1. Integrase Inhibitor Use Associated with Weight Gain in Women and Incident Diabetes Mellitus
- Author
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Archana Asundi, Alex Olson, Wenqing Jiang, Swati P. Varshney, Laura F. White, Manish Sagar, and Nina H. Lin
- Subjects
Male ,Immunology ,HIV Infections ,HIV Integrase ,Weight Gain ,Outcomes Research ,Infectious Diseases ,Diabetes Mellitus, Type 2 ,Virology ,Humans ,Female ,HIV Integrase Inhibitors ,Prospective Studies ,Retrospective Studies - Abstract
Excessive weight gain associated with integrase strand transfer inhibitor (InSTI) antiretrovirals is an emerging issue; however, the metabolic consequences of this effect have not been established. Our objective was to evaluate for InSTI-emergent weight gain and potential associated type 2 diabetes mellitus (T2DM) among a diverse HIV patient cohort. For this retrospective cohort study, we obtained clinical warehouse data for HIV+ patients between fiscal years 2007–17. We compared patients initiated on an InSTI with those started on an alternate regimen. Our primary outcome was percentage weight change from baseline to 24 months postinitiation using the linear mixed-effects model fit by restricted maximum likelihood. Our secondary outcome was incident T2DM as defined by a new prescription for antihyperglycemic medication within 18 months after antiretroviral therapy (ART) start. Diabetes-free survival was estimated using the Kaplan–Meier method, log-rank test, and Cox proportional-hazards model. The cohort included 1,235 individuals initiating ART, 136 (11.0%) with an InSTI. InSTI use in women was significantly associated with greater weight gain compared with non-InSTIs (11.0%, 95% confidence interval, CI: 5.22 to 16.8, p
- Published
- 2022