanometric patterns as normal criteria was a simple way to evaluate young children s' middle ear function. 1 000 Hz tympanometry should be given priority to the children within 36-month old in detection middle ear function,the 226 and 1 000 Hz tympanometry should be done at the same time within 36-60 months old.

To assess the contribution of the temporal fine structure cues on speech recognition, especially tone perception of cochlear implant users whose native language is Mandarin Chinese.Twelve Mandarin speaking users of the MED-EL COMBI 40+ cochlear implants with the standard COMBI 40+ electrode array participated in the study. The subjects were followed up and studied using the longitudinal method for six weeks to compare the difference in speech identification results between fine structure processing (FSP) and continuous interleaved sampler (CIS). The test battery comprised two objective speech tests, including tone identification in quiet as well as a sentence recognition task in quiet and noise.The scores of acute speech test: after replacing FSP strategy, the acute tone test results were similar to that of daily used CIS strategy(male version t = 0.791, P = 0.446;female version t = 0.679, P = 0.511), but the scores of MHINT were decreased significantly (t = -4.365, P = 0.001). The scores of long-lasting speech test were as follows the scores of tone identification test were sharply increased after subjects used the new coding strategy for six weeks continuously(male version t = 3.023, P = 0.018;female version t = 3.883, P = 0.003) and the MHIN results were similar to that of daily used CIS strategy(t = 1.475, P = 0.173).The extraction of temporal fine structure cues supplemented in speech processing strategy of cochlear implant benefits the improvements in tone perception and the understanding of speech in cochlear implant recipients, which can further promotes their quality of life.

To investigate the lexical tone perception and quality of life of Nurotron cochlear implant users.Forty-nine adult cochlear implant users participated in this study. Mandarin tone identification test developed by Beijing Institute of Otolaryngology was used to evaluate the tone perception. Nijmegen cochlear im plantation questionnaire (NCIQ) was administered to quantify the quality of life.(1) The average scores of tone perception in quiet was 67.26%. The tone perception rates under quiet condition for all cochlear implant recipients were higher than the opportunity level. (2) The average scores of tone perception under noisy condition was 51.92%. Exc ept for two recipients, the tone perception rates under noise condition for the rest recipients were better than chance. (3) The confusion patterns of tone recognition showed that Tone 3 was the easiest tone to perceive. (4) The postimplant scores for the total , basic sound perception, advanced sound perception, speech pro duction, self-esteem, activity and social interactions of NCIQ were 55.4, 72.4, 54.0, 63.4, 50.7, 47.3 and 44.7, respectively.The Nurotron cochlear implant users had the ability for lexical tone perception and had an improvement in quality of life after cochlear implantation.

The aim of this study is to evaluate the development of auditory performance and speech intelligibility within the first year after hearing aid fitting in children with moderate or severe hearing loss, investigate the effects of hearing level on auditory performance and speech intelligibility and provide a clinical database for their hearing and speech habilitation.Twenty-nine children participated in this study, ranging in age at hearing aid fitting from 3 to 8 years old with a mean of 5. 6 years old. 19 were boys and 10 were girls. According to their hearing level, they were divided into two groups. 14 children were in group of moderate hearing loss (41-60 dB HL). 15 children were in group of severe hearing loss (61-80 dB HL). The categories of auditory performance (CAP) and speech intelligibility rating (SIR) were used to evaluate their auditory performance and speech intelligibility. The evaluation was performed before hearing aid fitting and 1, 3, 6, 9, 12 months after fitting.There was significant difference in mean score of CAP between group of moderate hearing loss and severe hearing loss before hearing aid fitting (P0.05). However, no significant differences were observed between these two groups at 1, 3, 6, 9, 12 months after fitting (P0.05). There was also significant difference in mean score of SIR between group of moderate hearing loss and severe hearing loss before hearing aid fitting (P0.05). How ever, no significant differences were also observed between these two groups at 1, 3, 6, 9, 12 months after fitting (P0.05). The mean scores of CAP for group of moderate hearing loss at 6, 9, 12 months after fitting were significantly superior in comparison with the score before hearing aid fitting (P0.05). The mean scores of SIR for group of moderate hearing loss at 6, 9, 12 months after fitting were significantly superior in comparison with the score before hearing aid fitting (P0.05); the mean score at 12 months after fitting was also significantly superior in comparison with the score at 1 month after fitting (P0.05). The mean scores of CAP for group of severe hearing loss at 3, 6, 9, 12 months after fitting were significantly superior in comparison with the score before hearing aid fitting (P0.05); the mean scores at 9,12 months after fitting were significantly superior in comparison with the score at 1 month after fitting (P0.05). The mean scores of SIR for group of severe hearing loss at 3, 6, 9, 12 months after fitting were significantly superior in comparison with the score before hearing aid fitting (P0.05); the mean scores at 6, 9, 12 months after fitting were also significantly superior in comparison with the score at 1 month after fitting (P0.05).Auditory performance and speech intelligibility in children with moderate or severe hearing loss improved significantly within the first year after hearing aid fitting. The development followed different trajectory.

To investigate the law of auditory remodeling by studying the Cortical Auditory Evoked Potential in a group of post-lingually deaf adults in the early stage of the cochlear implant use.Ten post-lingually deaf adults implanted with PULSAR ci 100 of Medel device ranged from 19 to 52 years old with duration of deafness from 3 months to 23 years.were involved. Their P1-N1-P2 responses to /ba/ at around 60-70 dB SPi and open-set speech recognition scores of mono-syllabic words were recorded at 1. 3 and 6 months after the switch-on of cochlear implants.Six out of 10 typical waveforms of Pl-N1-P2 were obtained. The other I were with atypical waveforms. The group with atypical waveform was characterized by long duration and early onset of deafness. There was no significant difference regarding either the amplitude or the latency of each peak at the 3 data collection time points. There was significant difference among the 3 data collection time points about the speech recognition scores with the highest score at the 6th month of switch on. There was no significant correlation between the peak of the CAEP and speech recognition score.In the first 6 months of cochlear implant use in the post-lingually deaf adults, the duration and the onset age of deafness played important role in respect of the presence and waveform morphology of the CAEPs. It needs at least 6 months for the central auditory system to make use of the audio input from the cochlear implant.

Recently a huge amount of fluoride in coal has been released into indoor environments by the combustion of coal and fluoride pollution seems to be increasing in some rural areas in China. Combustion of coal and coal bricks is the primary source of gaseous and aerosol fluoride and these forms of fluoride can easily enter exposed food products and the human respiratory tract. Major human fluoride exposure was caused by consumption of fluoride contaminated food, such as corn, chilies and potatoes. For each diagnostic syndrome of dental fluorosis, a log-normal distribution was observed on the logarithm of urinary fluoride concentration in students in China. Urinary fluoride content was found to be a primary health indicator of the prevalence of dental fluorosis in the community. In the fluorosis areas, osteosclerosis in skeletal fluorosis patients was observed with a high prevalence. A biochemical marker of bone resorption, urinary deoxypyridinoline content was much higher in residents in China than in residents in Japan. It was suggested that bone resorption was stimulated to a greater extent in residents in China and fluoride may stimulate both bone resorption and bone formation. Renal function especially glomerular filtration rate was very sensitive to fluoride exposure. Inorganic phosphate concentrations in urine were significantly lower in the residents in fluorosis areas in China than in non-fluorosis area in China and Japan. Since airborne fluoride from the combustion of coal pollutes extensively both the living environment and food, it is necessary to reduce fluoride pollution caused by coal burning.

Objective To evaluate the auditory and speech abilities in children with auditory neuropathy spectrum disorder (ANSD) after cochlear implantation (CI) and determine the role of age at implantation. Methods Ten children participated in this retrospective case series study. All children had evidence of ANSD. All subjects had no cochlear nerve deficiency on magnetic resonance imaging and had used the cochlear implants for a period of 12–84 months. We divided our children into two groups: children who underwent implantation before 24 months of age and children who underwent implantation after 24 months of age. Their auditory and speech abilities were evaluated using the following: behavioral audiometry, the Categories of Auditory Performance (CAP), the Meaningful Auditory Integration Scale (MAIS), the Infant-Toddler Meaningful Auditory Integration Scale (IT-MAIS), the Standard-Chinese version of the Monosyllabic Lexical Neighborhood Test (LNT), the Multisyllabic Lexical Neighborhood Test (MLNT), the Speech Intelligibility Rating (SIR) and the Meaningful Use of Speech Scale (MUSS). Results All children showed progress in their auditory and language abilities. The 4-frequency average hearing level (HL) (500 Hz, 1000 Hz, 2000 Hz and 4000 Hz) of aided hearing thresholds ranged from 17.5 to 57.5 dB HL. All children developed time-related auditory perception and speech skills. Scores of children with ANSD who received cochlear implants before 24 months tended to be better than those of children who received cochlear implants after 24 months. Seven children completed the Mandarin Lexical Neighborhood Test. Approximately half of the children showed improved open-set speech recognition. Conclusion Cochlear implantation is helpful for children with ANSD and may be a good optional treatment for many ANSD children. In addition, children with ANSD fitted with cochlear implants before 24 months tended to acquire auditory and speech skills better than children fitted with cochlear implants after 24 months.

To establish music reference values for normal-hearing (NH) person in China, in order to give convenience in clinical application.The NH participant group included 39 subjects, of which 21 females and 18 males. Musical Sounds in Cochlear Implants test battery was used to assess the music perception ability for normal-hearing participants.The median pitch difference NH participants could discriminate for string was 2.5 semitones and 0.5 for flute. The average scores of rhythm discrimination, melody discrimination, chord discrimination, instrument identification and instrument number detection test were 86.1% (SD = 11.2), 76.5% (SD = 11.1), 75.6% (SD = 11.4), 89.9% (SD = 13.0) and 74.1% (SD = 20.7), respectively.The MuSIC test could be a test for music perception ability for China users and in further study the material that more suited for our culture should be added into it.

The purpose of this study is to investigate the effects of hearing level on auditory performance in infants with hearing aids and provide a clinical database for their hearing and speech habilitation.A total of 32 infants with prelingual hearing loss participated in this study, ranging in age at hearing aid fitting from 3 to 34 months with a mean of 16 months. According to their hearing level, they were divided into three groups. Infants in group A were with moderate hearing loss (41-60 dB HL). Infants in group B were with severe hearing loss (61-80 dB HL). Infants in group C were with profound hearing loss (81 dB HL). The infant-toddler meaningful auditory integration scale (IT-MAIS) was used to evaluate their auditory performance. The evaluation was performed before hearing aid fitting and 1, 3, 6, 9, 12 months after fitting.The mean scores of auditory performance showed significant improvements with time of hearing aid use for the three groups of infants (P0.05). The mean score of auditory performance for group A at 3 months after fitting was significantly superior in comparison with the scores before hearing aid fitting and at 1 month after fitting (P0.05). The mean score of auditory performance for group B at 6 months after fitting was significantly superior in comparison with the scores before hearing aid fitting and at 1, 3 months after fitting (P0.05). The mean score of auditory performance for group C at 9 months after fitting was significantly superior in comparison with the scores before hearing aid fitting and at 1, 3, 6 months after fitting (P0.05). There were no significant differences in mean scores between group A and B at each evaluating interval (P0.05). However, significant differences were observed between group A and C at 3, 6, 9, 12 months after fitting (P0.05). Significant differences were also shown between group B and C at 1, 3, 6, 9, 12 months after fitting (P0.05).Auditory performance of infants with prelingual hearing loss developed significantly with the use of hearing aids within the first year after fitting. The degree of hearing loss in infants had significant influence on the development of auditory performance.

To evaluate the auditory performance of infants with cochlear implants at the early stage after surgery, summarize the development of auditory ability, investigate the effect of age at cochlear implantation on auditory performance within the first year after surgery and provide a reference for their habilitation program.A total of 272 infants with prelingually profound hearing loss participated in this study, ranging in age at cochlear implantation from 18 to 36 months. The mean age was 21 months with a standard deviation of 7 months. Infants with cochlear implants were divided into three groups according to their age at implantation. Infants in group A were implanted under 18 months of age. Infants in group B were implanted between 18 and 24 months of age. Infants in group C were implanted between 25 and 36 months of age. Categories of auditory performance (CAP) was used to evaluate the auditory performance, which rates auditory abilities in eight categories for a scale of 0 to 7.The mean scores of CAP for all infants at each interval were significantly different after implantation. Significant differences were observed in mean scores of CAP among these three groups in 1 and 3 months after switch-on. However there were no significant differences in pre-operation, 6, 9 and 12 months after switch-on.There is a significant improvement in auditory performance of infants with prelingually profound hearing loss within the first year after cochlear implantation. The age at cochlear implantation has no critical influence on the development of auditory capabilities at the early stage after surgery. CAP is a practical tool which can be used in clinic in China.

Objectives/Hypothesis: The present study's aim was to assess the music perception ability for Chinese adult cochlear implant users and to investigate the correlation between music and Mandarin-Chinese lexical tone perception. Study Design: Case-control study. Methods: Twenty normal-hearing and 21 adult cochlear implant users participated in the Musical Sounds in Cochlear Implants (MuSIC) perception test, including six objective and two subjective musical subtests. The comparison of music perception performance was made between normal-hearing and cochlear implant subjects. Sixteen of the 21 cochlear implant users also performed a tone identification test to investigate the correlation between music and tone perception. Results: Cochlear implant users performed significantly worse than normal-hearing subjects on pitch discrimination, instrument identification, and instrument detection tests, whereas close to normal-hearing subjects on melody discrimination, chords discrimination, rhythm discrimination, and emotion and dissonance rating subtests. Lexical tone perception was significantly correlated with pitch discrimination, melody discrimination, and instrument identification tests. Duration of hearing aid use was found to be correlated with pitch discrimination ability of cochlear implant users. Conclusions: Chinese postlingually deafened cochlear implant users performed significantly poorer in pitch discrimination and timbre perception tasks than normal-hearing listeners. Lexical tone perception was found to be significantly correlated with music pitch perception, supporting the notion that tone and music perception may share a similar pitch perception mechanism.

To evaluate preverbal communication skills in Chinese deaf children with cochlear implants, and to provide a basis for designing the habilitation program and establish a precursor for outcomes of habilitation.Thirty children with cochlear implants participated in this study with a mean age of 32 months. They all had used the cochlear implant system within 12 months with a mean of 5. 8 months. All the children were diagnosed with prelingual profound hearing loss before cochlear implantation. Tait video analysis was used to analyze and assess the preverbal communication skills including turn-taking, autonomy, eye contact and auditory awareness. All statistical analyses were performed using the SPSS 13.0 statistical software package with a criterion of statistical significance set at P0.05.The skill of turn-taking developed quickly within 12 months after cochlear implantation. The vocal turn developed in a similar pattern, and the score of gesture turn decreased slowly. The skills of autonomy and appropriate eye contact showed small changes over time at a lower level. The score of auditory awareness increased gradually after surgery.Children established a vocal/auditory mode of early communicative behavior following cochlear implantation. They preferred to communicate with others in a more vocal style. Video analysis is a useful tool to assess preverbal communication skills in deaf children with cochlear implants in China.

Objective The purpose of this study was to investigate the auditory performance of infants with isolated Large Vestibular Aqueduct Syndrome (LVAS) after cochlear implantation, compare their performance with those of infants with a normal inner ear, and establish a database of auditory development. Method 435 infants with congenital severe to profound hearing loss participated in this study. 62 infants in group A were diagnosed with isolated LVAS. 373 infants in group B had a normal inner ear. Infant–Toddler Meaningful Auditory Integration Scale (IT-MAIS) was used to evaluate the development of auditory skills. Results The mean scores for auditory ability showed no significant difference between groups A and B. The mean scores for the three different auditory skills increased significantly over time. The differences were statistically significant in mean scores among the three different auditory skills for group B. Conclusion Auditory skills of infants with isolated LVAS developed rapidly after cochlear implantation, in a similar manner to those of infants with a normal inner ear. Cochlear implantation is an effective interventional approach and an established therapeutic option for infants with isolated LVAS.

A current technology for detecting and controlling transient noise in hearing aids (AntiShock) was evaluated. The objective was to evaluate AntiShock on loudness control and whether results in negative changes in sound quality of speech, transient noise and environmental noise and provide implications for hearing aid fitting.Twenty-four subjects with sensorineural hearing loss participated in the study. In a single-blinded paradigm, the subjects were asked to rate loudness of transient noise and distortion of speech, transient noise and environmental noise with the AntiShock in both on and off conditions.(1) The percentage of the transient noise rated as soft, comfortable, loud, too loud was 3.0%, 72.7%, 22.9% and 1.4%, respectively. There were significant differences in mean scores of loudness perception among listening conditions and between genders by a Two-Way ANOVA, the P values were 0.009 and 0.001, respectively. (2) The percentage of the speech rated as mild distorted, understandable, clear and very clear was 2.5%, 30.6%, 32.9% and 34.0%, respectively. There were significant differences in mean scores of speech distortion under different listening conditions by an One-Way ANOVA (P0.01). (3) The percentage of the transient noise rated as mild distorted, clear and natural was 2.9% and 97.1%, respectively. No significant differences in mean scores of nature of transient noise was found under different listening conditions by an One-Way ANOVA (P0.05). (4) The percentage of the environmental noise rated as mild distorted, clear but soft, clear and natural was 0.4%, 0.8% and 98.8%, respectively. No significant differences in mean scores of nature of environmental noise was found between different listening conditions by an Independent-Samples T Test (P0.05).AntiShock showed positive effects on the loudness control of the transient noise. Quality of speech, transient noise and environmental noise were not impacted by AntiShock.

To analyze the characteristics and development of auditory skill for infants with different age before and after cochlear implantation by using infant-toddler meaningful auditory integration scale (IT-MAIS) questionnaire, and provide the useful information for the criteria of candidacy for cochlear implantation in infants and habilitation after cochlear implantation.One hundred and thirty-nine prelingually infants with profound hearing loss were included in this study. According to the age at implantation, the infants were divided into 5 groups. They were group A (or =12 months), B (13-18 months), C (19-24 months), D (25-30 months) and E (31-36 months). Audiologists who were trained before this study used the IT-MAIS questionnaire to evaluate the auditory skill for all the infants and asked for the parents' or guardians' answers face to face. All the information about the infants spontaneous auditory behavioural responses was recorded in detail. The evaluation was performed before operation and 1 month, 3 months, 6 months, 12 months after switch-on.There were no significant differences in mean scores over time between different gender who received cochlear implants by Independent-Samples T Test (P0.05). There were no significant differences in mean scores over time among the 5 groups by Multiple Comparison in ANOVA (P0.05). The scores were increased with time and there were significant differences in mean scores among the different time before and after switch-on by Multiple Comparison in ANOVA (P0.05) for each group.The development of the auditory skill for infants followed the same rate in different gender. The auditory skill for infants after cochlear implantation developed rapidly regardless of age at implantation. Most of infants indicated rapid improvement in auditory skill within the first 6 months after switch-on, and then showed relative slow increase in the following 6 months.

To test non-mandarin native-speaker of normal hearing with MHINT.Eighty-two non-native Mandarin speakers with normal hearing were included. The test were done under four test conditions by HINT for Windows V6.1. The results were compared between non-mandarin native-speakers' with mandarin native-speakers'. The results were analyzed statistically.Three hundred and twenty-eight results of the subjects were gained. There was evident significantly difference between mandarin and non-mandarin native speakers (P0.01), and between non-mandarin native speakers with high educational level and low educational level ( P0.01), but there was no difference when compared with their age, time of use Mandarin in the results (P0.05).Non-mandarin native-speakers' results are lower than mandarin native-speakers'. The primary factor affect MHINT results are native language and educational experiences.

The purpose of this study is to compare the characteristics of psychophysical tests between cochlear implant children with large vestibular aqueduct syndrome and normal inner ear and to analyse the characteristics of psychophysical and impedance tests for cochlear implant patients with large vestibular aqueduct syndrome.One hundred and thirty-one cochlear implant pre-lingual deafness patients participated in this study. They received cochlear implant surgery at the age of 1.5 to 12 years old from Nov, 1998 to Aug, 2003. The patients were divided into two groups. Group A had 111 patients with normal inner ear. Group B had 20 patients with radiographically proven large vestibular aqueduct syndrome. All of the patients were inserted with Nucleus 24M. The time of the first programming session was approximately 4 weeks after surgery. The psychophysical tests included T and C-Level tests. The programming techniques used in the test were suitable for the age of the patients. The R116 and R126 software were used to test the impedance of the electrodes automatically.Using the independent-samples t-test, the impedance and T/C-Level of each electrode did not differ significantly between group A and B ( P0.05). The impedance and T/C-Level were not significantly different between group A and B at the time of switch-on, 1 week, 2 weeks, 3 weeks, 2 months, 3 months, 6 months, 9 months and 1 year after switch-on (P0.05).The parameters of mapping were not significantly different between cochlear implant children with large vestibular aqueduct syndrome and normal inner ear. The management and procedure of mapping used in cochlear implant children with normal inner ear can be used in the children with large vestibular aqueduct syndrome.

The purpose of this study is to analyze the auditory capability of infants before and after cochlear implantation by using IT-MAIS questionnaire.Eighty-six prelingually deaf patients participated in this study. They received a cochlear implant at the age of 1 to 3 yr. The audiologists who were trained for the research used the IT-MAIS questionnaire. Audiologists asked for the parents' answers face to face and recorded all the information about the patient's spontaneous auditory behavioural responses including vocalization, behaviour, spontaneous alerting to sound and deriving meaning from sound. The evaluation was performed before operation and 1 month, 3 months, 6 months, 1 year after switch-on.The scores of question 1 were significantly different between pre-operation and 1, 3, 6, 12 months after switch-on (P = 0.000, 0.000, 0.000, 0.000). The scores of question 2 were significantly different between pre-operation and 6, 12 months after switch-on (P = 0.000, 0.000). The scores of question 3 were significantly different between pre-operation and 3, 6, 12 months after switch-on (P = 0.001, 0.000, 0.000). The scores of question 4 were significantly different between pre-operation and 3, 6, 12 months after switch-on (P = 0.002, 0.000, 0.000). The scores of question 5 were significantly different between pre-operation and 1, 3, 6, 12 months after switch-on (P = 0.046, 0.00, 0.000, 0.000, 0.000). The scores of question 6 were significantly different between pre-operation and 3, 6, 12 months after switch-on (P = 0.037, 0.000, 0.000). The scores of question 7 were significantly different between pre-operation and 3, 6, 12 months after switch-on ( P = 0.000, 0.000, 0.000). The scores of question 8 were significantly different between pre-operation and 6, 12 months after switch-on (P = 0.001, 0.001). The scores of question 9 were significantly different between pre-operation and 3, 6, 12 months after switch-on ( P = 0.023, 0.000, 0.000). The scores of question 10 were significantly different between pre-operation and 12 months after switch-on (P = 0.048).Most of the patients showed no consistent response to sound in everyday life before implantation. After cochlear implantation, a significant increase in auditory capability occurred. The children demonstrated faster development of vocalization behaviour and spontaneous alerting to sound than deriving meaning from sound.

To provide an objective method to estimate T-levels and C-levels using neural response telemetry (NRT) thresholds for children, from whom we can not get accurate responses because they are very young or have other disabilities, by comparing NRT thresholds and T/C levels.Seventy patients implanted with the nucleus CI24M multiple cochlear implant system participated in this study. 329 electrodes were tested. The software used in this study was NRT 2.04. Monopolar stimulation mode was used during NRT threshold measurement. No. 3, 5, 10, 15, 20 electrodes were tested for each patient. The T-levels and C-levels were obtained at the same visit.92.7% of all the tested electrodes recorded NRT responses. There were variations in the amplitudes and thresholds of NRT responses across subjects and electrodes. NRT thresholds fell within the different points of the MAP dynamic range. The mean of NRT thresholds was shown to fall between the mean of T-levels and C-levels. The NRT thresholds and T/C levels reduced from basal to apical ends of the cochlear.Considerable variability across subjects was noted. So it is difficult to estimate T-levels and C-levels accurately by testing only NRT thresholds only. NRT technology provides a new objective method for estimating T-levels and C-levels for children who are unable to cooperate with audiologists during mapping after operation. The new NRT technology should be improved in the future.

The aim of this study is to survey and compare the development of auditory skills in young children with Mondini dysplasia and profoundly-deaf young children with radiologically normal inner ears over a period of 3 years after cochlear implantation. A total of 545 young children (age 7 to 36 months) with prelingual, severe to profound hearing loss participated in this study. All children received cochlear implantation. Based on whether or not there was a Mondini dysplasia as diagnosed with CT scanning, the subjects were divided into 2 groups: (A) 514 young children with radiologically normal inner ears and (B) 31 young children with Mondini dysplasia. The Infant-Toddler Meaningful Auditory Integration Scale (IT-MAIS) was used to assess the children's auditory skills that include vocalization changes, spontaneous alerting to sounds in everyday living environments, and the ability to derive meaning from sounds. The assessment was performed prior to surgery and at 1, 3, 6, 9, 12, 24, and 36 months after implant device switch-on. The mean scores for overall auditory skills were not significantly different between groups A and B at pre-surgery, 1, 12, 24, and 36 months post-surgery, but were significantly different at 3, 6, and 9 months post-surgery. The mean scores for all auditory skills in children with Mondini dysplasia showed significant improvement over time. The mean scores for the three subcategories of auditory skills in children with Mondini dysplasia also showed significant differences at pre-surgery, 1, 3, 6, and 9 months, however, there were no significant differences at 12, 24, and 36 months. Overall, the auditory skills of young children with Mondini dysplasia developed rapidly after cochlear implantation, in a similar manner to that of young children with radiologically normal inner ears. Cochlear implantation is an effective intervention for young children with Mondini dysplasia.