1. Plasma concentration of soluble intercellular adhesion molecule-1 in women with polycystic ovary syndrome
- Author
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Bogdan Marek, Dariusz Kajdaniuk, Wanda Foltyn, Zofia Ostrowska, Lucyna Siemińska, Beata Kos-Kudła, and M Nasiek
- Subjects
Adult ,Blood Glucose ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Intercellular Adhesion Molecule-1 ,Physiology ,Body Mass Index ,Endocrinology ,Internal medicine ,medicine ,Humans ,Insulin ,Testosterone ,Endothelial dysfunction ,Estradiol ,Dehydroepiandrosterone Sulfate ,business.industry ,Androstenedione ,Obstetrics and Gynecology ,Mean age ,Luteinizing Hormone ,Anthropometry ,medicine.disease ,Lipids ,Polycystic ovary ,Prolactin ,Solubility ,Plasma concentration ,Female ,Follicle Stimulating Hormone ,business ,Body mass index ,Polycystic Ovary Syndrome ,Hormone - Abstract
Soluble intercellular adhesion molecule-1 (sICAM-1) is ranked as one of the endothelial dysfunction markers and factors predicting diseases of the cardiovascular system. The main objective of this study was to assess the serum concentration of sICAM-1 in women with polycystic ovary syndrome (PCOS) and to verify correlations between serum sICAM-1 levels and selected anthropometric, metabolic and hormonal indices. The study assessed 57 women with PCOS (mean age 28.2 +/- 6.4 years). That group was further divided into two subgroups: the first with body mass index (BMI)or =25 kg/m2 (21 women of mean age 27.4 +/- 7.0 years) and the second with BMI25 kg/m2 (36 women of mean age 28.6 +/- 6.0 years). In the control group there were 22 healthy women (mean age of 31.6 +/- 8.5 years). That group again was divided accordingly to BMI into two subgroups: the first with BMI25 kg/m2 (ten women, mean age 30.2 +/- 8.4 years) and the second with BMI25 kg/m2 (12 women, mean age 31.7 +/- 8.7 years). The results demonstrated statistically significantly higher mean concentrations of sICAM-1 in women with PCOS as compared to healthy individuals from the whole control group and also from the control subgroup of women with BMI25 kg/m2. There was no statistically significant difference in sICAM-1 concentration between the PCOS group and the control subgroup with BMIor =25 kg/m2 In conclusion, higher concentrations of sICAM-1 in women with PCOS may confirm the presence of a higher risk for cardiovascular diseases in this group. Further studies are therefore necessary to identify both the factors that are responsible for the increase in sICAM-1 concentration and the clinical usefulness of routine sICAM-1 measurement in females with PCOS.
- Published
- 2004