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12 results on '"Plotti F."'

1. Prenatal genetic diagnosis: fetal therapy as a possible solution to a positive test

Author

Kiani, A. K., Paolacci, S., Scanzano, P., Michelini, S., Capodicasa, N., D'Agruma, L., Notarangelo, A., Tonini, G., Piccinelli, D., Farshid, K. R., Petralia, P., Fulcheri, E., Buffelli, F., Chiurazzi, P., Terranova, C., Plotti, F., Angioli, R., Castori, M., Pos, O., Szemes, T., and Bertelli, M.

Subjects
prenatal gene therapy, Fetal Therapies, prenatal diagnosis, prenatal stem cell therapy, Pregnancy, fetal drug therapy, Humans, Original Article, Female, prenatal interventions, Aneuploidy, Hernias, Diaphragmatic, Congenital, Fetal drug therapy, Prenatal diagnosis, Prenatal gene therapy, Prenatal interventions, Prenatal stem cell therapy
Abstract

Background: Fetal abnormalities cause 20% of perinatal deaths. Advances in prenatal genetic and other types of screening offer great opportunities for identifying high risk pregnancies. Methods: Through a literature search, here we summarise what are the prenatal diagnostic technique that are being used and how those techniques may allow for prenatal interventions. Results: Next generation sequencing and non-invasive prenatal testing are fundamental for clinical diagnostics because of their sensitivity and accuracy in identifying point mutations, aneuploidies, and microdeletions, respectively. Timely identification of genetic disorders and other fetal abnormalities enables early intervention, such as in-utero gene therapy, fetal drug therapy and prenatal surgery. Conclusion: Prenatal intervention is mainly focused on conditions that may cause death or lifelong disabilities, like spina bifida, congenital diaphragm hernia and sacrococcygeal teratoma; and may be an alternative therapeutic option to termination of pregnancy. However, it is not yet widely available, due to lack of specialized centers. (www.actabiomedica.it)

Published
2020

2. Gynecological cancers in developing countries: the challenge of chemotherapy in low-resources setting

Author

Basile, Stefano, Angioli, R., Manci, N., Palaia, Innocenza, Plotti, F., Panici, P. B., and BENEDETTI PANICI, Pierluigi

Subjects
medicine.medical_specialty, Cyclophosphamide, Genital Neoplasms, Female, medicine.medical_treatment, Medically Underserved Area, Antineoplastic Agents, chemotherapy, medicine, Humans, Intensive care medicine, developing countries, gynecological cancer, Cervical cancer, Vaginal cancer, Chemotherapy, business.industry, Endometrial cancer, Obstetrics and Gynecology, Cancer, medicine.disease, Surgery, Oncology, Health Resources, Female, business, Ovarian cancer, Developed country, medicine.drug
Abstract

The epidemiologic pattern of cancers in developing countries differs in many aspects from that of industrialized nations. Cancer natural history, microbiologic environment, patient's immune system, and drug availability may differ as well. Four of five new cases of cervical cancer and most of cervical cancer deaths occur in developing countries. Where chemoradiation and supportive care facilities are unavailable, it would be logical to consider an inexpensive effective drug. In locally advanced cases, neoadjuvant chemotherapy followed by surgery should be considered the treatment of choice. For ovarian cancer, it may be reasonable to maintain a secure supply of platinum and/or taxanes. For endometrial cancer, platinum compounds are proved active chemotherapic single agents. Oral medroxyprogesterone acetate (MPA) may represent a good chance for treating an advanced or recurrent disease. For vulvar/vaginal cancer, the role of chemotherapy alone is currently considered limited, and it is mostly used as palliative treatment in advanced or recurrent cases. Whenever possible, standard western chemotherapic regimens should be applied in developing countries as well. When standard therapies are unavailable, drugs of choice should be easily accessible, inexpensive, and effective. The most commonly used drugs are cisplatin, cyclophosphamide, and MPA.

Published
2006

3. [Vulvovaginal candidiasis: a therapeutic approach]

Author

Battaglia, F., Mariani, L., Anglana, F., Milite, V., Quattrini, M., Plotti, F., Tomao, Federica, Plotti, G. R., and Gineco, Minerva

Subjects
Antifungal Agents, Boric Acids, Candida albicans, candidiasis, vulvo-vaginal infection. therapy, Humans, Female, Candidiasis, Vulvovaginal
Abstract

The vulvovaginal candidiasis represents, after the bacterial vaginosis, the most frequent cause of vaginal affection. It is esteemed that around the 75% of the women of reproductive age suffered from an episode of vulvovaginitis from candida and 40-45% have had more episodes, of which 10-20% in complicated form. The kind of candida more frequently isolated in the vagina of symptomatic women is the Candida albicans: in the 10-20% of the cases the agent is present in absence of symptomatology, and we can almost consider it a saprophytic. On the other hand, always with greater frequency fetterses can be isolated of not albicans Candida, particularly the tropicalis and the glabrata kind, usually resistant to the common therapies. The classification of the vulvovaginal candidiasis proposed by Sobel, and by now universally approved, foresees 2 clinical forms of vulvovaginal candidiasis, the vulvovaginitis from not complicated candida (VVC) and the vulvovaginitis from complicated candida (VVCC): different for pathogenesis, elapsed clinical, symptomatology and frequency. They have to be considered in the substance 2 different nosological entities, and they request a diagnostic approach and a well different therapeutic appointment. In this study we will shortly reassume the principal characteristics of it, detaining us on the most recent acquisitions in theme of therapy. The base medicines of ac. boric, to parity of effectiveness, seem to introduce the most contained cost and the best compliance, and they offer him to a complementary use or, in some cases, alternative to the more you consolidate therapies with azoli.

Published
2005

4. Factors predicting morbidity in surgically-staged high-risk endometrial cancer patients

Author

Francesco Raspagliesi, Anna Myriam Perrone, Alessandro Buda, Daniela Luvero, Maria Luisa Gasparri, Giorgio Bogani, Fabio Barra, Fabio Ghezzi, Andrea Papadia, Michael D. Mueller, Pierluigi Benedetti Panici, Francesco Plotti, Antonella Cromi, Innocenza Palaia, Simone Ferrero, Roberto Angioli, Fabio Landoni, Violante Di Donato, Ciro Pinelli, Ludovico Muzii, Jvan Casarin, Alice Indini, Chiara Cimmino, Pierandrea De Iaco, Giampaolo Di Martino, Bogani G., Papadia A., Buda A., Casarin J., Di Donato V., Plotti F., Gasparri M.L., Cimmino C., Pinelli C., Perrone A.M., Barra F., Cromi A., Di Martino G., Palaia I., Ferrero S., Indini A., De Iaco P., Angioli R., Luvero D., Muzii L., Ghezzi F., Landoni F., Mueller M.D., Benedetti Panici P., Raspagliesi F., Bogani, G, Papadia, A, Buda, A, Casarin, J, Di Donato, V, Plotti, F, Gasparri, M, Cimmino, C, Pinelli, C, Perrone, A, Barra, F, Cromi, A, Di Martino, G, Palaia, I, Ferrero, S, Indini, A, De Iaco, P, Angioli, R, Luvero, D, Muzii, L, Ghezzi, F, Landoni, F, Mueller, M, Benedetti Panici, P, and Raspagliesi, F

Subjects
medicine.medical_specialty, Multivariate analysis, medicine.medical_treatment, Endometrium, Endometrial cancer, Retrospective Studie, Humans, Medicine, 610 Medicine & health, Retrospective Studies, Sentinel node mapping, business.industry, endometrial cancer, lymphadenectomy, morbidity, sentinel node mapping, endometrium, female, humans, lymph node excision, retrospective studies, endometrial neoplasms, Obstetrics and Gynecology, Lymphadenectomy, Retrospective cohort study, Sentinel node, medicine.disease, Endometrial Neoplasms, Surgery, Reproductive Medicine, Lymph Node Excision, Female, Morbidity, business, Complication, Body mass index, Human, Abdominal surgery
Abstract

OBJECTIVE To investigate factors predicting the risk of developing 90-day postoperative complications and lymphatic-specific morbidity in patients undergoing surgical staging for high-risk endometrial cancer. METHODS This is a multi-institutional retrospective cohort study. Patients affected by apparent early-stage high-risk endometrial cancer (endometrioid FIGO grade 3 with deep myometrial invasion and non-endometrioid endometrial cancer) undergoing surgical staging between 2007 and 2019. Complications were graded according to the Clavien-Dindo classification system. Martin criteria were applied to improve quality of complications reporting. RESULTS Charts of 279 patients were evaluated. Lymphadenectomy, sentinel node mapping (SNM), and SNM followed by back-up lymphadenectomy were performed in 83 (29.7%), 50 (17.9%), and 146 (52.4%) patients, respectively. The former group of patients included 13 patients who had lymphadenectomy after the failure of the SNM technique. Thirteen (4.6%) patients developed severe postoperative events (grade 3 or worse). At multivariate analysis, body mass index (OR: 1.08 (95%CI: 1.01, 1.17)) and open abdominal surgery (OR: 2.27 (95%CI: 1.02, 5.32)) were the two independent factors predictive of surgery-related morbidity. Seven severe lymphatic complications occurred. The adoption of laparoscopic approach (p��

Published
2021

5. Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic

Author

Giorgio Bogani, Giovanni Scambia, Chiara Cimmino, Francesco Fanfani, Barbara Costantini, Matteo Loverro, Gabriella Ferrandina, Fabio Landoni, Luca Bazzurini, Tommaso Grassi, Domenico Vitobello, Gabriele Siesto, Anna Myriam Perrone, Vanna Zanagnolo, Pierandrea De Iaco, Francesco Multinu, Fabio Ghezzi, Jvan Casarin, Roberto Berretta, Vito A Capozzi, Errico Zupi, Gabriele Centini, Antonio Pellegrino, Silvia Corso, Guido Stevenazzi, Serena Montoli, Anna Chiara Boschi, Giuseppe Comerci, Pantaleo Greco, Ruby Martinello, Francesco Sopracordevole, Giorgio Giorda, Tommaso Simoncini, Marta Caretto, Enrico Sartori, Federico Ferrari, Antonio Cianci, Giuseppe Sarpietro, Maria Grazia Matarazzo, Fulvio Zullo, Giuseppe Bifulco, Michele Morelli, Annamaria Ferrero, Nicoletta Biglia, Fabio Barra, Simone Ferrero, Umberto Leone Roberti Maggiore, Stefano Cianci, Vito Chiantera, Alfredo Ercoli, Giulio Sozzi, Angela Martoccia, Sergio Schettini, Teresa Orlando, Francesco G Cannone, Giuseppe Ettore, Andrea Puppo, Martina Borghese, Canio Martinelli, Ludovico Muzii, Violante Di Donato, Lorenza Driul, Stefano Restaino, Alice Bergamini, Giorgio Candotti, Luca Bocciolone, Francesco Plotti, Roberto Angioli, Giulia Mantovani, Marcello Ceccaroni, Chiara Cassani, Mattia Dominoni, Laura Giambanco, Silvia Amodeo, Livio Leo, Raphael Thomasset, Diego Raimondo, Renato Seracchioli, Mario Malzoni, Franco Gorlero, Martina Di Luca, Enrico Busato, Sami Kilzie, Andrea Dell'Acqua, Giovanna Scarfone, Paolo Vercellini, Marco Petrillo, Salvatore Dessole, Giampiero Capobianco, Andrea Ciavattini, Giovanni Delli Carpini, Luca Giannella, Liliana Mereu, Saverio Tateo, Flavia Sorbi, Massimiliano Fambrini, Stefania Cicogna, Federico Romano, Giuseppe Ricci, Giuseppe Trojano, Roberto Consonni, Simona Cantaluppi, Antonio Lippolis, Raffaele Tinelli, Giovanni D'Ippolito, Lorenzo Aguzzoli, Vincenzo D Mandato, Stefano Palomba, Davide Calandra, Maurizio Rosati, Cinzia Gallo, Daniela Surico, Valentino Remorgida, Francesco Ruscitto, Paolo Beretta, Pierluigi Benedetti Panici, Francesco Raspagliesi, Bogani G., Scambia G., Cimmino C., Fanfani F., Costantini B., Loverro M., Ferrandina G., Landoni F., Bazzurini L., Grassi T., Vitobello D., Siesto G., Perrone A.M., Zanagnolo V., De Iaco P., Multinu F., Ghezzi F., Casarin J., Berretta R., Capozzi V.A., Zupi E., Centini G., Pellegrino A., Corso S., Stevenazzi G., Montoli S., Boschi A.C., Comerci G., Greco P., Martinello R., Sopracordevole F., Giorda G., Simoncini T., Caretto M., Sartori E., Ferrari F., Cianci A., Sarpietro G., Matarazzo M.G., Zullo F., Bifulco G., Morelli M., Ferrero A., Biglia N., Barra F., Ferrero S., Maggiore U.L.R., Cianci S., Chiantera V., Ercoli A., Sozzi G., Martoccia A., Schettini S., Orlando T., Cannone F.G., Ettore G., Puppo A., Borghese M., Martinelli C., Muzii L., Di Donato V., Driul L., Restaino S., Bergamini A., Candotti G., Bocciolone L., Plotti F., Angioli R., Mantovani G., Ceccaroni M., Cassani C., Dominoni M., Giambanco L., Amodeo S., Leo L., Thomasset R., Raimondo D., Seracchioli R., Malzoni M., Gorlero F., Di Luca M., Busato E., Kilzie S., Dell'acqua A., Scarfone G., Vercellini P., Petrillo M., Dessole S., Capobianco G., Ciavattini A., Delli Carpini G., Giannella L., Mereu L., Tateo S., Sorbi F., Fambrini M., Cicogna S., Romano F., Ricci G., Trojano G., Consonni R., Cantaluppi S., Lippolis A., Tinelli R., D'ippolito G., Aguzzoli L., Mandato V.D., Palomba S., Calandra D., Rosati M., Gallo C., Surico D., Remorgida V., Ruscitto F., Beretta P., Panici P.B., Raspagliesi F., Bogani, Giorgio, Scambia, Giovanni, Cimmino, Chiara, Fanfani, Francesco, Costantini, Barbara, Loverro, Matteo, Ferrandina, Gabriella, Landoni, Fabio, Bazzurini, Luca, Grassi, Tommaso, Vitobello, Domenico, Siesto, Gabriele, Perrone, Anna Myriam, Zanagnolo, Vanna, De Iaco, Pierandrea, Multinu, Francesco, Ghezzi, Fabio, Casarin, Jvan, Berretta, Roberto, Capozzi, Vito A, Zupi, Errico, Centini, Gabriele, Pellegrino, Antonio, Corso, Silvia, Stevenazzi, Guido, Montoli, Serena, Boschi, Anna Chiara, Comerci, Giuseppe, Greco, Pantaleo, Martinello, Ruby, Sopracordevole, Francesco, Giorda, Giorgio, Simoncini, Tommaso, Caretto, Marta, Sartori, Enrico, Ferrari, Federico, Cianci, Antonio, Sarpietro, Giuseppe, Matarazzo, Maria Grazia, Zullo, Fulvio, Bifulco, Giuseppe, Morelli, Michele, Ferrero, Annamaria, Biglia, Nicoletta, Barra, Fabio, Ferrero, Simone, Leone Roberti Maggiore, Umberto, Cianci, Stefano, Chiantera, Vito, Ercoli, Alfredo, Sozzi, Giulio, Martoccia, Angela, Schettini, Sergio, Orlando, Teresa, Cannone, Francesco G, Ettore, Giuseppe, Puppo, Andrea, Borghese, Martina, Martinelli, Canio, Muzii, Ludovico, Di Donato, Violante, Driul, Lorenza, Restaino, Stefano, Bergamini, Alice, Candotti, Giorgio, Bocciolone, Luca, Plotti, Francesco, Angioli, Roberto, Mantovani, Giulia, Ceccaroni, Marcello, Cassani, Chiara, Dominoni, Mattia, Giambanco, Laura, Amodeo, Silvia, Leo, Livio, Thomasset, Raphael, Raimondo, Diego, Seracchioli, Renato, Malzoni, Mario, Gorlero, Franco, Di Luca, Martina, Busato, Enrico, Kilzie, Sami, Dell'Acqua, Andrea, Scarfone, Giovanna, Vercellini, Paolo, Petrillo, Marco, Dessole, Salvatore, Capobianco, Giampiero, Ciavattini, Andrea, Delli Carpini, Giovanni, Giannella, Luca, Mereu, Liliana, Tateo, Saverio, Sorbi, Flavia, Fambrini, Massimiliano, Cicogna, Stefania, Romano, Federico, Ricci, Giuseppe, Trojano, Giuseppe, Consonni, Roberto, Cantaluppi, Simona, Lippolis, Antonio, Tinelli, Raffaele, D'Ippolito, Giovanni, Aguzzoli, Lorenzo, Mandato, Vincenzo D, Palomba, Stefano, Calandra, Davide, Rosati, Maurizio, Gallo, Cinzia, Surico, Daniela, Remorgida, Valentino, Ruscitto, Francesco, Beretta, Paolo, Benedetti Panici, Pierluigi, Raspagliesi, Francesco, Bogani, G., Scambia, G., Cimmino, C., Fanfani, F., Costantini, B., Loverro, M., Ferrandina, G., Landoni, F., Bazzurini, L., Grassi, T., Vitobello, D., Siesto, G., Perrone, A. M., Zanagnolo, V., De Iaco, P., Multinu, F., Ghezzi, F., Casarin, J., Berretta, R., Capozzi, V. A., Zupi, E., Centini, G., Pellegrino, A., Corso, S., Stevenazzi, G., Montoli, S., Boschi, A. C., Comerci, G., Greco, P., Martinello, R., Sopracordevole, F., Giorda, G., Simoncini, T., Caretto, M., Sartori, E., Ferrari, F., Cianci, A., Sarpietro, G., Matarazzo, M. G., Zullo, F., Bifulco, G., Morelli, M., Ferrero, A., Biglia, N., Barra, F., Ferrero, S., Leone Roberti Maggiore, U., Cianci, S., Chiantera, V., Ercoli, A., Sozzi, G., Martoccia, A., Schettini, S., Orlando, T., Cannone, F. G., Ettore, G., Puppo, A., Borghese, M., Martinelli, C., Muzii, L., Di Donato, V., Driul, L., Restaino, S., Bergamini, A., Candotti, G., Bocciolone, L., Plotti, F., Angioli, R., Mantovani, G., Ceccaroni, M., Cassani, C., Dominoni, M., Giambanco, L., Amodeo, S., Leo, L., Thomasset, R., Raimondo, D., Seracchioli, R., Malzoni, M., Gorlero, F., Di Luca, M., Busato, E., Kilzie, S., Dell'Acqua, A., Scarfone, G., Vercellini, P., Petrillo, M., Dessole, S., Capobianco, G., Ciavattini, A., Delli Carpini, G., Giannella, L., Mereu, L., Tateo, S., Sorbi, F., Fambrini, M., Cicogna, S., Romano, F., Ricci, G., Trojano, G., Consonni, R., Cantaluppi, S., Lippolis, A., Tinelli, R., D'Ippolito, G., Aguzzoli, L., Mandato, V. D., Palomba, S., Calandra, D., Rosati, M., Gallo, C., Surico, D., Remorgida, V., Ruscitto, F., Beretta, P., Benedetti Panici, P., Raspagliesi, F., Bogani, G, Scambia, G, Cimmino, C, Fanfani, F, Costantini, B, Loverro, M, Ferrandina, G, Landoni, F, Bazzurini, L, Grassi, T, Vitobello, D, Siesto, G, Perrone, A, Zanagnolo, V, De Iaco, P, Multinu, F, Ghezzi, F, Casarin, J, Berretta, R, Capozzi, V, Zupi, E, Centini, G, Pellegrino, A, Corso, S, Stevenazzi, G, Montoli, S, Boschi, A, Comerci, G, Greco, P, Martinello, R, Sopracordevole, F, Giorda, G, Simoncini, T, Caretto, M, Sartori, E, Ferrari, F, Cianci, A, Sarpietro, G, Matarazzo, M, Zullo, F, Bifulco, G, Morelli, M, Ferrero, A, Biglia, N, Barra, F, Ferrero, S, Leone Roberti Maggiore, U, Cianci, S, Chiantera, V, Ercoli, A, Sozzi, G, Martoccia, A, Schettini, S, Orlando, T, Cannone, F, Ettore, G, Puppo, A, Borghese, M, Martinelli, C, Muzii, L, Di Donato, V, Driul, L, Restaino, S, Bergamini, A, Candotti, G, Bocciolone, L, Plotti, F, Angioli, R, Mantovani, G, Ceccaroni, M, Cassani, C, Dominoni, M, Giambanco, L, Amodeo, S, Leo, L, Thomasset, R, Raimondo, D, Seracchioli, R, Malzoni, M, Gorlero, F, Di Luca, M, Busato, E, Kilzie, S, Dell'Acqua, A, Scarfone, G, Vercellini, P, Petrillo, M, Dessole, S, Capobianco, G, Ciavattini, A, Delli Carpini, G, Giannella, L, Mereu, L, Tateo, S, Sorbi, F, Fambrini, M, Cicogna, S, Romano, F, Ricci, G, Trojano, G, Consonni, R, Cantaluppi, S, Lippolis, A, Tinelli, R, D'Ippolito, G, Aguzzoli, L, Mandato, V, Palomba, S, Calandra, D, Rosati, M, Gallo, C, Surico, D, Remorgida, V, Ruscitto, F, Beretta, P, Benedetti Panici, P, Raspagliesi, F, Maggiore, U. L. R., and Panici, P. B.

Subjects
medicine.medical_specialty, endometrial neoplasms, Coronavirus disease 2019 (COVID-19), Endometrial Cancer, COVID-19, Uterine cancer, SARS-CoV-2, covid-19, endometrial cancer, sars-cov-2, uterine cancer, female, humans, pandemics, retrospective studies, NO, Retrospective Studie, Pandemic, medicine, Patterns of care, Obstetrics, business.industry, Endometrial cancer, Obstetrics and Gynecology, General Medicine, medicine.disease, Endometrial Neoplasms, Settore MED/40 - GINECOLOGIA E OSTETRICIA, Oncology, Original Article, Female, business, Human
Abstract

Objective Coronavirus disease 2019 (COVID-19) outbreak has correlated with the disruption of screening activities and diagnostic assessments. Endometrial cancer (EC) is one of the most common gynecological malignancies and it is often detected at an early stage, because it frequently produces symptoms. Here, we aim to investigate the impact of COVID-19 outbreak on patterns of presentation and treatment of EC patients. Methods This is a retrospective study involving 54 centers in Italy. We evaluated patterns of presentation and treatment of EC patients before (period 1: March 1, 2019 to February 29, 2020) and during (period 2: April 1, 2020 to March 31, 2021) the COVID-19 outbreak. Results Medical records of 5,164 EC patients have been retrieved: 2,718 and 2,446 women treated in period 1 and period 2, respectively. Surgery was the mainstay of treatment in both periods (p=0.356). Nodal assessment was omitted in 689 (27.3%) and 484 (21.2%) patients treated in period 1 and 2, respectively (p, Synopsis The prevalence of patients with early-stage endometrial cancer (EC) has been lower during coronavirus disease 2019 (COVID-19) pandemic than before its onset. Further evidence is needed to assess the impact of COVID-19 pandemic on survival outcomes of EC patients.

Published
2022

6. Sentinel node mapping vs. sentinel node mapping plus back-up lymphadenectomy in high-risk endometrial cancer patients: Results from a multi-institutional study

Author

Simone Ferrero, Valentina Chiapp, Francesco Raspagliesi, Maria Luisa Gasparri, Violante Di Donato, Ciro Pinelli, Pierandrea De Iaco, Salvatore Lopez, Debora Ferrari, Maria Chiara Paderno, Mauro Signorelli, Jvan Casarin, Andrea Papadia, Claudia Brusadelli, Pierluigi Benedetti Panici, Antonella Cromi, Alessandro Buda, Innocenza Palaia, Michael D. Mueller, Anna Myriam Perrone, Fabio Barra, Giorgio Bogani, Fabio Ghezzi, Umberto Maggiore, Fabio Landoni, Francesco Plotti, Roberto Angioli, Antonino Ditto, Rocco Guerrisi, Bogani, G, Papadia, A, Buda, A, Casarin, J, Di Donato, V, Gasparri, M, Plotti, F, Pinelli, C, Paderno, M, Lopez, S, Perrone, A, Barra, F, Guerrisi, R, Brusadelli, C, Cromi, A, Ferrari, D, Chiapp, V, Signorelli, M, Maggiore, U, Ditto, A, Palaia, I, Ferrero, S, De Iaco, P, Angioli, R, Panici, P, Ghezzi, F, Landoni, F, Mueller, M, Raspagliesi, F, Bogani G., Papadia A., Buda A., Casarin J., Di Donato V., Gasparri M.L., Plotti F., Pinelli C., Paderno M.C., Lopez S., Perrone A.M., Barra F., Guerrisi R., Brusadelli C., Cromi A., Ferrari D., Chiapp V., Signorelli M., Maggiore U.L.R., Ditto A., Palaia I., Ferrero S., De Iaco P., Angioli R., Panici P.B., Ghezzi F., Landoni F., Mueller M.D., and Raspagliesi F.

Subjects
survival rate, 0301 basic medicine, medicine.medical_specialty, endometrial neoplasms, Staging, disease-free survival, Survival, medicine.medical_treatment, lymph node excision, Nodal disease, 03 medical and health sciences, sentinel lymph node, 0302 clinical medicine, Endometrial cancer, lymph nodes, middle aged, 80 and over, medicine, Overall survival, risk factors, humans, neoplasm staging, sentinel lymph node biopsy, 610 Medicine & health, Aged, 80 and over, business.industry, adult, Obstetrics and Gynecology, Small sample, Retrospective cohort study, Lymphadenectomy, Sentinel node, medicine.disease, aged, retrospective studies, female, 030104 developmental biology, endometrial cancer, lymphadenectomy, sentinel node, staging, survival, Oncology, 030220 oncology & carcinogenesis, Population study, Radiology, business
Abstract

OBJECTIVE Sentinel node mapping (SLN) has replaced lymphadenectomy for staging surgery in apparent early-stage low and intermediate risk endometrial cancer (EC). Only limited data about the adoption of SNM in high risk EC is still available. Here, we evaluate the outcomes of high-risk EC undergoing SNM (with or without back-up lymphadenectomy). METHODS This is a multi-institutional international retrospective study, evaluating data of high-risk (FIGO grade 3 endometrioid EC with myometrial invasion >50% and non-endometrioid histology) EC patients undergoing SNM followed by back-up lymphadenectomy and SNM alone. RESULTS Chart of consecutive 196 patients were evaluated. The study population included 83 and 113 patients with endometrioid and non-endometrioid EC, respectively. SNM alone and SNM followed by back-up lymphadenectomy were performed in 50 and 146 patients, respectively. Among patients having SNM alone, 14 (28%) were diagnosed with nodal disease. In the group of patients undergoing SNM plus back-up lymphadenectomy 34 (23.2%) were diagnosed with nodal disease via SNM. Back-up lymphadenectomy identified 2 (1%) additional patients with nodal disease (in the para-aortic area). Back-up lymphadenectomy allowed to remove adjunctive positive nodes in 16 (11%) patients. After the adoption of propensity-matched algorithm, we observed that patients undergoing SNM plus back-up lymphadenectomy experienced similar disease-free survival (p��=��0.416, log-rank test) and overall survival (p��=��0.940, log-rank test) than patients undergoing SLN alone. CONCLUSIONS Although the small sample size, and the retrospective study design this study highlighted that type of nodal assessment did not impact survival outcomes in high-risk EC. Theoretically, back-up lymphadenectomy would be useful in improving the removal of positive nodes, but its therapeutic value remains controversial. Further prospective evidence is needed.

Published
2021

7. High-risk HPV-positive and -negative high-grade cervical dysplasia: Analysis of 5-year outcomes

Author

Giovanni Scambia, Mario Malzoni, Lavinia Mosca, Lorenzo Aguzzoli, Nicola Colacurci, Gabriele Carlinfante, Marco Petrillo, Stefano Greggi, Paolo Vercellini, Antonio Cianci, Francesco Raspagliesi, Andrea Giannini, Andrea Ciavattini, Viola Liberale, Sara Bosio, Luca Giannella, Maurizio Serati, Rocco Guerrisi, Simone Ferrero, Michele Desiato, Pierandrea De Iaco, Anna Myriam Perrone, Giorgio Bogani, Fabio Ghezzi, Biagio Contino, Francesca Falcone, Arsenio Spinillo, Francesco Sopracordevole, Claudia Brusadelli, Antonio Simone Laganà, Simona Ruisi, Maria Grazia Matarazzo, Pierluigi Benedetti Panici, Paola Carunchio, Giuseppe Sarpietro, Alessandro Ghelardi, Barbara Gardella, Francesco Plotti, Alice Bergamini, Margherita Fischetti, Antonino Ditto, Gian Franco Zannoni, Gabriella Ferrandina, Vincenzo Dario Mandato, Valentina Chiappa, Violante Di Donato, Raffaele Tinelli, Ermelinda Monti, Roberto Angioli, Salvatore Dessole, Annunziata Carlea, Ciro Pinelli, Fulvio Zullo, Salvatore Lopez, Sara Lovati, Tommaso Simoncini, Maria Giovanna Salerno, Mauro Signorelli, Rosa De Vincenzo, Cono Scaffa, Jvan Casarin, Chiara Borghi, Cristina Donfrancesco, Ludovico Muzii, Giovanni D'ippolito, Gaetano Valenti, Andrea Dell'Acqua, Giulia Dondi, Bogani, G., Sopracordevole, F., Di Donato, V., Ciavattini, A., Ghelardi, A., Lopez, S., Simoncini, T., Plotti, F., Casarin, J., Serati, M., Pinelli, C., Valenti, G., Bergamini, A., Gardella, B., Dell'Acqua, A., Monti, E., Vercellini, P., Fischetti, M., D'Ippolito, G., Aguzzoli, L., Mandato, V. D., Carunchio, P., Carlinfante, G., Giannella, L., Scaffa, C., Falcone, F., Borghi, C., Ditto, A., Malzoni, M., Giannini, A., Salerno, M. G., Liberale, V., Contino, B., Donfrancesco, C., Desiato, M., Perrone, A. M., Dondi, G., De Iaco, P., Chiappa, V., Ferrero, S., Sarpietro, G., Matarazzo, M. G., Cianci, A., Bosio, S., Ruisi, S., Guerrisi, R., Brusadelli, C., Mosca, L., Lagana', A. S., Tinelli, R., Signorelli, M., De Vincenzo, R., Zannoni, G. F., Ferrandina, G., Lovati, S., Petrillo, M., Dessole, S., Carlea, A., Zullo, F., Angioli, R., Greggi, S., Spinillo, A., Ghezzi, F., Colacurci, N., Muzii, L., Benedetti Panici, P., Scambia, G., Raspagliesi, F., Bogani G., Sopracordevole F., Di Donato V., Ciavattini A., Ghelardi A., Lopez S., Simoncini T., Plotti F., Casarin J., Serati M., Pinelli C., Valenti G., Bergamini A., Gardella B., Dell'acqua A., Monti E., Vercellini P., Fischetti M., D'ippolito G., Aguzzoli L., Mandato V.D., Carunchio P., Carlinfante G., Giannella L., Scaffa C., Falcone F., Borghi C., Ditto A., Malzoni M., Giannini A., Salerno M.G., Liberale V., Contino B., Donfrancesco C., Desiato M., Perrone A.M., Dondi G., De Iaco P., Chiappa V., Ferrero S., Sarpietro G., Matarazzo M.G., Cianci A., Bosio S., Ruisi S., Guerrisi R., Brusadelli C., Mosca L., Lagana' A.S., Tinelli R., Signorelli M., De Vincenzo R., Zannoni G.F., Ferrandina G., Lovati S., Petrillo M., Dessole S., Carlea A., Zullo F., Angioli R., Greggi S., Spinillo A., Ghezzi F., Colacurci N., Muzii L., Benedetti Panici P., Scambia G., and Raspagliesi F.

Subjects
0301 basic medicine, Adult, medicine.medical_specialty, HPV, Uterine Cervical Neoplasm, Prognosi, CIN, conization, negative, positive, Conization, Uterine Cervical Neoplasms, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Risk Factors, Retrospective Studie, medicine, Humans, Cervical Intraepithelial Neoplasia, Prospective cohort study, Propensity Score, Papillomavirus Infection, Retrospective Studies, Obstetrics, Proportional hazards model, business.industry, Risk Factor, Papillomavirus Infections, Obstetrics and Gynecology, Retrospective cohort study, Middle Aged, Prognosis, medicine.disease, Negative, Uterine Cervical Dysplasia, female genital diseases and pregnancy complications, 030104 developmental biology, Settore MED/40 - GINECOLOGIA E OSTETRICIA, Oncology, Dysplasia, 030220 oncology & carcinogenesis, Cohort, Propensity score matching, Population study, Female, business, Positive, Cohort study, Human
Abstract

Objective: To evaluate the outcomes of high-risk (HR) HPV-positive and -negative women affected by high-grade cervical dysplasia. Methods: This is a retrospective multi-institutional study. Medical records of consecutive patients with high-grade cervical dysplasia undergoing conization between 2010 and 2014 were retrieved. All patients included had at least 5 years of follow-up. A propensity-score matching was adopted in order to reduce the presence of confounding factors between groups. Kaplan-Meir and Cox hazard models were used to estimate 5-year outcomes. Results: Overall, data of 2966 women, affected by high-grade cervical dysplasia were reviewed. The study population included 1478 (85%) and 260 (15%) women affected by HR-HPV-positive and HR-HPV-negative high-grade cervical dysplasia. The prevalence of CIN2 and CIN3 among the HR-HPV-positive and -negative cohort was similar (p = 0.315). Patients with HR-HPV-positive high-grade cervical dysplasia were at higher risk of 5-year recurrence (after primary conization) that HR-HPV-negative patients (p < 0.001, log-rank test). Via multivariate analysis, HR-HPV-negative women were at low risk of recurrence (HR: 1.69 (95%CI: 1.05, 4.80); p = 0.018, Cox Hazard model). A propensity-score matched comparison was carried out in order to reduce biases that are related to the retrospective study design. In comparison to HR-HPV-negative patients, thosewith HR-HPV-positive CIN3 was associate with a 8-fold increase in the risk of recurrence (p < 0.001, log-rank test). Conclusions: HR-HPV-negative high-grade cervical dysplasia is not uncommon, accounting for 15% of our study population. Those patients experience more favorable outcomes than patients with documented HR-HPV infection(s). Further prospective studies are needed to corroborate our data.

Published
2021

8. Recurrence rate after loop electrosurgical excision procedure (LEEP) and laser Conization: A 5-year follow-up study

Author

Giuseppe Sarpietro, Giovanni D'ippolito, Gabriele Carlinfante, Marco Petrillo, Claudia Brusadelli, Paola Carunchio, Maria Giovanna Salerno, Cono Scaffa, Arsenio Spinillo, Francesco Sopracordevole, Gian Franco Zannoni, Violante Di Donato, Francesco Plotti, Viola Liberale, Francesco Raspagliesi, Giovanni Scambia, Fabio Ghezzi, Antonino Ditto, Simona Ruisi, Michele Desiato, Ermelinda Monti, Valentina Chiappa, Pierandrea De Iaco, Stefano Greggi, Francesca Falcone, Lorenzo Aguzzoli, Roberto Angioli, Salvatore Dessole, Paolo Vercellini, Antonio Cianci, Gaetano Valenti, Giulia Dondi, Luca Giannella, Maurizio Serati, Andrea Giannini, Sara Bosio, Margherita Fischetti, Raffaele Tinelli, Tommaso Simoncini, Cristina Donfrancesco, Ludovico Muzii, Nicola Colacurci, Alessandro Ghelardi, Andrea Dell'Acqua, Ciro Pinelli, Salvatore Lopez, Rocco Guerrisi, Giorgio Bogani, Mauro Signorelli, Rosa De Vincenzo, Jvan Casarin, Pierluigi Benedetti Panici, Andrea Ciavattini, Lavinia Mosca, Umberto Leone Roberti Maggiore, Biagio Contino, Barbara Gardella, Vincenzo Dario Mandato, Mario Malzoni, Maria Grazia Matarazzo, Simone Ferrero, Gabriella Ferrandina, Anna Myriam Perrone, Chiara Borghi, Alice Bergamini, Bogani, G., DI DONATO, V., Sopracordevole, F., Ciavattini, A., Ghelardi, A., Lopez, S., Simoncini, T., Plotti, F., Casarin, J., Serati, M., Pinelli, C., Valenti, G., Bergamini, A., Gardella, B., Dell'Acqua, A., Monti, E., Vercellini, P., Fischetti, M., D'Ippolito, G., Aguzzoli, L., Mandato, V. D., Carunchio, P., Carlinfante, G., Giannella, L., Scaffa, C., Falcone, F., Borghi, C., Ditto, A., Malzoni, M., Giannini, A., Salerno, M. G., Liberale, V., Contino, B., Donfrancesco, C., Desiato, M., Perrone, A. M., Dondi, G., De IACO, P., LEONE ROBERTI MAGGIORE, U., Signorelli, M., Chiappa, V., Ferrero, S., Sarpietro, G., Matarazzo, M. G., Cianci, A., Bosio, S., Ruisi, S., Guerrisi, R., Brusadelli, C., Mosca, L., Tinelli, R., DE VINCENZO, R., Zannoni, G. F., Ferrandina, G., Petrillo, M., Dessole, S., Angioli, R., Greggi, S., Spinillo, A., Ghezzi, F., Colacurci, N., Muzii, L., BENEDETTI PANICI, P., Scambia, G., Raspagliesi, F., BOGANI G., DI DONATO V., SOPRACORDEVOLE F., CIAVATTINI A., GHELARDI A., LOPEZ S., SIMONCINI T., PLOTTI F., CASARIN J., SERATI M., PINELLI C., VALENTI G., BERGAMINI A., GARDELLA B., DELL'ACQUA A., MONTI E., VERCELLINI P., FISCHETTI M., D'IPPOLITO G., AGUZZOLI L., MANDATO V.D., CARUNCHIO P., CARLINFANTE G., GIANNELLA L., SCAFFA C., FALCONE F., BORGHI C., DITTO A., MALZONI M., GIANNINI A., SALERNO M.G., LIBERALE V., CONTINO B., DONFRANCESCO C., DESIATO M., PERRONE A.M., DONDI G., De IACO P., LEONE ROBERTI MAGGIORE U., SIGNORELLI M., CHIAPPA V., FERRERO S., SARPIETRO G., MATARAZZO M.G., CIANCI A., BOSIO S., RUISI S., GUERRISI R., BRUSADELLI C., MOSCA L., TINELLI R., DE VINCENZO R., ZANNONI G.F., FERRANDINA G., PETRILLO M., DESSOLE S., ANGIOLI R., GREGGI S., SPINILLO A., GHEZZI F., COLACURCI N., MUZII L., BENEDETTI PANICI P., SCAMBIA G., and RASPAGLIESI F.

Subjects
0301 basic medicine, Uterine Cervical Neoplasm, Neoplasm, Residual, Conization, Uterine Cervical Neoplasms, Cervix Uteri, Laser conization, Hpv persistence, Cervical dysplasia, 0302 clinical medicine, Risk Factors, Retrospective Studie, Aged, 80 and over, Medical record, Obstetrics and Gynecology, Margins of Excision, Middle Aged, Oncology, 030220 oncology & carcinogenesis, HPV, LEEP, Female, Human, Adult, medicine.medical_specialty, 5 year follow up, Adolescent, Electrosurgery, Laser, Follow-Up Studie, 03 medical and health sciences, Young Adult, medicine, Humans, In patient, Cervical Intraepithelial Neoplasia, Papillomavirus Infection, Retrospective Studies, Aged, business.industry, Lasers, Risk Factor, Papillomavirus Infections, Uterine Cervical Dysplasia, medicine.disease, Surgery, Settore MED/40 - GINECOLOGIA E OSTETRICIA, 030104 developmental biology, Uterine cervix, Increased risk, Dysplasia, Loop electrosurgical excision procedure, Neoplasm Grading, Neoplasm Recurrence, Local, business, Follow-Up Studies
Abstract

Objective: Conization aims to remove pre-neoplastic lesions of the uterine cervix. Several techniques for conization have been compared, but evidence regarding the most effective therapeutic option is scant. Here, we aimed to compare the recurrence rate following laser conization and loop electrosurgical excision procedure (LEEP) in patients with high-grade cervical dysplasia (HSIL/CIN2+). Methods: This is a retrospective multi-institutional study. Medical records of consecutive patients with HSIL/CIN2+ undergoing conization between 2010 and 2014 were retrieved. A propensity-score matching (PSM) was applied in order to reduce allocation bias. The risk of developing recurrence was estimated using Kaplan-Meir and Cox hazard models. Results: Overall, 2966 patients had conization over the study period, including 567 (20%) and 2399 (80%) patients having laser conization and LEEP, respectively. Looking at predictors of recurrence, diagnosis of CIN3 (HR:3.80 (95%CI:2.01,7.21); p < 0.001) and HPV persistence (HR:1.81 (95%CI:1.11,2.96); p < 0.001) correlated with an increased risk of recurrence. After applying a PSM we selected 500 patients undergoing laser conization and 1000 undergoing LEEP. Patients undergoing LEEP were at higher risk of having positive surgical margins in comparison to patients undergoing laser conization (11.2% vs. 4.2%). The risk of having persistence of HPV was similar between the two groups (15.0% vs. 11.6%;p = 0.256). Five-year recurrence rate was 8.1% and 4% after LEEP and laser conization, respectively (p = 0.023). HPV persistence was the only factor associated with [5-]year recurrence after both laser conization (p = 0.003) and LEEP (p = 0.001). Conclusions: HPV persistence is the only factor associated with an increased risk of recurrence after either laser conization or LEEP. Owing to the lack of data regarding obstetrical outcomes, we are not able to assess the best therapeutic option for women with cervical dysplasia.

Published
2020

9. Assessing the role of minimally invasive radical hysterectomy for early-stage cervical cancer

Author

Giorgio Bogani, Violante Di Donato, Ludovico Muzii, Jvan Casarin, Fabio Ghezzi, Mario Malzoni, Stefano Greggi, Fabio Landoni, Luca Bazzurini, Vanna Zanagnolo, Francesco Multinu, Roberto Angioli, Francesco Plotti, Giuseppe Caruso, Margherita Fischetti, Gabriella Ferrandina, Innocenza Palaia, Pierluigi Benedetti Panici, Giovanni Scambia, Francesco Raspagliesi, Bogani, G, Di Donato, V, Muzii, L, Casarin, J, Ghezzi, F, Malzoni, M, Greggi, S, Landoni, F, Bazzurini, L, Zanagnolo, V, Multinu, F, Angioli, R, Plotti, F, Caruso, G, Fischetti, M, Ferrandina, G, Palaia, I, Benedetti Panici, P, Scambia, G, and Raspagliesi, F

Subjects
Uterine Cervical Neoplasms, Obstetrics and Gynecology, Hysterectomy, Robotic, Settore MED/40 - GINECOLOGIA E OSTETRICIA, Reproductive Medicine, Cervical cancer, Humans, Minimally Invasive Surgical Procedures, Radical hysterectomy, Female, Laparoscopy, Neoplasm Staging, Retrospective Studies
Abstract

Surgery is the mainstay of treatment in the management of early-stage cervical cancer. Until the publication of the Laparoscopic Approach to Cervical Cancer (LACC) trial, minimally invasive radical hysterectomy was the recommended approach to treat patients with early-stage disease. The results of the LACC trial questioned the adoption of minimally invasive surgery in cervical cancer. In comparison with the open approach, minimally invasive surgery correlated with worse disease-free and cancer-specific survival. Similarly, other retrospective studies highlighted this correlation, thus corroborating the results of the LACC trials. In the present review, we evaluated current evidence and further prospective of the adoption of minimally invasive radical hysterectomy in cervical cancer. Moreover, we sought to assess some unsolved issues regarding the role of minimally invasive surgery in early-stage cervical cancer patients.

Published
2022

10. Evaluating long-term outcomes of three approaches to retroperitoneal staging in endometrial cancer

Author

Giorgio Bogani, Violante Di Donato, Andrea Papadia, Alessandro Buda, Jvan Casarin, Francesco Multinu, Francesco Plotti, Ilaria Cuccu, Tullio Golia D'Auge, Maria Luisa Gasparri, Ciro Pinelli, Anna Myriam Perrone, Fabio Barra, Flavia Sorbi, Antonella Cromi, Giampaolo Di Martino, Innocenza Palaia, Giorgia Perniola, Simone Ferrero, Pierandrea De Iaco, Chiara Perrone, Roberto Angioli, Daniela Luvero, Ludovico Muzii, Fabio Ghezzi, Fabio Landoni, Michael D. Mueller, Pierluigi Benedetti Panici, Francesco Raspagliesi, Bogani, G, Di Donato, V, Papadia, A, Buda, A, Casarin, J, Multinu, F, Plotti, F, Cuccu, I, D'Auge, T, Gasparri, M, Pinelli, C, Perrone, A, Barra, F, Sorbi, F, Cromi, A, Di Martino, G, Palaia, I, Perniola, G, Ferrero, S, De Iaco, P, Perrone, C, Angioli, R, Luvero, D, Muzii, L, Ghezzi, F, Landoni, F, Mueller, M, Benedetti Panici, P, and Raspagliesi, F

Subjects
Sentinel node mapping, Staging surgery, Sentinel Lymph Node Biopsy, Obstetrics and Gynecology, Lymphadenectomy, Endometrial Neoplasms, Oncology, Endometrial cancer, Humans, Lymph Node Excision, Laparoscopy, Female, Lymph Nodes, 610 Medicine & health, Neoplasm Staging, Retrospective Studies
Abstract

OBJECTIVE Sentinel lymph node mapping (SNM) has gained popularity in managing apparent early-stage endometrial cancer (EC). Here, we evaluated the long-term survival of three different approaches of nodal assessment. METHODS This is a multi-institutional retrospective study evaluating long-term outcomes of EC patients having nodal assessment between 01/01/2006 and 12/31/2016. In order to reduce possible confounding factors, we applied a propensity-matched algorithm. RESULTS Overall, 940 patients meeting inclusion criteria were included in the study, of which 174 (18.5%), 187 (19.9%), and 579 (61.6%) underwent SNM, SNM followed by backup lymphadenectomy (LND) and LND alone, respectively. Applying a propensity score matching algorithm (1:1:2) we selected 500 patients, including 125 SNM, 125 SNM/backup LND, and 250 LND. Baseline characteristics of the study population were similar between groups. The prevalence of nodal disease was 14%, 16%, and 12% in patients having SNM, SNM/backup LND and LND, respectively. Overall, 19 (7.6%) patients were diagnosed with low volume nodal disease. The survival analysis comparing the three techniques did not show statistical differences in terms of disease-free (p = 0.750) and overall survival (p = 0.899). Similarly, the type of nodal assessment did not impact survival outcomes after stratification based on uterine risk factors. CONCLUSION Our study highlighted that SNM provides similar long-term oncologic outcomes than LND.

Published
2022

11. Practice patterns and 90-day treatment-related morbidity in early-stage cervical cancer

Author

Giorgio Bogani, Violante Di Donato, Giovanni Scambia, Fabio Landoni, Fabio Ghezzi, Ludovico Muzii, Pierluigi Benedetti Panici, Francesco Raspagliesi, Jvan Casarin, Giampaolo Di Martino, Tommaso Grassi, Anna Myriam Perrone, Pierandrea De Iaco, Francesco Multinu, Roberto Berretta, Vito A. Capozzi, Errico Zupi, Gabriele Centini, Antonio Pellegrino, Silvia Corso, Guido Stevenazzi, Anna Chiara Boschi, Giuseppe Comerci, Pantaleo Greco, Gennaro Scutiero, Francesco Sopracordevole, Giorgio Giorda, Mariasole Fichera, Tommaso Simoncini, Marta Caretto, Enrico Sartori, Federico Ferrari, Antonio Cianci, Giuseppe Sarpietro, Maria Grazia Matarazzo, Pierluigi Giampaolino, Giuseppe Bifulco, Michele Morelli, Michele Di Dio, Annamaria Ferrero, Nicoletta Biglia, Fabio Barra, Simone Ferrero, Stefano Cianci, Vito Chiantera, Giulio Sozzi, Alfredo Ercoli, Sergio Schettini, Teresa Orlando, Francesco G. Cannone, Giuseppe Ettore, Andrea Puppo, Elena Olearo, Umberto Leone Roberti Maggiore, Valeria Artuso, Innocenza Palaia, Giorgia Perniola, Rossana Tripodi, Tullio Golia D'Augè, Ilaria Cuccu, Margherita Fischetti, Giusi Santangelo, Assunta Casorelli, Andrea Giannini, Ottavia D’Oria, Giuseppe Vizzielli, Stefano Restaino, Alice Bergamini, Luca Bocciolone, Francesco Plotti, Roberto Angioli, Giulia Mantovani, Marcello Ceccaroni, Chiara Cassini, Mattia Dominoni, Laura Giambanco, Silvia Amodeo, Livio Leo, Raphaël Thommaset, Diego Raimondo, Renato Seracchioli, Mario Malzoni, Francesca Falcone, Franco Gorlero, Martina Di Luca, Enrico Busato, Sami Kilzie, Andrea Dell'Acqua, Giovanna Scarfone, Paolo Vercellini, Marco Petrillo, Giampiero Capobianco, Andrea Ciavattini, Liliana Mereu, Paolo Scollo, Flavia Sorbi, Massimiliano Fambrini, Federico Romano, Giuseppe Ricci, Giuseppe Trojano, Gianluca Raffaello Damiani, Roberto Consonni, Nadia Di Lorenzo, Antonio Lippolis, Raffaele Tinelli, Lorenzo Aguzzoli, Vincenzo D. Mandato, Stefano Palomba, Marcello Tripodi, Davide Calandra, Franco Pellegrini, Fulvio Zullo, Daniela Surico, Valentino Remorgida, Francesco Ruscitto, Paolo Beretta, Enrico Vizza, Bogani, Giorgio, Donato, Violante Di, Scambia, Giovanni, Landoni, Fabio, Ghezzi, Fabio, Muzii, Ludovico, Panici, Pierluigi Benedetti, Raspagliesi, Francesco, Giampaolino, Pierluigi, Bogani, G, Donato, V, Scambia, G, Landoni, F, Ghezzi, F, Muzii, L, Panici, P, Raspagliesi, F, Casarin, J, Di Martino, G, Grassi, T, Perrone, A, De Iaco, P, Multinu, F, Berretta, R, Capozzi, V, Zupi, E, Centini, G, Pellegrino, A, Corso, S, Stevenazzi, G, Boschi, A, Comerci, G, Greco, P, Scutiero, G, Sopracordevole, F, Giorda, G, Fichera, M, Simoncini, T, Caretto, M, Sartori, E, Ferrari, F, Cianci, A, Sarpietro, G, Matarazzo, M, Giampaolino, P, Bifulco, G, Morelli, M, Dio, M, Ferrero, A, Biglia, N, Barra, F, Ferrero, S, Cianci, S, Chiantera, V, Sozzi, G, Ercoli, A, Schettini, S, Orlando, T, Cannone, F, Ettore, G, Puppo, A, Olearo, E, Leone Roberti Maggiore, U, Artuso, V, Palaia, I, Perniola, G, Tripodi, R, D'Auge, T, Cuccu, I, Fischetti, M, Santangelo, G, Casorelli, A, Giannini, A, D'Oria, O, Vizzielli, G, Restaino, S, Bergamini, A, Bocciolone, L, Plotti, F, Angioli, R, Mantovani, G, Ceccaroni, M, Cassini, C, Dominoni, M, Giambanco, L, Amodeo, S, Leo, L, Thommaset, R, Raimondo, D, Seracchioli, R, Malzoni, M, Falcone, F, Gorlero, F, Di Luca, M, Busato, E, Kilzie, S, Dell'Acqua, A, Scarfone, G, Vercellini, P, Petrillo, M, Capobianco, G, Ciavattini, A, Mereu, L, Scollo, P, Sorbi, F, Fambrini, M, Romano, F, Ricci, G, Trojano, G, Damiani, G, Consonni, R, Di Lorenzo, N, Lippolis, A, Tinelli, R, Aguzzoli, L, Mandato, V, Palomba, S, Tripodi, M, Calandra, D, Pellegrini, F, Zullo, F, Surico, D, Remorgida, V, Ruscitto, F, Beretta, P, Vizza, E, Casarin, Jvan, Di Martino, Giampaolo, Grassi, Tommaso, Perrone, Anna Myriam, De Iaco, Pierandrea, Multinu, Francesco, Berretta, Roberto, Capozzi, Vito A., Zupi, Errico, Centini, Gabriele, Pellegrino, Antonio, Corso, Silvia, Stevenazzi, Guido, Boschi, Anna Chiara, Comerci, Giuseppe, Greco, Pantaleo, Scutiero, Gennaro, Sopracordevole, Francesco, Giorda, Giorgio, Fichera, Mariasole, Simoncini, Tommaso, Caretto, Marta, Sartori, Enrico, Ferrari, Federico, Cianci, Antonio, Sarpietro, Giuseppe, Matarazzo, Maria Grazia, Bifulco, Giuseppe, Morelli, Michele, Dio, Michele Di, Ferrero, Annamaria, Biglia, Nicoletta, Barra, Fabio, Ferrero, Simone, Cianci, Stefanoa, Chiantera, Vitoa, Ercoli, Alfredo, Schettini, Sergio, Orlando, Teresa, Cannone, Francesco G., Ettore, Giuseppe, Puppo, Andrea, Olearo, Elena, Maggiore, Umberto Leone Roberti, Artuso, Valeria, Palaia, Innocenza, Perniola, Giorgia, Tripodi, Rosanna, D'Augè, Tullio Golia, Cuccu, Ilaria, Fischetti, Margherita, Santangelo, Giusi, Casorelli, Assunta, Giannini, Andrea, D’Oria, Ottvaio, Vizzielli, Giuseppe, Restaino, Stefano, Bergamini, Alice, Bocciolone, Luca, Plotti, Francesco, Angioli, Roberto, Mantovani, Giulia, Ceccaroni, Marcello, Cassini, Chiara, Dominoni, Mattia, Giambanco, Laura, Amodeo, Silvia, Leo, Livio, Thommaset, Raphaël, Raimondo, Diego, Seracchioli, Renato, Malzoni, Mario, Falcone, Francesca, Gorlero, Franco, Di Luca, Martina, Busato, Enrico, Kilzie, Sami, Dell'Acqua, Andrea, Scarfone, Giovanna, Vercellini, Paolo, Petrillo, Marco, Capobianco, Giampiero, Ciavattini, Andrea, Mereu, Liliana, Scollo, Paolo, Sorbi, Flavia, Fambrini, Massimiliano, Romano, Federico, Ricci, Giuseppe, Trojano, Giuseppe, Damiani, Gianluca Raffaello, Consonni, Roberto, Di Lorenzo, Nadia, Lippolis, Antonio, Tinelli, Raffaele, Aguzzoli, Lorenzo, Mandato, Vincenzo D., Palomba, Stefano, Tripodi, Marcello, Calandra, Davide, Pellegrini, Franco, Zullo, Fulvio, Surico, Daniela, Remorgida, Valentino, Ruscitto, Francesco, Beretta, Paolo, and Vizza, Enrico.

Subjects
Complications, Obstetrics and Gynecology, Uterine Cervical Neoplasms, Hysterectomy, Settore MED/40 - GINECOLOGIA E OSTETRICIA, Oncology, Retrospective Studie, Laparoscopy, Morbidity, Radical hysterectomy, Female, Humans, Neoplasm Staging, Retrospective Studies, Complication, Human
Abstract

Background. To evaluate the impact of the Laparoscopic Approach to Cervical Cancer (LACC) Trial on patterns of care and surgery-related morbidity in early-stage cervical cancer. Methods. This is a retrospective, a multi-institutional study evaluating 90-day surgery-related outcomes of patients undergoing treatment for early-stage cervical cancer before (period I: 01/01/2016-06/01/2018) and after (period II: 01/01/2019-06/01/2021) the publication of the results of the LACC trial. Results. Charts of 1295 patients were evaluated: 581 (44.9%) and 714 (55.1%) before and after the publication of the LACC trial, respectively. After the publication of the LACC trial, the number of patients treated with minimally invasive radical hysterectomy decreased from 64.9% to 30.4% (p < 0.001). Overall, 90-day complications occurred in 110 (18.9%) and 119 (16.6%) patients in the period I and period II, respectively (p = 0.795). Similarly, the number of severe (grade 3 or worse) complications did not differ between the two periods (38 (6.5%) vs. 37 (5.1%); p = 0.297). Overall and severe 90-day complications were consistent between periods even evaluating stage IA (p = 0.471), IB1 (p = 0.929), and IB2 (p = 0.074), separately. Conclusions. The present investigation highlighted that in referral centers the shift from minimally invasive to open radical hysterectomy does not influence 90-day surgery-related morbidity. (c) 2022 Elsevier Inc. All rights reserved.

Published
2022

12. Efficacy of fractional CO2 laser treatment in postmenopausal women with genitourinary syndrome: a multicenter study

Author

Massimo Candiani, Francesco Plotti, Roberto Angioli, Daniela Luvero, Maurizio Filippini, Stefano Salvatore, Roberto Montera, Annalisa Pieralli, Filippini, M., Luvero, D., Salvatore, S., Pieralli, A., Montera, R., Plotti, F., Candiani, M., and Angioli, R.

Subjects
medicine.medical_specialty, General Mathematics, Vaginal Diseases, Genitourinary syndrome of menopause, 030209 endocrinology & metabolism, Vulva, 03 medical and health sciences, 0302 clinical medicine, Atrophy, Vaginal laser therapy, medicine, Humans, Vaginal atrophy, Aged, Retrospective Studies, 030219 obstetrics & reproductive medicine, Postmenopausal women, Co2 laser, business.industry, Genitourinary system, Obstetrics, Applied Mathematics, Reproducibility of Results, Obstetrics and Gynecology, Retrospective cohort study, Middle Aged, medicine.disease, laser, Postmenopause, CO, Menopause, Treatment Outcome, Multicenter study, Vagina, Lasers, Gas, Itching, Female, Laser Therapy, Vulvar Diseases, medicine.symptom, business, Postmenopausal symptom, Follow-Up Studies
Abstract

OBJECTIVE Genitourinary syndrome of menopause (GSM), especially vulvovaginal atrophy (VVA), is one of the most common conditions among women in either natural (4%-47%) or medically induced (23.4%-61.5%) menopause. The aims of this study are to assess the efficacy and effectiveness of CO2 laser in postmenopausal women with clinical signs and symptoms of GSM, in particular VVA, and to evaluate both possible early and late side effects related to this kind of treatment. METHODS This retrospective, multicenter study was conducted after collecting data from a pre-existing database. We performed three to four CO2 laser treatments on all the women enrolled in this protocol. We used a fractional CO2 laser system (SmartXide VLR, Deka m.e.l.a., Florence, Italy) with a VulvoVaginal Laser Reshaping (VLR) scanning system and appropriate handpieces for the vaginal area. All women before and after the treatment were assessed. The pre- and post-treatment averages of the symptoms, the standard deviation, and the P values were calculated. RESULTS Six hundred forty-five women who met the inclusion criteria were considered. In all the parameters examined (dyspareunia, vaginal orifice pain, dryness/atrophy, itching, burning, pH) statistically significant data were found between the pretreatment and the post-treatment (dryness: before = 8.30, after = 2.97 [P

Published
2019

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