1. Ocular Graft-versus-Host Disease in a Chemotherapy-Based Minor-Mismatch Mouse Model Features Corneal (Lymph-) Angiogenesis
- Author
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Michael E. Stern, Philipp Steven, Gwen Musial, Katarina Riesner, Daniela Stary, Uta Gehlsen, Martina Maass, and Olaf Penack
- Subjects
Pathology ,genetic structures ,Angiogenesis ,medicine.medical_treatment ,Graft vs Host Disease ,Disease ,Hematopoietic stem cell transplantation ,chemotherapy ,Pathogenesis ,Cornea ,Mice ,0302 clinical medicine ,pre-clinical model ,Biology (General) ,Spectroscopy ,ocular graft-versus-host-disease ,Hematopoietic Stem Cell Transplantation ,Lacrimal Apparatus ,General Medicine ,Computer Science Applications ,Lymphangiogenesis ,lymphangiogenesis ,Chemistry ,030220 oncology & carcinogenesis ,Female ,medicine.symptom ,medicine.medical_specialty ,QH301-705.5 ,Inflammation ,Antineoplastic Agents ,Article ,Catalysis ,Inorganic Chemistry ,03 medical and health sciences ,medicine ,Animals ,oGVHD ,Physical and Theoretical Chemistry ,Blepharitis ,QD1-999 ,Molecular Biology ,business.industry ,Organic Chemistry ,medicine.disease ,eye diseases ,Mice, Inbred C57BL ,Disease Models, Animal ,Graft-versus-host disease ,030221 ophthalmology & optometry ,blepharitis ,business - Abstract
Ocular graft-versus-host disease (oGVHD) is a fast progressing, autoimmunological disease following hematopoietic stem cell transplantation, leading to severe inflammation of the eye and destruction of the lacrimal functional unit with consecutive sight-threatening consequences. The therapeutic “window of opportunity” is narrow, and current treatment options are limited and often insufficient. To achieve new insights into the pathogenesis and to develop new therapeutic approaches, clinically relevant models of oGVHD are desirable. In this study, the ocular phenotype was described in a murine, chemotherapy-based, minor-mismatch GVHD model mimicking early-onset chronic oGVHD, with corneal epitheliopathy, inflammation of the lacrimal glands, and blepharitis. Additionally, corneal lymphangiogenesis was observed as part of oGVHD pathogenesis for the first time, thus opening up the investigation of lymphangiogenesis as a potential therapeutic and diagnostic tool.
- Published
- 2021
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