1. PHGDH Inhibitor CBR-5884 Inhibits Epithelial Ovarian Cancer Progression via ROS/Wnt
- Author
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Xiaocui, Zhang, Meige, Sun, Yisheng, Jiao, Bei, Lin, and Qing, Yang
- Subjects
Ovarian Neoplasms ,Antineoplastic Agents ,Apoptosis ,Carcinoma, Ovarian Epithelial ,Poly(ADP-ribose) Polymerase Inhibitors ,Piperazines ,Cell Line, Tumor ,Humans ,Phthalazines ,Female ,Reactive Oxygen Species ,Wnt Signaling Pathway ,Phosphoglycerate Dehydrogenase ,beta Catenin - Abstract
PHGDH attaches importance to serine biosynthesis in cancer cells and maintaining mitochondrial redox homeostasis. However, the role of PHGDH inhibitor CBR-5884 in cell ROS level and its downstream pathways has not been explored in epithelial ovarian cancer. Thus, we investigated the function and possible mechanism of PHGDH inhibitor CBR-5884 on epithelial ovarian cancer in vitro and in vivo. A2780, OVCAR3, and ES-2 were treated with CBR-5884 at different concentrations or different time points. Results showed that CBR-5884 inhibited epithelial ovarian cancer cell proliferation, migration, and invasion and increases cell ROS level. Meanwhile, CBR-5884 exerts antitumor effect through activating ROS/Wnt/
- Published
- 2022