1. No Evidence for a Causal Link between Serum Uric Acid and Nonalcoholic Fatty Liver Disease from the Dongfeng-Tongji Cohort Study
- Author
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Yuhan Tang, Yanyan Xu, Peiyi Liu, Cheng Liu, Rong Zhong, Xiao Yu, Lin Xiao, Min Du, Ling Yang, Jing Yuan, Youjie Wang, Weihong Chen, Sheng Wei, Yuan Liang, Xiaomin Zhang, Tangchun Wu, Meian He, Xiaoping Miao, and Ping Yao
- Subjects
Cohort Studies ,Aging ,Article Subject ,Non-alcoholic Fatty Liver Disease ,Risk Factors ,Glucose Transport Proteins, Facilitative ,Odds Ratio ,Humans ,Female ,Cell Biology ,General Medicine ,Biochemistry ,Uric Acid - Abstract
Background and Aims. Elevated serum uric acid (SUA) is associated with an increased risk of nonalcoholic fatty liver disease (NAFLD); however, whether this association is causal is undetermined. Methods. Each participant from the Dongfeng-Tongji cohort study based on 27,009 retirees was interviewed face-to-face following a clinical examination. Covariance, logistic regression analysis, and instrumental variables were used to assess associations between SUA and (severity of) NAFLD and the causal link. Results. Among 8,429 subjects free of NAFLD at baseline, 2,007 participants developed NAFLD after 5 years of follow-up. The multivariable-adjusted odds ratio (OR) for NAFLD for individuals in the fourth quartile of SUA level versus those in the first was 1.71 (95% CI: 1.45-2.01, P for trend P = 0.25 ) from what was expected (1.03, 95% CI: 1.03-1.03). Conclusions. SUA was positively associated with NAFLD incidence especially in female and normal-weight individuals and the suspected progression risk of newly developed NAFLD. However, the Mendelian randomization analyses lend no causal evidence, suggesting high SUA as a marker and not a cause of NAFLD.
- Published
- 2022