Search

Learning from others allows young children to acquire vast amounts of information quickly, but doing so effectively also requires epistemic vigilance. Although preschool-age children have some capacity to engage in such processes, they often have trouble resisting information from misleading informants. The present research takes a novel

Background: Breast cancer is more likely to metastasize to the bone. Previous researches have revealed that the vitamin D receptor (VDR) contributes to breast cancer progression and bone metastasis in mouse and human breast cells, and hairless (Hr) protein interacts with VDR in the mammalian hair cycle. This study aimed to explore the expression of VDR/Hr in breast cancer, and the correlation between VDR/Hr and prognosis, bone metastasis, and metastasis-related prognosis. Methods: The expression of VDR and Hr was analyzed on 119 breast cancer tissues and corresponding normal breast tissue from each of the breast cancer samples by immunohistochemistry staining, and the databases were supplemented as well. Results: The expression of the VDR protein was significantly decreased in breast cancer patients (p < 0.05), inversely, the UALCAN (p = 0.000) and GEPIA (p > 0.05) databases showed that the VDR mRNA expression tended to be higher in tumor tissues. The Hr protein was expressed at a low level within breast cancer specimens (p < 0.05), which was in agreement with the level of Hr mRNA in UALCAN (p = 0.005) and GEPIA (p > 0.05). The protein levels of VDR and Hr were positively correlated (p > 0.05), while the mRNA levels suggested a close relationship with GEPIA (p < 0.05). Low expression of Hr protein displayed a tendency for longer overall survival (OS) and recurrence-free survival (RFS), and its mRNA data also revealed the same trend in the Kaplan-Meier dataset (both p > 0.05). However, VDR protein and mRNA with low expression had markedly shorter OS and RFS (both p < 0.05). The downregulation of VDR protein was significantly associated with an advanced stage (p < 0.05). Low VDR protein was an independent risk factor for poor prognosis (p < 0.05) and was negatively correlated with bone metastasis (p < 0.05). VDR protein and mRNA levels were both downregulated in breast cancer with bone metastasis (both p < 0.05). The area under ROC curve (AUC) for VDR protein expression to identify patients with bone metastasis was 0.661 (p < 0.05) and the AUC for VDR level to predict 1-year, 3-year, and 5-year OS was 0.621, 0.664, and 0.805 in patients with bone metastasis, respectively (p < 0.05). VDR with low expression accelerated bone metastasis and metastasis-related poor survival (both p < 0.05). Conclusion: VDR expression is a notable prognostic factor in primary breast cancer patients for predicting bone metastases and unfavorable clinical outcome.

ObjectiveStudies on the association between sleep behavior and health often ignored the confounding effects of biorhythm-related factors. This study aims to explore the independent and joint effects of sleep duration and sleep quality on suboptimal self-rated health (SRH) in medical students.MethodsCross-sectional study. Proportional stratified cluster sampling was used to randomly recruit students from various medical specialties at a medical university in eastern China. Our questionnaire mainly included information on basic demographic characteristics, SRH, sleep behavior, and biorhythm-related factors. The independent and joint effects of sleep duration and sleep quality on suboptimal SRH were assessed by logistic regression after controlling for potential confounders.ResultsOf 1,524 medical students (mean age = 19.9 years, SD = 1.2 years; 59.1% female), 652 (42.8%) had suboptimal SRH. Most medical students (51.5%) slept for 7 h/night, followed by ≥8 (29.1%) and ≤ 6 h (19.4%). After adjusting for basic demographic characteristics and biorhythm-related factors, compared with students who slept for ≥8 h/night, the adjusted ORs (95%CI) for those who slept 7 and ≤ 6 h/night were 1.36 (1.03, 1.81) and 2.28 (1.60, 3.26), respectively (P < 0.001 for trend); compared with those who had good sleep quality, the adjusted ORs (95%CI) for those who had fair and poor sleep quality were 4.12 (3.11, 5.45) and 11.60 (6.57, 20.46), respectively (P < 0.001 for trend). Further, compared with those who slept for ≥8 h/night and good sleep quality, those who slept ≤ 6 h and poor sleep quality had the highest odds of suboptimal SRH (OR 24.25, 95%CI 8.73, 67.34).ConclusionsShort sleep and poor sleep quality were independently and jointly associated with higher odds of suboptimal SRH among medical students.

In this meta-analysis, the association between endometrial thickness (EMT) and cycle outcomes after IVF is explored. Associations between EMT and cycle outcomes according to study and individual characteristics were also assessed.Studies evaluating associations between EMT and pregnancy, implantation, miscarriage, live birth or ongoing pregnancy and ectopic pregnancy rates in individuals after IVF were identified on PubMed, Embase and the Cochrane Library (from their inception up to December 2018). Pooled odds ratios with 95% confidence intervals, calculated using the random-effects model, were used.Nine prospective and 21 retrospective studies, including a total of 88,056 cycles, were retrieved. The summary odds ratios indicated that women with lower EMT were associated with lower pregnancy rates than those with higher EMT (n = 30, OR 0.61; 95% CI 0.52 to 0.70; P0.001). Moreover, the implantation rate in women with lower EMT was significantly reduced (n = 9, OR 0.49; 95% CI 0.32 to 0.74; P = 0.001). Furthermore, no significant association was found between EMT and the miscarriage rate (n = 12). In addition, women with lower EMT were associated with reduced live birth or ongoing pregnancy rate (11 studies, OR 0.60; 95% CI 0.48 to 0.73; P0.001). Finally, the incidence of ectopic pregnancy rate between lower and higher EMT showed no statistically significant association (n = 3).Lower EMT was associated with lower pregnancy, implantation and live birth or ongoing pregnancy rates.

Early on, young children begin to learn the social skills which will help them navigate through an increasingly complex social world. We explored how deceiving for personal gain potentially interacts with sharing the resulting resources and how they both relate to theory of mind (ToM) and inhibitory control in 3- to 5-year-old children (N = 92, 43 girls). Children played a hide-and-seek zero-sum game in which they could win stickers if they discovered how to deceive the experimenter. Then they were prompted to share their stickers in a dictator game paradigm. Using a microgenetic design, we tracked deceptive behavior across ten sessions and sharing behavior across five of these sessions, plus a follow-up session 15 months later. Children polarized into a group who never deceived across all sessions, and a group who constantly deceived above chance levels (around 85 % of the time). Sharing behavior was extremely low (under 6 % of stickers) across the sessions. At follow-up, deceptive behavior was above 80 %, while sharing remained at a low level (under 5 %). The novelty of our findings was that children who initially discovered how to deceive shared less than the children who didn't use this deceptive strategy. Nonetheless, this pattern was reversed at follow-up. Furthermore, ToM positively predicted deceptive behavior across all sessions and improved after the microgenetic sessions but wasn't related with deception at follow-up. Implications for enabling children to deploy the growing understanding of their worlds in a more prosocial way are discussed.

The present study examined the role of executive function in lying for children with autism spectrum disorder (ASD). The temptation resistance paradigm was used to elicit children's self-protective lies and the Hide-and-seek task was used to elicit children's self-benefiting lies. Results showed that children with ASD told fewer lies in the two deception tasks compared to children with intellectual disability (ID) and typically developing (TD) children. Furthermore, children with ASD's lying were positively correlated with their working memory, but not with their theory of mind. These findings demonstrate that the mechanisms underlying deception for children with ASD are distinct from that of TD children.

Recent evolutionary, cultural, and economic theories have postulated strong connections between human sociality and complex cognition. One prediction derived from this work is that deception should confer cognitive benefits on children. The current research tests this possibility by examining whether learning to deceive during early childhood promotes more advanced theory of mind and executive function skills during a time when these skills are undergoing rapid development. A total of 42 children (Mage = 40.45 months; 22 boys and 20 girls) who showed no initial ability to deceive were randomly assigned to an experimental condition or a control condition. In both conditions, they played a hide-and-seek game against an adult opponent on 4 consecutive days, but only the children in the experimental condition were taught how to deceive the opponent in order to win the game. Unlike children in the control condition, children in the experimental condition significantly improved their executive function and theory of mind skills, providing the first evidence that learning to deceive causally enhances cognitive skills in young children.

The current study investigated the development of second-order lying and its relation to theory of mind and executive function. Previous studies have examined only first-order lying, in which a child makes an untruthful statement to intentionally deceive an unsuspecting opponent. As opposed to first-order lying, second-order lying requires the use of both lies and truths to deceive an opponent because the opponent is fully aware of the liar’s deceptive intention. Here, we used a modified hide-and-seek task, in which children were asked to hide a coin in either one of their hands for opponents to find. In this task, the opponents did not consistently look for the coin in the location indicated by the children. Thus, children could not win the desirable reward if they only told lies to deceive; they needed to switch between telling lies and telling truths (i.e., second-order lies) to deceive opponents. The results showed that children could tell second-order lies by 4 years of age, and their ability to do so was significantly related only to the second-order ignorance scores (early second-order theory of mind understanding). The current findings suggest that second-order ignorance, but not second-order false belief understanding, contributes to children’s second-order lying.

Past research shows that parental mental state talk (MST) is closely associated with children’s theory-of-mind (ToM) understanding. The current study extends previous work by investigating whether parental MST is also associated with children’s ToM in action (i.e., lying). A total of 90 Singaporean 3- to 5-year-olds participated in this study with their parents. Parental MST was measured using a storytelling task with a wordless picture book. Mediation analysis revealed an indirect effect: Children’s ToM understanding served as a mediator in the path between parental MST and children’s lying, whereas there was no significant direct effect of parental MST on children’s lying. This study is the first to focus on the relation between parental MST and ToM in an applied setting. Our findings suggest that parental MST can help children to develop sociocognitive skills, which in turn can help children to gain the insight that lying may be used as a strategy for personal gain.

Objective To compare the clinical outcomes of intracytoplasmic sperm injection (ICSI) between spermatozoa retrieved from testicular biopsy and from ejaculate in cryptozoospermia patients. Materials and Methods The clinical data of 285 cryptozoospermia patients who underwent ICSI treatment in our center during the period from March 2009 to November 2013 were retrospectively analyzed. Within them, ejaculated sperms were used in 214 cases (group 1), and testicular sperms extracted by testicular sperm aspiration or conventional testis dissection sperm extraction were used in 71 cases (group 2). Good-quality embryo, fertilization, embryo implantation, pregnancy, and birth rates after ICSI were compared between the 2 groups. Results Comparing the ejaculated sperm group with the testicular sperm group, fertilization rates were 59.6% and 60.6%, good-quality embryo rates were 36.8% and 46.1%, embryo implantation rates were 30.7% and 52.1%, pregnancy rates were 33.3% and 53.6%, and birth rates were 27.1% and 44.6%, respectively. Conclusion Using testicular sperms can achieve higher rates of embryo implantation, pregnancy, and birth compared with those using ejaculated sperms for ICSI treatment in cryptozoospermia patients.

This study explored whether children's (N = 158; 4- to 9 years old) nonverbal facial expressions can be used to identify when children are being deceptive. Using a computer vision program to automatically decode children's facial expressions according to the Facial Action Coding System, this study employed machine learning to determine whether facial expressions can be used to discriminate between children who concealed breaking a toy(liars) and those who did not break a toy(nonliars). Results found that, regardless of age or history of maltreatment, children's facial expressions could accurately (73%) be distinguished between liars and nonliars. Two emotions, surprise and fear, were more strongly expressed by liars than nonliars. These findings provide evidence to support the use of automatically coded facial expressions to detect children's deception.

Background Accurate diagnosis of delirium is very important for prevention and treatment. Present study was designed to validate the 3-Minute Diagnostic Interview for CAM-defined Delirium Chinese version (3D-CAM-CN) in surgical ICU patients. Methods In this prospective diagnostic study, the 3D-CAM was translated into Chinese with culture adaption. Two interviewers (Roles A and B) independently administrated 3D-CAM-CN assessment in adult patients from postoperative days 1 to day 3. At the meantime, a panel of psychiatrists diagnosed delirium according to the Diagnostic and Statistical Manual of Mental Disorders-fifth edition as the reference standard. The sensitivity and specificity were calculated to analyze the diagnostic character of the 3D-CAM-CN. Kappa coefficient was used to evaluate interrater reliability. Results Two hundred forty-five adult patients were assessed for at least 2 days, resulting a total of 647 paired-assessments. When compared with the reference standard, the sensitivity and specificity of the 3D-CAM-CN assessment were 87.2 and 96.7%, respectively, by Role A and 84.6 and 97.4%, respectively, by Role B, with good interrater reliability (Kappa coefficient = 0.82, P Conclusion Our results showed that the 3D-CAM-CN can be used as a reliable and accurate instrument for delirium assessment in surgical patients. Trial registration This trail was approved by the Clinical Research Ethic Committee of Peking University First Hospital (No. 2017–1321) and registered on Chinese clinical trial registry on July 6, 2017 (ChiCTR-OOC-17011887).

Starting in early childhood, children are socialized to be honest. However, they are also expected to avoid telling the truth in sensitive situations if doing so could be seen as inappropriate or impolite. Across two studies (total N = 358), the reasoning of 3- to 5-year-old children in such a scenario was investigated by manipulating whether the information in question would be helpful to the recipient. The studies used a reverse rouge paradigm, in which a confederate with a highly salient red mark on her nose asked children whether she looked okay prior to having her picture taken. In Study 1, children tended to tell the truth only if they were able to observe that the mark was temporary and the confederate did not know it was there. In Study 2, children tended to tell the truth only if they were able to observe that the mark could be concealed with makeup. These findings show that for children as young as age 3, decisions about whether to tell the truth are influenced by the likelihood that the information would be helpful to the recipient.

Prior research has suggested that bilingual children demonstrate reduced social bias relative to their monolingual peers. In particular, they exhibit less implicit bias against racial outgroups. However, the cognitive determinants of racial bias in bilingual children remain unclear. In the current study, relationships between racial bias and three cognitive factors (inhibitory control, cognitive flexibility, and perspective-taking ability), along with language proficiency and parental education, were investigated in a sample of bilingual preschoolers (N = 55). Children were bilingual learners of English and Mandarin. Results demonstrated that implicit bias was predicted by cognitive flexibility, independent of variation in inhibitory control, second language vocabulary, perspective taking, and parental education. In contrast, explicit bias was predicted by parental education alone and not by cognitive or linguistic factors. Findings suggest that increased cognitive flexibility, often thought to be an outgrowth of bilingual experience, may also be associated with a reduction in implicit bias. Findings are discussed in terms of specific mechanisms that may link cognitive factors, bilingualism, and racial bias.

Several honesty promotion techniques have been established for children living in Western cultures; however, limited research has examined the effectiveness of these techniques among non-Western children. Recently, inducing self-awareness (by looking at oneself in a mirror) was found to be effective in promoting young Western children's honesty. The present investigation compared the effectiveness of this self-awareness technique to a novel other-awareness technique (looking at a photograph of a peer) in promoting young Chinese children's honesty. Chinese children aged 3 and 4 years (N = 121) completed a modified temptation resistance paradigm where they were requested not to peek at a toy in the experimenter's absence. Children were randomly assigned to a Self-Awareness, Peer (other-awareness), or Control condition. When asked whether they peeked at the toy, children in the Self-Awareness condition were significantly more likely to tell the truth compared to those in the Control condition. No significant differences in truth-telling emerged between the Peer and Control conditions. The present results demonstrate the cross-cultural application of self-awareness as an honesty promoting technique with young children. Statement of contribution What is already known on this subject? High rates of dishonesty persist across cultures. Social and cultural values can shape lie-telling behaviours. Inducing self-awareness promotes honesty in Western children. What does this study add? A tool for promoting honesty in non-Western cultures. Inducing self-awareness promotes honesty in Chinese children. Inducing other-awareness was not effective in promoting honesty in Chinese children.

Theory of mind (ToM) has long been recognized to play a major role in children’s social functioning. However, no direct evidence confirms the causal linkage between the two. In the current study, we addressed this significant gap by examining whether ToM causes the emergence of lying, an important social skill. We showed that after participating in ToM training to learn about mental-state concepts, 3-year-olds who originally had been unable to lie began to deceive consistently. This training effect lasted for more than a month. In contrast, 3-year-olds who participated in control training to learn about physical concepts were significantly less inclined to lie than the ToM-trained children. These findings provide the first experimental evidence supporting the causal role of ToM in the development of social competence in early childhood.

The present study examined how different brain regions interact with each other during spontaneous honest vs. dishonest communication. More specifically, we took a complex network approach based on the graph-theory to analyze neural response data when children are spontaneously engaged in honest or dishonest acts. Fifty-nine right-handed children between 7 and 12 years of age participated in the study. They lied or told the truth out of their own volition. We found that lying decreased both the global and local efficiencies of children’s functional neural network. This finding, for the first time, suggests that lying disrupts the efficiency of children’s cortical network functioning. Further, it suggests that the graph theory based network analysis is a viable approach to study the neural development of deception.

We investigated how the ability to deceive emerges in early childhood among a sample of young preschoolers (Mean age = 34.7 months). We did this via a 10-session microgenetic method that took place over a 10-day period. In each session, children played a zero-sum game against an adult to win treats. In the game, children hid the treats and had opportunities (10 trials) to win them by providing deceptive information about their whereabouts to the adult. Although children initially showed little or no ability to deceive, most spontaneously discovered deception and systematically used it to win the game by the tenth day. Both theory of mind and executive function skills were predictive of relatively faster patterns of discovery. These results are the first to provide evidence for the importance of cognitive skills and social experience in the discovery of deception over time in early childhood.

Elementary school children’s cheating behavior and its cognitive correlates were investigated using a guessing game. Children ( n = 95) between 8 and 12 years of age were asked to guess which side of the screen a coin would appear on and received rewards based on their self-reported accuracy. Children’s cheating behavior was measured by examining whether children failed to adhere to the game rules by falsely reporting their accuracy. Children’s theory-of-mind understanding and executive functioning skills were also assessed. The majority of children cheated during the guessing game, and cheating behavior decreased with age. Children with better working memory and inhibitory control were less likely to cheat. However, among the cheaters, those with greater cognitive flexibility use more tactics while cheating. Results revealed the unique role that executive functioning plays in children’s cheating behavior: Like a double-edged sword, executive functioning can inhibit children’s cheating behavior, on the one hand, while it can promote the sophistication of children’s cheating tactics, on the other.

The present study focused on the potential application of fNIRS in the detection of concealed information. Participants either committed a mock crime or not and then were presented with a randomized series of probes (crime-related information) and irrelevants (crime-irrelevant information) in a standard concealed information test (CIT). Participants in the guilty group were instructed to conceal crime-related information they obtained from the mock crime, thus making deceptive response to the probes. Meanwhile, their brain activity to probes and irrelevants was recorded by functional near-infrared spectroscopy (fNIRS). At the group level, we found that probe items were associated with longer reaction times and greater activity in bilateral dorsolateral prefrontal cortex and supplementary motor cortex than irrelevant items in the guilty group, but not in the innocent group. These findings provided evidence on neural correlates of recognition during a CIT. Finally, on the basis of the activity in bilateral dorsolateral prefrontal cortex and supplementary motor cortex, the correct classification of guilty versus innocent participants was approximately 75 % and the combination of fNIRS and reaction time measures yielded a better classification rate of 83.3 %. These findings illustrate the feasibility and promise of using fNIRS to detect concealed information.

The present study used the functional Near-infrared Spectroscopy (fNIRS) methodology to investigate the neural correlates of elementary school children's own- and other-race face processing. An old-new paradigm was used to assess children's recognition ability of own- and other-race faces. FNIRS data revealed that other-race faces elicited significantly greater [oxy-Hb] changes than own-race faces in the right middle frontal gyrus and inferior frontal gyrus regions (BA9) and the left cuneus (BA18). With increased age, the [oxy-Hb] activity differences between own- and other-race faces, or the neural other-race effect (NORE), underwent significant changes in these two cortical areas: at younger ages, the neural response to the other-race faces was modestly greater than that to the own-race faces, but with increased age, the neural response to the own-race faces became increasingly greater than that to the other-race faces. Moreover, these areas had strong regional functional connectivity with a swath of the cortical regions in terms of the neural other-race effect that also changed with increased age. We also found significant and positive correlations between the behavioral other-race effect (reaction time) and the neural other-race effect in the right middle frontal gyrus and inferior frontal gyrus regions (BA9). These results taken together suggest that children, like adults, devote different amounts of neural resources to processing own- and other-race faces, but the size and direction of the neural other-race effect and associated functional regional connectivity change with increased age.

Deception is commonly seen in everyday social interactions. However, most of the knowledge about the underlying neural mechanism of deception comes from studies where participants were instructed when and how to lie. To study spontaneous deception, we designed a guessing game modeled after Greene and Paxton (2009) "Proceedings of the National Academy of Sciences, 106(30), 12506-12511", in which lying is the only way to achieve the performance level needed to end the game. We recorded neural responses during the game using near-infrared spectroscopy (NIRS). We found that when compared to truth-telling, spontaneous deception, like instructed deception, engenders greater involvement of such prefrontal regions as the left superior frontal gyrus. We also found that the correct-truth trials produced greater neural activities in the left middle frontal gyrus and right superior frontal gyrus than the incorrect-truth trials, suggesting the involvement of the reward system. Furthermore, the present study confirmed the feasibility of using NIRS to study spontaneous deception.

The present study focused on neural correlates underlying second-order deception. In first-order deception, the recipient of deception is unaware of the deceiver's deceptive intention. However, during second-order deception, the recipient is fully aware of the deceiver's deceptive intention and thus the deceiver needs to use both lies and truths to deceive the recipient. Using the functional near-infrared spectroscopy (fNIRS) methodology and a naturalistic interactive game, we found that second-order deception elicited significantly greater [oxy-Hb] changes in the prefrontal cortex (the right superior frontal gyrus (SFG), BA6) than the non-deceptive control condition. This finding suggests that second-order deception, like first-order deception, engages specifically the cortical regions associated with the planning of complex actions and goal processing. We also found that lying to deceive produced greater neural activities in the right middle frontal gyrus than truth-telling to deceive. This suggests that although both actions serve deceptive purposes, making a false statement contradicting the true state of affairs still requires more executive control and thus greater neural responses in the cortical regions associated with this function. In addition, we found that the successful deception produced greater neural activities in a broad area of the prefrontal frontal cortex than failure to deceive, indicating the involvement of the cortical reward system during second-order deception. Further, failure of truth-telling to deceive produced greater neural responses in the right SFG than failure of lying to deceive. The present findings taken together suggest that second-order deception engages both the cortical executive and reward systems.

The neural basis of self and identity has received extensive research. However, most of these existing studies have focused on situations where the internal representation of the self is consistent with the external one. The present study used fMRI methodology to examine the neural correlates of two different types of identity conflict: identity faking and concealment. Participants were presented with a sequence of names and asked to either conceal their own identity or fake another one. The results revealed that the right insular cortex and bilaterally inferior frontal gyrus were more active for identity concealment compared to the control condition, whereas identity faking elicited a significantly larger percentage signal increase than the control condition in the right superior frontal gyrus, left calcarine, and right caudate. These results suggest that different neural systems associated with both identity processing and deception were involved in identity concealment and faking.