1. Changes in cytokines during treatment of elderly, hospitalized psychiatric patients – a naturalistic study
- Author
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Ole Kristian Grønli, Maria I. Lapid, Erlend Bugge, Rolf Wynn, Tom Eirik Mollnes, and Solveig Merete Klæbo Reitan
- Subjects
Male ,medicine.medical_specialty ,Clinical variables ,Psychogeriatric ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Neuroimmunology ,Population ,03 medical and health sciences ,Broad spectrum ,0302 clinical medicine ,Endocrinology ,Naturalistic observation ,Neuroinflammation ,Humans ,Medicine ,Gerontopsychiatric ,Psychiatry ,education ,Cytokine ,Biological Psychiatry ,Depression (differential diagnoses) ,Aged ,Aged, 80 and over ,education.field_of_study ,Depression ,Endocrine and Autonomic Systems ,business.industry ,Mental Disorders ,Age Factors ,VDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710 ,Middle Aged ,VDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710 ,030227 psychiatry ,Hospitalization ,Psychiatry and Mental health ,Younger adults ,Cytokines ,Female ,business ,030217 neurology & neurosurgery - Abstract
Immunological abnormalities have been demonstrated in several psychiatric disorders. Predominantly, studies have focused on younger adults, and research on elderly psychiatric in-patients is scant. In this naturalistic study, we investigated changes in cytokine levels during the treatment of diagnostically unselected elderly psychiatric in-patients, and whether these changes could be related to clinical outcomes. Clinical variables, demographic data, lifestyle data, and blood samples, including 27 plasma cytokines representing a broad spectrum of inflammatory mediators, were collected from 81 patients, 60 years and older, at admission and discharge. A subgroup of 49 patients also completed a self-reported clinical, psychiatric status form, indicating their level of recovery during hospitalisation. Statistical analyses demonstrated that a broad range of cytokines fell during treatment, and the fall was associated with clinical improvement, irrespective of psychiatric and somatic diagnoses. Exploiting cytokines as biomarkers of clinical traits might to be of limited use in a general population of elderly psychiatric in-patients as the field stands now. © 2019 The Authors. Published by Elsevier Ltd. Open Access CC-BY-NC-ND
- Published
- 2019