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Women with breast cancer experience social disruption during and after treatment. Brief cognitive-behavioral (CBT) and relaxation (RT) interventions may improve social disruption by increasing positive affect. Using the Broaden-and-Build Theory as a framework, this study examined whether short-term CBT- and RT-related increases in positive affect mediate long-term reductions in social disruption in women with breast cancer undergoing treatment (N = 183). This secondary analysis used latent change score and growth models to test 6- and 12-month intervention effects on positive affect and social disruption, respectively; a parallel-process model assessed mediation. RT demonstrated larger reductions in social disruption across 12 months compared to CBT and a health education control. Six-month latent change in positive affect was significant but not driven by condition. There was a significant direct effect linking the latent slopes of positive affect and social disruption but meditation was not observed. These preliminary findings hint at the value of promoting positive affect and inform the development of brief behavioral interventions that aim to augment social functioning among women surviving breast cancer.

Background The challenging combination of breastfeeding and work is one of the main reasons for early breastfeeding cessation. Although the availability of a lactation room (defined as a private space designated for milk expression or breastfeeding) is important in enabling the combination of breastfeeding and work, little is known about the effects of lactation room quality on mothers’ feelings and thoughts related to breastfeeding and work. We hypothesized that a high-quality lactation room (designed using the Theory of Supportive Design) would cause mothers to experience less stress, have more positive thoughts about milk expression at work, perceive more organizational support, and report more subjective well-being, than a low-quality lactation room. Methods In an online randomized controlled trial (Study 1), Dutch mothers (N = 267) were shown either a high-quality or a low-quality lactation room (using pictures and descriptions for the manipulation) and were then asked about their feelings and thoughts. In a subsequent field experiment (Study 2) we modified the lactations rooms in a large organization in Groningen, the Netherlands, to manipulate lactation room quality, and asked mothers (N = 61) who used either a high-quality or low-quality lactation room to fill out surveys to assess the dependent variables. Results The online study showed that mothers exposed to the high-quality lactation room anticipated less stress, more positive cognitions about milk expression at work, more perceived organizational support, and more subjective well-being than mothers exposed to the low-quality lactation room (p p p Conclusion The current studies show that not only the availability, but also the quality of lactation rooms is important in facilitating the combination of breastfeeding and work.

Introduction: Insomnia affects up to half of the U.S. population, and due to limitations of current treatments, there is a growing interest in mind–body practices to reduce insomnia. To understand ...

Background Prenatal maternal stress can have adverse effects on birth outcomes and fetal development. Relaxation techniques have been examined as potential countermeasures. This study investigates different relaxation techniques and their effect on self-reported stress levels and physiological stress levels in pregnant women. Methods In this cross-sectional study, 38 pregnant women in their 30th to 40th gestational week were assigned to one of three, 20-min lasting relaxation groups: listening to music (N = 12), following a guided imagery (N = 12) or resting (N = 12). The intervention, i.e., acute relaxation (music, guided imagery or resting) took place once for each study participant. Study inclusion criteria were age over 18 years, German speaking, singleton and uncomplicated pregnancy during the 30th and 40th week of gestation. The stress levels were determined during the study. Current stress level during the study was assessed by a visual analogue scale. Chronic stress levels were assessed by the Trier Inventory of Chronic Stress and the Pregnancy Distress questionnaire. Multivariate analyses of covariance were performed and dependent measures included stress levels as well as physiological measures, i.e., cardiovascular activity (electrocardiogram) and skin conductance levels. Results All three forms of relaxation led to reduced maternal stress which manifested itself in significantly decreased skin conductance, F(3,94) = 18.011, p = .001, ηp2 = .365, and subjective stress levels after the interventions with no significant group difference. Post-intervention stress ratings were further affected by gestational age, with less subjective relaxation in women later in gestation, F (1, 34)=4.971, p = .032, ηp2 = .128. Conclusion Independent of relaxation technique, single, 20-min relaxation intervention (music, guided imagery or resting) can significantly reduce maternal stress. Notably, women at an earlier stage in their pregnancy reported higher relaxation after the intervention than women later in gestation. Hence, gestational age may influence perceived stress levels and should be considered when evaluating relaxation or stress management interventions during pregnancy. Trial registration Not applicable. Supplementary Information The online version contains supplementary material available at 10.1186/s12884-021-04099-4.

Gaming addiction and its negative consequences have attracted public concern, but relatively little is known regarding its impact on adult workers. This study aims to test the association between gaming addiction and emotional exhaustion as well as the protective effect of recovery experiences on such an association among white-collar workers. We recruited 205 working adults (female = 58%) who voluntarily completed an online questionnaire. The results showed that male and younger workers were more vulnerable to gaming addiction. Emotional exhaustion was significantly and positively associated, while two (i.e., relaxation and control) of the four recovery experiences were negatively correlated with gaming addiction. Control experience had an indirect effect on gaming addiction via emotional exhaustion. Moreover, relaxation experience buffered the risk effect of emotional exhaustion on gaming addiction so that the effect is less pronounced at high levels of relaxation. Interventions are suggested to raise workers’ awareness of effective recovery experiences (especially for control and relaxation) and to facilitate their recovery opportunities.

This study aimed to measure the interoceptive accuracy (IA) of individuals with high (highs), medium (mediums), and low hypnotizability (lows) through the heartbeat-counting task during 3 relaxation trials. Participants completed the Multidimensional Assessment of Interoceptive Awareness (MAIA), ECG and skin conductance (SC) were monitored, and the experienced difficulty in counting was reported. Results showed similar counting difficulty and number of actual heartbeats in highs, mediums, and lows. SC decreased in highs during all trials, in mediums and lows only in the third trial. IA measured as [1 - (ǀrecorded heartbeats-counted heartbeatsǀ)/recorded heartbeats] was negatively correlated with hypnotizability and not correlated with interoceptive sensitivity (IS) measured by MAIA scales. Among mediums, IA was higher in males than in females.

CA extern Lifestyle interventions can have a positive impact on quality of life and psychological parameters in patients with metabolic syndrome (MetS). In this randomized controlled trial, 145 participants with MetS (62.8% women; 59.7 +/- 9.3 years) were randomized to (1) 5-day fasting followed by 10 weeks of lifestyle modification (F + LM; modified DASH diet, exercise, mindfulness; n = 73) or (2) 10 weeks of lifestyle modification only (LM; n = 72). Outcomes were assessed at weeks 0, 1, 12, and 24, and included quality of life (Short-Form 36 Health Survey Questionnaire, SF-36), anxiety/depression (Hospital Anxiety and Depression Scale, HADS), stress (Cohen Perceived Stress Scale, CPSS), mood (Profile of Mood States, POMS), self-efficacy (General Self-Efficacy Scale, GSE), mindfulness (Mindfulness Attention Awareness Scale, MAAS), and self-compassion (Self-Compassion Scale, SCS). At week 1, POMS depression and fatigue scores were significantly lower in F + LM compared to LM. At week 12, most self-report outcomes improved in both groups-only POMS vigor was significantly higher in F + LM than in LM. Most of the beneficial effects within the groups persisted at week 24. Fasting can induce mood-modulating effects in the short term. LM induced several positive effects on quality of life and psychological parameters in patients with MetS.

BACKGROUND Effective concepts are required to overcome the negative impact of daily stressful overwhelming. We investigated the effectiveness of a 1-week multimodal program for stress reduction. METHODS We performed a randomized controlled trial including adults with above-average stress level. The intervention consisted of health coaching, relaxation, physical activity, and balneotherapeutic elements. Individuals were randomized either to the intervention group (IG) or to one of the two control groups B and C. The main outcome was change in stress (Perceived Stress Questionnaire PSQ, Screening Scale of Chronic Stress of the Trier Inventory for Chronic Stress TICS-SSCS) at 6 months post intervention; further outcomes were well-being (World Health Organization 5-Item Well-Being Index WHO-5) and health status (EuroQol visual analog scale EQ-5D VAS). Data were collected pre/post intervention as well as after 1, 3, and 6 months. RESULTS Data of 96 individuals (mean age 48.0 years, 74{\%} female) were available for analyses. The IG improved overtime with -13.45 points for the PSQ and -6.44 points for the TICS-SSCS after 6 months. At 6-month follow-up the IG did not significantly differ from group B (PSQ: p = 0.2332; TICS-SSCS: p = 0.0805) or group C (PSQ: p = 0.0950; TICS-SSCS: p = 0.0607) when controlling for baseline (ANCOVA). Compared to group C, ANCOVA revealed significant differences in WHO-5 (p = 0.0292) and EQ-5D VAS (p = 0.0177) post intervention. At the 3- and 6-month follow-up and compared to group B, no substantial differences could be found for WHO-5 and EQ-5D VAS. CONCLUSION The results indicate that even a short-term multimodal program for stress reduction appears to set a positive trend towards less perceived and chronic stress. Hintergrund: Es bedarf effektiver Ans{\"a}tze, um den negativen Einfl{\"u}ssen t{\"a}glicher stressreicher Belastungen zu begegnen. Wir untersuchten die Wirksamkeit eines einw{\"o}chigen multimodalen Programms zur Stressreduzie­rung. Methoden: Wir f{\"u}hrten eine randomisierte kontrollierte Studie mit Erwachsenen durch, die ein erh{\"o}htes Stresslevel aufwiesen. Die Intervention beinhaltete ein Gesundheitscoaching, Entspannungs- und Bewegungs­einheiten sowie balneotherapeutische Elemente. Die Teilnehmenden wurden entweder in die Interventionsgruppe (IG) oder in eine von zwei Kontrollgruppen B oder C randomisiert. Die prim{\"a}re Zielgr{\"o}{\ss}e war die Ver{\"a}nde­rung im Stressniveau (Perceived Stress Questionnaire PSQ, Screening Scale of Chronic Stress of the Trier Inventory for Chronic Stress TICS-SSCS) 6 Monate nach der Intervention; weitere Zielgr{\"o}{\ss}en waren das Wohlbefinden (World Health Organization 5-Item Well-Being Index WHO-5) und der aktuelle Gesundheitsstatus (EuroQol visuelle Analogskala EQ-5D VAS). Daten wurden vor und nach der Intervention erfasst sowie nach 1, 3 und 6 Mona­ten. Ergebnisse: Daten von 96 Teilnehmenden (mittleres Alter 48.0 Jahre, 74{\%} weiblich) standen f{\"u}r die Analyse zur Verf{\"u}gung. Die IG verbesserte sich im Zeitverlauf, mit --13.45 Punkten im PSQ sowie --6.44 Punkten im TICS-SSCS nach 6 Monaten. Zum 6-Monats-Follow-up unterschied sich die IG nicht signifikant von Gruppe B (PSQ: p = 0.2332; TICS-SSCS: p = 0.0805) oder Gruppe C (PSQ: p = 0.0950; TICS-SSCS: p = 0.0607), kontrolliert f{\"u}r den Ausgangswert (ANCOVA). Verglichen mit Gruppe C zeigte die ANCOVA nach der Intervention signifikante Unterschiede im WHO-5 (p = 0.0292) und der EQ-5D VAS (p = 0.0177). Zum 3- und 6-Monats-Follow-up sowie verglichen mit Gruppe B konnten keine substanziellen Unterschiede im WHO-5 und der EQ-5D VAS gefunden werden. Schlussfolgerung: Die Ergebnisse weisen darauf hin, dass selbst ein kurzes multimodales Programm zur Stressreduzierung einen positiven Trend hin zu weniger subjektiv wahrgenommenem und chronischem Stress setzen kann.

Higher arousal and cortical excitability have been observed in high hypnotizable individuals (highs) with respect to low hypnotizables (lows), which may be due to differences in the activation of ascending activating systems. The present study investigated the possible hypnotizability-related difference in the cortical noradrenergic tone sustained by the activity of the Locus Coeruleus which is strongly related to pupil size. This was measured during relaxation in three groups of participants—highs (N = 15), lows (N = 15) and medium hypnotizable individuals (mediums, N = 11)—in the time and frequency domains and through the Recurrence Quantification Analysis. ECG and Skin Conductace (SC) were monitored to extract autonomic indices of relaxation (heart interbeats intervals, parasympathetic component of heart rate variability (RMSSD) and tonic SC (MeanTonicSC). Most variables indicated that participants relaxed throughout the session. Pupil features did not show significant differences between highs, mediums and lows, except for the spectral Band Median Frequency which was higher in mediums than in lows and highs at the beginning, but not at the end of the session.Thus, the present findings of pupil size cannot account for the differences in arousal and motor cortex excitability observed between highs and lows in resting conditions.

The present study examined the daily relationship between job performance, relaxation, positive affect, and emotional labor. Drawing on the effort-recovery model and broaden-and-build theory, we proposed that job performance on a particular day fosters evening relaxation and next-morning positive affect and that this leads to increased deep acting and decreased surface acting the next day. To test our propositions, we conducted 2 diary studies using the experienced sampling method. In Study 1, 93 flight attendants participated in morning and end-of-workday surveys for 5 workdays. In Study 2, 98 hotel employees responded to morning, end-of-workday, and evening surveys for 5 workdays. In both studies, we found positive relationships between daily job performance, evening relaxation, next-morning positive affect, and next-day deep acting. We further found support for the indirect effect of daily job performance on next-day deep acting through evening relaxation and next-morning positive affect. Although next-morning positive affect had a marginally negative relationship with next-day surface acting in Study 1, this relationship became nonsignificant when next-morning negative affect was included in the model (Study 2). The robustness of these findings was validated in supplementary analyses. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Numerous studies have reported a significant increase in stress experienced by students owing to the COVID-19 pandemic. Recently, interest in stress management using nature-derived substances has increased. However, studies examining the effects of olfactory stimulation by fir are lacking. The aim of this study was to investigate the physiological and psychological effects of inhaling fir essential oil. Additionally, differences between male and female participants were compared. Twenty-six university students (16 female and 10 male students; mean age, 21.5 ± 1.9 years) participated in this study. Fir essential oil was used for olfactory stimulation, with normal room air as the control. The odor was administered for 3 min. Heart rate variability and heart rate were used as indicators of autonomic nervous system activity. The Profile of Mood States and State-Trait Anxiety Inventory were used as psychological indicators. The ln(Low Frequency/High Frequency) ratio, which is an indicator of sympathetic nervous activity reflecting a stressful or aroused state during stimulation with fir essential oil, was significantly lower than during the control condition. Assessment of psychological indicators showed that the positive mood of “vigor” improved significantly and negative moods of “tension–anxiety”, “depression”, “anger–hostility”, “fatigue” and anxiety levels reduced significantly after inhaling fir essential oil compared to the control condition. This study showed that inhalation of fir essential oil has physiologically and psychologically relaxing effects, with differences in results depending on the sex of the participants.

The Locus Coeruleus (LC) and the Substantia Nigra (SN) are small brainstem nuclei that change with aging and may be involved in the development of various neurodegenerative and psychiatric diseases. Magnetization Transfer (MT) MRI has been shown to facilitate LC and the SN visualization, and the observed contrast is assumed to be related to neuromelanin accumulation. Imaging these nuclei may have predictive value for the progression of various diseases, but interpretation of previous studies is hindered by the fact that the precise biological source of the contrast remains unclear, though several hypotheses have been put forward. To inform clinical studies on the possible biological interpretation of the LC- and SN contrast, we examined an agar-based phantom containing samples of natural Sepia melanin and synthetic Cys-Dopa-Melanin and compared this to the in vivo human LC and SN. T1 and T2* maps, MT spectra and relaxation times of the phantom, the LC and the SN were measured, and a two-pool MT model was fitted. Additionally, Bloch simulations and a transient MT experiment were conducted to confirm the findings. Overall, our results indicate that Neuromelanin-MRI contrast in the LC likely results from a lower macromolecular fraction, thus facilitating interpretation of results in clinical populations. We further demonstrate that in older individuals T1 lengthening occurs in the LC.

Objectives: Integrative therapies have been incorporated increasingly into health and wellness in the United States in recent decades. Their potential benefits are under evaluation in various situations, including pain and symptom relief for cancer patients and survivors. This pilot study evaluated whether combining two integrative complementary approaches augments a patient's benefit by reducing postoperative stress, pain, anxiety, muscle tension, and fatigue compared with one integrative complementary approach alone. Design: Patients undergoing autologous tissue breast reconstruction were randomly assigned to one of two postoperative complementary alternative therapies for three consecutive days. All participants were observed for up to 3 months. Subjects: Forty-two participants were recruited from January 29, 2016 to July 11, 2018. Interventions: Twenty-one participants were randomly assigned to massage alone and 21 to massage and acupuncture. Outcome measures: Stress, anxiety, relaxation, nausea, fatigue, pain, and mood (score 0–10) were measured at enrollment before surgery and postoperative days 1, 2, and 3 before and after the intervention. Patient satisfaction was evaluated. Results: Stress decreased from baseline for both Massage-Only Group and Massage+Acupuncture Group after each treatment intervention. Change in stress score from baseline decreased significantly more in the Massage-Only Group at pretreatment and posttreatment (p = 0.03 and p = 0.04). After adjustment for baseline values, change in fatigue, anxiety, relaxation, nausea, pain, and mood scores did not differ between groups. When patients were asked whether they would recommend the study, 100% (19/19) of Massage-Only Group and 94% (17/18) of Massage+Acupuncture Group responded yes (p = 0.49). Conclusion: No additive beneficial effects were observed with addition of acupuncture to massage for pain, anxiety, relaxation, nausea, fatigue, and mood. Combined massage and acupuncture was not as effective in reducing stress as massage alone, although both groups had significant stress reduction. These findings indicate a need for larger studies to explore these therapies further.

Aim: To explore people’s visual attention and psychological and physiological responses to viewing a Japanese garden (an asymmetrically designed garden) and an herb garden (a symmetrically designed garden). Background: There are few studies of eye movements when observing different style gardens, and how they are connected to the interpretation of the space, and physiological and psychological responses. Method: Thirty subjects were recruited and their physiological and psychological responses to viewing the garden types were assessed using a heart-rate monitor and questionnaire. Eye movements while viewing projected slide images of the gardens were tracking using an eye-tracking monitor. Results: A significant decrease in heart rate was observed when subjects were viewing the Japanese garden as opposed to viewing the herb garden. Mood was significantly improved in both gardens, but eye-gaze patterns differed. The Japanese garden elicited far more comments about expectations for the coming season; unlike the herb garden, it also induced memories of viewing other landscapes. Conclusion: The physiological and psychological responses to viewing gardens differs based on the quality of landscape design and the prior experience of viewers.

Objective High-frequency deep brain stimulation (DBS) of anterior thalamic nuclei (ANT) reduces the frequency and intensity of focal and focal to bilateral tonic-clonic epileptic seizures. We investigated the impact of high-frequency ANT-DBS on vigilance in epilepsy patients during relaxed and drowsy wakefulness, to better understand the effects and the mechanisms of action of this intervention in humans. Methods Four patients with different structural epileptic pathologies were included in this retrospective case-cohort study. Short- and long-term electroencephalography (EEG) was used to determine states of relaxed or drowsy wakefulness and the vigilance changes during stimulation-on and stimulation-off intervals. Results In relaxed, wakeful patients with eyes closed, the eyelid artifact rate increased acutely and reproducibly during stimulation-on intervals, suggesting an enhanced vigilance. This effect was accompanied by a slight acceleration of the alpha rhythm. In drowsy patients with eyes closed, stimulation generated acutely and reproducibly alpha rhythms, similar to the paradoxical alpha activation during eyes opening. The occurrence of the alpha rhythms reflected an increase in the vigilance of the drowsy subjects during ANT-DBS. Significance This is the first demonstration that ANT-DBS increases the vigilance of wakeful epilepsy patients. Our results deliver circumstantial evidence that high-frequency ANT-DBS activates thalamocortical connections that promote wakefulness.

Being able to psychologically relax after work in the evening is important to the day-to-day recovery process and should enable employees to wake up feeling energized for the next workday. Drawing on affective events theory and allostatic load theory, we expected that employees will be able to psychologically relax when they get home from work if during work (a) they experienced less work-related goal-frustration events and more work-related goal-achievement events and (b) if they were adaptively regulating physiological stress arousal (as indexed by heart rate variability). As such, this research considers that work events, as well as a physiological indicator of parasympathetic regulation, can be important antecedents to off-the-job recovery. Over the course of 5 consecutive workdays, 72 employees completed daily surveys (on waking, at work, and in the evening) and wore an ambulatory electrocardiograph to measure their heart rate variability while at work that afternoon. Multilevel mediation analyses revealed support for our hypotheses at the within-person level, except for the role of goal-attainment events. The finding that goal-frustration events and heart rate variability both contribute to evening relaxation, and then indirectly to next-morning energy, provides initial insights on how both mind and body impact off-the-job recovery. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Introduction: Dental anxiety is common and causes symptomatic use of oral health services. Objectives: The aim was to study if a short-term virtual reality intervention reduced preoperative dental anxiety. Methods: A randomized controlled single-center trial was conducted with 2 parallel arms in a public oral health care unit: virtual reality relaxation (VRR) and treatment as usual (TAU). The VRR group received a 1- to 3.5-min 360° immersion video of a peaceful virtual landscape with audio features and sound supporting the experience. TAU groups remained seated for 3 min. Of the powered sample of 280 participants, 255 consented and had complete data. Total and secondary sex-specific mixed effects linear regression models were completed for posttest dental anxiety (Modified Dental Anxiety Scale [MDAS] total score) and its 2 factors (anticipatory and treatment-related dental anxiety) adjusted for baseline (pretest) MDAS total and factor scores and age, taking into account the effect of blocking. Results: Total and anticipatory dental anxiety decreased more in the VRR group than the TAU group (β = −0.75, P < .001, for MDAS total score; β = −0.43, P < .001, for anticipatory anxiety score) in patients of a primary dental care clinic. In women, dental anxiety decreased more in VRR than TAU for total MDAS score (β = −1.08, P < .001) and treatment-related dental anxiety (β = −0.597, P = .011). Anticipatory dental anxiety decreased more in VRR than TAU in both men (β = −0.217, P < .026) and women (β = −0.498, P < .001). Conclusion: Short application of VRR is both feasible and effective to reduce preoperative dental anxiety in public dental care settings (ClinicalTrials.gov NCT03993080). Knowledge Transfer Statement: Dental anxiety, which is a common problem, can be reduced with short application of virtual reality relaxation applied preoperatively in the waiting room. Findings of this study indicate that it is a feasible and effective procedure to help patients with dental anxiety in normal public dental care settings.

International audience; Introduction: Two aspects of noise annoyance were addressed in the present laboratory study: (1) the disturbance produced by vehicle passby noise while engaging in a challenging non-auditory task, and (2) the evaluative response elicited by the same sounds while imagining to relax at home in the absence of a primary activity. Methods and Material: In Experiment 1, N = 29 participants were exposed to short (3-6 s) pass-by recordings presented at graded levels between 50 and 70 dB(A). Concurrent with each sound presentation, they performed a visual multiple-object tracking task, and subsequently rated the annoyance of the sounds on a VAS scale. In Experiment 2, N = 30 participants judged the sounds while imagining to relax, without such a cognitive task. Results and Discussion: Annoyance was reduced when participants were engaged in the cognitively demanding task, in Experiment 1. Furthermore, when occupied with the task, annoyance slightly, but significantly increased with task load. Across both experiments, the magnitude of simultaneously recorded skin conductance responses in the first 1-4 s after the onset of stimulation increased significantly with sound pressure level. Annoyance ratings tended to be elevated across all sound levels, though significantly only in Experiment 2, in participants classified as noise sensitive based on a 52-item questionnaire. Conclusions: The results suggest that noise annoyance depends on the primary activity the listener is engaged in. They demonstrate that phasic skin conductance responses may serve as an objective correlate of the degree of annoyance experienced. Finally, noise sensitivity is once more shown to augment annoyance ratings in an additive fashion. Key Messages: Two laboratory experiments demonstrate that annoyance due to vehicle pass-by noise depends on both the kind of primary task those exposed are performing, and their individual noise sensitivity. Furthermore, skin conductance responses to the noises were shown to provide an objective measure of the degree of annoyance, primarily reflecting exposure level. Text

This study was designed to assess the physiological and psychological benefits of visually looking at foliage plants in adults. This study involved 30 adults in their 20s (11 males, 19 females), and using a crossover design, participants looked at four different types of visual stimuli, namely, real plants, artificial plants, a photograph of plants, and no plants for 5 min. Brain waves were measured while viewing each type of plant, and a subjective evaluation of emotions was performed after each visual stimulus. Semantic differential methods (SDM) and Profile of Mood States (POMS) were used for the subjective evaluation. During the real plant visual stimulation, relative theta (RT) power spectrum was increased in the bilateral occipital lobes, while relative high beta (RHB) power spectrum was reduced in the left occipital lobe, indicating a reduction in stress, anxiety, and tension. The subjective survey results revealed that when looking at real plants, the participants exhibited significantly higher “comfort,” “natural,” and “relaxed” scores as well as an increase in positive mood conditions. In conclusion, among the four types of plants, visual stimulation with real plants induces physiological relaxation in adults and has a positive psychological effect.

Purpose of Review Migraine is primary headache which commonly affects women of childbearing age. Migraine and other primary headache disorders are also common during pregnancy. Understanding which treatments are effective and can be safely given to patients with primary headache during pregnancy and lactation is essential in supporting these patients before, during, and after childbirth. Behavioral modalities have the potential to improve the health of both mother and baby, while empowering patients to make informed decisions in family planning and creating future treatment plans. Recent Findings Research shows that behavioral therapies can be powerful tools to treat pain conditions with minimal side effects. Recent literature prioritizes behavioral therapies in preparation for pregnancy, during pregnancy, and during lactation due to the superior safety profile of such therapies. Digital resources for behavioral therapy are another well-received recent direction supported by growing evidence of both efficacy and safety. Popular with patients and headache specialists, digital behavioral therapy has taken various forms during the pandemic, such as telemedicine, online psychology support groups, and smartphone applications that patients can interact with on their own time. Summary In summary, the purpose of this review is to equip providers with important information and updates on the use of behavioral modalities for the treatment of primary headache during pregnancy and lactation.

Research suggests that stays in a forest promote relaxation and reduce stress compared to spending time in a city. The aim of this study was to compare stays in a forest with another natural environment, a cultivated field. Healthy, highly sensitive persons (HSP, SV12 score > 18) aged between 18 and 70 years spent one hour in the forest and in the field at intervals of one week. The primary outcome was measured using the Change in Subjective Self-Perception (CSP-14) questionnaire. Secondary outcomes were measured using the Profile Of Mood States (POMS) questionnaire and by analyzing salivary cortisol. We randomized 43 participants. Thirty-nine were allocated and included in the intention-to-treat analysis (90% female, mean age 45 years). CSP-14 in part showed significant differences—total score (p = 0.054, Cohen’s d = 0.319), item “integration” (p = 0.028, Cohen’s d = 0.365)—favoring the effects of the forest. These effects were more pronounced in summer (August). In October, during rainfall, we detected no relevant differences. POMS only showed a significant difference in the subcategory “depression/anxiety” in favor of the field. The amount of cortisol in saliva was not different between the groups. A short-term stay in a forest in summer caused a greater improvement in mood and well-being in HSP than in a field. This effect was not detectable during bad weather in the fall.

Objective To investigate in the literature the studies on the benefits ofmusic therapy interventions among pregnant women in the prenatal, delivery and postpartum periods. Data Sources The search for articles was carried out in the following electronic databases: VHL, LILACS, SciELO, Portal CAPES, PsycINFO, ERIC, PubMed/Medline, and journals specialized in this field: Revista Brasileira de Musicoterapia (“Brazilian Journal of Music Therapy”) and Voices. Study Selection Descriptors in Portuguese (musicoterapia, gravidez, gestantes, revisão), English (music therapy, pregnancy, pregnant women, review) and Spanish (musicoterapia, embarazo, mujeres embarazadas, revisión) were used. The search was delimited between January 2009 and June 2019. The process of selection and evaluation of the articles was performed through peer review. Data Collectio n The following data were extracted: article title, year of publication, journal, author(s), database, country and date of collection, purpose of the study, sample size, type of care, intervention, instruments used, results, and conclusion. The data were organized in chronological order based on the year of publication of thestudy. Summary of the Data In total, 146 articles were identified, and only 23 studies were included in this systematic review. The articles found indicate among their results relaxation, decreased levels of anxiety, psychosocial stress and depression, decreased pain, increase in the maternal bond, improvement in the quality of sleep, control of the fetal heart rate and maternal blood pressure, and decreased intake of drugs in the postoperative period. Conclusion Music therapy during the prenatal, delivery and postpartum periods can provide benefits to pregnant women and newborns, thus justifying its importance in this field. Resumo Objetivo Investigar na literatura os estudos sobre os benefícios das intervenções musicoterapêuticas em gestantes no pré-natal, parto e pós-parto. Fontes dos dados A busca dos artigos foi realizada nas seguintes bases de dados eletrônicas: BVS, LILACS, SciELO, Portal CAPES, PsycINFO, ERIC, PubMed/Medline e revistas especializadas da área: Revista Brasileira de Musicoterapia e Voices. Seleção dos estudos Utilizaram-se descritores em português (musicoterapia, gravidez, gestantes, revisão), em inglês (music therapy, pregnancy, pregnant women, review) e em espanhol (musicoterapia, embarazo, mujeres embarazadas, revisión). A busca foi delimitada de janeiro de 2009 até junho de 2019. Os processos de seleção e avaliação dos artigos foram realizados por revisão por pares. Coleta de dados Os seguintes dados foram extraídos: título do artigo, ano da publicação, revista, autor(es), base de dados, país e data da coleta, objetivo do estudo, tamanho da amostra, tipo de atendimento, intervenção, instrumentos utilizados, resultados, e conclusão. Os dados foram organizados emordem cronológica a partir do ano de publicação do estudo. Síntese dos dados Foram identificados 146 artigos e incluídos apenas 23 estudos na revisão sistemática. Os artigos encontrados indicam em seus resultados relaxamento, diminuição dos níveis de ansiedade, de estresse psicossocial e de depressão, diminuição da dor, aumento do vínculo materno, melhora da qualidade do sono, controle da frequência cardíaca fetal e da pressão arterial materna, e diminuição da ingestão de fármacos no pós-operatório. Conclusões A musicoterapia durante o pré-natal, parto e pós-parto pode trazer benefícios para a gestante e para o neonato, o que justifica sua importância nessa área.

Forty percent of somatotroph tumors harbor recurrent activating GNAS mutations, historically called the gsp oncogene. In gsp-negative somatotroph tumors, GNAS expression itself is highly variable; those with GNAS overexpression most resemble phenotypically those carrying the gsp oncogene. GNAS is monoallelically expressed in the normal pituitary due to methylation-based imprinting. We hypothesize that changes in GNAS imprinting of gsp-negative tumors affect GNAS expression levels and tumorigenesis. We characterized the GNAS locus in two independent somatotroph tumor cohorts: one of 23 tumors previously published (PMID: 31883967) and classified by pan-genomic analysis, and a second with 82 tumors. Multi-omics analysis of the first cohort identified a significant difference between gsp-negative and gsp-positive tumors in the methylation index at the known differentially methylated region (DMR) of the GNAS A/B transcript promoter, which was confirmed in the larger series of 82 tumors. GNAS allelic expression was analyzed using a polymorphic Fok1 cleavage site in 32 heterozygous gsp-negative tumors. GNAS expression was significantly reduced in the 14 tumors with relaxed GNAS imprinting and biallelic expression, compared to 18 tumors with monoallelic expression. Tumors with relaxed GNAS imprinting showed significantly lower SSTR2 and AIP expression levels. Altered A/B DMR methylation was found exclusively in gsp-negative somatotroph tumors. 43% of gsp-negative tumors showed GNAS imprinting relaxation, which correlated with lower GNAS, SSTR2 and AIP expression, indicating lower sensitivity to somatostatin analogues and potentially aggressive behavior.

BACKGROUND: Mind-body interventions are a viable holistic approach to rehabilitation; however, evidence for mind-body approaches in hand therapy is lacking. OBJECTIVES: This study explored the experiences of clients with musculoskeletal disorders undergoing two mind-body interventions within hand therapy. METHODOLOGY: Qualitative data were obtained from clients who received mindfulness meditation and sonographic biofeedback as part of hand therapy. Semi-structured interviews conducted after four therapy sessions elicited participants’ experiences and acceptability. Emergent themes were identified through an iterative, qualitative descriptive process. RESULTS: Three themes emerged: insight on the body; relaxation and relief; and I am in control. A fourth theme was identified in the acceptability data, that is, mindfulness as a meaningful activity. At least one of the interventions was acceptable to each participant. IMPLICATIONS: Positive participant experiences support further consideration of mind-body interventions as a useful holistic approach in hand therapy to support wellness, quality of care, and participation in recovery.

PurposeThe study had three aims. We investigated, first, how six recovery experiences (i.e., detachment, relaxation, control, mastery, meaning, and affiliation) during off-job time suggested by the DRAMMA model (Newman et al. in J Happiness Stud 15(3):555–578.10.1007/s10902-013-9435-x, 2014) are related to well-being (i.e., vitality, life satisfaction, and work ability). Second, we examined how age related to these outcomes, and third, we investigated whether age moderated the relationships between recovery experiences and well-being outcomes.MethodsA sample of 909 Finnish teachers responded to an electronic questionnaire (78% women, average age 51 years). The data were analyzed with moderated hierarchical regression analyses.ResultsDetachment from work, relaxation, control, and mastery were associated with higher vitality. Detachment, relaxation, meaning, and affiliation were related to higher life satisfaction. Older age was related to lower work ability, but not to vitality or life satisfaction. Older teachers benefited more from control and mastery during off-job time than did younger teachers in terms of vitality, whereas younger teachers benefited more from relaxation in terms of all well-being outcomes.ConclusionsDetachment, relaxation, control, mastery, meaning, and affiliation during off-job time were related to higher well-being, supporting the DRAMMA model. Age moderated the relationships between control, mastery, and relaxation and vitality and life satisfaction. The role of aging in recovery from work needs further research.

Non-invasive quantification of the in vivo myelin content may provide valuable information regarding healthy maturation of the brain, as well as insights into demyelination of several neurological disorders. However, these scans are often long thereby limiting acquisition of large brain parts in clinically feasible acquisition times. Therefore, fast acquisition of whole brain myelin content is important. To avoid errors related to slice-selective pulses, most of the previous whole brain studies on myelin content relied on a 3D acquisition. However, multi-slice (2D) acquisition methods are often faster, and less susceptible to motion artifacts. Therefore, multi-slice approaches can be beneficial in a clinical setting.We investigated the applicability and reproducibility of whole brain multi-slice GRASE myelin-water imaging with post-acquisition slice-profile correction in healthy volunteers (aged 25-32y). The applicability was evaluated using the agreement between the multi-slice GRASE and the reference method for myelin-water imaging, single-slice multi spin-echo (MSE) acquisition. Additionally, we assessed the effect of varying acquisition acceleration using parallel imaging on the reproducibility values.First, the multi-slice myelin-water maps showed good agreement with the single-slice reference method, with a bias of at most 1.2% in absolute MWF values. Second, we found an average within-subject coefficient of variation (CoV) of 5.9% and an average intra-class correlation coefficient (ICC) of 0.90 for myelin-water estimation using a multi-slice GRASE sequence without parallel acceleration (scan time 14:06 min), while acquisition with a parallel acceleration factor of 2 resulted in a slightly worse average within-subject CoV of 6.4% and an average ICC of 0.83 at half the scan time. Hence, a multi-slice GRASE acquisition with parallel acceleration factor 2 and a scan time of 7:30 min still provides an excellent reproducibility.

Background Bed bath in daily nursing care is crucial for cleaning and moisturizing patients’ skin. The purpose of this study was to compare the effectiveness of cleaning and level of comfort of towel and disposable baths. The 2 methods were evaluated based on measurements of the transition of resident skin bacteria, stratum corneum water content, transepidermal water loss, and perceived relaxation levels. Methods Twenty-six healthy women aged 65-90 years participated in this study and received disposable and towel baths. We measured 4 indicators before and after bathing. The participants’ relaxation levels were measured by the Japanese adult version of the Profile of Mood States Second Edition short form. Results Both disposable and towel baths significantly decreased resident skin bacteria. Disposable bath also significantly reduced Staphylococcus aureus and effectively maintained the water content of the stratum corneum. Furthermore, disposable bath was as effective as towel bath at contributing to participants’ relaxation levels. Conclusions This study suggested that using a disposable bath for daily cleaning of patients’ skin is more comfortable and effective than using a towel bath.

P2Y1 receptors play an essential role in inhibitory neuromuscular transmission in the gastrointestinal tract. The signalling pathway involves the opening of small conductance calcium activated potassium-channels (Kca2 family) that results in smooth muscle hyperpolarization and relaxation. Inorganic polyphosphates and dinucleotidic polyphosphates are putative neurotransmitters that potentially act on P2Y1 receptors. A pharmacological approach using both orthosteric (MRS2500) and allosteric (BPTU) blockers of the P2Y1 receptor and openers (CyPPA) and blockers (apamin) of Kca2 channels was used to pharmacologically characterise the effect of these neurotransmitters. Organ bath and microelectrodes were used to evaluate the effect of P1,P4-Di (adenosine-5′) tetraphosphate ammonium salt (Ap4A), inorganic polyphosphates (PolyP) and CyPPA on spontaneous contractions and membrane potential of mouse colonic smooth muscle cells. PolyP neither modified contractions nor membrane potential. In contrast, Ap4A caused a concentration-dependent inhibition of spontaneous contractions reaching a maximum effect at 100 μM Ap4A response was antagonised by MRS2500 (1 μM), BPTU (3 μM) and apamin (1 μM). CyPPA (10 μM) inhibited spontaneous contractions and this response was antagonised by apamin but it was not affected by MRS2500 or BPTU. Both CyPPA and Ap4A caused smooth muscle hyperpolarization that was blocked by apamin and MRS2500 respectively. We conclude that Ap4A but not PolyP activates P2Y1 receptors causing smooth muscle hyperpolarization and relaxation. Ap4A signalling causes activation of Kca2 channels through activation of P2Y1 receptors. In contrast, CyPPA acts directly on Kca2 channels. Further studies are needed to evaluate if dinucleotidic polyphosphates are released from inhibitory motor neurons.

The use of a placebo is the gold standard for establishing the efficacy of new treatments in randomized controlled trials (RCTs). Placebo treatments are inert; this allows specific effects of the experimental treatment to be separated from nonspecific physiological, psychological, and social effects. The aim of this study was to scrutinize the workings of an audiobook (AB) placebo treatment, which was used in a placebo-controlled, investigator-blinded, RCT of the effect of guided imagery (GI) to improve pain and function in persons undergoing total knee replacement. A secondary analysis of quantitative and narrative data collected during the RCT was performed. The AB treatment provided attention control. Participants in the AB group identified benefits—pleasant get-away, new knowledge, quiet time-out, and inspiration; however, there was also evidence of resentful demoralization, especially in the postoperative period. The use of ABs as a placebo treatment in GI RCTs should be executed with caution.

This study examines the role of negative work rumination and recovery experiences in explaining the association between workplace incivility and employee insomnia symptoms. Drawing on the perseverative cognition model of stress and the effort-recovery model, we hypothesize a moderated mediation model in which workplace incivility is associated with insomnia symptoms via negative work rumination. This indirect effect is proposed to be conditional on employees' reported level of recovery experiences (i.e., psychological detachment from work and relaxation during nonwork time). In examining this model, we further establish a link between workplace incivility and sleep and identify one pathway to explain this relationship, as well as resources that may be used to halt the negative spillover of workplace incivility on sleep. Based on a sample of 699 U.S. Forest Service employees, we find support for a moderated mediation model in which the association between workplace incivility and increased insomnia symptoms via increased negative work rumination was weakest for employees reporting high levels of recovery experiences during nonwork time. Findings from the current study contribute to our understanding of why workplace incivility is associated with nonwork outcomes, as well as point to implications for interventions aimed at promoting employees' recovery from work. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

PURPOSE: Research by our group has shown that acupressure bands are efficacious in reducing chemotherapy-induced nausea (CIN) for breast cancer patients who expect nausea, and that their effectiveness in controlling CIN can largely be accounted for by patients’ expectations of efficacy, i.e., a placebo effect. The present research examined if the effectiveness of acupressure bands could be enhanced by boosting patients’ expectation of the bands’ efficacy. METHODS: 242 Chemotherapy-naïve patients with breast cancer who expected nausea were randomized. Arms 1 and 2 received acupressure bands, plus a relaxation MP3 and written handout that were either expectancy-enhancing (Arm 1) or expectancy-neutral (Arm 2). Arm 3 was the control without bands or MP3, and received standard care. All participants received guidelines specified antiemetics. RESULTS: Peak CIN for Arms 1, 2, and 3 on a 1–7 scale was 3.52, 3.55, and 3.87, respectively (p=0.46). Because no differences were observed between Arms 1 and 2 (primary analysis), we combined these two arms (intervention) and compared them to controls for the following analyses. Significant interaction was found between intervention/control and receiving doxorubicin-based chemotherapy (yes/no) and pre-treatment anxiety (high/low). Intervention patients receiving doxorubicin had lower peak CIN than controls (3.62 vs. 4.38; p=0.02). Similarly, intervention patients with high pre-treatment anxiety had a lower peak CIN than controls (3.62 vs. 4.62; p=0.01). CONCLUSIONS: In breast cancer patients undergoing chemotherapy and having high CIN expectation, acupressure bands combined with a relaxation recording were effective in reducing CIN for patients who received doxorubicin or had high anxiety.

Introduction The American Academy of Pediatrics recommends that adolescents be screened for mental health concerns and receive anticipatory guidance on stress management strategies. Methods Eighty-six participants (50 participants in the intervention group; 36 participants in the control group) participated in the study. Intervention group participants received training in diaphragmatic breathing, progressive muscle relaxation, and use of no-cost/low-cost exercise options. Biofeedback was used to guide relaxation. Subjective distress and heart rate variability was measured before and after the intervention. Results After the intervention, decreased levels of perceived stress and increased heart rate variability were reported compared with the control group. Discussion This study show that an integrated care model in a primary care setting is feasible and effective at improving stress management.

Cities are increasingly home to the world's population. Creating healthy and vibrant cities is one way to positively contribute to the health of populations. Parks and green spaces in cities contribute many health benefits. This case study explored the perceived health and well-being effects of access to Natural Area Parks in Edmonton, Canada through photovoice interviews with 33 participants. The research found the wild aspects of the parks of particular importance. Critically, the therapeutic value of the park emerged from the totality of the experience rather than from its individual components. Access to wilderness increased opportunities for relaxation, deep connection, and reflection.

Hintergrund: Zunehmende Evidenz weist auf positive Wirkungen der Meditation bei psychischen und korperlichen Symptomen hin. Ziel dieser national reprasentativen Umfrage war die Erhebung der Lebenszeitpravalenz und Punktpravalenz der Meditations-Praxis in Deutschland, der Grunde fur Meditation und der wahrgenommenen Veranderungen durch die Meditation. Methoden: In dieser national reprasentativen Umfrage mit 2'126 TeilnehmerInnen ab 14 Jahren wurde im April und Mai 2018 die derzeitige und fruhere Meditations-Praxis erhoben. Unterschiede zwischen soziodemographischen Subgruppen wurden mittels Chi-Quadrat-Tests analysiert. Ergebnisse: Die Lebenszeitpravalenz der Meditations-Praxis lag bei 15,1%, die Punkt-Pravalenz bei 6,6%. Eine hohere Pravalenz war assoziiert mit weiblichem Geschlecht (p < 0,001), erwerbsfahigem Alter (p = 0,015), Abitur/Hochschulabschluss (p = 0,002) und Berufs-tatigkeit (p = 0,027). Die durchschnittliche Dauer der Meditations-Praxis betrug 47,1 Monate. Die haufigsten Grunde zu meditieren waren Verbesserungen des geistigen Befindens (71,1%), der geistigen Leistungsfahigkeit (50,3%), bei regelmasig Meditierenden auch des korperlichen Befindens (59,3%). Positive Veranderungen durch die Meditations-Praxis berichteten 95,8%, insbesondere grosere Ausgeglichenheit, Entspannung und Wohlbefinden. Weitere 12,4% der aktuell nicht meditierenden Befragten konnten sich vorstellen, in den nachsten 12 Monaten mit Meditation zu beginnen. Auserdem praktizierten 5,6% der Befragten Yoga; 46,6% der aktuell Yoga Praktizierenden meditierten auch, und 39,0% der aktuell Meditierenden ubten auch Yoga. Schlussfolgerung: Geschatzte 15,7 Millionen Menschen in Deutschland meditieren aktuell oder sind daran interessiert, mit Meditation zu beginnen. Frauen und berufstatige Personen mit Abitur/Hochschulabschluss im erwerbsfahigen Alter meditieren haufiger. Uber 95% der Praktizierenden berichten positive Veranderungen durch die Meditation. BACKGROUND Increasing evidence suggests positive effects of meditation on mental and physical conditions. The aim of this nationally representative survey was to analyze prevalence and patterns of meditation use in Germany. METHODS In this nationally representative survey with 2,126 participants of at least 14 years of age conducted from April to May 2018, current and prior meditation use was assessed. Differences between sociodemographic subgroups were analyzed using chi squared tests. RESULTS Lifetime prevalence of meditation use was 15.1%, point prevalence 6.6%. Higher prevalence was associated with female gender (p < 0.001), age 20–59 years (p = 0.015), higher education (p = 0.002), and occupation (p = 0.027). Mean duration of meditation use was 47.1 months. The main reasons for meditation use were improved mental well-being (71.1%), mental capacity (50.3%), and (for regular meditation users) also physical well-being (50.3%). Positive changes due to meditation were reported by 95.8% of meditation users, mainly increased inner calmness, relaxation, and well-being. Another 12.4% of those who were not currently meditating could imagine starting meditation in the next 12 months. Further, 5.6% of participants used yoga; 46.6% of yoga users also used meditation; and 36.0% of meditation users also used yoga. CONCLUSIONS An estimated 15.7 million German individuals are currently using meditation or are at least interested in starting to meditate. More than 95% of meditation users report positive changes due to meditation.

Objectives We investigated the perceptions and experiences of a therapeutic yoga form, MediYoga, which is evolved from Kundaliniyoga among patients with symptomatic paroxysmal atrial fibrillation (PAF). Design and setting an inductive exploratory design was chosen with individual semi-structured interviews. The study was conducted with 12 participants (7 men and 5 women, average age 63.5) at a university hospital, Sweden. Informed consent was obtained from all participants. The data were analyzed using a qualitative content analysis with an inductive method and a manifest approach. Results Three categories were found in the analysis. In the category “A time for a sense of existence and presence”, the patients described an increased thoughtfulness and experiences of gaining access to an inner self. The category “A way of gaining well-being and increased consciousness” describes patients` feelings of relaxation and feeling of comfort, with components of mental and physical well-being. Furthermore, “Access to a tool to gain willpower and relieve symptoms” describes the perceptions from patients to obtained access to a tool for handling the emotions, such as fear and anxiety, as well as symptoms that they could struggling with between, and during, their episodes of atrial fibrillation. No adverse events were reported by the yoga group, during the study. Conclusions Patients with PAF described MediYoga as an accessible tool to manage emotions and symptoms related to episodes of AF. MediYoga may also assist in enhancing body awareness, whereby physical, mental and spiritual components are integrated. MediYoga may strengthen self-management among patients with PAF.

Omecamtiv mecarbil (OM) is a novel medicine for systolic heart failure, targeting myosin to enhance cardiomyocyte performance. To assist translation to clinical practice we investigated OMs effect on explanted human failing hearts, specifically; contractile dynamics, interaction with the β1–adrenoceptor (AR) agonist (−)‐noradrenaline and spontaneous contractions. Left and right ventricular trabeculae from 13 explanted failing hearts, and trabeculae from 58 right atrial appendages of non‐failing hearts, were incubated with or without a single concentration of OM for 120 min. Time to peak force (TPF) and 50% relaxation (t 50%) were recorded. In other experiments, trabeculae were observed for spontaneous contractions and cumulative concentration‐effect curves were established to (−)‐noradrenaline at β1‐ARs in the absence or presence of OM. OM prolonged TPF and t 50% in ventricular trabeculae (600 nM, 2 µM, p, In human failing ventricular trabeculae, omecamtiv mecarbil preserved contractile force over time, but produced concentration dependent increases in time to peak force and time to 50% relaxation. In the presence of omecamtiv mecarbil, (−)‐noradrenaline reversed the negative diastolic effects, but its potency remain unchanged.

This study combines electroencephalogram (EEG) with virtual reality (VR) technologies to measure the EEG responses of users experiencing changes to architectural elements. We analyze the ratio of alpha to beta waves (RAB) indicators to determine the pre- and poststimulation changes. In our methodology, thirty-three females experience using private rooms in a postpartum care center participated in the experiment. Their brain waves are measured while they are experiencing the VR space of a private room in a postpartum care center. Three architectural elements (i.e., aspect ratio of space, ceiling height, and window ratio) are varied in the VR space. In addition, a self-report questionnaire is administered to examine whether the responses are consistent with the results of the EEG response analysis. As a result, statistically significant differences (p &lt, 0.05) are observed in the changes in the RAB indicator values of the pre- and poststimulation EEG while the subjects are experiencing the VR space where the architectural elements are varied. That is, the effects of the changes to architectural elements on users’ relaxation-arousal responses are statistically verified. Notably, in all the RAB indicator values where significant differences are observed, the poststimulation RAB decreases in comparison to the prestimulus ratios, which is indicative of the arousal response. However, the arousal levels vary across the architectural elements, which implies it would be possible to find out the elements that could induce less arousal response using the proposed method. Moreover, following the experience in the VR space, certain lobes of the brain (F4 and P3 EEG channels) show statistically significant differences in the relaxation-arousal responses. Unlike previous studies, which measured users’ physiological responses to abstract and primordial spatial elements, this study extends the boundaries of the literature by applying the architectural elements applicable to design in practice.

Nidrâ yoga is an ancient yogic practice capable of inducing altered states of consciousness characterized by deep relaxation, strong concentration, acute self-awareness, and joy. In modern contemplative neuroscience language, it is known by the name yoga nidra, and few studies have investigated its phenomenological and psychophysiological effects. Six healthy volunteers (four females aged 31–74) performed 12 yoga nidra sessions guided by an expert during a 6-day retreat. Each session consisted of 10 minutes in a resting state (baseline) followed by 2 hours of yoga nidra. Psychometric data regarding dissociative experiences (Clinician Administered Dissociative States Scale) and the state of consciousness (Phenomenology of Consciousness Inventory) were collected after baseline and yoga nidra, while high-density EEG was recorded during the entire session. During nidra sessions, no sleep hallmarks (i.e., K-complexes and sleep spindles) were detected by the EEG in any subject. Psychometric data we re analyzed using a Wilcoxon signed-rank test corrected with the false discovery rate approach for multiple comparisons. Compared to baseline, yoga nidra practice was related to: (1) increased dissociative effects (p = 0.022); (2) perception of being in an altered state of consciousness (p = 0.026); (3) alterations in perceived body image (p = 0.022); (4) increased “meaningfulness” attributed to the experience (p = 0.026); (5) reduced rational thinking (p = 0.029); and (6) reduced volitional thought control (p = 0.026). First-person experience is discussed in relation to descriptive EEG power spectral density analysis, which was performed in one subject because of severe EEG artifacts in the other recordings; that subject showed, compared to baseline: (1) early increase of alpha and beta power, followed by a progressive widespread reduction; (2) widespread early increase of theta power, followed by a progressive reduction; and (3) widespread increase of gamma power in the latest stages. The present preliminary results enrich the knowledge of yoga nidra, elucidating its phenomenology and suggesting some psychophysiological correlates that future studies may address.

This study compared the effectiveness of a 12-day stress-prevention program (SGS) supplemented by individualized, structured, four-session telephone-coaching to that of an SGS without telephone-coaching in entrepreneurs from the green professions presenting with increased stress levels. All participants went through the SGS before being randomized either to the telephone-coaching group (TC) or to the control group without telephone-coaching (noTC). SGS included four key therapeutic elements: stress-management intervention, relaxation, physical exercise, and balneotherapy. The primary outcome was the current degree of subjectively experienced stress assessed with the Perceived Stress Questionnaire (PSQ) at a 9-month follow-up. Secondary outcomes included burnout symptoms, well-being, health status, sleep disorders, expectation of self-efficacy, depression, anxiety, ability to work, pain, and days of sick leave. Assessments were conducted at baseline, 12 days (end of program), and 1 (start telephone-coaching), 3, 6 (end of telephone-coaching), and 9 months. Data from 103 adults (TC = 51, noTC = 52), mostly fulltime farmers, were available for analysis (mean age: 55.3, 49.1% female). Participants experienced significant immediate improvement in all outcome measurements, which declined somewhat during the first three months after the end of SGS and then remained stable for at least another six months. While within-group changes from baseline to 9 months showed significant improvements at medium to large effect sizes for all target variables (PSQ-total, TC: &minus, 13.38 (&plusmn, 14.98), 95%-CI: (&minus, 17.68, &minus, 9.07), noTC: &minus, 11.09 (&plusmn, 14.15), 15.11, 7.07)), no statistically significant differences were found between the groups at any time and for any target variable (between-group ANCOVA for PSQ-total at 9 months, parameter estimator for the group: &minus, 1.58, 7.29, 4.13)). The stress-prevention program SGS is a feasible, effective, and practical way to reduce perceived stress and improve participants&rsquo, resources. Four subsequent telephone-coaching sessions do not seem to contribute to a further improvement in the results.

The aim of this pilot intervention study was to assess the effectiveness of selected forms of therapy (massage and relaxation) in reducing the perceived burden and improving the emotional status of caregivers of people with dementia and to determine which form of physical intervention is most effective. The study group was made up of 45 informal caregivers, who were divided into three subgroups (the massage group, relaxation group and control group). The Caregiver Burden Scale (CBS), Beck Depression Inventory (BDI), Berlin Social Support Scale (BSSS) and the Satisfaction with Life Scale (SWLS) were used. In the study group of caregivers, an average level of perceived burden, satisfactory life satisfaction and moderate severity of depressive symptoms were found. Massage led to a reduction in perceived burden and an improvement in mood and well-being of the examined group of caregivers. Group relaxation activities had no effect on the level of burden experienced by the caregivers, but significantly improved their mood. Both massage and relaxation were equally effective in improving the well-being of caregivers. Due to the lower cost of group activities, relaxation activities seem to be more effective and easier to organize, but further studies are necessary.

BACKGROUND: Worry increases risk for long-term health issues by prolonging the physiological stress response. In contrast, relaxation may ameliorate the psychological and physiological burden resulting from worry. This study examined the impact of experimentally induced worry and relaxation on cortisol, heart rate variability (HRV), and inflammation. METHOD: Participants (N = 75) completed both a worry and relaxation induction (presented in a fixed order) while HRV was collected continuously. Three blood samples were taken (at baseline, after the worry induction, and after the relaxation induction) to measure IL-6, IFN-γ, TNF-α and serum cortisol. RESULTS: There were significant changes in IL-6 (p < 0.001), IFN-γ (p < 0.001), HRV (p < .001), and cortisol (p < .001) but not in TNF-α (p = 0.19) across conditions. IFN-γ and HRV increased significantly from baseline to worry and then decreased following relaxation. IL-6 changed significantly between worry and relaxation and continued to increase following relaxation. Cortisol decreased significantly across conditions. Several patterns of covariance between inflammation and HRV and/or cortisol also emerged. CONCLUSIONS: These findings offer novel insight into how worry influences the immune system and emphasize the utility of a multi-methods approach to understanding the impact of worry on physical health.