1. Expression of apoptosis regulatory proteins p53, bcl-2 and bax in recurrent aphthous ulceration
- Author
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J F N, Pinto Rodrigues, C T, Fujiyama Oshima, A P, Ribeiro Paiotti, M, Franco, S S, Miki Ihara, and D A, Ribeiro
- Subjects
Adult ,Male ,Proto-Oncogene Proteins c-bcl-2 ,Recurrence ,Humans ,Female ,Stomatitis, Aphthous ,Middle Aged ,Tumor Suppressor Protein p53 ,Immunohistochemistry ,bcl-2-Associated X Protein - Abstract
Recurrent aphthous ulceration (RAU) is considered to be an acute inflammatory disease of unknown pathogenesis. Apoptosis may represent an important event in the control of inflammation.The aim of this study was to investigate apoptosis process in RAU using immunohistochemistry.We studied the expression and location of p53, bcl-2 and bax in ulcerated lesions clinically diagnosed as RAU (n = 12) and compared it with that of oral clinically normal mucosa (n = 6) and of other inflammatory chronic disease such as oral fibrous inflammatory hyperplasia (FIH; n = 18).Significant statistically differences (n0.05) in p53 expression were noticed in RAU when compared with normal mucosa. No significant statistically differences (P0.05) were noticed between FIH and RAU. Bcl-2 and bax did not show remarkable differences between groups.Taken together, the data suggest that RAU induces p53 immunoexpression. Therefore, the protein might be related to the aetiopathogenesis of the ulcerated oral lesions.
- Published
- 2011